Explore the vast range of titles available.

The present study shows the opportunity of using biofilm in the hydrolysis step of food waste (FW) to increase biogas production. Therefore, screened biofilm-producing microorganisms were adopted to facilitate the biodegradation of organic compounds (OCs) and enhance the volume of biogas production. The biofilm-producing microorganisms were first immobilized on a granular activated carbon (GAC) surface, and the optimum values of immobilization time, mass of the GAC surface, and size of the microbial inoculums were found using the statistical methods of one-factor-at-a-time (OFAT) and the response surface methodology (RSM) using a face-centered central composite design (FCCCD). Based on the results, 48 h of incubation, 8 g of GAC, and 1 mL of inoculum were the optimum conditions when shaken at 37 °C and 150 rpm. Different biofilm amounts (328 mg, 492 mg, 656 mg, 820 mg, and 984 mg) were used in hydrolysis flasks operated in batch mode to increase the degradation of the OCs. The optimal level of the hydrolysis degradation was on day 3 and at 328 mg of biofilm; the total solid (TS) content was decreased from 115 gL−1 to 79 gL−1 (31%), and the TCOD was decreased from 85.33 gL−1 to 54.50 gL−1 (36%).

Background Human Immunodeficiency Virus (HIV) infection causes a myriad of neurological complications including cognitive deficits referred to as HIV-Associated Neurocognitive Disorders (HAND). With the introduction of combination antiretroviral therapy, there has been an epidemiological shift in cognitive disorders with a decline in the more severe HIV-Associated Dementia (HAD) to an increase in the less severe HAND: Asymptomatic Neurocognitive Impairment (ANI) and HIV-associated Mild Neurocognitive Disorder (MND). Central Nervous System (CNS) involvement in HIV interferes with cognitively demanding activities of daily living and hence a worse quality of life. Early diagnosis is delayed until symptoms are overt. Methods We conducted a cross sectional analytical study of HIV infected persons on antiretroviral therapy attending HIV clinic. A systematic random sampling was done to select 360 patients. An interviewer administered structured questionnaire was used to collect socio-demographic data while the CD4 count and viral load were retrieved from the Academic Model Providing Access to Healthcare (AMPATH) database. Pearson’s Chi Square test was used to compare proportions while independent sample t- test was used to compare continuous variables between the patients diagnosed with HAND and those without HAND. Logistic regression model was used to assess the factors associated with HAND. Results The mean age of the study participants was 40.2 years. The overall prevalence of HAND was (81.1%) N  = 292. Mild HAND (ANI and MND) was present (78.6%) N  = 283, Severe HAND (HAD) (2.5%) N  = 9. The factors associated with HAND were older age OR: 1.06 (95% CI: 1.03, 1.10), male gender OR: 0.48 (95% CI: 0.24, 0.97), Advanced WHO clinical staging OR: 2.45 (95% CI: 1.20, 5.01) and a higher level of education; secondary/tertiary OR: 0.16 (95% CI: 0.07, 0.38); 0.11 (95% CI: 0.04, 0.35). Conclusion The prevalence of HAND in this study population was found to be high (81.1%). Older age and advanced WHO clinical staging were associated with an increased risk of hand while higher level of education and male gender were protective.

The production of biogas from food waste is a good approach to the minimization of food waste and increase in the production of renewable energy. However, the use of food waste as a feedstock for biogas production currently poses a difficulty due to an ineffective hydrolysis process, which is a pretreatment procedure and the initial step of the biogas conversion process. This restriction results from the food waste polymers’ solubilization and breakdown. This has an impact on the volume of biogas produced during the methanogenesis stage. It is essential to increase the biodegradation of organic compounds (OC) during the hydrolysis process to increase biogas generation. This study focuses on the enhancement of biogas production by the anaerobic digestion (AD) of food waste (FW). FW was hydrolyzed by the immobilized biofilm and digested anaerobically in a semi-continuous digester. Four different digesters including the control were prepared. The control digester composed of no hydrolyzed food waste had no immobilized biofilm while the other three digesters had immobilized biofilm-hydrolyzed food waste with inoculum concentrations of 10%, 30%, and 50%. The results showed that the 50% digester had the highest biogas yield of about 2000 mL/500 mL. The 10%, 30%, and control digesters had a biogas yield of 1523 mL, 753 mL, and 502 mL respectively. Thus, the analysis of total volatile solid (TVS) reduction in the digesters with 10%, 30%, and 50% inoculum and the control have increased to 43.4% for the digesters with 30% and 10%, 60% for the digester with 50% inoculum, and only 29% for the control. Total chemical demand (TCOD) removal increased to 29%, 33%, 43%, and 56% for the control, and 10%, 30%, and 50%, respectively for the inoculum-to-feed ratio. From these results, the 50% inoculum-to-feed ratio has shown the highest biogas production and highest degradation based on TVS reduction and TCOD reduction. Based on this study, the biofilm pretreatment method can be considered a promising method for the enhancement of biogas volume and biodegradation. Biogas production was high (2000 mL) for hydraulic retention time (HRT = 20) days but the HRT = 15 days was also able to produce a significant amount (1400 mL) of biogas and the 50% inoculum-to-feed ratio has shown the highest volume of biogas production.

Centres for Disease Control and prevention (CDC) reports that there are limited data and information about the impact of underlying medical conditions and the risk of infection. To date, there are no studies that report on the risk of infection among patients with haematological diseases or abnormalities. This cross-sectional study reports on the baseline complete blood count in patients attending publicly funded primary care settings with a diagnosis of suspected COVID-19 infections in the state of Qatar. The study will report on the de0.001, Chi-square test) (OR 2.56, 95% CI 1.73-3.77). Categories for haematological abnormalities were not associated with increased risk of having a positive PCT test result. In a population attending primary healthcare settings with early presentation of symptoms of COVID-19 infection, the risk of infection among our cohort was not affected by the prior haematological values of those patients. Gender was the most influential parameter in the risk of infection in our population. Analysis of the results using gender-specific categories for different haematological parameters suggested that patients with abnormal haematological values were not at increased risk of having a positive COVID-19 infection.

Centres for Disease Control and prevention (CDC) reports that there are limited data and information about the impact of underlying medical conditions and the risk of infection. To date, there are no studies that report on the risk of infection among patients with haematological diseases or abnormalities. This cross-sectional study reports on the baseline complete blood count in patients attending publicly funded primary care settings with a diagnosis of suspected COVID-19 infections in the state of Qatar. The study will report on the descriptive characteristics of the population, including gender, age and prior abnormalities to their blood test results. We will compare the results of those with positive and negative PCR test results, where appropriate. Nine hundred sixty-two adult patients attended publicly funded primary health care settings in the state of Qatar between 10 February and 30 April 2020 with a diagnosis of suspected COVID-19 infections had prior recorded blood investigations in the last six months and were included in this study. The population was young, mean of age is 38.8 ± 11.6. (Median: 36 [Min: 19–Max: 85]). Complete blood count of the sample had minimal missing data points. Females were more presented in our samples, Female (n = 560, 58.21%) and Male (n = 402, 41.79%). Most of our sample had a documented PCR test result, negative (n = 831, 86.38%); positive (n = 123, 12.79%) and missing (n = 8, 0.83%). Low haemoglobin values (n = 265, 27.5%) and low red blood cell count (n = 170, 17.7%) were the most prevalent complete blood count abnormality in the population. Leukopenia was less common (n = 50, 8.2%). Most of the population had normal platelet count (n = 895, 93%). Gender was the most influential factor in our sample to increase the odds of having a positive PCR t results; males were more likely to be affected (p < 0.001, Chi-square test) (OR 2.56, 95% CI 1.73–3.77). Categories for haematological abnormalities were not associated with increased risk of having a positive PCT test result. In a population attending primary healthcare settings with early presentation of symptoms of COVID-19 infection, the risk of infection among our cohort was not affected by the prior haematological values of those patients. Gender was the most influential parameter in the risk of infection in our population. Analysis of the results using gender-specific categories for different haematological parameters suggested that patients with abnormal haematological values were not at increased risk of having a positive COVID-19 infection.

يهدف هذا البحث إلى تسليط الضوء على الشيخ العلامة المؤرخ أبو الوليد محمد بن عبد الله الأزرقي وموارده ومنهجه في كتابه أخبار مكة، وقد تم تقسيم البحث إلى مقدمة وأربعة فصول وخاتمة؛ يتناول الفصل الأول التعريف بالأزرقي ومكانته العلمية والعصر الذي عاش فيه وأثره في حياته، ويتناول الفصل الثاني وصف كتاب أخبار مكة للأزرقي مع استعراض سريع لمحتويات هذا الكتاب القديم، ويتناول الفصل الثالث منهج الأزرقي في كتابة أخبار مكة، ويتناول الفصل الرابع موارد الأزرقي في كتابه أخبار مكة ويوضح الشيوخ الذين أسند إليهم الأزرقي رواياته، ثم ينتهي بالخاتمة وتشتمل على أبرز النتائج

Social data has shown important role in tracking, monitoring and risk management of disasters. Indeed, several works focused on the benefits of social data analysis for the healthcare practices and curing domain. Similarly, these data are exploited now for tracking the COVID-19 pandemic but the majority of works exploited Twitter as source. In this paper, we choose to exploit Facebook, rarely used, for tracking the evolution of COVID-19 related trends. In fact, a multilingual dataset covering 7 languages (English (EN), Arabic (AR), Spanish (ES), Italian (IT), German (DE), French (FR) and Japanese (JP)) is extracted from Facebook public posts. The proposal is an analytics process including a data gathering step, pre-processing, LDA-based topic modeling and presentation module using graph structure. Data analysing covers the duration spanned from January 1st, 2020 to May 15, 2020 divided on three periods in cumulative way: first period January-February, second period March-April and the last one to 15 May. The results showed that the extracted topics correspond to the chronological development of what has been circulated around the pandemic and the measures that have been taken according to the various languages under discussion representing several countries.

Tartrazine (E-102) is one of the most widely used artificial food azo-colors that can be metabolized to highly sensitizing aromatic amines such as sulphanilic acid. These metabolites are oxidized to N-hydroxy derivatives that cause neurotoxicity. Melatonin is a neurohormone. That possesses a free-radical scavenging effect. The present work was mainly designed to evaluate the possible ameliorative role of melatonin against tartrazine induced neurotoxicity in cerebral cortex and cerebellum of male rats. Adult male rats were administered orally with tartrazine (7.5 mg/kg) with or without melatonin (10 mg/kg) daily for four weeks. The data revealed that tartrazine induced redox disruptions as measured by significant (p < 0.05) increased malondialdehyde (MDA) level and inhibition of (GSH) concentration and catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) antioxidant enzyme activities. Besides, brain acetyl cholin (Ach) and gamma-aminobutyric acid (GABA) were elevated while, dopamine (DA) was depleted in trtrazine -treated rats. Moreover, tartrazine caused a significant (p < 0.05) increase in the brain interleukin-6 (IL-6), interleukin-1β (IL-1 β) and tumor necrosis factor-α (TNFα). At the tissue level, tartrazine caused severe histopathological changes in the cerebellum and cerebral cortex of rats. The immunohistochemical results elucidated strong positive expression for Caspase-3 and GFAP and weak immune reaction for BcL2 and synaptophysin in tatrazine- treated rats. The administration of melatonin to tartrazine -administered rats remarkably alleviated all the aforementioned tartrzine-induced effects. It could be concluded that, melatonin has a potent ameliorative effect against tartrazine induced neurotoxicity via the attenuation of oxidative/antioxidative responses.

Alzheimer’s disease (AD) is a devastating illness with limited therapeutic interventions. The aim of this study is to investigate the pathophysiological mechanisms underlying AD and explore the potential neuroprotective effects of cocoa, either alone or in combination with other nutraceuticals, in an animal model of aluminum-induced AD. Rats were divided into nine groups: control, aluminum chloride (AlCl3) alone, AlCl3 with cocoa alone, AlCl3 with vinpocetine (VIN), AlCl3 with epigallocatechin-3-gallate (EGCG), AlCl3 with coenzyme Q10 (CoQ10), AlCl3 with wheatgrass (WG), AlCl3 with vitamin (Vit) B complex, and AlCl3 with a combination of Vit C, Vit E, and selenium (Se). The animals were treated for five weeks, and we assessed behavioral, histopathological, and biochemical changes, focusing on oxidative stress, inflammation, Wnt/GSK-3β/β-catenin signaling, ER stress, autophagy, and apoptosis. AlCl3 administration induced oxidative stress, as evidenced by elevated levels of malondialdehyde (MDA) and downregulation of cellular antioxidants (Nrf2, HO-1, SOD, and TAC). AlCl3 also upregulated inflammatory biomarkers (TNF-α and IL-1β) and GSK-3β, leading to increased tau phosphorylation, decreased brain-derived neurotrophic factor (BDNF) expression, and downregulation of the Wnt/β-catenin pathway. Furthermore, AlCl3 intensified C/EBP, p-PERK, GRP-78, and CHOP, indicating sustained ER stress, and decreased Beclin-1 and anti-apoptotic B-cell lymphoma 2 (Bcl-2) expressions. These alterations contributed to the observed behavioral and histological changes in the AlCl3-induced AD model. Administration of cocoa, either alone or in combination with other nutraceuticals, particularly VIN or EGCG, demonstrated remarkable amelioration of all assessed parameters. The combination of cocoa with nutraceuticals attenuated the AD-mediated deterioration by modulating interrelated pathophysiological pathways, including inflammation, antioxidant responses, GSK-3β-Wnt/β-catenin signaling, ER stress, and apoptosis. These findings provide insights into the intricate pathogenesis of AD and highlight the neuroprotective effects of nutraceuticals through multiple signaling pathways.

Background As nursing education embraces e-learning as a vital component of its pedagogical approach, understanding the interplay between students’ readiness for E-learning and their academic self-efficacy becomes imperative in nurturing successful learning outcomes amidst evolving educational paradigms. Purpose This study aimed to explore the relationship between e-learning readiness, academic self-efficacy, and the academic achievement of nursing students within the dynamic educational environment. Design This study employed a cross-sectional design. Methods A total of 208 nursing students were recruited through convenience sampling at the end of the second semester in 2022. The evaluation included the utilization of Grade Point Average, the Online Learning Readiness Scale, and the Academic Self-Efficacy Scale. Findings Previous research has indicated a significant positive correlation between academic achievement and readiness for e-learning, suggesting that higher levels of readiness for e-learning among nursing students lead to improved academic achievement ( p  ≤ 0.001). Additionally, the findings of the current study revealed a notable positive correlation between academic achievement and academic self-efficacy ( p  ≤ 0.001). Conclusion This study provides valuable insights into the critical role of academic self-efficacy and e-learning readiness in enhancing academic achievement among nursing students.