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Konzo is a neglected paralytic neurological disease associated with food (cassava) poisoning that affects the world’s poorest children and women of childbearing ages across regions of sub-Saharan Africa. Despite understanding the dietary factors that lead to konzo, the molecular markers and mechanisms that trigger this disease remain unknown. To identify potential protein biomarkers associated with a disease status, plasma was collected from two independent Congolese cohorts, a discovery cohort (n = 60) and validation cohort (n = 204), sampled 10 years apart and subjected to multiple high-throughput assays. We identified that Glutathione Peroxidase 3 (GPx3), a critical plasma-based antioxidant enzyme, was the sole protein examined that was both significantly and differentially abundant between affected and non-affected participants in both cohorts, with large reductions observed in those affected with konzo. Our findings raise the notion that reductions in key antioxidant mechanisms may be the biological risk factor for the development of konzo, particularly those mediated through pathways involving the glutathione peroxidase family. The search for biomarkers associated with konzo disease has been a long-standing question within the research community. Here, the authors have uncovered a potential biomarker for konzo that is associated with the ability to manage oxidative damage.

Objectives: This study determined the current awareness and knowledge among physicians about biosimilars in Saudi Arabia. Methods: This study used a cross-sectional study design and data were acquired by the convenience sampling method. The research tool was self-developed, prevalidated and self-administered to achieve the sample size. The physicians from various parts of the country participated in the study. Both, inferential statistics with the help of descriptive statistics were applied using the Statistical Package for Social Sciences (SPSS) version 24.0 and Microsoft Excel. A p-value <0.05 was considered statistically significant. Results: A total of 105 practicing physicians throughout the country participated in the study. The majority of the participants were well informed and had adequate knowledge and awareness about numerous aspects of biosimilars except for the local healthcare policies and payer policies, where around half of them very aware of them. Statistically, a non-significant association (p-value >0.05) was observed. Conclusion: It is concluded that the study physicians had adequate knowledge and awareness about biosimilars in Saudi Arabia. Statistically, a non-significant association (p <0.05) was observed between adequate and inadequate knowledge among the studied physicians in Saudi Arabia.

The City Council will make a more formal announcement on who will be serving as Acting City Manager at a future meeting.\" According to a letter that Diaz wrote to the council, Williams had used a city credit card to pay $7,000 in legal fees to his attorney at San Francisco-based Ad Astra Law Group and signed off on the expenses as \"official city business.\" According to the city's operating procedures, an employee found guilty...

Tom Williams' personal attorney Claire Cochran of Ad Astra Law Group details allegations of civil rights violations, age discrimination and a hostile work environment by Tran in a 11-page document from April 13 to City Attorney Chris Diaz and Tran. In an 11-page letter to Tran and City Attorney Chris Diaz sent three weeks ago, Williams' personal attorney, Claire Cochran of San Francisco-based Ad Astra Law Group, wrote: \"This letter operates as both a demand to cease and desist violations of the Civil Rights Act, which continues to repeatedly and aggressively be violated by Mayor Tran on an almost daily basis, and also to serve as notice of pending litigation for age related discrimination, retaliation and hostile work environment, also stemming from Mayor Tran's behavior.\" The letter also alleges that, \"In addition to these repeated and misguided public comments about Mr. William's (sic) constitutionally protected job evaluations, Mayor Tran has followed up his statements by directly confronting Mr. Williams' (sic) about his age (53), suggesting repeatedly that Mr. Williams should quit his job because he is 'too old.'\" The letter goes on to accuse Tran of engaging in a \"witch hunt unnecessarily and with malice\" against Williams, in violation of...

[...]TIME RICHARD TRAN HAS BEEN ACCUSED OF COPYING WORDS

Newly elected Milpitas Mayor Richard Tran acknowledged to this newspaper he heavily lifted passages from President Barack Obama's 2008 acceptance speech into his own inauguration address on Dec. 13, explaining he did so because they were inspiring. Terry Christensen, a professor emeritus at San Jose State University and a specialist on local and state politics, wrote in an email that politicians using other politicians' speeches is not unusual.

Milpitas High School Principal Phil Morales was placed on administrative leave Thursday for using anti-Trump profanity during a student walkout in protest of Republican President-elect Donald Trump.