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\"What began as a passion project when Max Miller was furloughed during Covid-19 has become a viral YouTube sensation. The Tasting History with Max Miller channel has thrilled food enthusiasts and history buffs alike as Miller recreates a dish from the past, often using historical recipes from vintage texts, but updated for modern kitchens as he tells stories behind the cuisine and culture. From ancient Rome to Ming China to medieval Europe and beyond, Miller has collected the best-loved recipes from around the world and has shared them with his fans. Now, with beautiful photographs portraying the dishes and historical artwork throughout, Tasting History compiles over sixty dishes\"-- Provided by publisher

Cowpea is one of the most popular dry-land legumes cultivated for food and forage in arid and semi-arid areas. Genetic diversity for global germplasm can be organized into core collections providing optimum resources to serve breeding requirements. Here, we present diversity analysis and genome-wide association study (GWAS) results for part of the cowpea core collection of the United States Department of Agriculture (USDA) along with breeding line controls. Included in the analysis were a total of 373 accessions analyzed with 6880 Single Nucleotide Polymorphism (SNP) markers from Genotyping by Sequencing (GBS). Population structure differentiated accessions into two groups irrespective of geographical origin and formed three clusters based on taxa upon phylogenetic analysis. A total of 56 SNPs were significantly associated to nine traits including pod length (25 Quantitative Trait Nucleotides, QTNs), seed anti-oxidant content (7 QTNs), dry pod color (7 QTNs), plant maturity (5 QTNs), flower color (5 QTNs), seed weight (4 QTNs), tolerance to low phosphate (1 QTN), growth habit (1 QTN), and response to rock phosphate (1 QTN) using Bayesian-information, Linkage-disequilibrium Iteratively Nested Keyway (BLINK), and Fixed and random model Circulating Probability Unification (FarmCPU) association models. Key genes related to all significant SNPs were identified based on annotations of the cowpea reference genome, including a flavonoid gene controlling flower color (Vigun08g040200.1), a root nodulation regulator for tolerance to low phosphate (Vigun11g168000.1), and numerous genes involved in signaling, biosynthesis, metabolite transport, and abiotic stress. Our results highlight the importance of maintaining public phenotyping databases at USDA and strengthening collaborations for data collection in cowpea to maximize research impacts.

The Connecticut Valley Railroad once carried both passengers and freight along the west bank of the Connecticut River between Hartford and Old Saybrook. Completed in 1871, today the railroad is known throughout New England for the nostalgic steam-powered excursion trains that run on a portion of the line between Essex and Chester. Until now the history of this popular tourist attraction has been the stuff of local lore and legend. This book, written by railroad historian and former vice president and director of Valley Railroad, Max R. Miller, provides the first comprehensive history of the Connecticut Valley Railroad through maps, ephemera, and archival photographs of the trains, bridges, and scenery surrounding the line. Offering tales of train wrecks, ghost sightings, booms and busts, Along the Valley Line will be treasured by railroad enthusiasts and historians alike.

Efforts to combine the outstanding economic performance in the decades following the Second World War with social security appear to be endangered half way through the first decade of the 21st century. This book draws together an international team of contributors, including Douglass North, Harold Demsetz and Michael Piore to assess the current world order. Part 1: Social Institutions and Economic Change Social Institutions and Economic Performance Business Governance and the Institutions of Capitalism Understanding the Process of Economic Change Part 2: Varieties of Contemporary Capitalism The Flexibilities and Constraints of Contemporary Capitalism The Neo-Liberal Ideal and the Reality of Workplace Practice: Shifting Axes of Political Mobilization and New Regimes of Workplace Governance in the United States Adam Smith in Beijing: States, Markets, and Capitalism East and West The European Model of \"Social\" Capitalism: Can it Survive European Integration? Part Three: Capitalism and Social Critique in the Era of Globalization G lobalization and Loyalty: Who are we? Boom, Bubble, Bust: The US Economy Today The Role of Criticism in the Dynamics of Capitalism: Social Critique vs. Artistic Critique Globalization and Violence

A 66-year-old female with a history of two renal transplants due to recurrent thrombotic thrombocytopenic purpura presented to clinic with multiple lesions identified to be non-metastatic cutaneous squamous cell carcinoma (CSCC). The patient previously underwent multiple Mohs procedures and radiation therapy treatment but continued to develop CSCC lesions with increasing frequency. After discussing multiple treatment options, it was elected to pursue treatment with Talimogene laherparepvec (T-VEC) given the systemic immune responses it can cause, with low theoretical risk of graft rejection. After starting intratumoral T-VEC injections, treated lesions began to decrease in size, and a reduction in the rate of new CSCC lesions was observed. Treatment was held due to unrelated renal complications during which time new CSCCs developed. Patient was restarted on T-VEC therapy with no recurrent renal issues. Upon reinitiating treatment, injected and non-injected lesions showed reduction in size, and the development of new lesions again ceased. One injected lesion was resected via Mohs micrographic surgery due to its size and discomfort. On sectioning, this demonstrated an exuberant lymphocytic perivascular infiltrate which was consistent with treatment response to T-VEC, with little active tumor. With high rates of non-melanoma skin cancer in renal transplant patients, their transplant status significantly limits treatment options, specifically with regards to anti-PD-1 therapy. This case suggests T-VEC can generate local and systemic immune responses in the setting of immunosuppression and that T-VEC may be a beneficial therapeutic option for transplant patients with CSCC.

Recent efforts to personalize treatment with platinum-based chemotherapy and PARP inhibitors have produced promising results in homologous recombinant deficient (HRD) metastatic pancreatic cancer (MPC). However, new strategies are necessary to overcome resistance. The below case series documents patients treated at the HonorHealth Research Institute with a diagnosis of HRD MPC who received Mitomycin C (MMC) treatment from January 2013 until July 2018. Five HRD MPC patients treated with MMC were evaluated. All patients received at least one course of treatment. Mean age at MMC treatment initiation was 58 years. There were 3 females and 2 males. All patients had tumors that progressed on platinum-based chemotherapy, four patients had previous exposure to Olaparib. The median PFS was 10.1 months, and the median OS was 12.3 months. Responses were observed only in patients harboring BRCA2 mutations, no response was observed in the PALB2 mutation carrier. MMC in this heavily previously treated PC was safe, with overall manageable grade 2 gastrointestinal toxicities including nausea and vomiting, and G3 hematological toxicities including anemia and thrombocytopenia. Pancreatic cancer patients with HRD may benefit from MMC treatment. Further clinical investigation of MMC in pancreatic cancer is warranted.

Efforts to combine the outstanding economic performance in the decades following the Second World War with social security appear to be endangered half way through the first decade of the 21st century. This book draws together an international team of contributors, including Douglass North, Harold Demsetz and Michael Piore to assess the current world order.

This book draws together an international team of contributors, including Douglass North, Harold Demsetz and Michael Piore to assess the different types of capitalism that operate in the world today

The ability to utilize a motor vehicle is paramount in modern society. The impact of driving and the relationship it has with personal independence and quality of life is crucial. In the United States, people with a corrected visual acuity worse than 20/40 are denied general licensing to operate a car. Although, in over 40 states those who do not meet general visual acuity requirements and have low vision are able to gain special licensure through the use of a bioptic telescope. A bioptic telescope is a miniature telescope mounted to a carrier lens that allows the user increased vision capacity. The rationale behind the use of a bioptic telescope for driving is that it provides the driver with low vision the ability to view objects and assess their surroundings while driving in a safe manner that they otherwise would not be able capable of.Little research has been conducted to assess bioptic drivers in relation to the normal driving population and to people with similar visual acuity licensed without a bioptic. Prior research has returned mixed results on the safety and application of bioptics for driving. The nature of visually impaired driving is a constant additional workload to baseline driving. The workload and attention demand imposed by low vision and bioptic driving is analyzed through lateral control modeling of steering wheel reversals to assess baseline driver performance in an on-road pilot experiment.From the results, the study found that driving with a bioptic system and low vision significantly differs from the normal population in regard to lateral control. The attention demand and workload required by driving with a bioptic system was found to be elevated compared to the normal population and non-bioptic visually impaired drivers. With bioptic system users committing steering corrections at a higher frequency than the normal population. The study also found that even though the corrections made by drivers who use a bioptic are significantly larger than the normal sighted population, the steering corrections were not significantly different than visually impaired non-bioptic system drivers. In fact, non-bioptic visually impaired drivers were found to commit significantly larger reversals than visually impaired drivers who use a bioptic.Furthermore, it is apparent that visually impaired drivers exhibit more workload and attention demand while driving. The comparison between bioptic and non-bioptic visually impaired drivers did not deem the presence of a bioptic system to decrease driver safety in baseline driving. Future work should be done to assess the workload and performance of drivers who use a bioptic during explicit cases of bioptic use, such as sign scanning or object detection by incorporating a suite of lateral control metrics.

The first essay finds that democratizations negatively impact asset valuations due to increased redistribution risk. Analyzing 90 countries over 200 years, risk premia during democratizations are elevated, comparable in magnitude to financial crises. Using a shift in Catholic Church doctrine supporting democracy, I establish causal evidence linking democratizations to elevated risk premia. Successful democratizations result in redistribution, public sector growth, reduced income inequality, and increased labor share of income. A model where wealthy asset market participants face redistribution risk during democratizations quantitatively explains these findings and the negligible response to autocratizations.The second essay shows that foreign lobbying shapes US government spending and public policy. Introducing a dataset of 180,000 meetings between foreign agents and US legislators from 2000 to 2018, we find that meetings correlate with legislator lawmaking effectiveness and foreign affairs committee membership. Foreign agents maintain connections with legislators even after leaving important committees. Around these meetings, foreign countries benefit from increased financial aid and favorable tariffs, while foreign firms with more lobbying gain larger subsidies and US government contracts. We observe benefits for legislators, but no evidence of constituents punishing them for meeting foreign representatives.The third essay reevaluates recent findings of increased US wealth inequality, which exclude the value of social insurance programs like Social Security. Including Social Security retirement benefits, we find no increase in top wealth shares over the last three decades, irrespective of potential tax and benefit changes. Discounting at the risk-free rate, real Social Security wealth rose from $4.9 trillion in 1989 to $52.6 trillion in 2019. Adjusting for long-run macroeconomic risk, the increase remains substantial, from over $4.0 trillion in 1989 to $41.2 trillion in 2019. By 2019, Social Security wealth represents 59% of the wealth of the bottom 90% of the wealth distribution.