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Insulin resistance and other risk factors for atherosclerosis, such as hypertension and hypercholesterolemia, promote endothelial dysfunction and lead to development of metabolic syndrome which constitutes an introduction to cardiovascular disease. The insulin resistance and endothelial dysfunction cross talk between each other by numerous metabolic pathways. Hence, targeting one of these pathologies with pleiotropic treatment exerts beneficial effect on another one. Combined and expletive treatment of hypertension, lipid disorders, and insulin resistance with nonpharmacological interventions and conventional pharmacotherapy may inhibit the transformation of metabolic disturbances to fully developed cardiovascular disease. This paper summarises the common therapeutic targets for insulin resistance, endothelial dysfunction, and vascular inflammatory reaction at molecular level and analyses the potential pleiotropic effects of drugs used currently in management of cardiovascular disease, metabolic syndrome, and diabetes.

Despite long-term antiretroviral therapy (ART), HIV-1 persists within a reservoir of CD4+ T cells that contribute to viral rebound if treatment is interrupted. Identifying the cellular populations that contribute to the HIV-1 reservoir and understanding the mechanisms of viral persistence are necessary to achieve an effective cure. In this regard, through Full-Length Individual Proviral Sequencing, we observed that the HIV-1 proviral landscape was different and changed with time on ART across naive and memory CD4+ T cell subsets isolated from 24 participants. We found that the proportion of genetically intact HIV-1 proviruses was higher and persisted over time in effector memory CD4+ T cells when compared with naive, central, and transitional memory CD4+ T cells. Interestingly, we found that escape mutations remained stable over time within effector memory T cells during therapy. Finally, we provided evidence that Nef plays a role in the persistence of genetically intact HIV-1. These findings posit effector memory T cells as a key component of the HIV-1 reservoir and suggest Nef as an attractive therapeutic target.

The Politics of State Feminismaddresses essential questions of women's movement activism and political change in western democracies. The authors-top gender and politics scholars-provide a comparative analysis of the effectiveness of government agencies and women's movements regarding women's policy issues-if, how, and why they form a kind of state feminism. The central research questions are examined across five issue areas in thirteen postindustrial democracies in Europe and North America from the 1960s through the early 2000s. The authors explore a range of topics drawn from contemporary theory, interactions between descriptive and substantive representation, and the place of institutions in democratic change. Using the innovative qualitative and quantitative methods employed by the Research Network on Gender Politics and the State, the authors have developed a new body of theories about the role of state feminism and how it can help further women's rights.

A numerical model has been elaborated to calculate ULF electromagnetic fields in the ground-atmosphere–ionosphere system created by an underground horizontal current source of a finite length. The modeling has enabled us to examine in detail characteristic features of ULF response to an underground large-scale emitter that may be used for a search of electromagnetic earthquake precursors. The most promising features that might discriminate signals from an underground source and from a magnetosphere-ionosphere source are (a) the apparent impedance of the electromagnetic field derived from simultaneous observations of horizontal magnetic and electric fields, and (b) the ratio of vertical and horizontal magnetic component amplitudes. Besides that, the amplitude-phase gradients of signals from an underground source differ significantly from those of the magnetospheric source. For the same magnitude of horizontal magnetic disturbance on surface, an underground current source produces in a borehole a much larger vertical electric field E z than a magnetospheric source does. At the same time, some properties, such as the ratio between the vertical and horizontal electric components, are shown to be ineffective. However, all these differences with ionosphere-magnetosphere source reveal themselves only in a vicinity of lithospheric source (< 30 km for depth 20 km). Graphical Abstract

The significant inversion symmetry breaking specific to wurtzite semiconductors, and the associated spontaneous electrical polarization, lead to outstanding features such as high density of carriers at the GaN/(Al,Ga)N interface—exploited in high-power/high-frequency electronics—and piezoelectric capabilities serving for nanodrives, sensors and energy harvesting devices. Here we show that the multifunctionality of nitride semiconductors encompasses also a magnetoelectric effect allowing to control the magnetization by an electric field. We first demonstrate that doping of GaN by Mn results in a semi-insulating material apt to sustain electric fields as high as 5 MV cm −1 . Having such a material we find experimentally that the inverse piezoelectric effect controls the magnitude of the single-ion magnetic anisotropy specific to Mn 3+ ions in GaN. The corresponding changes in the magnetization can be quantitatively described by a theory developed here. The wurtzite crystal structure of nitride semiconductors results in strong piezoelectricity. Here, the authors also achieve electric-field control of the magnetization of gallium manganese nitride, thus showing that piezoelectric and magnetoelectric effects can be combined in the same material.

This article examines the interplay between gendered electoral financing (GEF) and other crucial factors in democratic elections worldwide to determine whether, how, and why these understudied mechanisms help achieve gender balance in national parliaments. Integrating qualitative comparative analysis and minimalist causal mechanism case studies, the sequential mixed methods study of GEF implementation in 31 elections in 17 countries shows that enhanced gender balance is achieved when GEF is combined with several conditions, providing a much-needed financial incentive—payments and penalties—for party gatekeepers and eligible women to change their behavior. In successful cases of top-down GEF implementation, gender quotas combine with a PR electoral system or a 15% minimum of women MPs, a measure developed for this study. Success in bottom-up GEF implementation is unexpected and complex and occurs without a quota. The article ends with a discussion of the research agenda, policy recommendations, and implications for the pursuit of democratic quality.