Explore the vast range of titles available.

This paper suggests an optimal maximum power point tracking (MPPT) control scheme for a grid-connected photovoltaic (PV) system using the arithmetic optimization algorithm (AOA). The parameters of the proportional-integral (PI) controller-based incremental conductance (IC) MPPT are optimally selected using AOA. To accomplish this study, a 100-kW benchmark PV system connected to a medium distribution utility is constructed and analyzed employing MATLAB/SIMULINK. The optimization framework seeks to minimize four standard benchmark performance indices, then select the best of the best among them. To verify the efficacy of the recommended methodology, a comprehensive comparison is conducted between AOA-based PI-IC-MPPT, modified incremental conductance MPPT (MIC), grey wolf optimization (GWO), genetic algorithm (GA), and particle swarm optimization (PSO)-based MPPT. The proposed control approach has achieved a reduction of 61, 3, 4.5, and 26.9% in the rise time and a decrease of 94, 84.7, 86.6, and 79.3% in the settling time compared with MIC, GWO, GA, and PSO in extracting MPPT of the proposed system, respectively.

This study systematically investigates the adsorption and degradation of methylene blue (MB) dye from wastewater using an activated carbon-zinc oxide-ammonia (AC-ZnO-NH 3 ) composite. The composite was synthesized through ammonia doping and integration of zinc oxide nanoparticles, enhancing its adsorption and catalytic capabilities. Batch experiments revealed optimal conditions for MB removal at pH 9, 50 ppm dye concentration, and a contact time of 180 min, achieving 97.4%removal efficiency. Kinetic studies indicated that the adsorption followed pseudo-second-order kinetics (R² = 0.998), typically suggesting chemisorption. However, mechanistic investigations—supported by FTIR, SEM, and zeta potential analysis—revealed that MB removal was primarily driven by strong electrostatic interactions, π–π stacking, hydrogen bonding, and photocatalytic degradation. This suggests a hybrid mechanism involving both physisorption and chemisorption pathways. Isotherm analysis confirmed the Langmuir model’s suitability ( ), with a maximum monolayer adsorption capacity of 106.38 mg/g. Fourier-transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) confirmed the functional groups and porous morphology responsible for adsorption. Furthermore, a cost analysis indicated that the AC-ZnO-NH₃ composite is economically viable for both small- and large-scale wastewater treatment applications, reinforcing its scalability, multifunctionality, and environmental compatibility. This cost-effective and eco-friendly composite provides a promising solution for treating dye-contaminated wastewater, emphasizing its scalability and multifunctionality in environmental remediation.

This work evaluates utilizing the native mussel Brachidontes pharaonis as a bioindicator and sentinel organism for monitoring heavy metals Cu, Zn, and Cd along the Red Sea coast of Egypt. Samples were collected from four coastal locations, and the concentrations of heavy metals in the mussels’ tissues, shells, seawater, and sediments were analyzed. Subsequently, bioassay experiments were conducted by exposing the organisms to single, binary, and tertiary metal mixtures, and the accumulation of heavy metals was determined to elucidate the dynamics of metal–metal interactions. Field samples revealed significant variations in heavy metal concentrations in the mussels’ soft tissues across different locations, with Zn ranging from 58.1 to 121.0 µg/g dw (dry weight), Cu ranging between 18.3 and 36.7 µg/g dw, and Cd ranging from 0.3 to 1.04 µg/g dw. Conversely, the shells exhibited minimal spatial variations, with much lower contents of Cu (ranging from 1.9 to 2.8 µg/g dw) and Zn (ranging from 1.8 to 1.9 µg/g dw). However, the shells accumulated Cd at higher levels (ranging from 1.4 to 2.1 µg/g dw) compared to the soft tissues. Following a 96-h bioassay experiment, the soft tissues displayed a linear accumulation of metals with increasing exposure dose, with Cd showing the highest accumulation rate (approximately threefold) followed by Zn (twofold) and Cu (1.7-fold). In binary and tertiary exposures, the metals exhibited a general antagonistic interaction, affecting each other’s accumulation. On the other hand, the accumulation of heavy metals in the shells after the 96-h bioassay exposure did not follow a consistent linear pattern, suggesting that accumulation during this short experimental period occurs primarily through adsorption rather than the biological pathway.

Environmental stressors (such as ammonia) in aquaculture could increase the risk of pathogenicity, posing a more severe threat to farmed fish. The aim of this study was to investigate the effects of ammonia stress on the pathogenicity of Shewanella spp. in Oreochromis niloticus . First, a 96-hour static test was used to determine the median lethal concentration (LC 50 ) of unionized ammonia to Nile tilapia. After 96 h of exposure, the Un-ionized ammonia (UIA) LC 50 was estimated to be 4.26 mg/L. Second, an experiment was conducted to test the effect of unionized ammonia stress on the pathogenicity of Shewanella spp. in O. niloticus for 30 days. A study involved 180 fish divided into six groups, with the first group serving as a control. The second group (AMN1/10) and the third group (AMN1/20) were not challenged and were exposed to 1/10 (0.42 mg/L) and 1/20 (0.21 mg/L) of the 96-hour LC 50 of UIA, respectively. Then 0.2 mL (0.14 × 10 5 ) of Shewanella spp. was intraperitoneally injected into the fourth (SH), fifth (SH + AMN1/10), and sixth (SH + AMN1/20) groups, which were subjected to 0, 1/10 (0.42 mg/L), and 1/20 (0.21 mg/L) of the 96-hour LC 50 of UIA, respectively. The survival rate, hematological indices, immunological parameters, and antioxidant activity of the fish significantly decreased when they were exposed to ammonia and Shewanella infection separately or together. Histopathological changes were also observed in the kidney and liver. Furthermore, both individual and combined exposures significantly altered renal and hepatic function, with notable increases in glucose and cortisol levels, as well as in the expression of proinflammatory cytokine genes ( TNF-α and IL-1ß ). However, the detrimental effects of co-exposure to ammonia stress and Shewanella infection were greater than those of separate exposures. As a result, we may say that increased ammonia concentrations enhance the infection of Shewanella spp. These findings could contribute to a better understanding of Shewanella infection in Nile tilapia.

This study evaluated the potential of Punica granatum peel ethanol extract (PPEE) in attenuating the liver and kidney tissue injury induced by vancomycin (VM) treatment in rats. Fifty rats were distributed equally into five groups: control group, PPEE-administered group (100 mg/kg BW/day for 2 weeks; orally), VM-treated group (443.6 mg/kg BW, every alternate day for 2 weeks; intraperitoneally), pre-treated group, and concomitant-treated group. The biochemical response and the histopathology of the hepatic and renal tissue of the treated animals were assessed. The results showed that VM treatment induced substantial hepatotoxicity and nephrotoxicity, evidenced by a significant elevation in tissue injury and lipid oxidative (malondialdehyde) and inflammatory response (C-reactive protein) biomarkers, with lowered antioxidants and protein levels. Additionally, VM treatment induced various morphological, cytotoxic, vascular, and inflammatory perturbations as well as upregulation in the immune-expression of Caspase-3 and downregulation of BCL-2. Moreover, PPEE co-treatment was found to reduce the VM-induced toxicity by protecting the tissue against reactive oxygen species (ROS)–mediated oxidative damage, and inflammation as well as hinder the apoptotic cell death by modulating the expression of apoptosis-related proteins. Thus, we conclude that the PPEE administration showed more restoring efficacy when administered prior to VM medication.

Background: This study explored the effect of vitamin C (Vit-C) administration on the reproductive function of adult male Wistar rats injected with boldenone undecylenate (BOL). Methods: Rats were randomly assigned into control, vehicle control, Vit-C (120 mg/kg b.wt./day, orally), BOL (received 5 mg/kg b.wt./week, IM) and BOL+Vit-C-treated groups. After eight weeks, hormonal assay, semen evaluation, testicular enzymes, and antioxidants biomarkers were assessed. Besides, the histopathological and immunohistochemical investigations of the androgen receptor (AR) expression were performed. Results: The results revealed that serum testosterone, acid phosphatase, sorbitol dehydrogenase, sperm abnormalities, and testicular malondialdehyde were significantly incremented in the BOL-treated group. Testicular weight, sperm count, and sperm motility together with serum levels of luteinizing hormone, follicle-stimulating hormone, and estradiol, and testicular testosterone, catalase, superoxide dismutase, and reduced glutathione showed a significant decrease following BOL treatment. Besides, the AR immunoreactivity was significantly decreased in testicular tissues. Vit-C co-administration with BOL significantly relieved the BOL-induced sperm abnormalities, reduced sperm motility, testicular enzyme leakage, and oxidative damage. However, Vit-C could rescue neither BOL-induced hormonal disturbances nor AR down-regulation. Conclusions: The results provide further insight into the mechanisms of BOL-induced reproductive dysfunction and its partial recovery by Vit-C.

In this study, the effects of Coriandrum sativum to control Aeromonas veronii infection in Oreochromis niloticus were determined. Coriandrum sativum extract (CE) was tested in vitro against A. veronii by the disc diffusion assay. In in vivo, 150 O. niloticus (from El-Abbassa, Sharkia, Egypt, weighing 34.95 ± 1.98 g) was distributed in five groups (with three replications) in glass aquariums (80 × 40 × 30 cm). The first group (control) was intraperitoneally injected with 0.2 ml of sterilized tryptic soya broth. Groups 2–5 were intraperitoneally challenged with 0.2 ml of A. veronii (4.3 × 106). The five groups were administered a basal diet until clinical signs appeared, and then therapeutic feeding (15 days) was followed: the first (CONT) and second (AV) groups were administered a normal basal diet. The third (AV+CP) and fourth (AV+CE) groups were administered diets supplemented with C. sativum powder and extract, respectively, each at 30 mg/kg. The fifth group (AV+OT) was administered a diet supplemented with oxytetracycline at 500 mg/kg diet. The results of the in vitro experiment revealed that CE has a zone of inhibition of 43 mm against A. veronii. The in vivo results showed that fish administered a therapeutic diet supplemented with CE showed a significant improvement in hematological, biochemical, and immunological parameters, as well as antioxidant capacity (P < 0.05) and the pathological findings of the liver and kidney tissues. The current findings supported that the administration of a CE-enriched diet (30 mg/kg) is an eco-friendly strategy for controlling A. veronii in O. niloticus.

Tilmicosin (Til) was purposed to be used in the treatment of a wide range of respiratory diseases in livestock. However, undesirable adverse effects, cardiac toxicity, in particular, may be associated with Til therapy. In the present study, the response of adult rats administered Til subcutaneously at different doses (10, 25, 50, 75, and 100 mg/kg b.w.; single injection) was evaluated. Astragalus polysaccharide (AP) at two doses (100 and 200 mg/kg b.w.; intraperitoneally) was investigated for its potential to counteract the cardiac influences, involving the oxidative stress-induced damage and apoptotic cell death, elicited by the Til treatment at a dose of 75 mg/kg b.w. in rats. Til induced mortalities and altered the levels of the biomarkers for the cardiac damage, particularly in the rats treated with the doses of 75 and 100 mg/kg b.w.; similarly, morphological alterations in cardiac tissue were seen at all studied doses. AP was found to cause a significant ( P  ˂ 0.05) decline in the levels of impaired cardiac injury markers (troponin, creatine phosphokinase, and creatine phosphokinase-MB), improvement in the antioxidant endpoints (total antioxidant capacity), and attenuation in the oxidative stress indices (total reactive oxygen species, 8-hydroxy-2-deoxyguanosine, lipid peroxides [malondialdehyde], and protein carbonyl), associated with a significant ( P  ˂ 0.05) modulation in the mRNA expression levels of the encoding genes ( Bcl-2 , Bax , caspase-3 , P53 , Apaf-1 , and AIF ), related to the intrinsic pathway of apoptotic cell death in the cardiac tissue. AP administration partially restored the morphological changes in the rat’s heart. The highest protective efficacy of AP was recorded at a dose level of 200 mg/kg b.w. Taken together, these results indicated that AP is a promising cardioprotective compound capable of attenuating Til-induced cardiac impact by protecting the rat cardiac tissue from Til-induced apoptosis when administered concurrently with and after the Til injection.

Exposure to alkaline stress is common in aquatic practices. The present research investigated the detrimental impacts of rearing Nile tilapia under alkaline water stress by investigating the liver function indices and transcriptomic profile. A 30-day study was conducted on 160 fish (16.02 ± 0.14 g) split into four groups, each with four replicates. Group 1 (G1) and G2 were fed on a basal diet fortified with 0 and 75 g/kg diet camel whey protein hydrolysates (CWP) and reared in freshwater (carbonate alkalinity = 1.4 mmol/L, pH = 7.19). Moreover, G3 and G4 were fed on a basal diet enriched with 0 and 75 g/kg diet CWP and reared in alkaline water (carbonate alkalinity = 23.8 mmol/L; pH = 8.65). The outcomes revealed elevated lipid indices (triglycerides, cholesterol, low- and high-density lipoproteins) and liver enzymes (alanine and aspartate aminotransferase, alkaline phosphatase, and gamma-glutamyltransferase) with lowered protein indices (total protein, albumin, and globulin) in alkaline-reared fish. Moreover, oxidative stress was initiated through lowered antioxidant enzymes (superoxide dismutase, catalase, and reduced glutathione) and higher malondialdehyde in the alkaline-exposed fish. Alkaline stress induced the activation of the mechanistic target of rapamycin and MAPK pathway (mitogen-activated protein kinase, c-Jun NH terminal kinase, and MAPK-1 ) with down-regulation of the autophagy-related genes ( ATG-5 , ATG-7 , and ATG-13 ) and cathepsin B expression. Feeding on a CWP-supplemented diet resulted in significant modulation of the lipid profile, liver enzyme activity, and improvement in protein indices and antioxidant enzyme activity. Furthermore, modulation of the transcriptomic profile of the hepatic tissue of the alkaline-exposed fish was noticed due to feeding on a CWP-supplemented diet. Overall, CWP dietary addition at a level of 75 g/kg diet can alleviate the alkaline stress exposure in Nile tilapia. These outcomes could contribute to understanding the physiological circumstances of Nile tilapia when reared in alkaline water as well as provide a novel dietary additive for mitigating the bad consequences due to alkaline-stress exposure.

Due to their distinctive properties, several eco-friendly metal oxide nanoparticles were assessed for their possible cardioprotective properties. Acrylamide (ACD), a pervasive chemical in food and the environment, has been linked to cardiac toxicity. Therefore, this study examined the probable protective effect of green synthesized zinc oxide nanoparticles (GS-ZNPs) against ACD-oral exposure–induced cardiac damage in rats. For 60 days, 40 male Sprague-Dawley rats were separated into four sets that orally administered distilled water, 10-mg GS-ZNP/kg b.w., 20-mg ACD/kg b.w., or GS-ZNP + ACD. Then, cardiac damage indicators comprising CPK, CK-MB, cTn, and LDH were assessed. Besides, cardiac tissues’ architecture, oxidative stress indicators, and Zn content were evaluated. The mRNA expression of the ERS-related genes, including ATF3, ATF4, ATF6, XBP-1, CHOP, JNKs, and BiP, were determined. Moreover, ERS-dependent anti-apoptotic (BCL-2) and apoptotic (Caspase-3 and BAX) genes mRNA expression were analyzed. The results showed that GS-ZNP significantly alleviated the increased ACD-induced serum cardiac damage indicators, MDA tissue content, and histopathological changes. Furthermore, the ACD-induced reduction of antioxidants and Zn heart contents were significantly reestablished by GS-ZNP. Furthermore, the ACD-induced upregulation of the ERS-encoding genes and apoptotic genes was reversed by GS-ZNP. Besides, the ACD-induced BCL-2 downregulation was counteracted by GS-ZNP. Overall, GS-ZNP could be a biologically potent compound to alleviate ACD’s cardiotoxic effects, possibly by controlling the ERS and apoptosis-related genes and antioxidant activity.