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Misophonia is a neurobehavioral syndrome phenotypically characterized by heightened autonomic nervous system arousal and negative emotional reactivity (e. g., irritation, anger, anxiety) in response to a decreased tolerance for specific sounds. The aims of this review are to (a) characterize the current state of the field of research on misophonia, (b) highlight what can be inferred from the small research literature to inform treatment of individuals with misophonia, and (c) outline an agenda for research on this topic. We extend previous reviews on this topic by critically reviewing the research investigating mechanisms of misophonia and differences between misophonia and other conditions. In addition, we integrate this small but growing literature with basic and applied research from other literatures in a cross-disciplinary manner.

Plexiform neurofibromas are slow-growing chemoradiotherapy-resistant tumours arising in patients with neurofibromatosis type 1 (NF1). Currently, there are no viable therapeutic options for patients with plexiform neurofibromas that cannot be surgically removed because of their proximity to vital body structures. We undertook an open-label phase 2 trial to test whether treatment with imatinib mesylate can decrease the volume burden of clinically significant plexiform neurofibromas in patients with NF1. Eligible patients had to be aged 3–65 years, and to have NF1 and a clinically significant plexiform neurofibroma. Patients were treated with daily oral imatinib mesylate at 220 mg/m2 twice a day for children and 400 mg twice a day for adults for 6 months. The primary endpoint was a 20% or more reduction in plexiform size by sequential volumetric MRI imaging. Clinical data were analysed on an intention-to-treat basis; a secondary analysis was also done for those patients able to take imatinib mesylate for 6 months. This trial is registered with ClinicalTrials.gov, number NCT01673009. Six of 36 patients (17%, 95% CI 6–33), enrolled on an intention-to-treat basis, had an objective response to imatinib mesylate, with a 20% or more decrease in tumour volume. Of the 23 patients who received imatinib mesylate for at least 6 months, six (26%, 95% CI 10–48) had a 20% or more decrease in volume of one or more plexiform tumours. The most common adverse events were skin rash (five patients) and oedema with weight gain (six). More serious adverse events included reversible grade 3 neutropenia (two), grade 4 hyperglycaemia (one), and grade 4 increases in aminotransferase concentrations (one). Imatinib mesylate could be used to treat plexiform neurofibromas in patients with NF1. A multi-institutional clinical trial is warranted to confirm these results. Novartis Pharmaceuticals, the Indiana University Simon Cancer Centre, and the Indiana University Herman B Wells Center for Pediatric Research.

OBJECTIVE. Sensory modulation issues have a significant impact on participation in daily life. Moreover, understanding phenotypic variation in sensory modulation dysfunction is crucial for research related to defining homogeneous groups and for clinical work in guiding treatment planning. We thus evaluated the new Sensory Processing Scale (SPS) Assessment. METHOD. Research included item development, behavioral scoring system development, test administration, and item analyses to evaluate reliability and validity across sensory domains. RESULTS. Items with adequate reliability (internal reliability >.4) and discriminant validity (p < .01) were retained. Feedback from the expert panel also contributed to decisions about retaining items in the scale. CONCLUSION. The SPS Assessment appears to be a reliable and valid measure of sensory modulation (scale reliability >.90; discrimination between group effect sizes >1.00). This scale has the potential to aid in differential diagnosis of sensory modulation issues.

Saltmarsh environments are recognised as key components of many biophysical and biochemical processes at the local and global scale. Accurately mapping these environments, and understanding how they are changing over time, is crucial for better understanding these systems. However, traditional surveying techniques are time-consuming and are inadequate for understanding how these dynamic systems may be changing temporally and spatially. The development of uncrewed aerial vehicle (UAV) technology presents an opportunity for efficiently mapping saltmarsh extent. Here we develop a methodology which combines field vegetation surveys with multispectral UAV data collected at two scales to estimate saltmarsh area and organic carbon storage at three saltmarshes in Loch Fleet (Scotland). We find that the Normalised Difference Vegetation Index (NDVI) values for surveyed saltmarsh vegetation communities, in combination with local tidal data, can be used to reliably estimate saltmarsh area. Using these area estimates, together with known plant community and soil organic carbon relationships, saltmarsh soil organic carbon storage is modelled. Based on our most reliable UAV-derived saltmarsh area estimates, we find that organic carbon storage is 15 %–20 % lower than previous area estimates would indicate. The methodology presented here potentially provides a cheap, affordable, and rapid method for saltmarsh mapping which could be implemented more widely to test and refine existing estimates of saltmarsh extent and is particularly well-suited to the mapping of small areas of saltmarsh environments.

A new saltmarsh soil dataset comprising of geochemical and physical property data from 752 soil samples collected through a sampling program supported by citizen scientists has been brought together with existing data to make the first national estimates of the surficial (top 10 cm) soil OC stock for Great British (GB) saltmarshes. To allow the inclusion of secondary data in the soil stock estimate a new bespoke organic matter to organic carbon conversion for GB saltmarsh soil was developed allowing organic matter data measured using loss-on-ignition to be convert to organic carbon content. The total GB surficial soil OC stock is 2.320 ± 0.470 Mt; English saltmarshes hold 1.601 ± 0.426 Mt OC, Scottish saltmarshes hold 0.368 ± 0.091 Mt OC, and Welsh saltmarshes hold 0.351 ± 0.082 Mt OC. The stocks were calculated within a Markov Chain Monte Carlo framework allowing robust uncertainty estimates to be derived for the first time. Spatial mapping tools are available to accompany these stock estimates at individual saltmarsh habitats throughout GB. This data will aid in the protection and management of saltmarshes and represents the first steps towards the inclusion of saltmarsh OC in the national inventory accounting of blue carbon ecosystems.

For more than 50 years, “Sensory Integration” has been a theoretical framework for diagnosing and treating disabilities in children under the umbrella of “sensory integration dysfunction” (SID). More recently, the approach has been reframed as “the dimensions of sensory processing” or SPD in place of SID, so the review herein describes this collective framework as sensory integration/sensory processing treatment (SI/SP-T) for ASD. This review is not focused on diagnosis of SI/SPD. Broadly, the SI/SPD intervention approach views a plethora of disabilities such as ADHD, ASD, and disruptive behavior as being exacerbated by difficulties in modulating and integrating sensory input with a primary focus on contributions from tactile, proprioceptive, and vestibular systems which are hypothesized to contribute to core symptoms of the conditions (e.g., ASD). SI/SP intervention procedures include sensory protocols designed to enhance tactile, proprioceptive, and vestibular experiences. SI/SP-T procedures utilize equipment (e.g., lycra swings, balance beams, climbing walls, and trampolines), specific devices (e.g., weighted vests, sensory brushes) and activities (e.g., placing hands in messy substances such as shaving cream, sequenced movements) hypothesized to enhance sensory integration and sensory processing. The approach is reviewed herein to provide a framework for testing SI/SP-T using widely accepted clinical trials and event coding methods used in applied behavior analysis (ABA) and other behavioral interventions. Also, a related but distinct neuroscientific paradigm, multisensory integration , is presented as an independent test of whether SI/SP-T differentially impacts sensory integration and/or multisensory integration. Finally, because SI/SP-T activities include many incidental behavioral events that are known as developmental facilitators (e.g., contingent verbal models/recasts during verbal interactions), there is a compelling need to control for confounds to study the unique impact of sensory-based interventions. Note that SI/SP-T includes very specific and identifiable procedures and materials, so it is reasonable to expect high treatment fidelity when testing the approach. A patient case is presented that illustrates this confound with a known facilitator (recast intervention) and a method for controlling potential confounds in order to conduct unbiased studies of the effects of SI/SP-T approaches that accurately represent SI/SP-T theories of change.

Coastal wetlands, such as saltmarshes, are globally widespread and highly effective at capturing and storing ‘blue carbon’ and have the potential to regulate climate over varying timescales. Yet only Australia and the United States of America have national inventories of organic carbon held within saltmarsh habitats, hindering the development of policies and management strategies to protect and preserve these organic carbon stores. Here we couple a new observational dataset with 4,797 samples from 26 saltmarshes across Great Britain to spatially model organic carbon stored in the soil and the above and belowground biomass of Great British saltmarshes. Using average values derived from the 26 marshes, we deliver first-order estimates of organic carbon stocks across Great Britain’s 448 saltmarshes (451.66 km 2 ). The saltmarshes of Great Britain contain 5.20 ± 0.65 Mt of organic carbon, 93% of which is in the soil. On average, the saltmarshes store 11.55 ± 1.56 kg C m -2 with values ranging between 2.24 kg C m -2 and 40.51 kg C m -2 depending on interlinked factors such as geomorphology, organic carbon source, sediment type (mud vs sand), sediment supply, and relative sea level history. These findings affirm that saltmarshes represent the largest intertidal blue carbon store in Great Britain, yet remain an unaccounted for component of the United Kingdom’s natural carbon stores.

This article describes a Patient and Public Involvement (PPI) led creative workshop space held within a clinical trial of a talking therapy for distressing voices (AVATAR2). PPI adds significant value to clinical research and ensures the work is meaningful to patients and their supporters. However, known issues include tokenism, a common power imbalance between PPI colleagues and researchers and a lack of opportunity for PPI to shape the research. PPI has played a key role at all stages of the AVATAR2 trial, including design, recruitment of staff and participants, data collection, analysis, and dissemination. An active and creative group of people was established, with over 30 members flexibly involved across all four sites. PPI group members were from diverse backgrounds, with lived experience of mental health conditions and recovery, and including carers . During this work, PPI colleagues identified that they would value a creative space which would help to promote the study but extend beyond an exclusive focus on trial deliverables. A regular creative workshop was established to support PPI colleagues in their creative work, including material such as poetry, blogs, art and podcasts. PPI colleagues and trial staff have cowritten a reflective piece to share their experiences on the impact of the creative workshops, organised into four themes. We found the workshops to be a powerful tool for forging relationships among trial staff and PPI colleagues, while also fostering personal development. We reflected on how the workshops built up the confidence of attendees and supported demanding trial activities such as public speaking. Finally, we discussed the impact of the workshops on wider trial culture, by upholding the values of the team and challenging the status quo.

One goal of occupational therapists working with children who have sensory processing challenges is the regulation of arousal. Regulation strategies have not been evaluated using an empirical measure of physiological arousal. To establish the feasibility of using an objective physiologic measure of sympathetic arousal in therapeutic settings and explore the relation between therapeutic activities and sympathetic arousal. To evaluate changes in electrodermal activity (EDA) during occupational therapy sessions. Twenty-two children identified with sensory modulation dysfunction (SMD) wore a wireless EDA sensor during 50 min occupational therapy sessions ( = 77 sessions). All children were able to wear the sensor on the lower calf without being distracted by the device. The five insights below are based on a comparison of EDA recordings in relation to therapists' reflections describing how sympathetic arousal might correspond to therapeutic activities. Objective physiological assessment of a child's sympathetic arousal during therapy is possible using a wireless EDA measurement system. Changes in EDA may correspond directly with therapeutic activities. The article provides a foundation for designing future therapeutic studies that include continuous measures of EDA.

Background Crowdsourcing engages the help of large numbers of people in tasks, activities or projects, usually via the internet. One application of crowdsourcing is the screening of citations for inclusion in a systematic review. There is evidence that a ‘Crowd’ of non-specialists can reliably identify quantitative studies, such as randomized controlled trials, through the assessment of study titles and abstracts. In this feasibility study, we investigated crowd performance of an online, topic-based citation-screening task, assessing titles and abstracts for inclusion in a single mixed-studies systematic review. Methods This study was embedded within a mixed studies systematic review of maternity care, exploring the effects of training healthcare professionals in intrapartum cardiotocography. Citation-screening was undertaken via Cochrane Crowd, an online citizen science platform enabling volunteers to contribute to a range of tasks identifying evidence in health and healthcare. Contributors were recruited from users registered with Cochrane Crowd. Following completion of task-specific online training, the crowd and the review team independently screened 9546 titles and abstracts. The screening task was subsequently repeated with a new crowd following minor changes to the crowd agreement algorithm based on findings from the first screening task. We assessed the crowd decisions against the review team categorizations (the ‘gold standard’), measuring sensitivity, specificity, time and task engagement. Results Seventy-eight crowd contributors completed the first screening task. Sensitivity (the crowd’s ability to correctly identify studies included within the review) was 84% ( N  = 42/50), and specificity (the crowd’s ability to correctly identify excluded studies) was 99% ( N  = 9373/9493). Task completion was 33 h for the crowd and 410 h for the review team; mean time to classify each record was 6.06 s for each crowd participant and 3.96 s for review team members. Replicating this task with 85 new contributors and an altered agreement algorithm found 94% sensitivity ( N  = 48/50) and 98% specificity ( N  = 9348/9493). Contributors reported positive experiences of the task. Conclusion It might be feasible to recruit and train a crowd to accurately perform topic-based citation-screening for mixed studies systematic reviews, though resource expended on the necessary customised training required should be factored in. In the face of long review production times, crowd screening may enable a more time-efficient conduct of reviews, with minimal reduction of citation-screening accuracy, but further research is needed.