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Despite the technological improvement of radiologic, endoscopic and nuclear imaging, the accuracy of diagnostic procedures for tumors can be limited whenever a mass-forming lesion is identified. This is true also because bioptical sampling cannot be properly guided into the lesions so as to puncture neoplastic tissue and to avoid necrotic areas. Under these circumstances, invasive and expensive procedures are still required to obtain diagnosis which is mandatory to plan the most appropriate therapeutic strategy. In order to test if electrical impedance spectroscopy may be helpful in providing further evidence for cancer detection, resistivity measurements were taken on 22 mice, 11 wild‐type and 11 sparc – / – (knock out for the protein SPARC: secreted protein acidic and rich in cysteine), bearing mammary carcinomas, by placing a needle-probe into tumor, peritumoral and contralateral healthy fat areas. Tumor resistivity was significantly lower than both peritumoral fat and contralateral fat tissues. Resistivity in sparc – / – mice was lower than wild-type animals. A significant frequency dependence of resistivity was present in tissues analyzed. We conclude that accurate measurements of resistivity may allow to discriminate between tissues with different pathological and/or structural characteristics. Therefore, resistivity measurements could be considered for in vivo detection and differential diagnosis of tumor masses.

Borexino has been a neutrino detector based on ultrapure liquid scintillator, located at the Laboratori Nazionali del Gran Sasso, Italy. Its main scientific goal was the real-time measurement of solar neutrino fluxes, which play an irreplaceable role for the comprehension of the mechanisms powering our star. Over the past two years, the Borexino collaboration has pursued the improvement of the CNO flux measurement, obtaining further indications about the solar metallicity. In a parallel way, Borexino has demonstrated for the first time the possibility of exploiting the directional Cherenkov information, in a liquid scintillator detector, for the detection of sub-MeV solar neutrinos.

In the core of the Sun, energy is released through sequences of nuclear reactions that convert hydrogen into helium. The primary reaction is thought to be the fusion of two protons with the emission of a low-energy neutrino. These so-called pp neutrinos constitute nearly the entirety of the solar neutrino flux, vastly outnumbering those emitted in the reactions that follow. Although solar neutrinos from secondary processes have been observed, proving the nuclear origin of the Sun’s energy and contributing to the discovery of neutrino oscillations, those from proton–proton fusion have hitherto eluded direct detection. Here we report spectral observations of pp neutrinos, demonstrating that about 99 per cent of the power of the Sun, 3.84 × 10 33 ergs per second, is generated by the proton–proton fusion process. Spectral observations of the low-energy neutrinos produced by proton–proton fusion in the Sun demonstrate that about 99 per cent of the Sun’s power is generated by this process. Sun's elusive pp neutrinos tracked down The Sun's energy output derives from a sequence of nuclear reactions that converts hydrogen into helium, most of it from the fusion of two protons (the proton–proton or pp reaction) accompanied by the release of a low-energy neutrino. These neutrinos have proved elusive: only solar neutrinos from secondary reactions had been directly observed. But here the Borexino collaboration reports observations of the pp neutrinos themselves, so providing a direct view of the principal fusion process that powers the Sun.

For most of their existence, stars are fuelled by the fusion of hydrogen into helium. Fusion proceeds via two processes that are well understood theoretically: the proton–proton ( pp ) chain and the carbon–nitrogen–oxygen (CNO) cycle 1 , 2 . Neutrinos that are emitted along such fusion processes in the solar core are the only direct probe of the deep interior of the Sun. A complete spectroscopic study of neutrinos from the pp chain, which produces about 99 per cent of the solar energy, has been performed previously 3 ; however, there has been no reported experimental evidence of the CNO cycle. Here we report the direct observation, with a high statistical significance, of neutrinos produced in the CNO cycle in the Sun. This experimental evidence was obtained using the highly radiopure, large-volume, liquid-scintillator detector of Borexino, an experiment located at the underground Laboratori Nazionali del Gran Sasso in Italy. The main experimental challenge was to identify the excess signal—only a few counts per day above the background per 100 tonnes of target—that is attributed to interactions of the CNO neutrinos. Advances in the thermal stabilization of the detector over the last five years enabled us to develop a method to constrain the rate of bismuth-210 contaminating the scintillator. In the CNO cycle, the fusion of hydrogen is catalysed by carbon, nitrogen and oxygen, and so its rate—as well as the flux of emitted CNO neutrinos—depends directly on the abundance of these elements in the solar core. This result therefore paves the way towards a direct measurement of the solar metallicity using CNO neutrinos. Our findings quantify the relative contribution of CNO fusion in the Sun to be of the order of 1 per cent; however, in massive stars, this is the dominant process of energy production. This work provides experimental evidence of the primary mechanism for the stellar conversion of hydrogen into helium in the Universe. Direct experimental evidence of the carbon–nitrogen–oxygen fusion cycle in the Sun is provided by the detection of neutrinos emitted during this process.

Neutrinos emitted in the carbon, nitrogen, oxygen (CNO) fusion cycle in the Sun are a sub-dominant, yet crucial component of solar neutrinos whose flux has not been measured yet. The Borexino experiment at the Laboratori Nazionali del Gran Sasso (Italy) has a unique opportunity to detect them directly thanks to the detector’s radiopurity and the precise understanding of the detector backgrounds. We discuss the sensitivity of Borexino to CNO neutrinos, which is based on the strategies we adopted to constrain the rates of the two most relevant background sources, pep neutrinos from the solar pp -chain and 210 Bi beta decays originating in the intrinsic contamination of the liquid scintillator with 210 Pb. Assuming the CNO flux predicted by the high-metallicity Standard Solar Model and an exposure of 1000 days × 71.3 t, Borexino has a median sensitivity to CNO neutrino higher than 3 σ . With the same hypothesis the expected experimental uncertainty on the CNO neutrino flux is 23%, provided the uncertainty on the independent estimate of the 210 Bi  interaction rate is 1.5 cpd / 100 ton  . Finally, we evaluated the expected uncertainty of the C and N abundances and the expected discrimination significance between the high and low metallicity Standard Solar Models (HZ and LZ) with future more precise measurement of the CNO solar neutrino flux.

A bstract The Borexino detector measures solar neutrino fluxes via neutrino-electron elastic scattering. Observed spectra are determined by the solar- ν e survival probability P ee ( E ), and the chiral couplings of the neutrino and electron. Some theories of physics beyond the Standard Model postulate the existence of Non-Standard Interactions (NSI’s) which modify the chiral couplings and P ee ( E ). In this paper, we search for such NSI’s, in particular, flavor-diagonal neutral current interactions that modify the ν e e and ν τ e couplings using Borexino Phase II data. Standard Solar Model predictions of the solar neutrino fluxes for both high- and low-metallicity assumptions are considered. No indication of new physics is found at the level of sensitivity of the detector and constraints on the parameters of the NSI’s are placed. In addition, with the same dataset the value of sin 2 θ W is obtained with a precision comparable to that achieved in reactor antineutrino experiments .

A search for solar axions and axion-like particles produced in the p + d → 3 He + A ( 5.5 MeV ) reaction was performed using the complete dataset of the Borexino detector (3995 days of measurement live-time). The following interaction processes have been considered: axion decay into two photons ( A → 2 γ ) , inverse Primakoff conversion on nuclei ( A + Z → γ + Z ), the Compton conversion of axions to photons ( A + e → e + γ ) and the axio-electric effect ( A + e + Z → e + Z ). Model-independent limits on product of axion–photon ( g A γ ), axion–electron ( g Ae ), and isovector axion–nucleon ( g 3 A N ) couplings are obtained: | g A γ × g 3 A N | ≤ 2.3 × 10 - 11 GeV - 1 and | g Ae × g 3 A N | ≤ 1.9 × 10 - 13 at m A < 1 MeV (90% c.l.). The Borexino results exclude new large regions of g A γ , and g Ae coupling constants and axion masses m A , and leads to constraints on the products | g A γ × m A | and | g Ae × m A | for the KSVZ- and the DFSZ-axion models.

A bstract The very low radioactive background of the Borexino detector, its large size, and the well proved capability to detect both low energy electron neutrinos and antineutrinos make an ideal case for the study of short distance neutrino oscillations with artificial sources at Gran Sasso. This paper describes the possible layouts of 51 Cr ( ν e ) and 144 Ce- 144 Pr source experiments in Borexino and shows the expected sensitivity to eV mass sterile neutrinos for three possible different phases of the experiment. Expected results on neutrino magnetic moment, electroweak mixing angle, and couplings to axial and vector currents are shown too.

The search for neutrino events in correlation with gravitational wave (GW) events for three observing runs (O1, O2 and O3) from 09/2015 to 03/2020 has been performed using the Borexino data-set of the same period. We have searched for signals of neutrino-electron scattering and inverse beta-decay (IBD) within a time window of ± 1000  s centered at the detection moment of a particular GW event. The search was done with three visible energy thresholds of 0.25, 0.8 and 3.0 MeV. Two types of incoming neutrino spectra were considered: the mono-energetic line and the supernova-like spectrum. GW candidates originated by merging binaries of black holes (BHBH), neutron stars (NSNS) and neutron star and black hole (NSBH) were analyzed separately. Additionally, the subset of most intensive BHBH mergers at closer distances and with larger radiative mass than the rest was considered. In total, follow-ups of 74 out of 93 gravitational waves reported in the GWTC-3 catalog were analyzed and no statistically significant excess over the background was observed. As a result, the strongest upper limits on GW-associated neutrino and antineutrino fluences for all flavors ( ν e , ν μ , ν τ ) at the level 10 9 - 10 15 cm - 2 GW - 1 have been obtained in the 0.5–5 MeV neutrino energy range.

The search for neutrino events in correlation with gravitational wave (GW) events for three observing runs (O1, O2 and O3) from 09/2015 to 03/2020 has been performed using the Borexino data-set of the same period. We have searched for signals of neutrino-electron scattering and inverse beta-decay (IBD) within a time window of [Formula omitted] s centered at the detection moment of a particular GW event. The search was done with three visible energy thresholds of 0.25, 0.8 and 3.0 MeV. Two types of incoming neutrino spectra were considered: the mono-energetic line and the supernova-like spectrum. GW candidates originated by merging binaries of black holes (BHBH), neutron stars (NSNS) and neutron star and black hole (NSBH) were analyzed separately. Additionally, the subset of most intensive BHBH mergers at closer distances and with larger radiative mass than the rest was considered. In total, follow-ups of 74 out of 93 gravitational waves reported in the GWTC-3 catalog were analyzed and no statistically significant excess over the background was observed. As a result, the strongest upper limits on GW-associated neutrino and antineutrino fluences for all flavors ( [Formula omitted]) at the level [Formula omitted] have been obtained in the 0.5-5 MeV neutrino energy range.