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"Mei, Bin"
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The regulatory mechanism and biological significance of the Snail-miR590-VEGFR-NRP1 axis in the angiogenesis, growth and metastasis of gastric cancer
Vascular endothelial growth factor receptor (VEGFR) and neuropilins (NRPs), a co-receptor of VEGF, play a key role in the formation and development of blood vessels and in tumour growth and metastasis. However, whether VEGFR1/2 and NRP1 are regulated by the same upstream mechanism is unclear, especially in gastric cancer. We used prediction tools to detect miRNAs that may simultaneously regulate VEGFR1/2 and NRP1, and we finally determined that miR-590 can simultaneously regulate VEGFR1/2 and NRP1 in gastric cancer. We discovered that miR-590 was downregulated in gastric cancer tissues and cell lines, and this was related to the dysregulation of the transcription factor SNAIL. In addition, the overexpression of miR-590 inhibits the migration, invasion, proliferation and D-MVA levels of gastric cancer cells in vivo and in vitro by targeting VEGFR1/2 and NRP1. We also demonstrated that miR-590 may be a useful marker for the prognosis of gastric cancer with Kaplan–Meier survival analysis. Since the epithelial-to-mesenchymal transition (EMT) is an important mechanism of tumour invasion and metastasis and VEGFR1/2 and NRP1 can promote the occurrence of EMT, we speculated that miR-590 can regulate the occurrence of EMT. Immunoblot and immunofluorescence analyses confirmed that the overexpression of miR-590 can inhibit the EMT in gastric cancer cells. Since SNAIL is also a mesenchymal marker, our results revealed a new, positive feedback loop. As a transcription factor, SNAIL inhibits the expression of miR-590, thereby upregulating the expression levels of NRP1 and VEGFR1/2; this leads to the development of EMT in gastric cancer and the upregulation of SNAIL.
Journal Article
Fibrous configuration of the fascia iliaca compartment: An epoxy sheet plastination and confocal microscopy study
Background and Objectives:
The underlying anatomical mechanism of the ultrasound-guided fascia iliaca compartment (FIC) block for anaesthesia and analgesia in the lower limb has not been illuminated and numerous variations were attempted to achieve an optimal needle placement. This study aimed to define the fibrous configuration of the FIC.
Methods:
A total of 46 adult cadavers were studied using dissection, latex injection, epoxy sheet plastination and confocal microscopy.
Results:
(1) The fascia iliaca originated from the peripheral fascicular aponeurotic sheet of the iliopsoas. (2) The FIC was a funnel-shaped adipose space between the fascia iliaca and the epimysium of the iliopsoas, had a superior and an inferior opening and contained the femoral and lateral femoral cutaneous nerves but not obturator nerve. (3) The estimated volume of the FIC in the cadavers was about 23 mls, of which about one third was below the level of the anterior superior iliac spine.
Conclusions:
This study revealed that the fascia iliaca was aponeurotic and may be less permeable for the local anesthetics.
Conclusions:
The FIC contained only the femoral and lateral femoral cutaneous nerves and communicated with the extraperitoneal space and femoral triangle adipose space via its superior and inferior opening, respectively.
Journal Article
Efficacy of Telitacicept in treating IgA vasculitis nephritis: a two-case report
Telitacicept, a B lymphocyte stimulator/A proliferation-inducing ligand dual-target fusion protein, mainly used for IgA nephropathy and systemic lupus erythematosus. We present two cases where adult patients with IgA vasculitis (IgAV) nephritis were successfully treated with Telitacicept, experienced no adverse reactions during the follow-up. Therefore, Telitacicept represents a promising additional treatment option for patients suffering from IgA vasculitis (IgAV).
Journal Article
Fear of progression profiles and their association with quality of life and depression in ischemic stroke survivors: a latent profile analysis
Background
Fear of progression (FoP) has been well-documented in patients with cancer and chronic disease. However, there is little information in stroke patients. The purpose of this study was to explore the profiles and associated factors of FoP among ischemic stroke survivors, and to examine the association of FoP profiles with quality of life (QoL) and depression.
Methods
A cross-sectional study was conducted from July 2023 to June 2024. Two hundred ischemic stroke survivors were recruited. Data collection included a self-designed sociodemographic and clinical information questionnaire, the Fear of Progression Questionnaire-Short Form, the Stroke Specific Quality of Life Scale, and the Self-Rating Depression Scale. Latent profile analysis (LPA), univariate analysis, multinomial logistic regression analysis, and multiple hierarchical regression analysis were adopted in this study.
Results
LPA identified three subgroups of FoP: Group 1-the low FoP (23%), Group 2-the moderate FoP with family-related concerns (45%), and Group 3-the high FoP with work-related concerns (32%). Older age (OR = 0.245,
p
= 0.003) and lower functional independence (Barthel index, BI) (OR = 0.976,
p
= 0.034) were associated with Group 2, while younger age (OR = 8.771,
p
= 0.018) and lower monthly family income (OR = 9.960,
p
= 0.004) were associated with Group 3. FoP profiles explained 3.0% variance in QoL and 3.3% variance in depression (
p
< 0.05). Group 2 and 3 showed significantly lower QoL than Group 1 (
p
< 0.05), while Group 2 and Group 3 had higher depression than Group 1 (
p
< 0.05).
Conclusion
Three heterogeneous subgroups of FoP were identified in ischemic stroke survivors. Age, household monthly income, and functional independence were associated with different latent profiles of FoP. Healthcare providers should categorize patients with FoP into subgroups and provide targeted interventions based on each profile’s characteristics and associated factors. This could contribute to promoting their QoL and lowering their depression.
Journal Article
Assemble from 0D to 3D: anchored 0D molybdenum carbide on 3D octahedral amorphous carbon with excellent capacitive properties
Molybdenum carbide (Mo2C) is an attractive candidate as the electrode active material of supercapacitors (SCs) due to its low cost, outstanding electrical conductivity and superior chemical stability; however, the aggregation of Mo2C nanoparticles impedes its applications. Herein, zero-dimensional (0D) Mo2C nanoparticles are anchored on three-dimensional (3D) octahedral amorphous carbon (3DPO-Mo2C/C) by a mild and effective method with carbonizing and etching the Cu/Mo-based metal–organic framework. The 3DPO-Mo2C/C displays a large specific surface area, abundant mesopores and stable 3D structure, which not only expose more active reaction sites and shorten diffusion paths for electrolyte ions, but also prevent the aggregation and improve the structure stability of Mo2C nanoparticles. It exhibits an outstanding specific capacitances of 110 and 105 F g−1 in the electrolytes of 6 M KOH and 2 M EMIMA/AN. Employing the active carbon (AC) as counter electrode to assemble a SC with 3DPO-Mo2C/C as work electrode, which delivers higher energy and power densities of 12 Wh kg−1 and 1620 W kg−1, and the specific capacitance remains 91.3% after 6000 cycles. This approach not only prevents the aggregation of Mo2C nanoparticles successfully but also provides a possibility for Mo2C to be used in SCs.
Journal Article
Full-Scale Maneuvering Trials Correction and Motion Modelling Based on Actual Sea and Weather Conditions
Aiming at the poor accuracy and difficult verification of maneuver modeling induced by the wind, waves and sea surface currents in the actual sea, a novel sea trials correction method for ship maneuvering is proposed. The wind and wave drift forces are calculated according to the measurement data. Based on the steady turning hypothesis and pattern search algorithm, the adjustment parameters of wind, wave and sea surface currents were solved, the drift distances and drift velocities of wind, waves and sea surface currents were calculated and the track and velocity data of the experiment were corrected. The hydrodynamic coefficients were identified by the test data and the ship maneuvering motion model was established. The results show that the corrected data were more accurate than log data, the hydrodynamic coefficients can be completely identified, the prediction accuracy of the advance and tactical diameters were 93% and 97% and the prediction of the maneuvering model was accurate. Numerical cases verify the correction method and full-scale maneuvering model. The turning circle advance and tactical diameter satisfy the standards of the ship maneuverability of International Maritime Organization (IMO).
Journal Article
Comparison between transmural puncture combined with sensor tube technique with direct puncture in invasive blood pressure monitoring: a randomized controlled trial
This study primarily aimed to compare the efficacy of the transmural puncture combined with sensor tube technique and the direct puncture technique by examining the success of radial artery cannulation performed by nurses. The study was a prospective randomized controlled study. A total of 8 neurocritical nurses performed radial arterial insertion for 91 patients using both the transmural puncture combined with sensor tube technique and the direct puncture technique in random order. The primary outcome was successful cannulation of the radial artery in 3 or less attempts. Other collected data included the total number of attempts, total time for catheter cannulation, and occurrence of complications. In comparison with the direct puncture technique, transmural puncture combined with sensor tube increased the probability of successful initial catheterization (OR 3.27, [95% CI: 1.292–8.299];
P
= 0.012) and demonstrated less blood exposure (6.52% vs. 80.0%,
P
< 0.001,
φ
=-0.742). A combination of transmural puncture and a sensor tube resulted in fewer cases of extubation due to complications. Furthermore, immediate complications caused by puncture (4.34% vs. 17.78%;
P
= 0.039,
φ
=-0.215) and extubation due to complications were reduced (47.8% vs. 71.1%,
P
= 0.024,
φ
= 0.237). Transmural puncture combined with sensor tube was demonstrated to increase the success rate of the initial arterial puncture, reduce blood exposure and reduce the occurrence of complications. Therefore, the transmural puncture combined with sensor tube technique may be an acceptable option for cannulation of the radial artery.
Journal Article
Successful sequential treatment with ofatumumab followed by efgartigimod for refractory autoimmune encephalitis with dual anti-NMDAR and anti-GFAP antibody positivity: first case report
Autoimmune encephalitis (AE) is a heterogeneous disorder mediated by autoantibodies targeting neuronal or glial antigens, with anti-NMDAR encephalitis being the most common subtype, while cases with dual antibody positivity remain exceedingly rare. Standard treatment involves stepwise immunotherapy, but refractory cases often require advanced therapies. This study presents the first reported case of dual anti-NMDAR and anti-GFAP antibody-positive refractory AE in a 24-year-old female who failed first-line treatments (steroids, IVIG) and ovarian teratoma resection. During disease progression, innovative sequential therapy with ofatumumab (OFA), a novel anti-CD20 monoclonal antibody, followed by efgartigimod, an FcRn antagonist, was employed to mitigate profound B-cell depletion risks. The patient exhibited significant clinical improvement, with reduced Modified Rankin Scale (mRS) scores from 5 to 1. OFA induced rapid B-cell depletion, while efgartigimod effectively cleared pathogenic IgG, demonstrating synergistic efficacy. Comparative analysis with literature cases highlighted the superiority of this sequential approach in balancing efficacy and safety.
Journal Article
Influence of low-dose esketamine on postoperative depressive symptoms in patients with breast cancer (EASE): study protocol for a randomised controlled trial
IntroductionDepressive symptoms have surfaced as the principal mental health concern among patients with breast cancer, with surgical interventions potentially exacerbating these symptoms and adversely influencing clinical outcomes. This study protocol is designed to investigate the efficacy of low-dose esketamine administered perioperatively on depressive symptoms in patients with breast cancer. It also aims to illuminate the potential neurobiological underpinnings of this effect.Methods and analysisThis research represents a single-centre, prospective, randomised, double-blind, placebo-controlled study. The trial anticipates enrolling 108 female patients exhibiting mild-to-severe depressive symptoms who are slated for radical mastectomy. Through stratified randomisation, eligible patients will be systematically assigned to either the esketamine group (0.25 mg/kg) or placebo group (0.9% saline) in a 1:1 ratio. The primary outcome is the response rate at the third postoperative day. Secondary outcomes encompass the remission rate, depression-related scores, depression severity and safety-related endpoints. Tertiary (exploratory) outcomes involve alterations in brain-derived neurotrophic factor and resting-state functional brain connectivity.Ethics and disseminationThe Clinical Trial Ethics Committee at The First Affiliated Hospital of Anhui Medical University has conferred ethical approvals for this trial (approval number: PJ2023-05-25). Results from this trial will be disseminated in peer-reviewed journals and presented at professional symposiums.Trial registration numberChinese Clinical Trials Registry (ChiCTR2300071062).
Journal Article