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"Milner, George"
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This idea is brilliant : lost, overlooked, and underappreciated scientific concepts everyone should know
Presents essays responding to a question about what scientific term or concept ought to be more widely known, written by such authors as Jared Diamond, Richard Thaler, Richard Dawkins, Lisa Randall, Steven Pinker, and Carlo Roveri.
BOOK
Population trends and the transition to agriculture
Agriculture—specifically an intensification of the production of readily stored food and its distribution—has supported an increase in the global human population throughout the Holocene. Today, with greatly accelerated of growth during recent centuries, we have reached about 8 billion people. Human skeletal and archaeobotanical remains clarify what occurred over several millennia of profound societal and population change in small-scale societies once distributed across the North American midcontinent. Stepwise, not gradual, changes in the move toward an agriculturally based life, as indicated by plant remains, left a demographic signal reflecting age-independent (α₂) mortality as estimated from skeletons. Designated the age-independent component of the Siler model, it is tracked through the juvenility index (JI), which is increasingly being used in studies of archaeological skeletons. Usually interpreted as a fertility indicator, the JI is more responsive to age-independent mortality in societies that dominated most of human existence. In the midcontinent, the JI increased as people transitioned to a more intensive form of food production that prominently featured maize. Several centuries later, the JI declined, along with a reversion to a somewhat more diverse diet and a reduction in overall population size. Changes in age-independent mortality coincided with previously recognized increases in intergroup conflict, group movement, and pathogen exposure. Similar rises and falls in JI values have been reported for other parts of the world during the emergence of agricultural systems.
Journal Article
Differential preservation of endogenous human and microbial DNA in dental calculus and dentin
Dental calculus (calcified dental plaque) is prevalent in archaeological skeletal collections and is a rich source of oral microbiome and host-derived ancient biomolecules. Recently, it has been proposed that dental calculus may provide a more robust environment for DNA preservation than other skeletal remains, but this has not been systematically tested. In this study, shotgun-sequenced data from paired dental calculus and dentin samples from 48 globally distributed individuals are compared using a metagenomic approach. Overall, we find DNA from dental calculus is consistently more abundant and less contaminated than DNA from dentin. The majority of DNA in dental calculus is microbial and originates from the oral microbiome; however, a small but consistent proportion of DNA (mean 0.08 ± 0.08%, range 0.007–0.47%) derives from the host genome. Host DNA content within dentin is variable (mean 13.70 ± 18.62%, range 0.003–70.14%), and for a subset of dentin samples (15.21%), oral bacteria contribute > 20% of total DNA. Human DNA in dental calculus is highly fragmented, and is consistently shorter than both microbial DNA in dental calculus and human DNA in paired dentin samples. Finally, we find that microbial DNA fragmentation patterns are associated with guanine-cytosine (GC) content, but not aspects of cellular structure.
Journal Article
Selective mortality in middle-aged American women with Diffuse Idiopathic Skeletal Hyperostosis (DISH)
A mortality sample of white American male and female skeletons was examined to illustrate a simple means of identifying skeletal conditions associated with an increased risk of dying relatively early in adulthood and to determine if males and females with Diffuse Idiopathic Skeletal Hyperostosis (DISH) displayed the same general age-specific pattern of mortality.
Age-specific probability distributions for DISH were generated from 416 white Americans who died from the 1980s to the present, and whose remains were donated to the University of Tennessee Forensic Anthropology Center. The age-specific frequency of DISH is analyzed using an empirical smoothing algorithm. Doing so allows for the identification of deviations (i.e., local maxima) from monotonically increasing age-specific probabilities.
In females (N = 199), there is a peak in the frequency of individuals with DISH around 60 years of age where 37.0% of the individuals have DISH. It is matched only by the frequency (38.7%) in the oldest females, those over 85 years old. In contrast, DISH frequencies for males (N = 217) increase monotonically with advancing age, reaching 62.5% in the ≥86 years age group. There was an association between DISH and high body weight in women, particularly those who died before they reached the age of 75.
Early-onset DISH in white American women is associated with an increased risk of dying indicated by a local maximum in the probability curve. Should this finding be replicated in additional mortality samples and the reason DISH is associated with early death is established, beyond being heavy, this radiologically visible ossification of the spine could be a potential component of health-monitoring programs for middle-aged women.
Journal Article
Ongoing Work with Adult Skeletal Age Estimation
Improving adult age-at-death estimates using visible features of the human skeleton has been the subject of much research because such assessments are critical elements of forensic investigations and bioarchaeological studies. Beginning in 2014, a National Institute of Justice (NIJ)–funded research team developed a set of age-informative skeletal traits; collected reference data from collections in the United States, Portugal, Thailand, and South Africa; evaluated traits for their applicability; and developed alternative ways to generate age estimates from those traits. Here we present a comparison of two ways to produce age estimates: Stephen D. Ousley’s machine learning approach available as beta version computer software (TA3-ML) and an analytical procedure that originated with the version of transition analysis introduced two decades ago with different skeletal characteristics (TA3-TA). The two approaches are evaluated using the same 41 modern Portuguese and American skeletons. Both methods rely on NIJ-project skeletal data (TA3), but the number of traits used differs, as do reference sample sizes and compositions. Estimates generated through TA3-TA more closely approximate reported ages throughout adulthood than those from TA3-ML. Nevertheless, there remains a problem with underestimation in the TA3-TA approach, and neither method is ready for widespread implementation. Ongoing work is being directed toward resolving these issues by adjusting the mix of NIJ-project traits used in TA3-TA.
Journal Article
Trace element distribution in human cortical bone microstructure: the potential for unravelling diet and social status in archaeological bones
Variation in the trace element chemistry of cortical bone microstructure is delineated for interred and non-interred human femora. This was done to investigate the range of element concentrations that might occur within single bones, specifically the original laminar bone and later osteons, and its potential for investigating chemical life histories. To do so, femora were chosen from individuals who experienced quite different ways of life over the past two millennia. The distributions of Sr, Ba, Cu, and Pb, mostly in partial (early) and complete (late) osteons, in cross-sections of proximal femora were characterized through Laser Ablation Inductively Coupled Plasma Mass Spectrometry. Absolute calibrations of these data were obtained using solution Inductively Coupled Plasma Mass Spectrometry on adjacent dissolved bulk samples. Chemical life histories were approximated by classifying bone microstructure into four categories: laminar bone and 1st, 2nd, and 3rd generation osteons. This four-part sequence, on average, charts the temporal dimension of an individual’s life. Consistent with recent studies of medieval bones, Sr and Ba are thought to be mainly responsive to diet, presumably related to the consumption of mostly locally produced food, while Cu and Pb do the same for heavy metal exposure often attributable to social status or occupation. No systematic differences in these elements were found between interred and non-interred individuals. The effect of diagenesis on interpretations of life histories based on archaeological bone, therefore, are minimized by plotting element concentrations across cortical bone cross-sections.
Journal Article
Copper exposure in medieval and post-medieval Denmark and northern Germany: its relationship to residence location and social position
For medieval and post-medieval Denmark and northern Germany, trace elements can potentially contribute to our understanding of diet, migration, social status, exposure to urban settings, and disease treatment. Copper, of particular interest as a marker of access to everyday metal items, can be used to clarify socioeconomic distinctions between and within communities. Postmortem alteration of bone (diagenesis), however, must be ruled out before the elements can be used to characterize life in the past. Femoral cortical bone samples of ca. 40 mg were thoroughly decontaminated, and the concentrations of Al, Ca, Mn, Fe, Cu, As, Sr, Ba, and Pb were measured using inductively coupled plasma mass spectrometry. The concentrations of these elements were quantified in bone samples from 553 skeletons from 9 rural and urban cemeteries, and 34 soil samples obtained near three burials. Copper, the primary element of interest in this work, is generally absent from the femoral cortical bone of rural people, although it occurs in high concentrations in the skeletons of the inhabitants of towns. The Cu in medieval to post-medieval bones likely originated from everyday objects, notably kitchen utensils. A rural to urban distinction in Cu concentrations, found repeatedly at two sites, likely resulted from differential access to much-desired, although still utilitarian, household items. An uneven distribution of metal objects used in domestic contexts, demonstrated through bone chemistry, was greater between rural and urban communities than it was within urban centres, at least among the socioeconomic positions sampled in this study.
Journal Article
Eastern North American Population at ca. A.D. 1500
Archaeologically documented population aggregates are used to estimate the population of eastern North America around A.D. 1500 and by extension the entire continent north of heavily populated Mesoamerica. Occupied areas plotted from archaeological and historical information were increased by buffer areas with widths determined by average nearest neighbor distances. Population sizes assigned to these areas were based on three compilations of historic sources, each handled in various ways. Local densities were calculated and then used to interpolate density surfaces for a ca. 3.1 million km2 area. The surfaces were further modified by assessments of data quality and overall occupation intensity to provide upper and lower bounds for each estimate. The procedure, designed to produce a range that was overly wide, resulted in an eastern population between .5 and 2.6 million and a continental total, north of Mesoamerica, of 1.2 to 6.1 million. These figures fall in the lower third of current authoritative estimates for the continent as a whole, which range from 2.4 to 18 million.
Journal Article