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"Monti, Andrea"
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Importance of radiobiological studies for the advancement of boron neutron capture therapy (BNCT)
Boron neutron capture therapy (BNCT) is a tumour selective particle radiotherapy, based on the administration of boron carriers incorporated preferentially by tumour cells, followed by irradiation with a thermal or epithermal neutron beam. BNCT clinical results to date show therapeutic efficacy, associated with an improvement in patient quality of life and prolonged survival. Translational research in adequate experimental models is necessary to optimise BNCT for different pathologies. This review recapitulates some examples of BNCT radiobiological studies for different pathologies and clinical scenarios, strategies to optimise boron targeting, enhance BNCT therapeutic effect and minimise radiotoxicity. It also describes the radiobiological mechanisms induced by BNCT, and the importance of the detection of biomarkers to monitor and predict the therapeutic efficacy and toxicity of BNCT alone or combined with other strategies. Besides, there is a brief comment on the introduction of accelerator-based neutron sources in BNCT. These sources would expand the clinical BNCT services to more patients, and would help to make BNCT a standard treatment modality for various types of cancer. Radiobiological BNCT studies have been of utmost importance to make progress in BNCT, being essential to design novel, safe and effective clinical BNCT protocols.
Journal Article
Optimizing Boron Neutron Capture Therapy (BNCT) to Treat Cancer: An Updated Review on the Latest Developments on Boron Compounds and Strategies
Boron neutron capture therapy (BNCT) is a tumor-selective particle radiotherapy. It combines preferential boron accumulation in tumors and neutron irradiation. The recent initiation of BNCT clinical trials employing hospital-based accelerators rather than nuclear reactors as the neutron source will conceivably pave the way for new and more numerous clinical trials, leading up to much-needed randomized trials. In this context, it would be interesting to consider the implementation of new boron compounds and strategies that will significantly optimize BNCT. With this aim in mind, we analyzed, in this review, those articles published between 2020 and 2023 reporting new boron compounds and strategies that were proved therapeutically useful in in vitro and/or in vivo radiobiological studies, a critical step for translation to a clinical setting. We also explored new pathologies that could potentially be treated with BNCT and newly developed theranostic boron agents. All these radiobiological advances intend to solve those limitations and questions that arise during patient treatment in the clinical field, with BNCT and other therapies. In this sense, active communication between clinicians, radiobiologists, and all disciplines will improve BNCT for cancer patients, in a cost- and time-effective way.
Journal Article
Camelina, an ancient oilseed crop actively contributing to the rural renaissance in Europe. A review
Promoting crop diversification in European agriculture is a key pillar of the agroecological transition. Diversifying crops generally enhances crop productivity, quality, soil health and fertility, and resilience to pests and diseases and reduces environmental stresses. Moreover, crop diversification provides an alternative means of enhancing farmers’ income. Camelina (
Camelina sativa
(L.) Crantz) reemerged in the background of European agriculture approximately three decades ago, when the first studies on this ancient native oilseed species were published. Since then, a considerable number of studies on this species has been carried out in Europe. The main interest in camelina is related to its (1) broad environmental adaptability, (2) low-input requirements, (3) resistance to multiple pests and diseases, and (4) multiple uses in food, feed, and biobased applications. The present article is a comprehensive and critical review of research carried out in Europe (compared with the rest of the world) on camelina in the last three decades, including genetics and breeding, agronomy and cropping systems, and end-uses, with the aim of making camelina an attractive new candidate crop for European farming systems. Furthermore, a critical evaluation of what is still missing to scale camelina up from a promising oilseed to a commonly cultivated crop in Europe is also provided (1) to motivate scientists to promote their studies and (2) to show farmers and end-users the real potential of this interesting species.
Journal Article
Exploring intraspecific variation in salinity tolerance at germination and seedling development stages in Camelina sativa
is a promising oilseed crop for cultivation on saline marginal lands due to its abiotic stress tolerance and low input requirements. However, intraspecific variation in salinity tolerance remains poorly understood.
This study, through three sequential experiments, applied a screening framework integrating time-to-event modeling, stress tolerance indices (STIs), and multivariate clustering to dissect variation in salinity tolerance across early developmental stages. In experiment 1, two commercial varieties were germinated under a gradient from 0 to 300 mM of NaCl. In experiment 2, 57 camelina accessions were evaluated at 0 and 200 mM of NaCl for six germination indices (total germination, germination index, mean germination time, velocity coefficient, synchronization index, and normality rate) expressed as STIs, to quantify relative performance under salinity. In experiment 3, 13 representative accessions were assessed for seedling STIs (shoot length, main root length, lateral root length) under 0 and 200 mM of NaCl.
Time-to-event analysis revealed significant varietal differences in germination dynamics, with 200 mM identified as the optimal threshold for discriminating genotypic responses without complete germination inhibition. Most accessions retained ≥90% total germination under salinity, yet principal component analysis and hierarchical k-means clustering classified them into three phenotypic groups with distinct germination strategies. Salinity strongly reduced lateral root length (-90%), main root length (-80%), and shoot length (-30%), indicating altered biomass allocation in response to salt stress. Integration of germination clusters with seedling responses revealed three adaptive strategies: 1) high but delayed germination accompanied by strong seedling vigor, 2) low germination with intermediate seedling tolerance, and 3) high and rapid germination accompanied by poor seedling growth.
These findings highlight salinity tolerance as a stage-dependent trait, underscoring the need for multistage phenotyping to guide breeding of
for saline environments.
Journal Article
Along-Track Multistatic Synthetic Aperture Radar Formations of Minisatellites
The paper analyses an along-track multistatic Synthetic Aperture Radar (SAR) formation. The formation aims at achieving a high azimuth resolution maintaining at the same time a large swath width. The case with one transmitting sensor and all receiving is analyzed (Single Input Multiple Output, SIMO). An effective and novel reconstruction, in the two-dimensional frequency domain is introduced that is able to keep low the azimuth ambiguity and achieve a recombination gain close to the theoretical one. Degradation of the system performance due to the loss of the control of formation position is analyzed using probabilistic considerations. Moreover, some innovative methods to mitigate the loss of optimality are introduced and evaluated using simulations. Finally, considerations on the impact of the across-track non zero baseline are discussed.
Journal Article
Over-coverage in population registers leads to bias in demographic estimates
Estimating the number of individuals living in a country is an essential task for demographers. This study assesses the potential bias in estimating the size of different migrant populations due to over-coverage in population registers. Over-coverage-individuals registered but not living in a country-is an increasingly pressing phenomenon; however, there is no common understanding of how to deal with over-coverage in demographic research. This study examines different approaches to and improvements in over-coverage estimation using Swedish total population register data. We assess over-coverage levels across migrant groups, test how estimates of age-specific death and fertility rates are affected when adjusting for over-coverage, and examine whether over-coverage can explain part of the healthy migrant paradox. Our results confirm the existence of over-coverage and we find substantial changes in mortality and fertility rates, when adjusted, for people of migrating age. Accounting for over-coverage is particularly important for correctly estimating migrant fertility.
Journal Article
Performance and Requirements of GEO SAR Systems in the Presence of Radio Frequency Interferences
Geosynchronous Synthetic Aperture Radar (GEO SAR) is a possible next generation SAR system, which has the excellent performance of less than one-day revisit and hundreds of kilometres coverage. However, Radio Frequency Interference (RFI) is a serious problem, because the specified primary allocation frequencies are shared by the increasing number of microwave devices. More seriously, as the high orbit of GEO SAR makes the system have a very large imaging swath, the RFI signals all over the illuminated continent will interfere and deteriorate the GEO SAR signal. Aimed at the RFI impact in GEO SAR case, this paper focuses on the performance evaluation and the system design requirement of GEO SAR in the presence of RFI impact. Under the RFI impact, Signal-to-Interference-plus-Noise Ratio (SINR) and the required power are theoretically deduced both for the ground RFI and the bistatic scattering RFI cases. Based on the theoretical analysis, performance evaluations of the GEO SAR design examples in the presence of RFI are conducted. The results show that higher RFI intensity and lower working frequency will make the GEO SAR have a higher power requirement for compensating the RFI impact. Moreover, specular RFI bistatic scattering will give rise to the extremely serious impact on GEO SAR, which needs incredible power requirements for compensations. At last, real RFI signal behaviours and statistical analyses based on the SMOS satellite, Beidou-2 navigation satellite and Sentinel-1 A data have been given in the appendix.
Journal Article
Switchgrass and Giant Reed Energy Potential when Cultivated in Heavy Metals Contaminated Soils
The cultivation of energy crops on degraded soils contributes to reduce the risks associated with land use change, and the biomass may represent an additional revenue as a feedstock for bioenergy. Switchgrass and giant reed were tested under 300 and 600 mg Cr kg−1, 110 and 220 mg Ni kg−1, and 4 and 8 mg Cd kg−1 contaminated soils, in a two year pot experiment. Switchgrass yields (average aerial 330 g.m−2 and below ground 430 g.m−2), after the second year harvest, were not affected by Cd contamination and 110 mg Ni kg−1, but 220 mg Ni kg−1 significantly affected the yields (55–60% reduction). A total plant loss was observed in Cr-contaminated pots. Giant reed aboveground yields (control: 410 g.m−2), in the second year harvest, were significantly affected by all metals and levels of contamination (30–70% reduction), except in 110 mg Ni kg−1 pots. The belowground biomass yields (average 1600 g.m−2) were not affected by the tested metals. Contamination did not affect the high heating value (HHV) of switchgrass (average 18.4 MJ.kg−1) and giant reed aerial fractions (average 18.9 MJ.kg−1, stems, and 18.1 MJ.kg−1, leaves), harvested in the second year, indicating that the biomass can be exploited for bioenergy.
Journal Article
Water uptake efficiency and above- and belowground biomass development of sweet sorghum and maize under different water regimes
Background and aims Lately sweet sorghum (S) has attracted great interest as an alternative feedstock for biofuel production due to its high yielding potential and better adaptation to drought than maize (M). However, little is known about the response of newly developed sweet sorghum genotypes to water deficits, especially at the root level and its water uptake patterns. The objective of this study was to compare the water uptake capacity, growth and developmental characteristics at the root and canopy levels of a sweet sorghum hybrid (Sorghum bicolor cv. Sucro 506) with those of maize (Zea mays cv. PR32F73) at two water regimes. Methods The trial was setup in a total of 20 rhizotrons (1 m3), where calibrated soil moisture probes were installed for monitoring and adjusting the soil moisture content to 25% (well-watered, W) and 12% (drought stress, D). Results DS was able to sustain its physiological activity close to that of WS plants, while maize was not. The biomass production potential of DS was reduced about 38%, while in maize the reduction was 47%. The water use efficiency (WUE), however, was increased by 20% in sweet sorghum and reduced in 5% in maize. Moreover, in contrast to maize the root length density and water uptake capacity of DS was enhanced. Root water uptake efficiency in DM was sustained close to its potential, but not in sweet sorghum. Conclusions In summary, the better adaptation to drought of sweet sorghum is explained by increased WUE, sustained physiological activity and enlarged root system. It is also associated with a reduced water uptake efficiency compared to its control but maintained compared to maize.
Journal Article