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Calling all fans of Tahereh Mafi's New York Times bestselling Shatter Me series! This gorgeous paperback bind-up includes Shadow Me and Reveal Me, the third and fourth novellas in the series, both in print for the first time ever.
Type I and III interferon responses in SARS-CoV-2 infection
Coronavirus disease 2019 (COVID-19), the current pandemic disease, is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Type I and III interferons (IFNs) are innate cytokines that are important in the first-line defense against viruses. Similar to many other viruses, SARS-CoV-2 has evolved mechanisms for evading the antiviral effects of type I and III IFNs at multiple levels, including the induction of IFN expression and cellular responses to IFNs. In this review, we describe the innate sensing mechanisms of SARS-CoV-2 and the mechanisms used by SARS-CoV-2 to evade type I and III IFN responses. We also discuss contradictory reports regarding impaired and robust type I IFN responses in patients with severe COVID-19. Finally, we discuss how delayed but exaggerated type I IFN responses can exacerbate inflammation and contribute to the severe progression of COVID-19.
SARS-CoV-2: exploring virus-triggered immune system dysfunction
Extensive studies into how SARS-CoV-2 manipulates the immune system and influences the activity of host proteins are needed to improve treatments for COVID-19. SARS-CoV-2 evades or blocks elements of the immune system, including the antiviral activity of type I and type III interferons (IFN). You-Me Kim and Eui-Cheol Shin at the Korea Advanced Institute of Science and Technology, Daejeon, South Korea, reviewed understanding of how SARS-CoV-2 inhibits IFN responses. In infected cells, SARS-CoV-2 proteins use diverse methods to inhibit host IFN pathways, but type I IFN responses are still triggered in non-infected immune cells. The researchers believe this may explain the delayed but exaggerated type I IFN responses that contribute to the hyper-inflammation seen in critically ill patients. They call for further investigations into IFN and inflammatory responses in SARS-CoV-2 infection.
Journal Article
The master
\"Sasha Blake is scarred from a BDSM session gone wrong, but she can't deny how much a strong Master turns her on. Determined to overcome her fears and rejoin the Partners in Play community, she asks Abby and Nathaniel West to set her up with a Dom who can help her feel safe again as a sub. They know the very experienced Cole is exactly the kind of man who can push all of Sasha's buttons--and she soon wants to go much faster than she had planned. Cole knows that Sasha is not the kind of submissive he needs. He wants someone who will serve him 24-7, not a part-time partner. Still, the further they go into their play, the more Cole begins to wish he could make Sasha his all the time. When forbidden desires turn into scorching action, Sasha and Cole come face-to-face with their demons--and realize their scorching relationship might be too dangerous to last\"-- Provided by publisher.
Book
Cenozoic ultrahigh-temperature metamorphism in pelitic granulites from the Mogok metamorphic belt, Myanmar
Ultrahigh-temperature (UHT) metamorphism is critical for understanding the most extreme thermal evolution of continental crust. However, UHT metamorphism predominantly occurred in the Precambrian and is rarely observed in the modern Earth. Here, we report the discovery of ∼25 Ma UHT granulites from the Mogok metamorphic belt (MMB) in Myanmar via a combined study of petrology and geochronology. The studied pelitic granulites well preserve a peak mineral assemblage of garnet + sillimanite + plagioclase (antiperthite) + K-feldspar + quartz + Ti-rich biotite + rutile + ilmenite. Pressure (
P
)-temperature (
T
) pseudosections and conventional geothermobarometry data only constrain the
P
-
T
conditions of the peak stage to <12 kbar and 780–890°C. However, high Zr contents in the matrix rutile (3005–4308 ppm) and high Ti contents (up to 9.2 wt% TiO
2
) in the biotite demonstrate that the Mogok granulites may have experienced UHT metamorphism. The Zr-in-rutile thermometer and
X
Grs
isopleth in the pseudosections yield peak
P
-
T
conditions of ∼12 kbar and >900°C.
In situ
SIMS and LA-ICP-MS U-Pb dating and trace element analyses show that both metamorphic zircon cores and rims have flat heavy rare earth element (HREE) patterns with negative Eu anomalies. The metamorphic zircon rims show the lowest HREE contents and yield
206
Pb/
238
U ages of 24.9±0.5 and 25.4±0.6 Ma, respectively, representing the timing of UHT metamorphism. Our results indicate that the central MMB underwent ∼25 Ma UHT metamorphism, which is possibly induced by continental rifting along the thinned orogenic lithosphere. Our data, as well as reported Cenozoic UHT events, further suggest that UHT metamorphism can be produced in the modern plate tectonic regime by lithospheric extension.
Journal Article
Shatter me
One touch is all it takes. One touch, and Juliette Ferrars can leave a fully grown man gasping for air. One touch, and she can kill. No one knows why Juliette has such incredible power. It feels like a curse, a burden that one person alone could never bear. But The Reestablishment sees it as a gift, sees her as an opportunity. An opportunity for a deadly weapon. Juliette has never fought for herself before. But when she's reunited with the one person who ever cared about her, she finds a strength she never knew she had. Also includes the 'Destroy Me' novella, which is told from Warner's point of view, and a brand-new author's note.
BOOK
Fresh Produce Safety and Quality: Chlorine Dioxide’s Role
Maintaining microbial safety and quality of fresh fruits and vegetables are a global concern. Harmful microbes can contaminate fresh produce at any stage from farm to fork. Microbial contamination can affect the quality and shelf-life of fresh produce, and the consumption of contaminated food can cause foodborne illnesses. Additionally, there has been an increased emphasis on the freshness and appearance of fresh produce by modern consumers. Hence, disinfection methods that not only reduce microbial load but also preserve the quality of fresh produce are required. Chlorine dioxide (ClO 2 ) has emerged as a better alternative to chlorine-based disinfectants. In this review, we discuss the efficacy of gaseous and aqueous ClO 2 in inhibiting microbial growth immediately after treatment (short-term effect) versus regulating microbial growth during storage of fresh produce (long-term effect). We further elaborate upon the effects of ClO 2 application on retaining or enhancing the quality of fresh produce and discuss the current understanding of the mode of action of ClO 2 against microbes affecting fresh produce.
Journal Article
Japan
An Asian nation of more than 3,000 islands, Japan is about the same size as the U.S. state of California. Go on an in-depth tour of Japan with local guide Satchiko as she shows readers what life is like in her home country, from what foods people enjoy to how they spend their free time. Satchiko will also teach readers about Japanese history and culture, show them the country's most interesting places, and more.
Book
Gibberellin delays metabolic shift during tomato ripening by inducing auxin signaling
Fruit ripening involves the dynamic interaction of phytohormones. Ethylene (ET) and gibberellin (GA) antagonistically affect fruit ripening. However, the mechanism of GA and its potential interaction with ET during fruit ripening remain unknown. To identify the potential molecular mechanism of ET and GA interplay in tomato ( Solanum lycopersicum L.) fruit ripening, transcriptome and metabolomic profiling was carried out in tomato fruit treated with GA, ET or the combination of the two hormones (GA+ET). ET accelerated fruit ripening with the simultaneous repression of auxin signaling. In contrast, gibberellin delayed ripening by the upregulation of auxin signaling. ET signaling and response was inhibited by GA or combined with ET. At the metabolite level, while GA treatment inhibited metabolite shift during ripening, ET treatment promoted. In the combined hormone treatment, ET reduced or recovered GA inhibitory effect on specific metabolites. This study provided insight into ET and GA interaction, highlighting the importance of auxin signaling in metabolic shifts during tomato ripening progression.
Journal Article
China
\"Meet up with your guide Wang as he takes you on [a] ... journey across China\"--Back cover.
Book
Multispectral Fluorescence Imaging for Fast Identification of Cold Stress in Pepper Plants
This paper investigated the feasibility of snapshot multispectral fluorescence imaging for nondestructive identification of cold stress in pepper plants. Fluorescence spectra were obtained by exciting the plant with a 405 nm ultraviolet LED. The plants were grown under three temperature conditions: 17 °C (control), 10 °C (moderate cold stress), and 5 °C (severe cold stress). Raw fluorescence spectra extracted from the demosaiced snapshot images were used as inputs for a deep-learning pipeline consisting of feature extraction, an encoder–decoder GRU, and a multilayer perceptron (MLP), and the results were compared with conventional machine learning classifiers, including linear discriminant analysis (LDA), quadratic discriminant analysis (QDA), and a Gaussian support vector machine (G-SVM). Tukey’s HSD test indicated that the proposed deep-learning model achieved the highest cross-validation accuracy and consistently produced superior classification metrics (accuracy of 85.7%, precision of 85.3%, recall of 85.3%, F1-score of 85.2). The trained model was further applied to hyperspectral cubes to generate classification maps; however, moderate misclassification was observed, consistent with the overall prediction performance.
Journal Article