Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
7,303
result(s) for
"Miller, Susan"
Sort by:
Structural basis of long-range to short-range synaptic transition in NHEJ
DNA double-strand breaks (DSBs) are a highly cytotoxic form of DNA damage and the incorrect repair of DSBs is linked to carcinogenesis
1
,
2
. The conserved error-prone non-homologous end joining (NHEJ) pathway has a key role in determining the effects of DSB-inducing agents that are used to treat cancer as well as the generation of the diversity in antibodies and T cell receptors
2
,
3
. Here we applied single-particle cryo-electron microscopy to visualize two key DNA–protein complexes that are formed by human NHEJ factors. The Ku70/80 heterodimer (Ku), the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs), DNA ligase IV (LigIV), XRCC4 and XLF form a long-range synaptic complex, in which the DNA ends are held approximately 115 Å apart. Two DNA end-bound subcomplexes comprising Ku and DNA-PKcs are linked by interactions between the DNA-PKcs subunits and a scaffold comprising LigIV, XRCC4, XLF, XRCC4 and LigIV. The relative orientation of the DNA-PKcs molecules suggests a mechanism for autophosphorylation in
trans
, which leads to the dissociation of DNA-PKcs and the transition into the short-range synaptic complex. Within this complex, the Ku-bound DNA ends are aligned for processing and ligation by the XLF-anchored scaffold, and a single catalytic domain of LigIV is stably associated with a nick between the two Ku molecules, which suggests that the joining of both strands of a DSB involves both LigIV molecules.
Double-strand DNA break repair by the non-homologous end joining pathway involves the transition from a complex that bridges the DNA ends to a complex that aligns the DNA for ligation through the dissociation of the kinase subunits of the DNA-PK complexes.
Journal Article
An analysis of the relationship of character strengths and quality of life in persons with multiple sclerosis
Purpose
To examine the relationship of character strengths and quality of life (QOL) in persons with multiple sclerosis (MS). Specifically, this study examined the relationship of the 24 character strengths in Peterson and Seligman’s model with QOL and three negative effects of MS (disability, fatigue, and depression). It also investigated whether the three negative effects of MS mediate the relationship of each of the character strengths and QOL.
Methods
Six hundred and twenty-four individuals with MS completed an online survey measuring character strengths, QOL, as measured by the
Leeds Multiple Sclerosis Quality of Life Scale,
disability, fatigue, and depression. SPSS was used to complete the correlational analysis, and Hayes’ PROCESS macro for SPSS was used to conduct the mediation analyses.
Results
The strengths endorsed most frequently by the participants were honesty, kindness, and fairness. The least-endorsed strengths were self-regulation, zest, and spirituality. The strengths with the strongest association with QOL were zest, hope, and gratitude. Disability was not found to mediate any of the relationships between character strengths and QOL. Many of the character strengths were associated with QOL both directly and indirectly through fatigue and depression.
Conclusions
Many of the character strengths in the Peterson and Seligman model enhance QOL in persons with MS, both directly and through their influence on negative effects of MS. The results provide support for the development of character strengths interventions to impact QOL, both directly and indirectly through improvements to MS-related symptoms such as fatigue and depression.
Journal Article
A history of modern Morocco
\"This book offers a richly documented survey of modern Moroccan history. Concise and readable, it will enthrall all those searching for the background to present-day events in the region\"-- Provided by publisher.
Book
Does Administrative Burden Influence Public Support for Government Programs? Evidence from a Survey Experiment
Research indicates that administrative burden influences the behaviors and views of clients and potential clients of government programs. However, administrative burden may also shape mass attitudes toward government programs. Taking a behavioral public administration approach, the authors consider whether and how exposure to information about administrative burden embedded within eligibility-based programs influences citizen favorability toward those programs. It is hypothesized that if information about the existing screening mechanisms is highlighted and made salient, this will lead to greater approval of eligibility-based programs. This expectation is evaluated using a survey experiment that explores administrative burden in the Temporary Assistance for Needy Families (TANF) program. The evidence shows that being exposed to information about administrative burden increases favorability toward TANF and its recipients, though these effects are conditional on party identification. The results provide insight into a potential consequence of administrative burden, showing the way in which information regarding burden can shape citizens' support for eligibility-based programs.
Journal Article
A History of Modern Morocco
Morocco is notable for its stable and durable monarchy, its close ties with the West, its vibrant cultural life and its centrality to regional politics. This book, by distinguished historian Susan Gilson Miller, offers a richly documented survey of modern Moroccan history. Arguing that pragmatism rather than ideology has shaped the monarchy's response to crisis, the book begins with the French invasion of Algeria in 1830 and Morocco's abortive efforts at reform, the duel with colonial powers and the loss of independence in 1912, the burdens and benefits of France's forty-four year dominion and the stunning success of the nationalist movement leading to independence in 1956. In the post-independence era, the book traces the monarchy's gradual monopolization of power and the resulting political paralysis, with a postscript bringing events up to 2012. This concise, readable book will inform and enthral students and all those searching for the background to present-day events in the region.
eBook
Years of glory : Nelly Benatar and the pursuit of justice in wartime North Africa
\"Years of Glory offers a rich narrative and a deeper understanding of the complex currents that shaped Jewish, North African, and world history over the course of the Second World War. The traumas of genocide, the struggle for anti-colonial liberation, and the eventual Jewish exodus from Arab lands all take on new meaning when reflected through the interstices of Benatar's life. A courageous woman with a deep moral conscience and an iron will, Nelly Benatar helped to lay the groundwork for crucial postwar efforts to build a better world over Europe's ashes\"-- Publisher web site.
BOOK
Function and Molecular Mechanism of the DNA Damage Response in Immunity and Cancer Immunotherapy
The DNA damage response (DDR) is an organized network of multiple interwoven components evolved to repair damaged DNA and maintain genome fidelity. Conceptually the DDR includes damage sensors, transducer kinases, and effectors to maintain genomic stability and accurate transmission of genetic information. We have recently gained a substantially improved molecular and mechanistic understanding of how DDR components are interconnected to inflammatory and immune responses to stress. DDR shapes both innate and adaptive immune pathways: (i) in the context of innate immunity, DDR components mainly enhance cytosolic DNA sensing and its downstream STimulator of INterferon Genes (STING)-dependent signaling; (ii) in the context of adaptive immunity, the DDR is needed for the assembly and diversification of antigen receptor genes that is requisite for T and B lymphocyte development. Imbalances between DNA damage and repair impair tissue homeostasis and lead to replication and transcription stress, mutation accumulation, and even cell death. These impacts from DDR defects can then drive tumorigenesis, secretion of inflammatory cytokines, and aberrant immune responses. Yet, DDR deficiency or inhibition can also directly enhance innate immune responses. Furthermore, DDR defects plus the higher mutation load in tumor cells synergistically produce primarily tumor-specific neoantigens, which are powerfully targeted in cancer immunotherapy by employing immune checkpoint inhibitors to amplify immune responses. Thus, elucidating DDR-immune response interplay may provide critical connections for harnessing immunomodulatory effects plus targeted inhibition to improve efficacy of radiation and chemotherapies, of immune checkpoint blockade, and of combined therapeutic strategies.
Journal Article