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10,349 result(s) for "Miller, R L"
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Star destroyers : big ships blowing things up
\"In space, size matters. Boomers. Ships of the Line. Star Destroyers. The bigger the ship, the better the bang. From the dawn of history onward, commanding the most powerful ship around has been a dream of admirals, sultans, emperors, kings, generalissimos, and sea captains everywhere. For what the intimidation factor alone doesn't achieve, a massive barrage from super-weapons probably will. Thus it was, and ever shall be, even into the distant future. From the oceans of Earth, to beneath the ice of Europa, to the distant reaches of galactic empires, it is the great warships and their crews that sometimes keep civilization safe for the rest of us -- but sometimes become an extinction-level event in and of themselves\"--Back cover.
Predicting the mineral composition of dust aerosols – Part 1: Representing key processes
Soil dust aerosols created by wind erosion are typically assigned globally uniform physical and chemical properties within Earth system models, despite known regional variations in the mineral content of the parent soil. Mineral composition of the aerosol particles is important to their interaction with climate, including shortwave absorption and radiative forcing, nucleation of cloud droplets and ice crystals, heterogeneous formation of sulfates and nitrates, and atmospheric processing of iron into bioavailable forms that increase the productivity of marine phytoplankton. Here, aerosol mineral composition is derived by extending a method that provides the composition of a wet-sieved soil. The extension accounts for measurements showing significant differences between the mineral fractions of the wet-sieved soil and the emitted aerosol concentration. For example, some phyllosilicate aerosols are more prevalent at silt sizes, even though they are nearly absent at these diameters in a soil whose aggregates are dispersed by wet sieving. We calculate the emitted mass of each mineral with respect to size by accounting for the disintegration of soil aggregates during wet sieving. These aggregates are emitted during mobilization and fragmentation of the original undispersed soil that is subject to wind erosion. The emitted aggregates are carried far downwind from their parent soil. The soil mineral fractions used to calculate the aggregates also include larger particles that are suspended only in the vicinity of the source. We calculate the emitted size distribution of these particles using a normalized distribution derived from aerosol measurements. In addition, a method is proposed for mixing minerals with small impurities composed of iron oxides. These mixtures are important for transporting iron far from the dust source, because pure iron oxides are more dense and vulnerable to gravitational removal than most minerals comprising dust aerosols. A limited comparison to measurements from North Africa shows that the model extensions result in better agreement, consistent with a more extensive comparison to global observations as well as measurements of elemental composition downwind of the Sahara, as described in companion articles.
Predicting the mineral composition of dust aerosols – Part 2: Model evaluation and identification of key processes with observations
A global compilation of nearly sixty measurement studies is used to evaluate two methods of simulating the mineral composition of dust aerosols in an Earth system model. Both methods are based upon a Mean Mineralogical Table (MMT) that relates the soil mineral fractions to a global atlas of arid soil type. The Soil Mineral Fraction (SMF) method assumes that the aerosol mineral fractions match the fractions of the soil. The MMT is based upon soil measurements after wet sieving, a process that destroys aggregates of soil particles that would have been emitted from the original, undisturbed soil. The second method approximately reconstructs the emitted aggregates. This model is referred to as the Aerosol Mineral Fraction (AMF) method because the mineral fractions of the aerosols differ from those of the wet-sieved parent soil, partly due to reaggregation. The AMF method remedies some of the deficiencies of the SMF method in comparison to observations. Only the AMF method exhibits phyllosilicate mass at silt sizes, where they are abundant according to observations. In addition, the AMF quartz fraction of silt particles is in better agreement with measured values, in contrast to the overestimated SMF fraction. Measurements at distinct clay and silt particle sizes are shown to be more useful for evaluation of the models, in contrast to the sum over all particles sizes that is susceptible to compensating errors, as illustrated by the SMF experiment. Model errors suggest that allocation of the emitted silt fraction of each mineral into the corresponding transported size categories is an important remaining source of uncertainty. Evaluation of both models and the MMT is hindered by the limited number of size-resolved measurements of mineral content that sparsely sample aerosols from the major dust sources. The importance of climate processes dependent upon aerosol mineral composition shows the need for global and routine mineral measurements.
Atmospheric dust modeling from meso to global scales with the online NMMB/BSC-Dust model – Part 1: Model description, annual simulations and evaluation
We describe and evaluate the NMMB/BSC-Dust, a new dust aerosol cycle model embedded online within the NCEP Non-hydrostatic Multiscale Model (NMMB). NMMB is a further evolution of the operational Non-hydrostatic Mesoscale Model (WRF-NMM), which together with other upgrades has been extended from meso to global scales. Its unified non-hydrostatic dynamical core is prepared for regional and global simulation domains. The new NMMB/BSC-Dust is intended to provide short to medium-range weather and dust forecasts from regional to global scales and represents a first step towards the development of a unified chemical-weather model. This paper describes the parameterizations used in the model to simulate the dust cycle including sources, transport, deposition and interaction with radiation. We evaluate monthly and annual means of the global configuration of the model against the AEROCOM dust benchmark dataset for year 2000 including surface concentration, deposition and aerosol optical depth (AOD), and we evaluate the daily AOD variability in a regional domain at high resolution covering Northern Africa, Middle East and Europe against AERONET AOD for year 2006. The NMMB/BSC-Dust provides a good description of the horizontal distribution and temporal variability of the dust. Daily AOD correlations at the regional scale are around 0.6–0.7 on average without dust data assimilation. At the global scale the model lies within the top range of AEROCOM dust models in terms of performance statistics for surface concentration, deposition and AOD. This paper discusses the current strengths and limitations of the modeling system and points towards future improvements.
Climate response to soil dust aerosols
The effect of radiative forcing by soil dust aerosols upon climate is calculated. Two atmospheric GCM (AGCM) simulations are compared, one containing a prescribed seasonally varying concentration of dust aerosols, and the other omitting dust. Each simulation includes a mixed laser ocean model. Which allows SST to change in response to the reduction in surface net radiation by dust. Dust aerosols reduce the surface net radiation both by absorbing and reflecting sunlight. For the optical properties of the dust particles assumed here, the reflection of sunlight is largely offset by the trapping of upwelling longwave radiation, so that the perturbation by dust to the net radiation gain at the top of the atmosphere is small in comparison to the surface reduction. Consequently the radiative effect of soil dust aerosols is to redistribute heating from the surface to within the dust layer. Beneath the dust layer, surface temperature is reduced on the order of 1 K, typically in regions where deep convection is absent. In contrast, surface temperature remains unperturbed over the Arabian Sea during Northern Hemisphere (NH) summer, even though the dust concentration is highest in this region. It is suggested that the absence of cooling results from the negligible radiative forcing by dust at the top of the atmosphere, along with the frequent occurrence of deep convection. which ties the surface temperature to the unperturbed value at the emitting level. Where convection is absent, (cooling at the surface occurs because radiative heating by dust reduces the rate of subsidence and the corresponding mass exchange with the convecting region). Thus, the temperature contrast between these two regions must increase to maintain the original transport of energy, which is unperturbed by dust. It is suggested that cooling over the Arabian Sea during NH winter, despite the much smaller dust loading is permitted by the absence of convection during this season. Thus, the change in surface temperature forced by dust depends upon the extent of overlap between the dust layer and regions of deep convection in addition to the magnitude of the radiative forcing. Surface temperature is also reduced outside of the dust cloud, which is unlikely to result solely from natural variability of the AGCM. It is suggested that the perturbation by dust to Indian and African monsoon rainfall may depend upon the extent to which ocean dynamical heat transports are altered by dust.
Adjustment to Radiative Forcing in a Simple Coupled Ocean–Atmosphere Model
This study calculates the adjustment to radiative forcing in a simple model of a mixed layer ocean coupled to the overlying atmosphere. One application of the model is to calculate how dust aerosols perturb the temperature of the atmosphere and ocean, which in turn influence tropical cyclone development. Forcing at the top of the atmosphere (TOA) is the primary control upon both the atmospheric and ocean temperature anomalies, both at equilibrium and during most of the adjustment to the forcing. Ocean temperature is directly influenced by forcing only at the surface, but is indirectly related to forcing at TOA due to heat exchange with the atmosphere. Within a few days of the forcing onset, the atmospheric temperature adjusts to heating within the aerosol layer, reducing the net transfer of heat from the ocean to the atmosphere. For realistic levels of aerosol radiative forcing, the perturbed net surface heating strongly opposes forcing at the surface. This means that surface forcing dominates the ocean response only within the first few days following a dust outbreak, before the atmosphere has responded. This suggests that, to calculate the effect of dust upon the ocean temperature, the atmospheric adjustment must be taken into account explicitly and forcing at TOA must be considered in addition to the surface forcing. The importance of TOA forcing should be investigated in a model where vertical and lateral mixing of heat are calculated with fewer assumptions than in the simple model presented here. Nonetheless, the fundamental influence of TOA forcing appears to be only weakly sensitive to the model assumptions.
Atmospheric dust modeling from meso to global scales with the online NMMB/BSC-Dust model – Part 2: Experimental campaigns in Northern Africa
The new NMMB/BSC-Dust model is intended to provide short to medium-range weather and dust forecasts from regional to global scales. It is an online model in which the dust aerosol dynamics and physics are solved at each model time step. The companion paper (Pérez et al., 2011) develops the dust model parameterizations and provides daily to annual evaluations of the model for its global and regional configurations. Modeled aerosol optical depth (AOD) was evaluated against AERONET Sun photometers over Northern Africa, Middle East and Europe with correlations around 0.6–0.7 on average without dust data assimilation. In this paper we analyze in detail the behavior of the model using data from the Saharan Mineral dUst experiment (SAMUM-1) in 2006 and the Bodélé Dust Experiment (BoDEx) in 2005. AOD from satellites and Sun photometers, vertically resolved extinction coefficients from lidars and particle size distributions at the ground and in the troposphere are used, complemented by wind profile data and surface meteorological measurements. All simulations were performed at the regional scale for the Northern African domain at the expected operational horizontal resolution of 25 km. Model results for SAMUM-1 generally show good agreement with satellite data over the most active Saharan dust sources. The model reproduces the AOD from Sun photometers close to sources and after long-range transport, and the dust size spectra at different height levels. At this resolution, the model is not able to reproduce a large haboob that occurred during the campaign. Some deficiencies are found concerning the vertical dust distribution related to the representation of the mixing height in the atmospheric part of the model. For the BoDEx episode, we found the diurnal temperature cycle to be strongly dependant on the soil moisture, which is underestimated in the NCEP analysis used for model initialization. The low level jet (LLJ) and the dust AOD over the Bodélé are well reproduced. The remaining negative AOD bias (due to underestimated surface wind speeds) can be substantially reduced by decreasing the threshold friction velocity in the model.
Consistent Simulations of Multiple Proxy Responses to an Abrupt Climate Change Event
Isotope, aerosol, and methane records document an abrupt cooling event across the Northern Hemisphere at 8.2 kiloyears before present (kyr), while separate geologic lines of evidence document the catastrophic drainage of the glacial Lakes Agassiz and Ojibway into the Hudson Bay at approximately the same time. This melt water pulse may have been the catalyst for a decrease in North Atlantic Deep Water formation and subsequent cooling around the Northern Hemisphere. However, lack of direct evidence for ocean cooling has lead to speculation that this abrupt event was purely local to Greenland and called into question this proposed mechanism. We simulate the response to this melt water pulse using a coupled general circulation model that explicitly tracks water isotopes and with atmosphere-only experiments that calculate changes in atmospheric aerosol deposition (specifically $^{10}Be$ and dust) and wetland methane emissions. The simulations produce a short period of significantly diminished North Atlantic Deep Water and are able to quantitatively match paleoclimate observations, including the lack of isotopic signal in the North Atlantic. This direct comparison with multiple proxy records provides compelling evidence that changes in ocean circulation played a major role in this abrupt climate change event.
Herpes Simplex Virus-Induced Epithelial Damage and Susceptibility to Human Immunodeficiency Virus Type 1 Infection in Human Cervical Organ Culture
Normal human premenopausal cervical tissue has been used to derive primary cell populations and to establish ex vivo organ culture systems to study infections with herpes simplex virus (HSV-1 or HSV-2) and human immunodeficiency virus type 1 (HIV-1). Infection with either HSV-1 or HSV-2 rapidly induced multinuclear giant cell formation and widespread damage in mucosal epithelial cells. Subsequent exposure of the damaged mucosal surfaces to HIV-1 revealed frequent co-localization of HSV and HIV-1 antigens. The short-term organ culture system provides direct experimental support for the epidemiological findings that pre-existing sexually transmitted infections, including primary and recurrent herpes virus infections at mucosal surfaces, represent major risk factors for acquisition of primary HIV-1 infection. Epithelial damage in combination with pre-existing inflammation, as described here for overtly normal human premenopausal cervix, creates a highly susceptible environment for the initiation and establishment of primary HIV-1 infection in the sub-mucosa of the cervical transformation zone.
Immunomodulatory effects of Toll-like receptor-7 activation on chronic lymphocytic leukemia cells
Weak immunogenicity of chronic lymphocytic leukemia (CLL) cells may contribute to disease progression and inhibit effective immunotherapy. Accordingly, agents that enhance the immunogenicity of CLL cells may be useful in immunotherapeutic approaches to this disease. Since Toll-like receptors (TLRs) are major regulators of innate immunity and initiation of adaptive immunity, we studied the effects of viral pathogen associated molecular pattern agonists (that are recognized by TLRs) on the costimulatory phenotype and function of CLL cells. CLL cells (especially those with high endogenous expression of CD38) responded to TLR7-activating imidazoquinolines and guanosine analogs by increasing costimulatory molecule expression, producing inflammatory cytokines, and becoming more sensitive to killing by cytotoxic effectors. Additional activation of protein kinase C pathways increased the ability to stimulate T-cell proliferation, blocked phosphorylation of the transcription factor, signal transducer and activator of transcription (STAT)3, and resulted in the acquisition of a dendritic cell surface phenotype by TLR7-activated CLL cells. Normal B cells also responded to TLR7 activation by increasing costimulatory molecule expression and cytokine production. These findings suggest a potential role for TLR7 agonists in CLL immunotherapy.