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27 result(s) for "Molinari, Elizabeth"
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The meanings of work : essay on the affirmation and negation of work
Contrary to the affirmation of the end of labour, The Meanings of Work explore the complexity of the working class today; the sexual division of labour and transversalities between the dimensions of class and gender; globalisation of capital and labour.
Narrative Literature
This chapter concentrates on the former and retraces evidence of the legacy of the Quran, focusing the sphere of a literary legacy, or the mark left by Quran narratives on Islamic Arabic literature. It defines the relationship between the Quran and post‐Quranic literature within each of the genres that developed from the three historical moments identified in the Quran. The chapter explores Islamic literature that covers pre‐Islamic history, the life of the prophet, and the eschatological future. The chapter draws some conclusions about the relationship between literary works written over time and the Quran to ascertain the extent to which the sacred text influenced the distinctive qualities of such literature. The significant aspect to emerge in the literature related to the stories of the prophets is the definition of a linear chronology. The Quran presents passages in open order, with frequent repetitions of the same episode in more than one sura.
A General Strategy to Enhance the Potency of Chimeric Transcriptional Activators
Efforts to increase the potency of transcriptional activators are generally unsuccessful because poor expression of activators in mammalian cells limits their delivery to target promoters. Here we report that the effectiveness of chimeric activators can be dramatically improved by expressing them as noncovalent tetrameric bundles. Bundled activation domains are much more effective at activating a reporter gene than simple monomeric activators, presumably because, at similar expression levels, up to 4 times as many the activation domains are delivered to the target promoter. These bundled activation domains are also more effective than proteins in which activation domains are tandemly reiterated in the same polypeptide chain, because such proteins are very poorly expressed and therefore not delivered effectively. These observations suggest that there is a threshold number of activation domains that must be bound to a promoter for activation, above which promoter activity is simply a function of the number of activators bound. We show that bundling can be exploited practically to enhance the sensitivity of mammalian two-hybrid assays, enabling detection of weak interactions or those between poorly expressed proteins. Bundling also dramatically improves the performance of a small-molecule-regulated gene expression system when the expression level of regulatory protein is limiting, a situation that may be encountered in gene therapy applications.