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Top predators can dramatically suppress populations of smaller predators, with cascading effects throughout communities, and this pressure is often unquestioningly accepted as a constraint on mesopredator populations. In this study, we reassess whether African lions suppress populations of cheetahs and African wild dogs and examine possible mechanisms for coexistence between these species. Using long‐term records from Serengeti National Park, we tested 30 years of population data for evidence of mesopredator suppression, and we examined six years of concurrent radio‐telemetry data for evidence of large‐scale spatial displacement. The Serengeti lion population nearly tripled between 1966 and 1998; during this time, wild dogs declined but cheetah numbers remained largely unchanged. Prior to their local extinction, wild dogs primarily occupied low lion density areas and apparently abandoned the long‐term study area as the lion population ‘saturated’ the region. In contrast, cheetahs mostly utilized areas of high lion density, and the stability of the cheetah population indicates that neither high levels of lion‐inflicted mortality nor behavioural avoidance inflict sufficient demographic consequences to translate into population‐level effects. Population data from fenced reserves in southern Africa revealed a similar contrast between wild dogs and cheetahs in their ability to coexist with lions. These findings demonstrate differential responses of subordinate species within the same guild and challenge a widespread perception that lions undermine cheetah conservation efforts. Paired with several recent studies that document fine‐scale lion‐avoidance by cheetahs, this study further highlights fine‐scale spatial avoidance as a possible mechanism for mitigating mesopredator suppression.

Population viability is driven by individual survival, which in turn depends on individuals balancing energy budgets. As carnivores may function close to maximum sustained power outputs, decreased food availability or increased activity may render some populations energetically vulnerable. Prey theft may compromise energetic budgets of mesopredators, such as cheetahs and wild dogs, which are susceptible to competition from larger carnivores. We show that daily energy expenditure (DEE) of cheetahs was similar to size-based predictions and positively related to distance traveled. Theft at 25% only requires cheetahs to hunt for an extra 1.1 hour per day, increasing DEE by just 12%. Therefore, not all mesopredators are energetically constrained by direct competition. Other factors that increase DEE, such as those that increase travel, may be more important for population viability.

1. Human-mediated changes in habitat structure may disturb predator–prey relationships. 2. We investigated the influence of perimeter fences on the diet of a reintroduced population of African wild dogs Lycaon pictus Temminck 1820 in a 316 km², fenced reserve in South Africa, by tracking radio-collared individuals during hunting periods to determine dietary composition from observed kills. 3. Nutritional status of impala Aepyceros melampus and kudu Tragelaphus strepsiceros prey, as measured by the percentage of femur marrow fat, was significantly lower than that of unselectively culled individuals. This supports the hypothesis that wild dog predation is at least partially compensatory. 4. Fence-impeded kills (those for which escape was deemed to be compromised by the fence) comprised 40·5% of kills (n = 316), and 54·1% of all edible biomass consumed. Compared with fence-unimpeded kills, fence-impeded kills comprised larger species (32·9 vs. 25·0 kg, W = 25667·0, P « 0·001), older age classes for one prey category (female kudu: Fisher's exact test, P = 0·02, n = 65) and animals in better condition for adult impala males (Mann–Whitney, W = 111·0, P = 0·012, n = 28). 5. Fence-impeded kills also provided greater catch per unit hunting effort (27·3 vs. 12·2 kg km⁻¹; χ² = 7·89, P = 0·005), resulting in longer interkill intervals. Movement of the pack towards the fence at the start of each hunting period suggested a decision to exploit the advantage that fences conferred for capturing prey. 6. Synthesis and applications. By enabling coursing predators to capture prey that would otherwise have escaped, fences may reduce the compensatory nature of predation, causing shifts in predator–prey dynamics that could influence the ability of small reserves to support such predators. The establishment of larger conservation areas to reduce perimeter-to-area ratios should be encouraged to limit the undesired effects of fences on predator–prey dynamics.

The dynamics of predator-prey pursuit appears complex, making the development of a framework explaining predator and prey strategies problematic. We develop a model for terrestrial, cursorial predators to examine how animal mass modulates predator and prey trajectories and affects best strategies for both parties. We incorporated the maximum speed-mass relationship with an explanation of why larger animals should have greater turn radii; the forces needed to turn scale linearly with mass whereas the maximum forces an animal can exert scale to a 2/3 power law. This clarifies why in a meta-analysis, we found a preponderance of predator/prey mass ratios that minimized the turn radii of predators compared to their prey. It also explained why acceleration data from wild cheetahs pursuing different prey showed different cornering behaviour with prey type. The outcome of predator prey pursuits thus depends critically on mass effects and the ability of animals to time turns precisely. A pursuit between a predator and its prey involves complex strategies. Prey often make sudden sharp turns when running to evade a predator. Any predator that cannot turn quickly enough will have to run further to catch up with the prey again, thus potentially allowing the prey to pull away from the predator. The timing of these turns is crucial; if the prey turns when the predator is too far away, the predator can cut the corner off the turn and catch up with the prey more easily. The speed at which animals can turn depends on the forces involved in cornering, and larger animals need to produce greater forces for any given turn. However, larger animals can apply relatively less force than smaller animals for turns and so cannot turn as rapidly. The effect of the relationship between mass and turning ability on the strategies used during land-based pursuits had not been investigated. Wilson et al. have now created a mathematical model that considers how the mass of a predator and its prey influences the course and strategies used in a land-based pursuit. The model is based in part on a mathematical problem called the ‘homicidal chauffeur game’, where a car driver attempts to run over a pedestrian. Wilson et al.'s model predicts that chases between large predators and smaller prey should feature frequent sharp turns, as the prey try to exploit their superior turning ability. However, when the predators and prey are of similar size, the prey gain little or no advantage from executing high-speed turns. Indeed, as turning slows the prey down, turning may often be disadvantageous, and so fewer turns should be seen during a pursuit. The predictions of the model were compared with the pursuit strategies of wild cheetahs, which were studied using collars equipped with tags to measure acceleration as the predators chased prey of different sizes—from hares to large antelopes called gemsboks. The tracking data confirmed the predictions of the model; thereby revealing that body mass and the ability of animals to choose when best to turn strongly determine the outcome of predator-prey pursuits.

African wild dogs (Lycaon pictus) are a seriously endangered species with only around 5000 individuals left. We examined the factors likely to be affecting the distribution and density of wild dogs living in the Kruger National Park, South Africa. We collected data, by traditional and satellite radio-tracking, on diet selection, sizes of packs, dispersion and sizes of territories, and patterns of habitat selection for eight packs of wild dogs. In Kruger wild dogs specialize on impala (Aepyceros melampus) and kudu (Tragelaphus strepsiceros). They live in packs averaging about nine dogs and inhabit territories of 350-950 km2. Neighboring territories overlap to some extent but packs meet very rarely. The dispersion pattern of food plays only a minor role in determining the density and distribution of dogs in the Kruger; dogs exist at their lowest density where their food is most abundant. This apparent paradox comes about because the dogs seem to avoid areas that, although prey-rich, are heavily used by lions. This is a sensible strategy because lions are a major cause of dog mortality, accounting for some 39% of natural pup deaths and at least 43% of natural adult deaths. Wild dogs may be conserved most successfully in areas with moderate to low densities of lions and spotted hyenas, and management strategies should be careful not to promote these species to the detriment of wild dogs and other carnivores. The densities of lions and spotted hyenas should be important criteria when considering an area for the reintroduction of wild dogs and other similar sized carnivores.

Population viability is driven by individual survival, which in turn depends on individuals balancing energy budgets. As carnivores may function close to maximum sustained power outputs, decreased food availability or increased activity may render some populations energetically vulnerable. Prey theft may compromise energetic budgets of mesopredators, such as cheetahs and wild dogs, which are susceptible to competition from larger carnivores. We show that daily energy expenditure (DEE) of cheetahs was similar to size-based predictions and positively related to distance traveled. Theft at 25% only requires cheetahs to hunt for an extra 1.1 hour per day, increasing DEE by just 12%. Therefore, not all mesopredators are energetically constrained by direct competition. Other factors that increase DEE, such as those that increase travel, may be more important for population viability.

Netea and colleagues provide a general guide to the cellular and humoral contributors to inflammation as well as the pathways that characterize inflammation in specific organs and tissues. Biologists, physicians and immunologists have contributed to the understanding of the cellular participants and biological pathways involved in inflammation. Here, we provide a general guide to the cellular and humoral contributors to inflammation as well as to the pathways that characterize inflammation in specific organs and tissues.

It is now 10 years since the last technical review on preventative foot care was published (1), which was followed by an American Diabetes Association (ADA) position statement on preventive foot care in diabetes (2). Many studies have been published proposing a range of tests that might usefully identify patients at risk of foot ulceration, creating confusion among practitioners as to which screening tests should be adopted in clinical practice. A task force was therefore assembled by the ADA to address and concisely summarize recent literature in this area and then recommend what should be included in the comprehensive foot exam for adult patients with diabetes. The committee was cochaired by the immediate past and current chairs of the ADA Foot Care Interest Group (A.J.M.B. and D.G.A.), with other panel members representing primary care, orthopedic and vascular surgery, physical therapy, podiatric medicine and surgery, and the American Association of Clinical Endocrinologists.

Patients with suspected nephrolithiasis were randomly assigned to ultrasonography performed by an emergency physician or a radiologist or to CT for initial study. Ultrasonography was associated with a lower cumulative radiation dose, with no significant difference in complications.