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Silver nanoparticle composites have abundant biomedical applications due to their unique antibacterial properties. In the current work, green tea leaf extract was used as a natural reducing agent to synthesize AgNPs (AgNPs) using microwave irradiation technology. Furthermore, microwave irradiation has been used for the preparation of AgNPs/chitosan (Ch) grafted polyvinyl alcohol (PVA) hydrogel samples. To approve the accomplishment of AgNPs hydrogel polymer, UV-spectrum, TEM, and FT-IR spectrum analyses and the release of silver ions, actions were taken. The wound-healing ability of the prepared hydrogel samples was measured via both the in vitro (fibroblast cells) and the in vivo using rat models. It was found that chitosan-grafted polyvinyl alcohol, including AgNPs, exhibited excellent antibacterial activity against E. coli and S. aureus using the agar diffusion method. It can be said that microwave irradiation was successful in creating a hydrogel that contained silver nanoparticles. A wound that was still open was successfully treated with these composites.

Wound healing is a biological process that involves a series of consecutive process, and its impairment can lead to chronic wounds and various complications. Recently, there has been a growing interest in employing nanotechnology to enhance wound healing. Silver nanoparticles (AgNPs) have expanded significant attention due to their wide range of applications in the medical field. The advantages of AgNPs include their easy synthesis, change their shape, and high surface area. Silver nanoparticles are very efficient for topical drug administration and wound healing because of their high ratio of surface area to volume. The efficiency of AgNPs depends on the synthesis method and the intended application. Green synthesis methods offer an eco-friendly approach by utilizing natural sources such as plant extracts and fungus. The characterization of nanoparticles plays an important character, and it is accomplished through the use of several characterization methods such as UV-Vis spectroscopy, Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffraction (XRD). These techniques are employed to confirm the specific characters of the prepared Silver Nanoparticles. Additionally, the review addresses the challenges and future perspectives of utilizing green-synthesized AgNPs loaded in Polyacrylamide hydrogel for wound healing applications, including the optimization of nanoparticle size, and release kinetics. Overall, this review highlights the potential of green-synthesized AgNPs loaded in Polyacrylamide hydrogel as promising for advanced wound healing therapies. There are different approaches of usage of AgNPs for wound healing such as polyacrylamide -hydrogels, and the mechanism after their antibacterial action, have been exposed.

The prevalence of chronic wounds is increasing owing to the expanding population and the growing number of individuals suffering from diabetes. Such a chronic wound continues to be a significant healthcare burden for diabetic patients because it frequently carries a high chance of limb loss due to amputation and reduces survival as a result. Development of innovative wound dressing materials with the potential to stop bacterial infections and accelerate the process of tissue regeneration is needed to increase the effectiveness of diabetic wound healing. In the current study, a co-polymerization process based on a free radical reaction was used to create a hydrogel of polysaccharides blend graft acrylamide (PsB-g-Am). Starch, chitosan, and alginate make up the polysaccharides blend (PsB). The produced hydrogel’s structure was characterized using FTIR spectroscopy. The antibacterial activities of silver nanoparticles synthesized through the green method using garlic bulb (Allium sativum) is reported. The silver nanoparticles’ physical characteristics were examined using scanning electron microscopy, transmission electron microscopy analysis, and UV-visible spectroscopy and they were found to range in size from 50 to 100 nm. The agar well diffusion technique is used to investigate the antibacterial characteristics. Inclusion of silver nanoparticles in the hydrogels demonstrated concentration-dependent antibacterial behavior against Gram-negative Klebsiella pneumoniae and Gram-positive Staphylococcus aureus during antimicrobial testing of the hydrogels. When hydrogels were applied to diabetic mice, the system was examined for its healing abilities, and positive therapeutic results were obtained in as little as 14 days. Thus, it can be inferred that graft copolymer of chitosan-AgNPs hydrogels can promote healing in chronic wounds over time and can be utilized as an alternative to conventional therapies for chronic wounds (such as those brought on by diabetes) in mouse models.

Skin wound healing is time-consuming and frequently accompanied by bacterial infections and the development of scars. The rise of antibiotic-resistant bacterial strains has sparked a growing interest in naturally occurring bioactive substances, like curcumin, that possess wound-healing capabilities. Silver is a natural antimicrobial agent, and finds extensive use in specialized wound dressings. Silver nanoparticles (AgNPs) were synthesized using an eco-friendly approach, employing curcumin. The prepared nanoparticles have been characterized using TEM, DLS, and zeta potential. The prepared AgNPs were loaded on sodium alginate-co-gum arabic hydrogel. Two hydrogel samples (with and without AgNPs) have been applied for wound healing. The developed silver nanoparticles that were created exhibited effective action against both types of bacteria, namely and . Alg-co-AG-AgNPs demonstrated faster wound healing rates compared to using the control hydrogel sample. The novel dressings of curcumin-silver nanoparticle-incorporated sodium alginate-co-gum arabic hydrogels (Alg-co-AG-AgNPs) exhibited exceptional biocompatibility and have the potential to serve as a wound dressing that possesses antibacterial properties and reduces scarring.

The Gels Editorial Office retracts the article, \"Employing of Curcumin-Silver Nanoparticle-Incorporated Sodium Alginate-Co-Acacia Gum Film Hydrogels for Wound Dressing\" [...].The Gels Editorial Office retracts the article, \"Employing of Curcumin-Silver Nanoparticle-Incorporated Sodium Alginate-Co-Acacia Gum Film Hydrogels for Wound Dressing\" [...].

Skin wound healing is time-consuming and frequently accompanied by bacterial infections and the development of scars. The rise of antibiotic-resistant bacterial strains has sparked a growing interest in naturally occurring bioactive substances, like curcumin, that possess wound-healing capabilities. Silver is a natural antimicrobial agent, and finds extensive use in specialized wound dressings. Silver nanoparticles (AgNPs) were synthesized using an eco-friendly approach, employing curcumin. The prepared nanoparticles have been characterized using TEM, DLS, and zeta potential. The prepared AgNPs were loaded on sodium alginate-co-gum arabic hydrogel. Two hydrogel samples (with and without AgNPs) have been applied for wound healing. The developed silver nanoparticles that were created exhibited effective action against both types of bacteria, namely Gram-negative and Gram-positive. Alg-co-AG-AgNPs demonstrated faster wound healing rates compared to using the control hydrogel sample. The novel dressings of curcumin–silver nanoparticle-incorporated sodium alginate-co-gum arabic hydrogels (Alg-co-AG-AgNPs) exhibited exceptional biocompatibility and have the potential to serve as a wound dressing that possesses antibacterial properties and reduces scarring.

Ulcerative colitis (UC) is an inflammatory bowel disease which causes irritation, inflammation, and ulcers in the mucosa of large intestine. The present study aimed to evaluate anti-oxidant and anti-inflammatory effects of intermittent fasting (IF) against UC in rats. Thirty- five mature rats weighing 225±5 g B.Wt. and 8 weeks age were used. Rats were distributed into 5 equal groups; Group1: negative control, group 2: positive control with UC and groups 3, 4 and 5: with UC and were fasted for 12, 16 and 20 hr, respectively. Feed intake (FI), body weight gain (BWG %), and feed efficiency ratio (FER) were calculated. Rats were then anesthetized and blood samples were collected for determination of activities of serum glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT) antioxidant enzymes. Serum proinflammatory cytokines IL1 β, IL6, and IL8 and total cholesterol (TC) and triglyceride (TG) were measured. Reduced glutathione (GSH), malondialdehyde (MDA) and lactate dehydrogenase (LDH) were measured in liver homogenate. Histopathology of large intestine was also performed. Results revealed that IF of rats with UC decreased FI, BWG% and FER, cytokines IL1 β, IL6 and IL8, TC and TG and increased serum concentrations of GPx SOD and CAT, as compared to the positive control (+ve) group. Liver tissue GSH was increased, but MDA and LDH were decreased. Histopathological examination of colons showed that IF ameliorated UC and inflammation. It could be concluded that IF induces recovery from UC due to its good anti-oxidant and anti-inflammatory properties via lowering oxidative stress and inflammation

Chrysin has been shown to exert several beneficial pharmacological activities. Chrysin has anti-cancer, anti-viral, anti-diabetic, neuroprotective, cardioprotective, hepatoprotective, and renoprotective as well as gastrointestinal, respiratory, reproductive, ocular, and skin protective effects through modulating signaling pathway involved in apoptosis, oxidative stress, and inflammation. In the current review, we discussed the emerging cellular and molecular mechanisms underlying therapeutic indications of chrysin in various cancers. Online databases comprising Scopus, PubMed, Embase, ProQuest, Science Direct, Web of Science, and the search engine Google Scholar were searched for available and eligible research articles. The search was conducted by using MeSH terms and keywords in title, abstract, and keywords. In conclusion, experimental studies indicated that chrysin could ameliorate cancers of the breast, gastrointestinal tract, liver and hepatocytes, bladder, male and female reproductive systems, choroid, respiratory tract, thyroid, skin, eye, brain, blood cells, leukemia, osteoblast, and lymph. However, more studies are needed to enhance the bioavailability of chrysin and evaluate this agent in clinical trial studies. Graphic abstract

Drug-induced liver injury (DILI) is a frequent cause of liver injury and acute liver failure. We aimed to review all hospitalized DILI cases in a tertiary Egyptian center from January 2015 through January 2016. Cases with elevated alanine aminotransferase more than 3-fold and/or alkaline phosphatase more than 2-fold the upper limit of normal value were prospectively recruited and followed for one year. Drug history, liver biopsy whenever feasible and application of Roussel Uclaf Causality Assessment Method (RUCAM) were the diagnostic prerequisites after exclusion of other etiologies of acute liver injury. In order of frequency, the incriminated drugs were: Diclofenac (31 cases, 41.3%), amoxicillin-clavulanate (14 cases, 18.7%), halothane toxicity (8 cases, 10.7%), ibuprofen (4 cases, 5.3%), Khat (3 cases, 4%), tramadol (3 cases, 4%), Sofosbuvir with ribavirin (2 cases, 2.7%), and acetylsalicylic acid (2 cases, 2.7%) with one offending drug in 93.3% of cases. Forty-four cases (58.7%) were males; while 56 cases (74.7%) had HCV related chronic liver disease. Thirty-two cases (42.7%) presented with pattern of hepatocellular injury, while 23 cases (30.7%) were with cholestasis, and 20 cases (20.7%) with a mixed hepatocellular/cholestatic injury. One case received a transplant (0.75%), 7 cases died (9.3%), 23 cases (30.6%) developed liver decompensation (hepatic encephalopathy and ascites), and 44 cases completely resolved (58.7%). In conclusion, Diclofenac is the commonest offender in DILI occurrence in an Egyptian cohort. Age and prothrombin concentration were the only predictors of unfavorable outcomes of DILI.