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7 result(s) for "Mikus, Marian"
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Sedation versus General Anesthesia for Cardiac Catheterization in Infants: A Retrospective, Monocentric, Cohort Evaluation
Background: Children with congenital heart disease require repeated catheterization. Anesthetic management influences the procedure and may influence outcome; however, data and recommendations are lacking for infants. We studied the influence of sedation versus general anesthesia (GA) on adverse events during catheterization for children <2 years old. Methods: We conducted a monocentric, retrospective study of all catheterization procedures (2008–2013). High-severity adverse event (HSAE) rates were compared using propensity-score-adjusted models, including pre- and intra-procedural variables. Results: 803 cases (619 patients) (368 (46%) GA, 435 (54%) sedation) with a mean age of 6.9 ± 6.1 months were studied. The conversion rate (GA after sedation) was 18 (4%). Hospital stay was 4.9 ± 4.0 and 4.1 ± 2.5 (p = 0.01) after GA or sedation, respectively. HSAE occurred in 75 (20%) versus 40 (9%) (p < 0.01) in GA versus sedation procedures, respectively. Risk factors (multivariable analysis) were older patients (p = 0.05), smaller weights (p < 0.01), palliated status (OR 3.2 [1.2–8.9], p = 0.02), two-ventricle physiology (OR 7.3 [2.7–20.2], p < 0.01), cyanosis (OR 4.6 [2.2–9.8], p < 0.01), pulmonary hypertension (OR 5.6 [2.0–15.5], p < 0.01), interventional catheterization (OR 1.8 [1.1–3.2], p = 0.02) and procedure-type risk category 4 (OR 28.9 [1.8–455.1], p = 0.02). Sedation did not increase the events rate and decreased the requirement for hemodynamic support (OR 5.2 [2.2–12.0], p < 0.01). Conclusion: Sedation versus GA for cardiac catheterization in children <2 years old is safe and effective with regard to HSAE. Sedation also decreases the requirement for hemodynamic support. Paradoxical effects (older age and two-ventricle physiology) on risk have been found for this specific age cluster.
Impact of the mother’s voice on sedation need and stress during cardiologic examination of children (SMUSS study): a prospective, interventional, randomised, controlled, monocentric study
Cardiac catheterisation is crucial for diagnosing and treating paediatric heart diseases, but it is poorly tolerated by small children, infants, and newborns without sedation. This study investigated whether maternal voice during sedation could lower stress and pain in children undergoing cardiac catheterisation and also assessed mothers' stress levels before and after the procedure. This was a prospective, monocentric, randomised, controlled interventional study at the University Hospital Bonn. Children aged 4 years or younger scheduled for elective cardiac catheterisation under procedural sedation and American Society of Anaesthesiologists class between 1 and 3 were eligible. At the end of cardiac catheterisation, the intervention group showed a higher Newborn Infant Parasympathetic Evaluation index with an adjusted mean difference of 9.5 (± 4.2) ( = 0.026) and a lower median Children's and Infants Postoperative Pain Scale score of 2.0 (IQR: 0.0-5.0) versus 4.5 (IQR: 3.0-6.0) than the control group ( = 0.027). No difference in the children's cortisol level was found ( = 0.424). The mothers in the intervention group had a lower cortisol level than those in the control group before cardiac catheterisation (adjusted mean difference: -4.5 nmol/l (± 1.8 nmol/l), = 0.011). Listening to the maternal voice during cardiac catheterisation could lead to less postoperative pain and significantly lower stress and discomfort level in children. Less pain could reduce the incidence of postoperative delirium.Additionally, mothers perceived involvement as positive. A reduced stress level of mothers can positively influence children and possibly reduce pain and anxiety.
Assessing entrepreneurial emotional intelligence: The development of the emotional intelligence in business questionnaire
Objective: The article aims to present the ‘Emotional Intelligence in Business‘ (EIB) questionnaire, developed using the four-component 4EI model of emotional intelligence. Research Design & Methods: The EIB questionnaire is based on the 19 competencies of the 4EI Model, which builds on D. Goleman’s mixed model of emotional intelligence. Its competencies are adapted to the business environment, and allow the identification of 4 components: 1) self-awareness (SA), 2) self-management (SM), 3) social awareness (SocA), and 4) relationship management (RM). One hundred fifty-eight respondents of different ages participated in the EIB questionnaire development procedures during 2020 and 2021. We validated the EIB questionnaire using classical test theory methods. We analysed data in MS Excel, SPSS, FACTOR, and R-Studio using techniques such as exploratory and confirmatory factor analyses, Cronbach’s alpha, and non-parametric tests (Mann-Whitney U, Kruskal-Wallis). Findings: The EIB questionnaire demonstrates robust psychometric properties, including high measurement accuracy and internal consistency. It also features a distinct factorial structure. Moreover, the tool demonstrates meaningful and theoretically congruent correlations with N.Hall’s Emotional Intelligence Test and D.Lyusin ‘AmIn‘ Questionnaire. The EIB questionnaire comprises 40 statements, each rated on a five-point Likert scale. According to the 4EI model, the EIB questionnaire is a reliable measuring tool for building an entrepreneur’s EI profile. Implications & Recommendations: The EIB questionnaire allows the building of profiles of entrepreneurs and tracking the dynamics of their EI components: SA, SM, SocA, and RM. Surveys with automatic follow-up recommendations can be easily conducted with the help of the user-friendly chatbot ‘Emotional Intelligence in Business’ specially created in Smart Sender. Contribution & Value Added: This research offers a valuable tool for measuring EI competencies in the business environment. Based on individual EI profiles, optimising project teams and improving collaboration in entrepreneurship, including online projects, is possible.
Comparison of Linear Regression and Artificial Neural Network Models for the Dimensional Control of the Welded Stamped Steel Arms
The production of parts by pressing and subsequent welding is commonly used in the automotive industry. The disadvantage of this method of production is that inaccuracies arising during pressing significantly affect the final dimension of the part. However, this can be corrected by the choice of the technological parameters of the following operation—welding. Suitably designed parameters make it possible to partially eliminate inaccuracies arising during pressing and thus increase the overall applicability of this technology. The paper is focused on the upper arm geometry of a car produced in this manner. There have been two neural networks proposed in which the optimal welding parameters are determined based on the stamped dimensions and the desired final dimensions. The Levenberg–Marquardt back-propagation algorithm and the Bayesian regularised back-propagation algorithm were used as the learning algorithm for ANNs in multi-layer feed-forward networks. The outputs obtained from the neural networks were compared with a linear prediction model based on a on the design of experiment methodology. The mean absolute percentage error of the linear regression model on the entire dataset was 3 × 10−3%. A neural network with Levenberg–Marquardt back-propagation learning algorithm had a mean absolute percentage error of 4 × 10−3. Similarly, a neural network with a Bayesian regularised back-propagation learning algorithm had a mean absolute percentage error of 3 × 10−3%.
Hellandite-(Y)–hingganite-(Y)–fluorapatite retrograde coronae: a novel type of fluid-induced dissolution–reprecipitation breakdown of xenotime-(Y) in the metagranites of Fabova Hoľa, Western Carpathians, Slovakia
Two contrasting reaction coronae were developed around rare earth element (REE) accessory phosphates in Variscan metagranitic rocks, which have been overprinted by Alpine blastomylonitisation from the Fabova Hol'a Massif, in the Veporic Unit, Western Carpathians, Central Slovakia. The Th–U–Pb total EPMA age determination of primary magmatic monazite-(Ce) from the metagranite indicates a Carboniferous (Mississippian, Tournaisian) age of 355 ± 1.9 Ma. Monazite-(Ce) breakdown resulted in impressive, though common, fluorapatite ± Th-silicate + allanite-(Ce) + clinozoisite coronae. The alteration of xenotime-(Y) produced a novel type of secondary coronal micro-texture consisting of a massive fluorapatite mantle zone and tiny satellite crystals of hellandite-(Y) [(Ca,REE) 4 Y 2 Al□ 2 (B 4 Si 4 O 22 )(OH) 2 ] and hingganite-(Y) [Y 2 □Be 2 Si 2 O 8 (OH) 2 ] of ~1–5 μm, and rarely ≤10 μm in size. The localised occurrence of Y–B–Be silicates, which are associated closely with other secondary minerals, suggests the involvement of B and Be during the metasomatic alteration transformation of xenotime-(Y). General reactions for monazite-(Ce) and xenotime-(Y) decomposition, including the fluids involved, can be written as follows: Mnz + (Ca, Fe, Si, Al and F)-rich fluid → FAp + Ht + Aln + Czo; Xtm + (Ca, Fe, Si, Al, F, B and Be)-rich fluid → FAp + Hld + Hin + Czo. The granitic rocks underwent Early Cretaceous burial metamorphism under greenschist- to lower amphibolite-facies P – T conditions. Subsequently, Alpine post-collisional uplift and exhumation of the Veporic Unit, starting from the Late Cretaceous epoch, was accompanied by a retrograde tectono-metamorphic overprint; the activity of external fluids, caused the formation of secondary coronae minerals around monazite-(Ce) and xenotime-(Y). A portion of B (± Be) should have been liberated from the metagranite feldspars, micas, or xenotime-(Y) enriched in (Nb,Ta)BO 4 (schiavinatoite or béhierite) components. However, the principal source of B and Be in fluids necessary for the production of hellandite and hingganite, was probably of external origin from adjacent magmatic, metamorphic, or sedimentary rocks (Permian granites, rhyolites and sedimentary rocks, and Palaeozoic metapelites).
Eclogites overprinted in the granulite facies from the Ďumbier Crystalline Complex (Low Tatra Mountains, Western Carpathians)
Metabasites with evidence for breakdown of former eclogites and recrystallization under granulite facies conditions occur in the Ďumbier Crystalline Complex of the Low Tatra Mountains, Central Western Carpathains. Textural relationships, phase equilibrium modelling and thermobarometry have been used to determine the P-T evolution of these rocks. Omphacite diagnostic for the eclogites facies stage is absent but its former presence is inferred from the symplectitic intergrowths of clinopyroxene + plagioclase. The re-equilibration in high-pressure granulite facies conditions is demonstrated by the assemblage garnet + clinopyroxene (< 10 % Jd) + plagioclase + quartz. The phase equilibrium modelling using THERIAK-DOMINO program and conventional geothermobarometry suggest the P-T conditions of 750-760 °C and 1.1-1.5 GPa for the high-pressure granulite stage. Orthopyroxene formed in the clinopyroxene + plagioclase symplectites and kelyphites and coronas around garnet at P-T conditions of ca. 0.7-1.0 GPa and 650-700 °C. P-T evolution of granulitized eclogites is interpreted as the result of two metamorphic events; early Variscan eclogite facies metamorphism was followed by granulite facies thermal overprint in the Carboniferous time. The second metamorphic event was crucial for breakdown of eclogites, these are only seldom preserved in the pre-Alpine basement of the Western Carpathians.