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Background Peri-implant femoral fractures occurring around an intramedullary nail (“around the nail” fractures) represent a complex challenge in orthopedic trauma. These fractures have been increasingly reported over the last two decades, and studies from 2001 to 2025 were selected to capture contemporary surgical techniques and implant designs. Management remains controversial due to both mechanical issues (implant loosening, malposition, nail breakage, and fracture at stress risers) and systemic complications (infections, thromboembolic events, and medical comorbidities). Materials and methods A systematic review was conducted following PRISMA guidelines. PubMed, Scopus, and Google Scholar were searched for studies published between 2001 and 2025. Inclusion criteria comprised studies on adult patients undergoing surgical treatment for peri-implant femoral fractures after anterograde nailing. Data on demographics, fracture patterns, implant characteristics, surgical strategies, and outcomes were extracted. Methodological quality was assessed using the MINORS score. Results The study included 315 patients with a mean age of 82.3 years, predominantly female (2:1 ratio). Most fractures were treated with anterograde intramedullary nails, mainly short nails. A total of 211 peri-implant fractures were analyzed, with the majority occurring around the nail (58.8%). Fractures were more common within 12 months post-surgery. Surgical treatment involved reinforcement with long nails or lateral plating. The union rate was 93.7%, with a mean healing time of 23.96 weeks. Complications included infections (19 cases), systemic issues, and mechanical problems (implant loosening, breakage, or malposition), leading to additional surgeries in some cases. Infection was linked to higher mortality rates (44.4% vs. 11.8%). Conclusion There is no definitive consensus on the optimal surgical treatment of “around the nail” femoral fractures. Treatment choice is influenced by fracture location, implant stability, and patient comorbidities. Plating, nail revision, and prosthetic replacement each carry specific risks and benefits. The high complication and mortality rates, along with variability in outcomes, highlight the need for standardized classification systems and high-quality comparative studies to guide treatment in this challenging clinical scenario.

This study applies the first three levels of analysis outlined in the recent Italian Bridge Guidelines to a stock of prestressed concrete bridges located along the highways connecting the cities of Palermo, Messina and Catania in Sicily, south of Italy. The examined levels of analysis include census, visual inspection and determination of the structural–foundational and seismic Classes of Attention of bridges and viaducts. Data of the census and visual inspection activities were gathered using a custom-made web application. The details, the methodologies and all the features implemented in the web platform were illustrated and discussed. Furthermore, the collected data were described and critically analyzed, offering insights into the strength and limitations of each of the three examined levels of analysis of the Italian Bridge Guidelines. Finally, based on the detected defects and their numerousness with respect to the total number of assessed bridges, the authors proposed a straightforward and practical methodology for prioritizing any subsequent repairing intervention on specific groups of bridges.

Toxoplasma gondii is a major foodborne pathogen capable of infecting all warm-blooded animals, including humans. Although oocyst-associated toxoplasmosis outbreaks have been documented, the relevance of the environmental transmission route remains poorly investigated. Thus, we carried out an extensive systematic review on T. gondii oocyst contamination of soil, water, fresh produce, and mollusk bivalves, following the PRISMA guidelines. Studies published up to the end of 2020 were searched for in public databases and screened. The reference sections of the selected articles were examined to identify additional studies. A total of 102 out of 3201 articles were selected: 34 articles focused on soil, 40 focused on water, 23 focused on fresh produce (vegetables/fruits), and 21 focused on bivalve mollusks. Toxoplasma gondii oocysts were found in all matrices worldwide, with detection rates ranging from 0.09% (1/1109) to 100% (8/8) using bioassay or PCR-based detection methods. There was a high heterogeneity (I2 = 98.9%), which was influenced by both the sampling strategy (e.g., sampling site and sample type, sample composition, sample origin, season, number of samples, cat presence) and methodology (recovery and detection methods). Harmonized approaches are needed for the detection of T. gondii in different environmental matrices in order to obtain robust and comparable results.

Pasteurellosis, a disease caused by Pasteurella multocida, is responsible for economic losses in rabbit industrial farms due to rhinitis, conjunctivitis, pneumonia, metritis, mastitis, orchitis, subcutaneous abscesses, otitis, encephalitis, and septicaemic forms. Although the occurrence of the disease is conditioned by predisposing factors that affect the rabbit immune response, the strains of P. multocida involved in the infection may have a different pathogenic ability. Therefore, typing of strains spread among the rabbits is important to assess their pathogenic potential. The aim of this study is to investigate the P. multocida strains responsible for disease in rabbit industrial farms. A total of 114 strains identified from different lesions were serotyped. Additionally, the presence of virulence-associated genes was investigated using three PCR (polymerase chain reaction) protocols. Capsular type A was prevalently found in strains from respiratory lesions while types D and F in those from metritis, mastitis, and other lesions. Different associations between some virulence-associated genes and both capsular type and lesions found in rabbits were detected. The presence of 8 virulence-associated genes seems to increase the occurrence of metritis. In addition, strains belonging to capsular type A and responsible for respiratory disorders especially, were found equipped with 10 and 11 virulence-associated genes. Nevertheless, the presence of strains responsible only for rhinitis was also detected among the latter, suggesting that the pathogenic ability of the bacteria depends on the expression rather than the presence of a gene.

Background: Estimates of the association between COVID-19 vaccines and myo-/pericarditis risk vary widely across studies due to scarcity of events, especially in age- and sex-stratified analyses. Methods: Population-based cohort study with nested self-controlled risk interval (SCRI) using healthcare data from five European databases. Individuals were followed from 01/01/2020 until end of data availability (31/12/2021 latest). Outcome was first myo-/pericarditis diagnosis. Exposures were first and second dose of Pfizer, AstraZeneca, Moderna, and Janssen COVID-19 vaccines. Baseline incidence rates (IRs), and vaccine- and dose-specific IRs and rate differences were calculated from the cohort The SCRI calculated calendar time-adjusted IR ratios (IRR), using a 60-day pre-vaccination control period and dose-specific 28-day risk windows. IRRs were pooled using random effects meta-analysis. Findings: Over 35 million individuals (49·2% women, median age 39–49 years) were included, of which 57·4% received at least one COVID-19 vaccine dose. Baseline incidence of myocarditis was low. Myocarditis IRRs were elevated after vaccination in those aged < 30 years, after both Pfizer vaccine doses (IRR = 3·3, 95%CI 1·2-9.4; 7·8, 95%CI 2·6-23·5, respectively) and Moderna vaccine dose 2 (IRR = 6·1, 95%CI 1·1-33·5). An effect of AstraZeneca vaccine dose 2 could not be excluded (IRR = 2·42, 95%CI 0·96-6·07). Pericarditis was not associated with vaccination. Interpretation: mRNA-based COVID-19 vaccines and potentially AstraZeneca are associated with increased myocarditis risk in younger individuals, although absolute incidence remains low. More data on children (≤ 11 years) are needed.

Staphylococcus aureus and coagulase-negative staphylococci (CNS) are the main causative agents of mastitis in sheep. Their ability to form biofilms in vivo is considered an important virulence factor underlying mastitis outbreaks refractory to antibiotic treatments. Furthermore, pre- and postdipping immersion during milking in iodine substances could determine the presence of residues in milk and therefore represent a health risk factor for consumers. The aim of this study was to evaluate the antibacterial and biofilm inhibitory activity of Thymus vulgaris L. essential oil (TEO) against staphylococci strains isolated from ovine clinical mastitis. In particular, 3 reference strains (S. aureus 25923 and 11623 and S. epidermidis 12228) and 12 clinical isolates (6 S. aureus and 6 CNS) were used. TEO solutions, from a concentration of 1% (v/v) to 1.25% (v/v), corresponding to 9.28–2.32 mg/mL, were obtained after solubilization in 10% dimethyl sulfoxide (DMSO) and used to evaluate the bacterial time-kill compared to that of an iodine-based solution. Antibacterial efficacy was then assessed by the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC), while biofilm inhibition was assessed by minimum biofilm inhibitory concentration (MBIC) using a spectrophotometer at a wavelength of 570 nm. Additionally, biofilm-associated genes (icaA and icaD) were evaluated in all tested strains by PCR. The tested TEO concentrations were able to significantly and prominently reduce bacterial growth compared to controls, as demonstrated by bacterial time-kills. The MIC value was obtained at a concentration of 0.50% (v/v) for a single coagulation-positive isolate (S. aureus (f)) and at a concentration of 0.25% (v/v) for all other isolates. TEO showed effective bactericidal action with a 99.9% reduction in CFU/mL of all isolates in the MBC test at a concentration of 0.25% (v/v) for most of the tested strains. Furthermore, a marked inhibition in biofilm formation at all tested concentrations was observed, with MBIC value of 0.25%. All S. aureus tested were biofilm-producing strains and positive for icaA and icaD genes, while two CNS biofilm-producing strains were negative for both genes. These preliminary results suggest that TEO could be a promising alternative as an udder disinfectant during milking practices. Although in vivo studies are needed to confirm the efficacy and safety of TEO as an adjuvant in the prevention and treatment of udder infections, TEO could help counteract the emergence of antimicrobial resistance and reduce the potential risk of iodine residues in milk.

In this paper I propose an interpretation ofCalvino's Cosmicomiche in the framework ofpossible-worldsfiction theory. I use this theoretical framework to make an ‘‘interpretative bet’’ on the name of the main character and narrator of these stories: can we readQfwfqas a stylistic constant which refers toKafkaas an interpretative function? In my reading, Kafka is not a descriptive content of the name ‘‘Qfwfq’’, but a semantic model relative to Qfwfq's possible worlds. The definition of this model provides a unified interpretation of the cosmicomic project and contributes to a new reading of Calvino's late works.

Bridges constitute important elements of the transportation network. A vast part of the Italian existing infrastructural system dates to around 60 years ago, which implies that the related bridge structures were constructed according to past design guidelines and underwent a probable state of material deterioration (e.g., steel corrosion, concrete degradation), especially in those cases in which proper maintenance plans have not been periodically performed over the structural lifetime. Consequently, elaborating rapid yet effective safety assessment strategies for existing bridge structures represents a topical research line. This contribution presents a systematic experimental-numerical approach for assessing the load-bearing capacity of existing prestressed concrete (PC) bridge decks. This methodology is applied to the Longano PC viaduct (southern Italy) as a case study. Initially, natural frequencies and mode shapes of the bridge deck are experimentally identified from vibration data collected in situ through Operational Modal Analysis (OMA), based on which a numerical finite element (FE) model is developed and calibrated. In situ static load tests are then carried out to investigate the static deflections under maximum allowed serviceability loads, which are compared to values provided by the FE model for further validation. Since prestressing strands appear corroded in some portions of the main girders, numerical static nonlinear analysis with a concentrated plasticity approach is finally conducted to quantify the effects of various corrosion scenarios on the resulting load-bearing capacity of the bridge at ultimate limit states. The proposed methodology, encompassing both serviceability and ultimate conditions, can be used to identify critical parts of a large infrastructure network prior to performing widespread and expensive material test campaigns, to gain preliminary insight on the structural health of existing bridges and to plan a priority list of possible repairing actions in a reasonable, safe, and costly effective manner.

Questo saggio esplora il rapporto di Pasolini con l’avanguardia degli anni Sessanta attraverso i suoi progetti di scrittura del Paradiso in una “lingua del futuro”. L’ipotesi di fondo è che questi progetti siano un tentativo d’integrare la poetica della mimesi dantesca con una critica linguistica della pop art, in quanto discorso “previssuto” della società post-industriale. L’ipotesi viene sviluppata all’incrocio di due principali linee tematiche. In primo luogo, l’identificazione delle prospettive linguistiche del futuro con “il progetto e la costruzione (in corso) dei Due Paradisi—quello neocapitalistico e quello comunista”, come leggiamo nella Divina Mimesis (1975). In secondo luogo, l’individuazione della fabbrica come centro di omologazione sociale della lingua tecnologica, secondo le conclusioni dell’Intervento sul discorso libero indiretto (1965). Nella parte finale, un confronto con il film di Elio Petri, La classe operaia va in Paradiso (1971), suggerisce la catena di montaggio come metafora dell’impossibilità critica di un nuovo realismo mimetico, che possa “far parlare la fabbrica, usufruire della sua lingua, reperirvi un margine di libertà, riviverla”.