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As conventional upwind wind turbines grow larger, the increased mass and flexibility of the longer blades present challenges concerning costs, structural loads, and safety constraints such as tower clearance. At extreme scales, wind turbines in a downwind configuration may provide a feasible alternative to address these challenges by allowing lightweight, flexible blades that can reduce capital costs and blade loads while maintaining safety margins. Downwind turbine blades suffer from increased fatigue loading due to the tower shadow effect. In this study, novel downwind, three-bladed wind turbine designs at 25 MW rating with lightweight, flexible blades are evaluated and compared in terms of power production and structural loading. To obtain a baseline performance, a standard collective blade pitch wind turbine controller is implemented for the two downwind and one upwind turbine designs. Individual pitch control is then added for the downwind turbines to reduce structural fatigue on the turbine blades. In summary, the two downwind turbine designs that differ in rotor pre-coning and shaft tilt angles using collective and individual pitch control are compared against a conventional upwind turbine with collective pitch control at the same scale under turbulent wind conditions.

Polyomaviruses (PyVs) are non-enveloped double-stranded DNA viruses that can cause significant morbidity in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients, particularly BK polyomavirus (BKPyV) and JC polyomavirus (JCPyV). BKPyV is primarily associated with hemorrhagic cystitis (HC), while JCPyV causes progressive multifocal leukoencephalopathy (PML). The pathogenesis of these diseases involves viral reactivation under immunosuppressive conditions, leading to replication in tissues such as the kidney, bladder, and central nervous system. BKPyV-HC presents as hematuria and urinary symptoms, graded by severity. PML, though rare after allo-HSCT, manifests as neurological deficits due to JCPyV replication in glial cells. Diagnosis relies on nucleic acid amplification testing for DNAuria or DNAemia as well as clinical criteria. Management primarily involves supportive care, as no antiviral treatments have proven consistently effective for either virus and need further research. This review highlights the virology, clinical presentations, and management challenges of PyV-associated diseases post-allo-HSCT, emphasizing the need for improved diagnostic tools and therapeutic approaches to mitigate morbidity and mortality in this vulnerable population.

The goal of further reducing the Levelized Cost of Energy (LCOE) has driven the investigation of large-scale wind turbines. This work presents a simple, rapid and detailed approach for the structural design of the tower and monopile without a controller, but with frequency and high fidelity structural verification. The approach uses an optimization to reduce the mass of the structures while meeting strength, buckling and geometric constraints by using analytical equations. A verification of frequency constraints is performed with BModes, and ANSYS Mechanical APDL is used for high fidelity verification of stress and buckling. The approach is applied to study the design space of three 25 MW offshore wind turbines with different rotor diameters and cone angles, and to evaluate the nacelle center of mass fore-aft location effect. Results obtained show that the tower and monopile are more susceptible to changes in the rotor thrust than the overturning moment even for designs with high pre-cone angle and large distance of the nacelle center of mass from the tower axis. But it is possible to obtain structurally feasible tower and monopile designs for the three 25 MW turbines studied while not exceeding diameter and wall thickness limits. However, mass penalties can be decreased by 0.8-14%, to further reduce the cost of energy, by increasing the diameter limit which may require manufacturing technology development. The approach applied and studies serve to understand the design space of the tower and monopile for a 25 MW turbine, and provide baseline designs that can be used in the development of a controller and evaluation of a full suite of design load cases.

Several key development areas have been identified as having high potential for reducing the levelized cost of energy of offshore wind. Two of the most anticipated developments are future generation large wind turbines and the use of floating foundations. There is thus a need for developing large floating substructures that are capable of hosting future generation wind turbines. This work presents the preliminary sizing of two semi-submersible platforms for supporting a 25 MW turbine through a design space search using a simplified parametric analysis. Compared to simple theoretical upscaling, the substructures resulting from the proposed simplified parametric analysis have significantly lower steel mass and stiffer tower.

This paper presents the design and manufacturing of two novel small floating Darrieus vertical axis wind turbines (VAWT) developed for a wind-wave basin test campaign. As with typical designs, the rotor design needed to satisfy the traditional structural safety requirements (such as strain, deflection, resonant-free dynamics) from design standards along with other manufacturing and assembly constraints. In addition, for this particular design, some special conditions are present as the facility (the wind-wave basin itself) and use of existing Floating Offshore-wind and Controls Advanced Laboratory (FOCAL) semi-submersible floating platform (originally designed for HAWT test) imposed an additional set of design requirements including wind speed and size constraints, and specific, target overturning moments and rotor mass. Addressing all these constraints (facility, existing hull, structural safety, and manufacturing) presented a challenging design task in this case, thus the focus of this paper is presenting the design approach and results leading to final designs satisfying all these competing requirements. Using the presented design process, two Darrieus troposkein-shaped vertical axis wind turbines (two-bladed and three-bladed versions) were designed and manufactured, after ensuring compliance with all the design requirements. The presented study can aid researchers interested in developing similar floating turbine test campaigns.

Wind turbine sizes have grown rapidly in recent years with machine ratings of 15-16 MW available from multiple manufacturers for offshore wind turbines. While the industry advances large-scale turbine designs, offshore developers have initially focused on siting in shallow waters on bottom-fixed foundations; however, eyes are also on deep-water locations where floating systems are required. The present study presents the definition for an initial baseline rotor design at 25 MW scale, designed for a floating offshore system. The purpose of this paper is to document this 25 MW blade definition for use as a reference design for future floating wind technology development by industrial and academic researchers and developers. As this is an initial reference design, some opportunities (and plans) for further mass or cost reduction are also noted. In summary, the paper documents the initial baseline rotor design including aerodynamic and structural design of the rotor blades, along with key details about the control system and floating system designs for the floating 25 MW wind turbine system.

Abstract PurposeSocial support is associated with breast cancer survivors’ health-related quality of life (HRQoL). More nuanced information is needed regarding aspects of social support associated with different HRQoL domains among diverse populations. We assessed the association between emotional/informational and tangible support and five HRQoL domains and evaluated race as an effect modifier.MethodsAfrican American and White women (n = 545) diagnosed with hormone-receptor-positive breast cancer completed a survey that assessed sociodemographic, clinical, and psychosocial factors. We assessed bivariate relationships between emotional/informational and tangible support along with overall HRQoL and each HRQoL domain.We tested interactions between race and emotional/informational and tangible social support using linear regression.ResultsThe sample included African American (29%) and White (71%) breast cancer survivors. Emotional/informational social support had a statistically significant positive association with emotional well-being (β = .08, p = 0.005), social well-being (β = 0.36, p < 0.001), functional well-being (β = .22, p < .001), breast cancer concerns (β = .16, p = 0.002), and overall HRQoL (β = .83, p < .001). Similarly, tangible social support had a statistically significant positive association with emotional well-being (β = .14, p = 0.004), social well-being (β = .51, p < .001), functional well-being (β = .39, p < .001), and overall HRQoL (β = 1.27, p < .001). The interactions between race and social support were not statistically significant (p > 0.05).ConclusionsResults underscore the importance of the different social support types among breast cancer survivors, regardless of survivors’ race.Implications for Cancer SurvivorsPopulation-based interventions can be standardized and disseminated to provide guidance on how to increase emotional/information and tangible support for all breast cancer survivors by caregivers, health providers, and communities.

Agave species possess substantial cultural, ecological, and economic significance, particularly in Mexico, where they are traditionally utilized for food, fiber, and beverages. Their industrial relevance has expanded to include bioenergy, nutraceuticals, and sustainable agriculture. However, conventional propagation methods are constrained by long life cycles, low seed germination rates, and susceptibility to phytopathogens. In vitro culture has emerged as a pivotal biotechnological strategy for clonal propagation, germplasm conservation, and physiological enhancement. This review presents a critical synthesis of plant growth regulators (PGRs) employed in agave micropropagation, emphasizing their roles in organogenesis, somatic embryogenesis, shoot proliferation, and rooting. Classical PGRs such as 6-benzylaminopurine (BAP), benzyladenine (BA), 2,4-dichlorophenoxyacetic acid (2,4-D), indole-3-acetic acid (IAA), and indole-3-butyric acid (IBA) are widely utilized, with BA + 2,4-D and BA + IAA combinations demonstrating high efficiency in embryogenic callus induction and shoot multiplication. Additionally, non-traditional regulators such as abscisic acid (ABA) and putrescine (Put) have been shown to affect embryo maturation. This review synthesizes recent studies on agave in vitro culture protocols, identifies trends in PGR use, and highlights key research gaps. These insights reveal opportunities for innovation and underscore the need for species-specific optimization and molecular validation to improve reproducibility and scalability.

Exposure to excessive visible light causes retinal degeneration and may influence the progression of retinal blinding diseases. However, there are currently no applied treatments. Here, we focused on endoplasmic reticulum (ER) stress, which can cause cellular degeneration and apoptosis in response to stress. We analyzed functional, histological, and molecular changes in the light-exposed retina and the effects of administering an ER-stress inhibitor, 4-phenylbutyric acid (4-PBA), in mice. We found that light-induced visual function impairment related to photoreceptor cell loss and outer segment degeneration were substantially suppressed by 4-PBA administration, following attenuated photoreceptor apoptosis. Induction of retinal ER stress soon after light exposure, represented by upregulation of the immunoglobulin heavy chain binding protein (BiP) and C/EBP-Homologous Protein (CHOP), were suppressed by 4-PBA. Concurrently, light-induced oxidative stress markers, Nuclear factor erythroid 2–related factor 2 (Nrf2) and Heme Oxygenase 1 (HO-1), and mitochondrial apoptotic markers, B-cell lymphoma 2 apoptosis regulator (Bcl-2)-associated death promoter (Bad), and Bcl-2-associated X protein (Bax), were suppressed by 4-PBA administration. Increased expression of glial fibrillary acidic protein denoted retinal neuroinflammation, and inflammatory cytokines were induced after light exposure; however, 4-PBA acted as an anti-inflammatory. Suppression of ER stress by 4-PBA may be a new therapeutic approach to suppress the progression of retinal neurodegeneration and protect visual function against photo-stress.

The use of chemical pesticides in agriculture has led to the development of resistant pest populations, posing a challenge to long-term pest management. This review aims to evaluate the scientific literature on the individual and combined use of baculoviruses with conventional chemical and biological insecticides to combat Plutella xylostella, Spodoptera exigua, and Spodoptera frugiperda in broccoli, tomato, and maize crops. Notable findings include that both individual Plutella xylostella nucleopolyhedrovirus (PxNPV) and the combination of Plutella xylostella granulovirus (PxGV) and azadirachtin at a low dose effectively control Plutella xylostella; both combinations of Spodoptera exigua multiple nucleopolyhedrovirus (SeMNPV) with emamectin benzoate and chlorfenapyr reduced resistance in Spodoptera exigua and increased the efficacy of the insecticides; and the combination of Spodoptera frugiperda nucleopolyhedrovirus (SfMNPV) and spinetoram is effective against Spodoptera frugiperda. Integrating baculoviruses into pest management strategies offers a promising approach to mitigate the adverse effects of chemical pesticides, such as resistance development, health risks, and environmental damage. However, there remains a broad spectrum of research opportunities regarding the use of baculoviruses in agriculture.