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"McHale, Jeanne L"
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Current Events as Subjects for Term Papers in an Honors Freshman Chemistry Class
Describes the use of current events for term paper subjects in a freshman chemistry class to address such problems as the detachment of freshman chemistry principles from world issues, and the tendency of high achieving students to memorize facts without thinking critically. Students gain appreciation for the relationship between textbook chemistry and real-world chemistry. Includes sample topics and related chemical concepts. (PVD)
Journal Article
Sepsis Attributed to Bacterial Contamination of Platelets Associated with a Potential Common Source — Multiple States, 2018
During May-October 2018, four patients from three states experienced sepsis after transfusion of apheresis platelets contaminated with Acinetobacter calcoaceticus-baumannii complex (ACBC) and Staphylococcus saprophyticus; one patient died. ACBC isolates from patients' blood, transfused platelet residuals, and two environmental samples were closely related by whole genome sequencing. S. saprophyticus isolates from two patients' blood, three transfused platelet residuals, and one hospital environmental sample formed two whole genome sequencing clusters. This whole genome sequencing analysis indicated a potential common source of bacterial contamination; investigation into the contamination source continues. All platelet donations were collected using apheresis cell separator machines and collection sets from the same manufacturer; two of three collection sets were from the same lot. One implicated platelet unit had been treated with pathogen-inactivation technology, and two had tested negative with a rapid bacterial detection device after negative primary culture. Because platelets are usually stored at room temperature, bacteria in contaminated platelet units can proliferate to clinically relevant levels by the time of transfusion. Clinicians should monitor for sepsis after platelet transfusions even after implementation of bacterial contamination mitigation strategies. Recognizing adverse transfusion reactions and reporting to the platelet supplier and hemovigilance systems is crucial for public health practitioners to detect and prevent sepsis associated with contaminated platelets.
Journal Article
Sepsis Attributed to Bacterial Contamination of Platelets Associated with a Potential Common Source - Multiple States, 2018
Bacterial contamination of platelets is rare (approximately one in 5,000 platelet units) but poses serious risk to platelet transfusion recipients. Sepsis resulting from bacterial contamination of platelets can occur even with implementation of bacterial mitigation strategies. Whole genome sequencing indicated a potential common source of bacterial contamination among four cases of septic transfusion reactions occurring in three states. Clinicians need to monitor for sepsis after platelet transfusions even after implementation of bacterial mitigation strategies and immediately report adverse reactions to platelet suppliers and hemovigilance systems.
Report