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A bstract We present results from a state-of-the-art fit of electroweak precision observables and Higgs-boson signal-strength measurements performed using 7 and 8 TeV data from the Large Hadron Collider. Based on the HEPfit package, our study updates the traditional fit of electroweak precision observables and extends it to include Higgs-boson measurements. As a result we obtain constraints on new physics corrections to both electroweak observables and Higgs-boson couplings. We present the projected accuracy of the fit taking into account the expected sensitivities at future colliders.

HEPfit is a flexible open-source tool which, given the Standard Model or any of its extensions, allows to (i) fit the model parameters to a given set of experimental observables; (ii) obtain predictions for observables. HEPfit can be used either in Monte Carlo mode, to perform a Bayesian Markov Chain Monte Carlo analysis of a given model, or as a library, to obtain predictions of observables for a given point in the parameter space of the model, allowing HEPfit to be used in any statistical framework. In the present version, around a thousand observables have been implemented in the Standard Model and in several new physics scenarios. In this paper, we describe the general structure of the code as well as models and observables implemented in the current release.

A bstract We propose to perform a combined analysis of B → ππ and B s → K + K − modes, in the framework of a global CKM fit. The method optimizes the constraining power of these decays and allows to derive constraints on NP contributions to penguin amplitudes or on the B s mixing phase. We illustrate these capabilities with a simplified analysis using the recent measurements by the LHCb Collaboration, neglecting correlations with other SM observables.

In this study, we aimed to evaluate and compare the effects of intravitreal aflibercept (IVA) and intravitreal faricimab (IVF) injections on the blood flow of retinal vessels in the peripapillary region and optic nerve head (ONH) in eyes with diabetic macular edema (DME) using laser speckle flowgraphy (LSFG). This study included 20 eyes of 18 patients treated with IVA and 15 eyes of 11 patients treated with IVF for DME. The mean blur rate (MBR) of the ONH and retinal artery and vein of the peripapillary region were measured using LSFG at baseline and 1 month after injection. Central retinal thickness (CRT) and best-corrected visual acuity (BCVA) were measured for all patients. CRT decreased significantly in both IVA-treated ( = 0.0003) and IVF-treated groups ( = 0.0004). Some of the MBR-related parameters of the ONH, such as MBR of all areas (MA), MBR of vascular areas (MV), and MBR of tissue areas (MT), decreased significantly 1 month after IVA and IVF compared to baseline values (MA of IVA, < 0.0001; MT of IVA, = 0.0220; MA of IVF, = 0.0002; MT of IVF, = 0.0461). MBR of the retinal artery (MBR-A) and vein (MBR-V) also decreased significantly 1 month after IVA and IVF compared with baseline values (MBR-A of IVA, = 0.0002; MBR-V of IVA, = 0.0010; MBR-A of IVF, = 0.0368). No significant difference in ocular perfusion was observed between the IVA-treated and IVF-treated groups. Intravitreal injection led to a reduction in ocular blood flow in both retinal peripapillary vessels and the ONH in both IVA-treated and IVF-treated groups. No significant difference was observed in MBR reduction between the IVA-treated and IVF-treated groups. Our findings warrant further long-term investigations to reveal differences between aflibercept and faricimab.

IntroductionAtrial fibrillation (AF) is associated with significantly impaired quality-of-life. Iron deficiency (ID) is prevalent in patients with AF. Correction of ID in other patient populations with intravenous iron supplementation has been shown to be a safe, convenient and effective way of improving exercise tolerance, fatigue and quality-of-life. The IRON-AF (Effect of Iron Repletion in Atrial Fibrillation) study is designed to assess the effect of iron repletion with intravenous ferric carboxymaltose in patients with AF and ID.Methods and analysisThe IRON-AF study is a double-blind, randomised controlled trial that will recruit at least 84 patients with AF and ID. Patients will be randomised to receive infusions of either ferric carboxymaltose or placebo, given in repletion and then maintenance doses. The study will have follow-up visits at weeks 4, 8 and 12. The primary endpoint is change in peak oxygen uptake from baseline to week 12, as measured by cardiopulmonary exercise testing (CPET) on a cycle ergometer. Secondary endpoints include changes in quality-of-life and AF disease burden scores, blood parameters, other CPET parameters, transthoracic echocardiogram parameters, 6-minute walk test distance, 7-day Holter/Event monitor burden of AF, health resource utilisation and mortality.Ethics and disseminationThe study protocol has been approved by the Central Adelaide Local Health Network Human Research Ethics Committee, Australia. The results of this study will be disseminated through publications in peer-reviewed journals and conference presentations.Trial registration numberAustralian New Zealand Clinical Trials Registry (ACTRN12620000285954).

A reduction in chemical phosphate (P) fertilizer application to farmland from 137.6 kg P ha⁻¹ in 1985 to 99.0 kg P ha⁻¹ in 2005 and in manure application from 42.4 kg P ha⁻¹ in 1985 to 32.8 kg P ha⁻¹ in 2005 did not reduce crop P uptake, which averaged 27 kg P ha⁻¹ over the period. Phosphate balance on farmland declined from 153.0 kg P ha⁻¹ in 1985 to 105.4 kg P ha⁻¹ in 2005 while livestock excreta disposal increased from 12.7 kg P ha⁻¹ in 1985 to 23.7 kg P ha⁻¹ in 2005. As a result, residual P associated with agriculture declined from 165.8 kg P ha⁻¹ in 1985 to 129.1 kg P ha⁻¹ in 2005. Phosphate utilization efficiency increased from 15.7% in 1985 to 20.1% in 2005. Median, minimum and maximum values of P flows by region showed similar trends. Phosphate input and withdrawal through crop production by region were not related to regional nitrogen (N) input and withdrawal through crop production. Although non-utilized P associated with agriculture has declined nationally and regionally, it is still higher than that in foreign countries, because of high chemical P fertilizer inputs and low crop yield withdrawal. Because soil P fertility was often sufficiently high previous large P surpluses, reducing P applications did not affect crop yields. Crop P uptake was less than half that of crop N yield. These results indicate that P inputs, especially by chemical fertilizer, for crop production could be reduced, thereby reducing negative environmental effects such as eutrophication of soil and water and conserving limited P resources.

HEPfit is a flexible open-source tool which, given the Standard Model or any of its extensions, allows to (i) fit the model parameters to a given set of experimental observables; (ii) obtain predictions for observables. HEPfit can be used either in Monte Carlo mode, to perform a Bayesian Markov Chain Monte Carlo analysis of a given model, or as a library, to obtain predictions of observables for a given point in the parameter space of the model, allowing HEPfit to be used in any statistical framework. In the present version, around a thousand observables have been implemented in the Standard Model and in several new physics scenarios. In this paper, we describe the general structure of the code as well as models and observables implemented in the current release.

Trends in nitrogen (N) and phosphate (P) balance for several crops were calculated for the nation and by prefecture for 5-year periods from 1985 to 2005. Prefectural chemical N and P fertilizer applications for paddy rice and upland crops declined but applications for vegetable crops increased during the period like as national trends. Prefectural chemical N and P applications for tea, orchard and forage remained unchanged in line with national trends. Manure N and P applications for each crop did not follow the trends for chemical fertilizer. Although chemical fertilizer application declined, N and P crop withdrawal for paddy rice, upland crops and tea increased as a result of optimizing fertilizer timing and placement. Nitrogen and P balance for each crop indicated a surplus; P surplus was larger than N surplus, because of higher P input and lower crop P withdrawal. Chemical N fertilizer determined N surplus except for forage, which was determined by manure application. Therefore N surplus on paddy rice, upland crops, orchard and tea declined and increased on vegetables. Forage recorded an N deficiency in two 5-year periods nationally because of low manure input. Because P balance was also determined by chemical P fertilizer, the P surplus for paddy rice and upland crops declined and the P surplus for vegetables increased during the period. Total P surplus was reduced on paddy rice and upland crops. Trends for chemical fertilizer, manure and N and P balance varied widely among prefectures, especially for P. Crop withdrawal of N and P varied relatively little. Although prefectural trends did not always follow the national trend, we could conclude that the negative environmental effects of Japanese crop production have diminished recently, and an improvement in N and P balance in vegetable production can be expected.

Steam reforming of ethanol, C2H5OH+H2O→2CO+4H2, was carried out over Co/Al2O3, Co/SiO2, Co/MgO, Co/ZrO2 and Co/C. The properties of the Co catalysts were greatly affected by the supports. Co/Al2O3 exhibited the highest selectivity for steam reforming of ethanol by suppression of methanation of CO and decomposition of ethanol.