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In the developed world, extreme prematurity is the leading cause of neonatal mortality and morbidity due to a combination of organ immaturity and iatrogenic injury. Until now, efforts to extend gestation using extracorporeal systems have achieved limited success. Here we report the development of a system that incorporates a pumpless oxygenator circuit connected to the fetus of a lamb via an umbilical cord interface that is maintained within a closed ‘amniotic fluid’ circuit that closely reproduces the environment of the womb. We show that fetal lambs that are developmentally equivalent to the extreme premature human infant can be physiologically supported in this extra-uterine device for up to 4 weeks. Lambs on support maintain stable haemodynamics, have normal blood gas and oxygenation parameters and maintain patency of the fetal circulation. With appropriate nutritional support, lambs on the system demonstrate normal somatic growth, lung maturation and brain growth and myelination. The ability to support the development of a premature fetus in the form of an extracorporeal system has had limited success. Here, the authors show that an extra-uterine device that mimics the intra-uterine environment can provide physiologic support for the extreme premature lamb fetus for four weeks.

Chemical analyses of ancient organic compounds absorbed into the pottery fabrics from sites in Georgia in the South Caucasus region, dating to the early Neolithic period (ca. 6,000–5,000 BC), provide the earliest biomolecular archaeological evidence for grape wine and viniculture from the Near East, at ca. 6,000–5,800 BC. The chemical findings are corroborated by climatic and environmental reconstruction, together with archaeobotanical evidence, including grape pollen, starch, and epidermal remains associated with a jar of similar type and date. The very large-capacity jars, some of the earliest pottery made in the Near East, probably served as combination fermentation, aging, and serving vessels. They are the most numerous pottery type at many sites comprising the so-called “Shulaveri-Shomutepe Culture” of the Neolithic period, which extends into western Azerbaijan and northern Armenia. The discovery of early sixth millennium BC grape wine in this region is crucial to the later history of wine in Europe and the rest of the world.

In a lively gastronomical tour around the world and through the millennia, Uncorking the Past tells the compelling story of humanity's ingenious, intoxicating search for booze. Following a tantalizing trail of archaeological, chemical, artistic, and textual clues, Patrick E. McGovern, the leading authority on ancient alcoholic beverages, brings us up to date on what we now know about the creation and history of alcohol, and the role of alcohol in society across cultures. Along the way, he integrates studies in food and sociology to explore a provocative hypothesis about the integral role that spirits have played in human evolution. We discover, for example, that the cereal staples of the modern world were probably domesticated in agrarian societies for their potential in fermenting large quantities of alcoholic beverages. These include the delectable rice wines of China and Japan, the corn beers of the Americas, and the millet and sorghum drinks of Africa. Humans also learned how to make mead from honey and wine from exotic fruits of all kinds: even from the sweet pulp of the cacao (chocolate) fruit in the New World. The perfect drink, it turns out-whether it be mind-altering, medicinal, a religious symbol, liquid courage, or artistic inspiration-has not only been a profound force in history, but may be fundamental to the human condition itself. This coffee table book will sate the curiosity of any armchair historian interested in the long history of food and wine.

Understanding demographic parameters such as survival is important for scientifically sound wildlife management. Survival can vary by region, sex, age-class, habitat, and other factors. White-tailed deer fawn survival is highly variable across the species' range. While recent studies have investigated fawn survival in several Midwestern states, there have been no published estimates from Iowa for 30 years. We radio-collared 48 fawns in central Iowa from 2015-2017 to estimate survival, home range size, and habitat composition and identity causes of mortality. Estimated fawn survival (± SE) was similar to other Midwest studies at 30 (0.78 ± 0.07)) and 60 days (0.69 ± 0.08), but considerably lower at 7 months (0.31 ± 0.02). Survival was positively associated with woodland habitat through 30 and 60 days, but not related to habitat at 7 months. Female fawns avoided agricultural habitat in their home ranges. Fawn 95% kernel density home ranges were smaller than in other studies in the Midwest (21.22 ± 2.74 ha at 30 days, 25.47 ± 2.87 ha at 60 days, and 30.59 ± 2.37 ha at 7 months). The large amount of woodland and grassland (>90%) in our study area meant that fawns did not have to travel far to find suitable cover, which may explain their small home ranges. We recorded 21 mortalities, the leading cause of which was disease (n = 9; 56% epizootic hemorrhagic disease [EHD]) followed by suspected predation (4) and harvest (3). The mortality associated with an outbreak of EHD in 2016, all of which occurred after 60 days post-capture, is the most likely explanation for our low survival estimate at 7 months. While predation, usually early in life, is the leading cause of mortality in most studies, sporadic diseases like EHD can be a major source of mortality in older fawns in some years.

Chemical analyses of ancient organics absorbed into pottery jars from the beginning of advanced ancient Egyptian culture, ca. 3150 B.C., and continuing for millennia have revealed that a range of natural products--specifically, herbs and tree resins--were dispensed by grape wine. These findings provide chemical evidence for ancient Egyptian organic medicinal remedies, previously only ambiguously documented in medical papyri dating back to ca. 1850 B.C. They illustrate how humans around the world, probably for millions of years, have exploited their natural environments for effective plant remedies, whose active compounds have recently begun to be isolated by modern analytical techniques.

This paper introduces a method and preliminary findings from a database that systematically measures the character and stringency of immigration policies. Based on the selection of that data for nine countries between 1999 and 2008, we challenge the idea that any one country is systematically the most or least restrictive toward admissions. The data also reveal trends toward more complex and, often, more restrictive regulation since the 1990s, as well as differential treatment of groups, such as lower requirements for highly skilled than low-skilled labor migrants. These patterns illustrate the IMPALA data and methods but are also of intrinsic importance to understanding immigration regulation.

Gravity data show a rectangular pattern of narrow linear anomalies bordering the lunar Procellarum region that are interpreted to be the frozen remnants of lava-filled rifts and underlying feeder dykes. Ancient rifts on the Moon The Procellarum region is a broad area on the nearside of the Moon, characterized by low elevations and thin crust, and largely covered by dark basalts that can be seen from Earth with the unaided eye. This structure has been interpreted as an ancient impact basin. Jeffrey Andrews-Hanna et al . use data from NASA's Gravity Recovery and Interior Laboratory (GRAIL) mission to examine the subsurface structure of the Procellarum. They find that a pattern of narrow linear anomalies border the region, interpreted to be the frozen remnants of lava-filled rifts and underlying feeder dikes. The discontinuous surface structures that were earlier interpreted as remnants of an impact basin rim are a part of this continuous set of quasi-rectangular border structures with angular intersections. The authors conclude that the Procellarum was formed in response to thermal stresses produced by the differential cooling of the province relative to its surroundings, coupled with magmatic activity driven by elevated heat flux. The Procellarum region is a broad area on the nearside of the Moon that is characterized by low elevations 1 , thin crust 2 , and high surface concentrations of the heat-producing elements uranium, thorium, and potassium 3 , 4 . The region has been interpreted as an ancient impact basin approximately 3,200 kilometres in diameter 5 , 6 , 7 , although supporting evidence at the surface would have been largely obscured as a result of the great antiquity and poor preservation of any diagnostic features. Here we use data from the Gravity Recovery and Interior Laboratory (GRAIL) mission 8 to examine the subsurface structure of Procellarum. The Bouguer gravity anomalies and gravity gradients reveal a pattern of narrow linear anomalies that border Procellarum and are interpreted to be the frozen remnants of lava-filled rifts and the underlying feeder dykes that served as the magma plumbing system for much of the nearside mare volcanism. The discontinuous surface structures that were earlier interpreted as remnants of an impact basin rim are shown in GRAIL data to be a part of this continuous set of border structures in a quasi-rectangular pattern with angular intersections, contrary to the expected circular or elliptical shape of an impact basin 9 . The spatial pattern of magmatic-tectonic structures bounding Procellarum is consistent with their formation in response to thermal stresses produced by the differential cooling of the province relative to its surroundings, coupled with magmatic activity driven by the greater-than-average heat flux in the region.

The Martian cryosphere is defined as that region of the crust where the temperature remains continuously below the freezing point of water. Previous estimates of its present thickness have ranged from ∼2.3–4.7 km at the equator to ∼6.5–12.5 km at the poles. Here we revisit these calculations, review some of the assumptions on which they were based, and investigate the effects of several parameters, not previously considered, on the cryosphere's thermal evolution and extent. These include astronomically driven climate change, the temperature‐dependent thermal properties of an ice‐rich crust, the potential presence of gas hydrate and perchlorate‐saturated groundwater, and consideration of recent lower estimates of present‐day global heat flow (which suggest a mean value roughly half that previously thought, effectively doubling the potential thickness of frozen ground). The implications of these findings for the continued survival of subpermafrost groundwater and its potential detection by the MARSIS radar sounder onboard Mars Express are then discussed. Although our estimates of the maximum potential thickness of the cryosphere have significantly increased, consideration of the likely range and spatial variability of crustal heat flow and thermal properties, in combination with the potential presence of potent freezing point depressing salts, may result in substantial local variations in cryosphere thickness. The locations that appear best suited for the detection of groundwater are those that combine low latitude (minimizing the thickness of frozen ground) and low elevation (minimizing the depth to a water table in hydrostatic equilibrium). Preliminary results from a MARSIS investigation of one such area are discussed.

Chemical analyses of ancient organics absorbed into pottery jars from the early Neolithic village of Jiahu in Henan province in China have revealed that a mixed fermented beverage of rice, honey, and fruit (hawthorn fruit and or grape) was being produced as early as the seventh millennium before Christ (B.C.). This prehistoric drink paved the way for unique cereal beverages of the proto-historic second millennium B.C., remarkably preserved as liquids inside sealed bronze vessels of the Shang and Western Zhou Dynasties. These findings provide direct evidence for fermented beverages in ancient Chinese culture, which were of considerable social, religious, and medical significance, and help elucidate their earliest descriptions in the Shang Dynasty oracle inscriptions.

What is the role of the market economy and of the European Union in shaping policies that limit migrants’ access to the labour market? While much of the existing research has examined the development of border policies in Europe, less attention has been given to post-entry measures regulating the employment of Third Country Nationals. We examine the role of different market economies and the European Union in devising lesser-known measures that target migrant labour market competition. Focusing on the period from 1990 to 2020, we analyse four case studies: Austria, Germany, Ireland, and the United Kingdom. We hypothesize that these migrant labour market competition measures (MCM) have emerged in ways that challenge both the marketization of migration thesis and predictions from theories of EU immigration policymaking and varieties of capitalism (VoC). While the European Union’s influence partially explains the adoption of some selective policies, the emergence of MCM transcends the VoC framework. Furthermore, contrary to marketization claims, states have sought to address labour market concerns about competition from migrants by adopting selective, rather than indiscriminate, regulatory approaches. We argue that the interplay between selectivity and measures restricting migrant labour market competition has become central to understanding how states regulate migration in the European Union.