Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
9,967
result(s) for
"McDonald, John"
Sort by:
Electricity slides
\"\"Electricity Slides\" describes a disjointed, somewhat dystopian, slightly connected series of events, written in the Dadaist \"cut-up\" style of the 1950s. The book first started out as a series of performance art monologues written and performed live for a multidisciplinary exhibition put on by the Indigenous Peoples Artists Collective every year in Prince Albert, Saskatchewan. The stories alternate between a third-person narrative and the first-person narrative of the protagonist, who goes without a name throughout the book, but whom we discover is a military officer who has suffered an emotional breakdown during a battle and as a result speaks in a lyrical, poem-prose manner. Throughout the book, the reader is taken through a psychotropic funhouse-like journey, like a dream, where vignettes are connected only slightly, but keep the reader moving.\"-- Provided by publisher.
Open source machine-learning algorithms for the prediction of optimal cancer drug therapies
Precision medicine is a rapidly growing area of modern medical science and open source machine-learning codes promise to be a critical component for the successful development of standardized and automated analysis of patient data. One important goal of precision cancer medicine is the accurate prediction of optimal drug therapies from the genomic profiles of individual patient tumors. We introduce here an open source software platform that employs a highly versatile support vector machine (SVM) algorithm combined with a standard recursive feature elimination (RFE) approach to predict personalized drug responses from gene expression profiles. Drug specific models were built using gene expression and drug response data from the National Cancer Institute panel of 60 human cancer cell lines (NCI-60). The models are highly accurate in predicting the drug responsiveness of a variety of cancer cell lines including those comprising the recent NCI-DREAM Challenge. We demonstrate that predictive accuracy is optimized when the learning dataset utilizes all probe-set expression values from a diversity of cancer cell types without pre-filtering for genes generally considered to be \"drivers\" of cancer onset/progression. Application of our models to publically available ovarian cancer (OC) patient gene expression datasets generated predictions consistent with observed responses previously reported in the literature. By making our algorithm \"open source\", we hope to facilitate its testing in a variety of cancer types and contexts leading to community-driven improvements and refinements in subsequent applications.
Journal Article
Electric power substations engineering
\"The electric power substation, whether generating station or transmission and distribution, remains one of the most challenging and exciting fields of electric power engineering. Recent technological developments have had tremendous impact on all aspects of substation design and operation. The objective of Electric Power Substations Engineering is to provide an extensive overview of substations, as well as a reference and guide for its study. The chapters are written for the electric power-engineering professional for detailed design information, as well as for other engineering professions (e.g., mechanical, civil) who want an overview or specific information in one particular area\"-- Provided by publisher.
Book
Adaptive Significance of Non-coding RNAs: Insights from Cancer Biology
Abstract
The molecular basis of adaptive evolution and cancer progression are both complex processes that share many striking similarities. The potential adaptive significance of environmentally-induced epigenetic changes is currently an area of great interest in both evolutionary and cancer biology. In the field of cancer biology intense effort has been focused on the contribution of stress-induced non-coding RNAs (ncRNAs) in the activation of epigenetic changes associated with elevated mutation rates and the acquisition of environmentally adaptive traits. Examples of this process are presented and combined with more recent findings demonstrating that stress-induced ncRNAs are transferable from somatic to germline cells leading to cross-generational inheritance of acquired adaptive traits. The fact that ncRNAs have been implicated in the transient adaptive response of various plants and animals to environmental stress is consistent with findings in cancer biology. Based on these collective observations, a general model as well as specific and testable hypotheses are proposed on how transient ncRNA-mediated adaptive responses may facilitate the transition to long-term biological adaptation in both cancer and evolution.
Journal Article
Romeo & Juliet : the graphic novel : original text version
Presents in graphic novel format an easy-to-follow adaptation of Shakespeare's play of the tragic consequences of a deadly feud between two rival families in Renaissance Verona.
BOOK
Attentional enhancement predicts individual differences in visual working memory under go/no-go search conditions
Attention-control processes transfer relevant information to visual working memory (WM) and prevent irrelevant information from consuming WM resources. Although event-related potentials (ERPs) have revealed attention-control processes associated with enhancement of relevant stimuli (targets) and suppression of irrelevant stimuli (distractors), only the suppressive processes have been found to predict WM capacity. We hypothesised a link between target-enhancement processes and WM capacity would be revealed in a task that requires more control than the conventional visual search paradigms used to study target selection. Here, participants searched for a pop-out target on Go trials and withheld responses on an equal number of randomly intermixed No-Go trials, depending on the colour of the stimulus array. Magnitudes of ERP indices associated with target enhancement (the singleton detection positivity, SDP, and N2pc) were positively correlated with individual differences in WM capacity. These relationships vanished when participants searched for the pop-out target on every trial, regardless of stimulus-array colour. Inhibitory processes associated with suppressing distractors (P D ) and withholding responses (no-go P3) on No-Go trials did not predict WM capacity. These findings indicate that target-enhancement mechanisms control access to WM in search tasks that require dynamic control and disconfirm the view that the gateway to WM is entirely inhibitory by nature.
Journal Article
A midsummer night's dream : the graphic novel : original text version
The entire Shakespeare play as a graphic novel.
BOOK
High throughput, label-free isolation of circulating tumor cell clusters in meshed microwells
Extremely rare circulating tumor cell (CTC) clusters are both increasingly appreciated as highly metastatic precursors and virtually unexplored. Technologies are primarily designed to detect single CTCs and often fail to account for the fragility of clusters or to leverage cluster-specific markers for higher sensitivity. Meanwhile, the few technologies targeting CTC clusters lack scalability. Here, we introduce the Cluster-Wells, which combines the speed and practicality of membrane filtration with the sensitive and deterministic screening afforded by microfluidic chips. The >100,000 microwells in the Cluster-Wells physically arrest CTC clusters in unprocessed whole blood, gently isolating virtually all clusters at a throughput of >25 mL/h, and allow viable clusters to be retrieved from the device. Using the Cluster-Wells, we isolated CTC clusters ranging from 2 to 100+ cells from prostate and ovarian cancer patients and analyzed a subset using RNA sequencing. Routine isolation of CTC clusters will democratize research on their utility in managing cancer.
Metastatic CTC clusters remain relatively unexplored due to the lack of optimized and practical technologies for their detection. Here the authors report Cluster-Wells to isolate CTC clusters in whole blood; they show this allows viable cluster retrieval for further molecular and functional analysis.
Journal Article
الدبلوماسية متعددة المسارات : منهج منظوماتي للسلام
يبحث هذا الكتاب في الاتجاهات الجديدة للدبلوماسية التي تطورت خلال القرن الماضي، ربما بسبب التنافس بين نظامين عالميين، لكن القوى اللاعبة، على الصعيد الدولي، استمرت باستخدام كل الطرق في علاقاتها الدولية، فالدبلوماسية عمل دولي لحل النزاعات بين الدول والجماعات المتناحرة أيضا، سلميا. ما يزيد في أهمية هذا الكتاب أن المؤلف دبلوماسي عمل في مناطق مختلفة في العالم، وكرس خبرة كبيرة لا بد من أن يلمسها المهتمون بالشؤون الدولية. سر دار الفرقد أن تقدم هذا الكتاب، الجديد في حقله، إلى المهتمين بالعلاقات الدولية والشأن العام لأن شعوبنا بحاجة إلى الكثير من المعرفة الدبلوماسية لمعالجة نزاعاتها وتسوية انقساماتها التي لا تفيد أحدا غير أعدائها.
Book
High Level of Trait Anxiety Leads to Salience-Driven Distraction and Compensation
Individuals with high levels of anxiety are hypothesized to have impaired executive control functions that would otherwise enable efficient filtering of irrelevant information. Pinpointing specific deficits is difficult, however, because anxious individuals may compensate for deficient control functions by allocating greater effort. Here, we used event-related-potential indices of attentional selection (the N2pc) and suppression (the PD) to determine whether high trait anxiety is associated with a deficit in preventing the misallocation of attention to salient, but irrelevant, visual search distractors. Like their low-anxiety counterparts (n = 19), highly anxious individuals (n = 19) were able to suppress the distractor, as evidenced by the presence of a PD. Critically, however, the distractor was found to trigger an earlier N2pc in the high-anxiety group but not in the low-anxiety group. These findings indicate that, whereas individuals with low anxiety can prevent distraction in a proactive fashion, anxious individuals deal with distractors only after they have diverted attention.
Journal Article