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Purpose Prostate-specific membrane antigen (PSMA) is a recognized target for imaging prostate cancer. Here we present initial safety, biodistribution, and radiation dosimetry results with [ 18 F]DCFPyL, a second-generation fluorine-18-labeled small-molecule PSMA inhibitor, in patients with prostate cancer. Procedures Biodistribution was evaluated using sequential positron-emission tomography (PET) scans in nine patients with prostate cancer. Time-activity curves from the most avid tumor foci were determined. The radiation dose to selected organs was estimated using OLINDA/EXM. Results No major radiotracer-specific adverse events were observed. Physiologic accumulation was observed in known sites of PSMA expression. Accumulation in putative sites of prostate cancer was observed (SUV max up to >100, and tumor-to-blood ratios up to >50). The effective radiation dose from [ 18 F]DCFPyL was 0.0139 mGy/MBq or 5 mGy (0.5 rem) from an injected dose of 370 MBq (10 mCi). Conclusions [ 18 F]DCFPyL is safe with biodistribution as expected, and its accumulation is high in presumed primary and metastatic foci. The radiation dose from [ 18 F]DCFPyL is similar to that from other PET radiotracers.

The inclusion of competences related to sustainability and blue entrepreneurship aligns with the 2030 Agenda, a global framework adopted by the United Nations to promote sustainability through 17 Sustainable Development Goals (SDGs). Universities, as agents of change, must address socio-environmental problems through research, education, innovation, collaboration, and sustainable practices, aiming for a positive societal and environmental impact. Through an R&D&I project under the Andalusian Plan for Research, Development, and Innovation conducted a study to diagnose the extent to which these competences are included in the teaching programs of nine Andalusian public universities. Using a mixed methodology, the study involved 22 teachers and analyzed 81 programs from 40 university degrees. Results show statistically significant differences by university and branch of knowledge, with Science and Engineering and Architecture incorporating these competences more extensively. The study indicates that sustainability is unevenly developed across universities, necessitating a review and modernization of study programs to meet the objectives of the Entrepreneurship Plan by the Conference of Rectors of Spanish Universities. Investigating whether environmental education competencies are included in course syllabi is relevant because it allows for an assessment of whether educational institutions are preparing students with a vision committed to current environmental challenges.

Imaging plays an increasing role in prostate cancer diagnosis and staging. Accurate staging of prostate cancer is required for optimal treatment planning. In detecting extraprostatic cancer and sites of early recurrence, traditional imaging methods (computed tomography, magnetic resonance imaging, radionuclide bone scan) have suboptimal performance. This leaves a gap between known disease recurrence as indicated by rising prostate-specific antigen and the ability to localize the recurrence on imaging. Novel positron emission tomography (PET) agents including radiolabeled choline, fluciclovine (18F-FACBC), and agents targeting prostate-specific membrane antigen are being developed and tested to increase diagnostic performance of non-invasive prostate cancer localization. When combined with CT or MRI, these tracers offer a combination of functional information and anatomic localization that is superior to conventional imaging methods. These PET radiotracers have varying mechanisms and excretion patterns affecting their pharmacokinetics and diagnostic performance, which will be reviewed in this article.

Abstract BackgroundHuntington’s disease (HD) is a neurodegenerative disorder characterized by cognitive, motor, and neuropsychiatric manifestations. Oxytocin is a neuropeptide studied for its role as a neuromodulator regulating multiple behaviors linked to social cognition. Genetic variation of oxytocin receptor (OXTR) might interact in the etiology and development of several impaired social behaviors. Our aim was to study OXTR polymorphisms and their relationship with apathy and social cognition in HD.MethodsOXTR was sequenced in 21 cases and 22 controls. We assessed apathy, anxiety, depression, and irritability (Hospital Anxiety and Depression Scale-Snaith Irritability scale, HADS-SIS) and social cognition (Ekman 60 faces test), motor symptoms and functionality with the total functional capacity (TFC), and the Unified HD rating Scale (UHDRS).ResultsWe identified ten variants in OXTR. Three variants were classified as possibly damaging (p.Arg40Gly) or probably damaging (p.Leu46Pro, p.Thr102Asn). Subjects carrying the wild-type genotype of the synonymous variant p.Val45 showed a significantly lower score in the HADS-SIS scale, related to lower irritability (p = 0.013). The only subject carrying the heterozygous genotype of the synonymous variant p.Leu62 showed a significantly higher score on Ekman scale, compared to wild-type (p = 0.049); however, this finding was not confirmed after bootstrapping.ConclusionVariations in OXTR could have a relevant role in the correct development of social and cognitive functions. Future approaches will include the molecular study of p.Arg40Gly, p.Leu46Pro, and p.Thr102Asn to confirm their pathogenicity, as well as the validation of the influence of p.Val45 and p.Leu62 variants for their involvement in irritability and social cognition in HD.

While prostate specific membrane antigen (PSMA) is overexpressed in high-grade prostate cancers, it is also expressed in tumor neovasculature and other malignancies, including hepatocellular carcinoma (HCC). Importantly, no functional imaging for HCC is clinically available, making diagnosis and surveillance following local therapies particularly challenging. 18F-DCFPyL binds with high affinity to PSMA yet clears rapidly from the blood pool. PET imaging with 18F-DCFPyL may represent a new tool for staging, surveillance and assessment of treatment response in HCC. The purpose of this Functional Imaging Liver Cancer (FLIC) trial is to assess the ability of 18F-DCFPyL-PET/CT to detect sites of HCC. This is a phase II multi-site prospective imaging trial with a plan to enroll 50 subjects with suspected HCC on standard of care CT or MRI and eligible for standard local treatment. Participants will undergo a baseline 18F-DCFPyL-PET/CT, prior to therapy. Subjects will also be scanned with 18F-FDG-PET/CT within 2 weeks of 18F-DCFPyL-PET/CT. Participants will undergo histopathologic assessment and standard of care local treatment for HCC within a multidisciplinary team context. Participants with histopathologic confirmation of HCC and a positive baseline 18F-DCFPyL-PET/CT will undergo a post-treatment 18F-DCFPyL-PET/CT during the first routine follow-up, typically within 4-8 weeks. Subjects with negative baseline 18F-DCFPyL-PET/CT will not be re-scanned after treatment but will remain in follow-up. Participants will be followed for 5-years to assess for progression-free-survival. The primary endpoint is the positive predictive value of 18F-DCFPyL-PET for HCC as confirmed by histopathology. Secondary endpoints include comparison of 18F-DCFPyL-PET/CT with CT, MRI, and 18F-FDG-PET/CT, and evaluation of the value of 18F-DCFPyL-PET/CT in assessing treatment response following local treatment. Exploratory endpoints include next generation sequencing of tumors, and analysis of extracellular vesicles to identify biomarkers associated with response to therapy. This is a prospective imaging trial designed to evaluate whether PSMA-PET/CT imaging with 18F-DCFPyL can detect tumor sites, assess local treatment response in HCC patients, and to eventually determine whether PSMA-PET/CT could improve outcomes of patients with HCC receiving standard of care local therapy. Importantly, this trial may help determine whether PSMA-selective radiopharmaceutical therapies may be beneficial for patients with HCC. NIH IND#133631. Submission date: 04-07-2021. Safe-to-proceed letter issued by FDA: 05.07.2021. NIH IRB #00080. ClinicalTrials.gov Identifier NCT05009979. Date of Registry: 08-18-2021. Protocol version date: 01-07-2022.

The noticeable lack of knowledge among Spanish university students regarding the disciplinary content of research methodology is notable, despite the considerable potential benefits for curriculum design. This study represents the initial phase of a project aimed at analysing and ameliorating this deficiency. It sought to develop a scale to measure the attitudes of education students towards the content of research methods. The psychometric properties were analysed using an incidental sample of 447 students, of whom 87.9% were women and 12.1% were men, aged between 18 and 52 years. Of the total number of participants, 43.2% belonged to the Pedagogy Degree, 36.7% to the Early Childhood Education Degree, and 20.1% to the Social Education Degree of the Faculty of Educational Sciences of the University of Malaga. The instrument was developed based on the ATSQ scale by Ordoñez et al. Both exploratory and confirmatory factor analyses were conducted to assess its validity. The results demonstrate adequate psychometric properties and confirm a three-dimensional model. This model encompasses measures pertaining to three factors: two emotional (emotion− and emotion+) and one cognitive (estimated utility), facilitating the study of the students’ attitude towards the subjects of research methods. Furthermore, it provides arguments to consider a second-order unidimensional model. This study concludes with a discussion on the concept of attitudes towards research methods. Additionally, it identifies future challenges in measuring this construct without linking it to teacher evaluation.

Background Prostate Membrane Specific Antigen (PSMA) positron emission tomography (PET) and multiparametric MRI (mpMRI) have shown high accuracy in identifying recurrent lesions after definitive treatment in prostate cancer (PCa). In this study, we aimed to outline patterns of failure in a group of post-prostatectomy patients who received adjuvant or salvage radiation therapy (PORT) and subsequently experienced biochemical recurrence, using 18 F-PSMA PET/CT and mpMRI. Methods PCa patients with biochemical failure post-prostatectomy, and no evident site of recurrence on conventional imaging, were enrolled on two prospective trials of first and second generation 18 F-PSMA PET agents ( 18 F-DCFBC and 18 F-DCFPyL) in combination with MRI between October 2014 and December 2018. The primary aim of our study is to characterize these lesions with respect to their location relative to previous PORT field and received dose. Results A total of 34 participants underwent 18 F-PSMA PET imaging for biochemical recurrence after radical prostatectomy and PORT, with 32/34 found to have 18 F-PSMA avid lesions. On 18 F-PSMA, 17/32 patients (53.1%) had metastatic disease, 8/32 (25.0%) patients had locoregional recurrences, and 7/32 (21.9%) had local failure in the prostate fossa. On further exploration, we noted 6/7 (86%) of prostate fossa recurrences were in-field and were encompassed by 100% isodose lines, receiving 64.8–72 Gy. One patient had marginal failure encompassed by the 49 Gy isodose. Conclusions 18 F-PSMA PET imaging demonstrates promise in identifying occult PCa recurrence after PORT. Although distant recurrence was the predominant pattern of failure, in-field recurrence was noted in approximately 1/5th of patients. This should be considered in tailoring radiotherapy practice after prostatectomy. Trial registration www.clinicaltrials.gov , NCT02190279 and NCT03181867. Registered July 12, 2014, https://clinicaltrials.gov/ct2/show/NCT02190279 and June 8 2017, https://clinicaltrials.gov/ct2/show/NCT03181867 .

Background Somatostatin receptor (SSR) targeting radiotracer 68 Ga-DOTATATE is used for Positron Emission Tomography (PET)/Computed Tomography (CT) imaging to assess patients with Pheochromocytoma and paraganglioma (PPGL), rare types of Neuroendocrine tumor (NET) which can metastasize thereby becoming difficult to quantify. The goal of this study is to develop an artificial intelligence (AI) model for automated lesion segmentation on whole-body 3D DOTATATE-PET/CT and to automate the tumor burden calculation. 132 68 Ga-DOTATATE PET/CT scans from 38 patients with metastatic and inoperable PPGL, were split into 70, and 62 scans, from 20, and 18 patients for training, and test sets, respectively. The training set was further divided into patient-stratified 5 folds for cross-validation. 3D-full resolution nnUNet configuration was trained with 5-fold cross-validation. The model’s detection performance was evaluated at both scan and lesion levels for the PPGL test set and two other clinical cohorts with NET ( n  = 9) and olfactory neuroblastoma (ONB, n  = 5). Additionally, quantitative statistical analysis of PET parameters including SUVmax, total lesion uptake (TLU), and total tumor volume (TTV), was conducted. Results The nnUNet AI model achieved an average 5-fold validation dice similarity coefficient of 0.84 at the scan level. The model achieved dice similarity coefficients (DSC) of 0.88, 0.6, and 0.67 at the scan level, the sensitivity of 86%, 61.13%, and 61.64%, and a positive predictive value of 89%, 74%, and 86.54% at the lesion level for the PPGL test, NET and ONB cohorts, respectively. For PPGL cohorts, smaller lesions with low uptake were missed by the AI model ( p  < 0.001). Anatomical region-based failure analysis showed most of the false negative and false positive lesions within the liver for all the cohorts, mainly due to the high physiologic liver background activity and image noise on 68 Ga- DOTATATE PET scans. Conclusions The developed deep learning-based AI model showed reliable performance for automated segmentation of metastatic PPGL lesions on whole-body 68 Ga-DOTATATE-PET/CT images, which may be beneficial for tumor burden estimation for objective evaluation during therapy follow-up. https://www.clinicaltrials.gov/study/NCT03206060 , https://www.clinicaltrials.gov/study/NCT04086485 , https://www.clinicaltrials.gov/study/NCT05012098 .

The responsible management and consumption of water is a challenge that involves all segments of society. Having access to sufficient quality and quantity of water is not only a technological issue, but requires that the adopted measures and programmes take into account the dimensions of society and education. Spanish agriculture, as in other areas of the world, is a major consumer of water and more so than other sectors, including household consumption. Within the field of environmental education, this study covered the water culture and consumption of Andalusian farmers, based on their own perceptions. For this purpose, a questionnaire was created and validated, and included a sample of 1030 farmers selected with pseudorandom number sampling. An analysis of the data showed relevant results with respect to the values and notions supporting the justification for farmer behaviours, both from a cognitive-representative viewpoint and from an affective-expressive stance, as well as assertions made by the irrigators about other key sectors concerning the responsible management of water usage and water consumption. The findings of this study may assist in the design of environmental education programmes addressing this sector, which could also include other similar populations.

La sociedad del siglo XXI es compleja y cambiante, y esto exige a la ciudadanía una adaptación permanente a dichos cambios que, sin lugar a duda, afecta también la evolución del lenguaje, pues nadie pone cuestiona que el lenguaje está vivo; de no estarlo, seguiríamos hablando en latín. Surgen nuevas realidades, nuevos fenómenos que deben ser nombrados, ya que lo que no se nombra no existe. El lenguaje construye la realidad, modifica nuestros pensamientos y, por tanto, modula nuestras acciones.Así, utilizar un lenguaje inclusivo contribuye a construir una sociedad más inclusiva, del mismo modo que utilizar un lenguaje sexista contribuye a construir una realidad más sexista y más machista. De ahí que el uso del lenguaje inclusivo sea el reflejo de una sociedad más respetuosa. En este libro se relata una experiencia llevada a cabo con alumnado universitario por parte de un grupo de personas concienciadas y sensibilizadas en la apuesta por un lenguaje que no oculte a más de la mitad de la población mundial, un lenguaje que no subordine a nadie, que no infravalore a las personas por razón de género, que no excluya y que no quite la palabra a nadie, porque consideramos que la lengua española dispone de recursos suficientes para que, sin apartarse de las normas que rigen su funcionamiento, pueda no solo reflejar un derecho humano como es la igualdad, sino también reforzarla.