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\"Mute is one of the most revered and influential indie labels of all time. Through the music of its tight-knit community of artists--ranging from Cabaret Voltaire, Nick Cave's The Birthday Party and Moby to Depeche Mode, Erasure, and Goldfrapp--it has had an incalculable impact on popular music for forty years. Daniel Miller created Mute to release his debut single (Warm Leatherette / T.V.O.D.), a pioneering electronic sound with a defiantly DIY punk attitude. Mute quickly established a reputation for cultivating the experimental, releasing cutting-edge industrial sounds, and chart-topping electronic music by the likes of Depeche Mode and Yazoo. The label was equally at home with the savage punk of Nick Cave's The Birthday Party and--to critical acclaim--his next outfit, The Bad Seeds. It also proved to be an Internet pioneer, launching the online site Mute Liberation Technologies in 1994. Mute features stunning artwork and photography--much of it previously unseen--and revelatory behind-the-scenes insights from the vibrant cast who have worked with the label\"-- Provided by publisher.

Molecular structures are imaged with sub-ångström precision and exposure times of a few femtoseconds. Catching up with molecular dynamics Molecular imaging, or the determination of the positions of atoms in molecules, is an important technique in the physical, chemical and biological sciences. But going beyond mere structure determination, recent technical developments offer the tantalizing prospect of access to ultrafast snapshots of biological molecules and condensed-phase systems undergoing structural changes. One approach uses laser-ionized bursts of coherent electron wave packets to self-interrogate the parent molecular structure. Here, Blaga et al . use this laser-induced electron diffraction (LIED) method to map the structural responses of oxygen and nitrogen molecules to ionization. By measuring a 0.1-ångström displacement in the oxygen bond length occurring in a time interval of about 5 femtoseconds, the authors establish LIED as a promising approach for imaging of gas-phase molecules with unprecedented spatio-temporal resolution. Establishing the structure of molecules and solids has always had an essential role in physics, chemistry and biology. The methods of choice are X-ray and electron diffraction, which are routinely used to determine atomic positions with sub-ångström spatial resolution. Although both methods are currently limited to probing dynamics on timescales longer than a picosecond, the recent development of femtosecond sources of X-ray pulses and electron beams suggests that they might soon be capable of taking ultrafast snapshots of biological molecules 1 , 2 and condensed-phase systems 3 , 4 , 5 , 6 undergoing structural changes. The past decade has also witnessed the emergence of an alternative imaging approach based on laser-ionized bursts of coherent electron wave packets that self-interrogate the parent molecular structure 7 , 8 , 9 , 10 , 11 . Here we show that this phenomenon can indeed be exploited for laser-induced electron diffraction 10 (LIED), to image molecular structures with sub-ångström precision and exposure times of a few femtoseconds. We apply the method to oxygen and nitrogen molecules, which on strong-field ionization at three mid-infrared wavelengths (1.7, 2.0 and 2.3 μm) emit photoelectrons with a momentum distribution from which we extract diffraction patterns. The long wavelength is essential for achieving atomic-scale spatial resolution, and the wavelength variation is equivalent to taking snapshots at different times. We show that the method has the sensitivity to measure a 0.1 Å displacement in the oxygen bond length occurring in a time interval of ∼5 fs, which establishes LIED as a promising approach for the imaging of gas-phase molecules with unprecedented spatio-temporal resolution.

\"World Music: A Global Journey, Fourth Edition takes students around the world to experience the diversity of musical expression and cultural traditions. It is known for its breadth in surveying the world's major cultures in a systematic study of world music within a strong pedagogical framework. As one would prepare for any journey, each chapter starts with background preparation, reviewing the historical, cultural, and musical overview of the region. Visits to multiple \"sites\" within a region provide in-depth studies of varied musical traditions. Music analysis begins with an experiential \"first impression\" of the music, followed by an \"aural analysis\" of the sound and prominent musical elements. Finally, students are invited to consider the cultural connections that give the music its meaning and life\"--Back cover.

While fundamental to molecular quantum mechanics, limitations of the Born-Oppenheimer Approximation (BOA) have long been known. Nonetheless, calculations that include molecular interactions, such as vibronic coupling and electron spin effects, that violate the BOA have remained a challenge due to their large demand on computational resources. The purpose of this paper is to describe two complementary software programs, SOCJT and XSIM, designed for efficient calculations that include these interactions. The programs are sufficiently general and user friendly that they can be readily applied to a variety of molecules of different symmetries, state degeneracies, and interaction strengths. The programs can typically produce spin-vibronic eigenvalues and eigenvectors with sufficient accuracy for the analysis and interpretation of molecular spectra with features attributable to violations of the BOA. The two programs utilize different matrix representations of the molecular Hamiltonian, with XSIM being Cartesian based and SOCJT being cylindrically based, and their advantages/disadvantages are discussed. Several algorithms can be chosen to obtain the Hamiltonian’s eigenvalues and eigenvectors and their speed and memory usage are compared. Examples of application of SOCJT and XSIM to explain spectral observations for particular molecules are briefly reviewed.

\"Walt Simonson's stunning, unmistakable art and storytelling are on full display here in his groundbreaking work ORION. Expanding the beloved universe originally created by Jack Kirby, Simonson's sprawling storylines and dynamic artwork elevate his titular hero, as well as the rest of the Fourth World's indispensible characters, to incredible new heights. Collected here for the first time are all twenty-five issues of Walter Simonson's ORION, as well as never-before reprinted short stories, pinups and sketch material.\"-- Provided by publisher.

Directly monitoring atomic motion during a molecular transformation with atomic-scale spatio-temporal resolution is a frontier of ultrafast optical science and physical chemistry. Here we provide the foundation for a new imaging method, fixed-angle broadband laser-induced electron scattering, based on structural retrieval by direct one-dimensional Fourier transform of a photoelectron energy distribution observed along the polarization direction of an intense ultrafast light pulse. The approach exploits the scattering of a broadband wave packet created by strong-field tunnel ionization to self-interrogate the molecular structure with picometre spatial resolution and bond specificity. With its inherent femtosecond resolution, combining our technique with molecular alignment can, in principle, provide the basis for time-resolved tomography for multi-dimensional transient structural determination. Developments in ultrafast optical science bring the promise of being able to directly monitor atomic motions during various physical processes. Towards this end, Xu et al. present fixed-angle broadband laser-induced electron scattering as a method to image molecular structures from photoelectron spectra.

The US Food and Drug Administration recognizes the unmet medical need for antibacterial drugs to treat serious bacterial diseases caused by resistant pathogens for which effective therapies are limited or lacking. The agency also recognizes that designing and conducting clinical trials to assess the safety and efficacy of drugs to treat resistant infections is challenging, especially for drugs only active against a single or a few bacterial species, and that a more flexible development program might be appropriate. In this article, we discuss several regulatory considerations for flexible development programs for antibacterial drugs intended to meet an unmet medical need. As an example, we use the recent approval of sulbactam for injection and durlobactam for injection (XACDURO) for the treatment of hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia caused by susceptible isolates of Acinetobacter baumannii-calcoaceticus complex.

Although American Roman Catholic priest Father Joseph Maier founded the Mercy Centre in the heart of Bangkok’s Khlong Toey slums in the early 1970s, music was not part of the program until around 2010 when Dr. Mick Moloney began raising funds to support the teaching of Thai classical music. With additional donations, the music program has grown exponentially, adding Northeast Thai pong lang ensemble and providing a dance teacher for the young women. Participation has risen from a mere handful to the majority of children living in the Centre. Having a music program has also made an increasing number of public performances possible, both on stage for various festivals and on television, giving the Centre a visibility and image it formerly lacked. Performing in public, wearing beautiful costumes, and receiving accolades has boosted each child’s self-esteem in ways not previously possible. While music from Thailand’s northeast is widely popular, its classical music and dance are less so. That such an apparently “elite” tradition could serve to express the artistry of slum children surprises many, since Mercy’s children all come from the city’s lowest social groups. Indeed, some have non-Thai (e.g., Cambodian) parents. The music and dance program has thus changed Mercy’s public image from one of despair into one of optimism and beauty.

Vadose zone transport of tritium and nitrate can be important considerations at radioactive waste sites, landfills, or areas with industrial impacts. These contaminants are of particular concern because they typically have a relatively higher mobility in the subsurface compared to other compounds. Here, we describe a semiarid site with tritium and nitrate contamination involving a manmade ponded water source above a thick unsaturated zone at Los Alamos National Laboratory in New Mexico, USA. This study demonstrates the value of vadose zone flow and transport modeling for the development of field investigation plans (i.e., identifying optimal borehole locations and depths for contaminant characterization), and how a combination of modeling with isotope and geochemical measurements can provide insight into how tritium and nitrate transport in the vadose zone in semiarid environments. Modeling results suggest that at this location, tritium transport is well predicted by classical multiphase theory. Our work expands the demonstrated usefulness of a standard tritium conceptual model to sites with ponded surface conditions and agrees with previous results where a standard model was able to explain the evolution of a tritium plume at an arid waste disposal site. In addition, depth-based analyses of δ18O and δ2H of pore waters helped confirm the extent of pond infiltration into the vadose zone, and the δ15N of nitrate showed that the contaminant release history of the site was different than originally assumed.