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"Miller, Greg"
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Is Pharma Running Out of Brainy Ideas?
Recent cutbacks raise concerns about the future of drug development for nervous system disorders. On 4 February, GlaxoSmithKline (GSK) announced that it planned to pull the plug on drug discovery in some areas of neuroscience, including pain and depression. A few weeks later, news came that AstraZeneca was closing research facilities in the United States and Europe and ceasing drug-discovery work in schizophrenia, bipolar disorder, depression, and anxiety. These cutbacks by two of the top players in drug development for disorders of the central nervous system have raised concerns that the pharmaceutical industry is pulling out, or at least pulling back, in this area. In direct response to the cuts at GSK and AstraZeneca, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders organized a meeting in late June that brought together leaders from government, academia, and private foundations to take stock. But the biggest problem, researchers say, is that there is almost nothing in the pipeline that gives any hope for a transformation in the treatment of mental illness. That's worrying, they say, because the need for better treatments for neurological and psychiatric disorders is vast. Hundreds of millions of people are afflicted worldwide. Yet for some common disorders, like Alzheimer's disease, no truly effective treatments exist; for others, like depression, the existing drugs have limited efficacy and substantial side effects.
Journal Article
The apprentice : Trump, Russia and the subversion of American democracy
\"It has been called the political crime of the century: a foreign government, led by a brutal authoritarian leader, secretly interfering with the American presidential election to help elect the candidate of its choice. Now ... Washington Post national security reporter Greg Miller investigates the truth about the Kremlin's covert attempt to destroy Hillary Clinton and help Donald Trump win the presidency, Trump's steadfast allegiance to Vladimir Putin, and Robert Mueller's ensuing investigation of the president and those close to him\"--Publisher marketing.
BOOK
The Promise and Perils of Oxytocin
Is oxytocin the next revolution in psychiatric medicine—or an overhyped hormone that could make some patients worse? Few substances produced by the human body have inspired as much hoopla as oxytocin. Although breathless media coverage often goes too far, it reflects a genuine and infectious excitement among many scientists about the hormone's role in social behavior: promoting trust and cooperation and making people more attuned to social cues. At first glance, oxytocin might seem like just what the doctor should be ordering. But as researchers have continued to explore the hormone's effect on human behavior, a darker side has emerged.
Journal Article
All over the map : a cartographic odyssey
\"Created for map lovers by map lovers, this rich book explores the intriguing stories behind maps across history and illuminates how the art of cartography thrives today. In this visually stunning book, award-winning journalists Betsy Mason and Greg Miller--authors of the National Geographic cartography blog \"All Over the Map\"--explore the intriguing stories behind maps from a wide variety of cultures, civilizations, and time periods. Based on interviews with scores of leading cartographers, curators, historians, and scholars, this is a remarkable selection of fascinating and unusual maps. This diverse compendium includes ancient maps of dragon-filled seas, elaborate graphics picturing unseen concepts and forces from inside Earth to outer space, devious maps created by spies, and maps from pop culture such as the schematics to the Death Star and a map of Westeros from Game of Thrones. If your brain craves maps--and Mason and Miller would say it does, whether you know it or not--this eye-opening visual feast will inspire and delight\"-- Provided by publisher.
Book
Cassini finds molecular hydrogen in the Enceladus plume
Saturn’s moon Enceladus has an ice-covered ocean; a plume of material erupts from cracks in the ice. The plume contains chemical signatures of water-rock interaction between the ocean and a rocky core. We used the Ion Neutral Mass Spectrometer onboard the Cassini spacecraft to detect molecular hydrogen in the plume. By using the instrument’s open-source mode, background processes of hydrogen production in the instrument were minimized and quantified, enabling the identification of a statistically significant signal of hydrogen native to Enceladus. We find that the most plausible source of this hydrogen is ongoing hydrothermal reactions of rock containing reduced minerals and organic materials. The relatively high hydrogen abundance in the plume signals thermodynamic disequilibrium that favors the formation of methane from CO₂ in Enceladus’ ocean.
Journal Article
Bad news for Labour : antisemitism, the party and public belief
During the summer of 2018, numerous members of the Labour Party were accused of anti-Semitic behaviour by their detractors. The controversy reached fever pitch amid claims that the Labour Party had become 'institutionally racist' under the leadership of Jeremy Corbyn, and that the prospect of a Corbyn-led government posed an 'existential threat' to Jewish life in Britain. Shrouded in confusion, hyped by the media, whether these accusations were true or not got lost in the mix. This book clears the confusion by drawing on deep and original research on public beliefs and media representation of antisemitism and the Labour Party, revealing shocking findings of misinformation spread by the press, including the supposedly impartial BBC, and the liberal Guardian.
Book
Why Is Mental Illness So Hard to Treat?
The human brain is complex and difficult to study, which has impeded development of drug treatments for mental illnesses. But new tools and new ways of thinking could help the field gain new traction. Uncovering the roots of psychiatric illness has not been easy. Not only is the brain the most complex organ in the body, but it's also harder to study. Doctors and researchers can't biopsy a patient's brain, and it's unclear how well disorders of the human mind can be studied in other species. Leaders in the field argue that too much effort has been spent looking for compounds similar to the early psychiatric drugs or tweaking their chemistry to eke out improvements in efficacy, reduce their side effects, and preserve the revenue stream generated by patent-protected drugs. However, several new tools and new ways of thinking could help the field gain new traction. (Read about more \" Mysteries of the Brain .\")
Journal Article