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Angular development with TypeScript
\"Angular Development with TypeScript, Second Edition teaches you how to build web applications with Angular and TypeScript. Written in an accessible, lively style, this illuminating guide covers core concerns like state management, data, forms, and server communication as you build a full-featured online auction app. You'll get the skills you need to write type-aware classes, interfaces, and generics with TypeScript, and discover time-saving best practices to use in your own work.\"--Page 4 of cover.
Book
Broadband quantum memory in a cavity via zero spectral dispersion
We seek to design experimentally feasible broadband, temporally multiplexed optical quantum memory with near-term applications to telecom bands. Specifically, we devise dispersion compensation (DC) for an impedance-matched narrow-band quantum memory by exploiting Raman processes over two three-level atomic subensembles, one for memory and the other for DC. DC provides impedance matching over more than a full cavity linewidth. Combined with 1 s spin-coherence lifetime the memory could be capable of power efficiency exceeding 90% leading to 10 6 modes for temporal multiplexing. Our design could lead to significant multiplexing enhancement for quantum repeaters to be used for telecom quantum networks.
Journal Article
Penetration Enhancers in Ocular Drug Delivery
There are more than 100 recognized disorders of the eye. This makes the development of advanced ocular formulations an important topic in pharmaceutical science. One of the ways to improve drug delivery to the eye is the use of penetration enhancers. These are defined as compounds capable of enhancing drug permeability across ocular membranes. This review paper provides an overview of anatomical and physiological features of the eye and discusses some common ophthalmological conditions and permeability of ocular membranes. The review also presents the analysis of literature on the use of penetration-enhancing compounds (cyclodextrins, chelating agents, crown ethers, bile acids and bile salts, cell-penetrating peptides, and other amphiphilic compounds) in ocular drug delivery, describing their properties and modes of action.
Journal Article
Trial of Intravenous Immune Globulin in Dermatomyositis
IVIG has been widely used for dermatomyositis but with limited evidence-based support. In a 16-week randomized trial, the percentage of patients with improvement was greater with IVIG than with placebo.
Journal Article
Darkness of two-mode squeezed light in Λ-type atomic system
We show that, under certain circumstances, an optical field in a two-mode squeezed vacuum (TMSV) state can propagate through a lossy atomic medium without degradation or evolution. Moreover, the losses give rise to that state when a different state is initially injected into the medium. Such a situation emerges in a Λ-type atomic system, in which both optical transitions are driven by strong laser fields that are two-photon resonant with the respective signal modes. Then the interactions of the two signal modes with the ground-state atomic coherence interfere destructively, thereby ensuring the preservation of the TMSV with a particular squeezing parameter. This mechanism permits unified interpretation of recent experimental results and predicts new phenomena.
Journal Article
Market capitalization shock effects on open innovation models in e-commerce: golden cut q-rung orthopair fuzzy multicriteria decision-making analysis
This research paper analyzes revenue trends in e-commerce, a sector with an annual sales volume of more than 340 billion dollars. The article evaluates, despite a scarcity of data, the effects on e-commerce development of the ubiquitous lockdowns and restriction measures introduced by most countries during the pandemic period. The analysis covers monthly data from January 1996 to February 2021. The research paper analyzes relative changes in the original time series through the autocorrelation function. The objects of this analysis are Amazon and Alibaba, as they are benchmarks in the e-commerce industry. This paper tests the shock effect on the e-commerce companies Alibaba in China and Amazon in the USA, concluding that it is weaker for companies with small market capitalizations. As a result, the effect on estimated e-trade volume in the USA was approximately 35% in 2020. Another evaluation considers fuzzy decision-making methodology. For this purpose, balanced scorecard-based open financial innovation models for the e-commerce industry are weighted with multistepwise weight assessment ratio analysis based on q-rung orthopair fuzzy sets and the golden cut. Within this framework, a detailed analysis of competitors should be made. The paper proves that this situation positively affects the development of successful financial innovation models for the e-commerce industry. Therefore, it may be possible to attract greater attention from e-commerce companies for these financial innovation products.
Journal Article
Global climate change and greenhouse effect
The climate has changed significantly under the influence of human behavior. And first of all, this is due to the change in the proportionality and concentration of greenhouse gases in the atmosphere (water vapor, carbon dioxide, methane, ozone, PFC (perfluorocarbons). This paper analyzes the dynamics of greenhouse gas emissions. Climate change has many consequences on human health throughout the world, especially in African countries. The growth of greenhouse gas emissions is viewed as a cause of infectious and non-infectious diseases, negative effects on nutrition, water security and other social disruptions. The global average temperature gradually increases, and the atmospheric CO2 concentration has exceeded 400 ppm due to the intensification of greenhouse effect. The method of energy balance was featured to simulate the trends in Greenhouse Gas Emission Forecast in different sectors until 2030. Through sensitivity analysis, we found that the reduction of anthropogenic CO2 emissions from people (cars and households) would deescalate the consequences of the above trends. Emissions are mostly associated with industries, which can be reduced if local Government will want to achieve the Paris Agreement goal.
Journal Article
Recent Plant Diversity Changes on Europe's Mountain Summits
In mountainous regions, climate warming is expected to shift species' ranges to higher altitudes. Evidence for such shifts is still mostly from revisitations of historical sites. We present recent (2001 to 2008) changes in vascular plant species richness observed in a standardized monitoring network across Europe's major mountain ranges. Species have moved upslope on average. However, these shifts had opposite effects on the summit floras' spedes richness in boreal-temperate mountain regions (+3.9 species on average) and Mediterranean mountain regions (-1.4 species), probably because recent climatic trends have decreased the availability of water in the European south. Because Mediterranean mountains are particularly rich in endemic species, a continuation of these trends might shrink the European mountain flora, despite an average increase in summit species richness across the region.
Journal Article
Scanning Fabry–Perot Interferometer of the 6-m SAO RAS Telescope
Abstract—The scanning Fabry–Perot interferometer (FPI) is the oldest method of optical 3D spectroscopy. It is still in use because of the high spectral resolution it provides over a large field of view. The history of the application of this method for the study of extended objects (nebulae and galaxies) and the technique of data reduction and analysis are discussed. The paper focuses on the performing observations with the scanning FPI on the 6-m telescope of the Special Astrophysical Observatory of the Russian Academy of Sciences. The instrument is currently used as a part of the SCORPIO-2 multimode focal reducer. The results of studies of various galactic and extragalactic objects with the scanning FPI on the 6-m telescope—star-forming regions and young stellar objects, spiral, ring, dwarf and interacting galaxies, gas subsystems associated with the ionization cones of active galactic nuclei, galactic winds, etc. are briefly discussed. Further prospects for research with the scanning FPI of the Special Astrophysical Observatory of the Russian Academy of Sciences are discussed.
Journal Article
Long-term outcomes of ruxolitinib therapy in steroid-refractory graft-versus-host disease in children and adults
Acute and chronic steroid-refractory graft-versus-host disease (srGVHD) is a life-threatening complication of allogeneic stem cell transplantation. There are a number of reports on case series describing efficacy of ruxolitinib in both acute and chronic srGVHD. We conducted a prospective study (NCT02997280) in 75 patients with srGVHD (32 acute, 43 chronic, 41 adults, and 34 children). Patients with chronic GVHD had severe disease in 83% of cases, and acute GVHD patients had grade III–IV disease in 66% of cases. The overall response rate (ORR) was 75% (95% CI 57–89%) in acute GVHD and 81% (95% CI 67–92%) in chronic. Overall survival was 59% (95% CI 49–74%) in acute group and 85% (95% CI 70–93%). The major risk factors for lower survival were grade III–IV gastrointestinal involvement (29% vs 93%, p = 0.0001) in acute form and high disease risk score in chronic (65% vs 90%, p = 0.038). Toxicity was predominantly hematologic with 79% and 44% of grade III–IV neutropenia in acute and chronic groups, respectively. There was no difference between adults and children in terms of ORR (p = 0.31, p = 0.35), survival (p = 0.44, p = 0.12) and toxicity (p > 0.93). The study demonstrated that ruxolitinib is an effective option in acute and chronic srGVHD and can be used both in adults and children.
Journal Article