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The visionary talents of writer Chris Claremont and legendary illustrator Bill Sienkiewicz bring the Demon Bear that has haunted Danielle Moonstar's dreams to horrifying life! It took her parents, and now it has returned for Dani - and only the combined efforts of her fellow New Mutants can stop it from finishing the job! Sink your teeth into a true classic! Then, Dani's nightmare returns years later as San Francisco - and her new team X-Force, come under attack from a similarly unholy ursine!

Careless responding in surveys threatens data quality in psychological research, potentially distorting findings and leading to erroneous conclusions. This meta-analysis investigates the prevalence of careless responding in I-O psychology surveys and examines factors influencing its occurrence. A comprehensive literature search identified 249 studies from top I-O psychology journals, encompassing 107,034 participants. I employed a multi-faceted analytical strategy comprising random-effects meta-analysis with subgroup analyses (examining detection methods, sample characteristics, and publication contexts), meta-regression to identify key moderators, and multilevel modeling to address hierarchical data structures and position effects in sequential screening procedures. The primary meta-analysis yielded an overall careless responding prevalence of 6.96% (95% CI [6.05%, 8.01%]). Detection method characteristics strongly influenced observed rates: attention check items identified the highest proportion of careless responses (8.17%), while response pattern analysis detected the lowest (1.19%). Notably, a priori methods (embedded within survey design) detected approximately three times more careless responding (7.91%) than post hoc methods (analytic methods applied after data collection) (2.56%). This difference suggests that careless responding often manifests as intermittent lapses in attention during the survey completion process rather than as consistent patterns detectable through post hoc statistical analysis. Regarding sample platforms, university-based samples showed slightly higher rates (7.99%) compared to MTurk (7.23%) and Prolific (6.30%), though these differences were not statistically significant. For studies using sequential screening, I found a 72% decrease in detection rates from the first to second method in the sequence, revealing important methodological effects that influence reported careless responding rates. Meta-regression analyses showed that detection method type was the strongest moderator (R² = 13.7%, p < .001). These findings provide researchers with empirical benchmarks for careless responding prevalence, evidence-based guidance for detection method selection, and insights into the methodological artifacts that influence reported rates. By describing the nature and prevalence of careless responding, this study advances efforts to improve the quality of survey-based research in psychological science.

The Commission on Accreditation of Healthcare Management Education (CAHME) has recently eliminated the 120-hour requirement of synchronous education as an eligibility requirement for any program seeking to achieve and maintain accreditation. This change provides an opportunity for graduate programs to pursue CAHME accreditation via a wider range of educational modalities, but naturally leads to a question of which modality is most suitable for delivering value to the various stakeholder groups involved with health management education. Thus, the purpose of this systematic review was to evaluate the literature attributed to synchronous, asynchronous, and blended educational modalities, and compare their potential value among students, faculty, and employers. To date, no studies to our knowledge have examined the specific question of perceived value of content delivery modality among stakeholders within the healthcare administration field. Following an extensive literature search of over 500 articles, our final analysis included a review of 33 documents that met our inclusion criteria. Of the 33 articles, 24 discussed student performance, 15 discussed student perception, and 7 discussed employer perception. Our results generally indicate student and faculty perceptions are mixed on the value of each modality, but most employers and employee gatekeepers believe that educational programs should have a synchronous component within the curriculum.

The Centers for Disease Control and Prevention's National Center for Environmental Health and the Agency for Toxic Substances and Disease Registry committed to making their 2009 National Environmental Public Health Conference a model for green and healthy conferences. The conference included increased opportunities for physical activity, both as part of conference events and for transportation to the conference. In addition, conference meals were healthy and sustainably sourced. The conference also implemented intuitive, accessible recycling; online scheduling and evaluation to minimize hard-copy materials; and the purchase of carbon offsets to reduce the unwanted environmental impact of the conference. Public health professionals have an opportunity and obligation to support healthy behaviors at their events and to serve as leaders in this area. Facilitating healthy and sustainable choices is in alignment with goals for both public health and broader social issues—such as environmental quality—that have a direct bearing on public health.

Precise navigation and positioning require clear communication among personnel from vastly different backgrounds. When the offshore operation costs tens of thousands of dollars per hour, such communication is critical. In the current deepwater construction market, water depths of five or even six thousand feet are not uncommon. Visibility at such depths can be limited from zero to a few feet. The ability to coordinate complex operations, convey immediate plans and events, and relate information and concepts to personnel working on a unique construction site that is humanly inaccessible is a challenge. STARFIX.Hydro Vista, a software package that combines a personal computer and 3-D graphics technology, was developed by John E. Chance & Associates Inc. (Chance) to address this complex need on the Shell Deepwater Development Services (SDDS) Angus deepwater project in the Gulf of Mexico. The utilization of this application on the Angus deepwater project is a testament to the close link between innovation, necessity and communication.

Mitochondria form interconnected networks that dynamically remodel in response to cellular needs. Using live-cell imaging, we investigate the role of the actin cytoskeleton in regulating mitochondrial fission and fusion. We identify cycling of actin filaments onto and off of subsets of cellular mitochondria. The association of actin filaments with mitochondrial subpopulations is transient; actin quickly disassembles, then reassembles around a distinct subpopulation, efficiently cycling through all cellular mitochondria within 14 min. The focal assembly of actin induces local, Drp1-dependent fragmentation of the mitochondrial network. On actin disassembly, fragmented mitochondria undergo rapid fusion, leading to regional recovery of the tubular mitochondrial network. Cycling requires dynamic actin polymerization and is blocked by inhibitors of both Arp2/3 and formins. We propose that cyclic assembly of actin onto mitochondria modulates the fission/fusion balance, promotes network remodelling and content mixing, and thus may serve as an essential mechanism regulating mitochondrial network homeostasis. Mitochondria are dynamic organelles that can undergo fission and fusion. Here the authors identify a novel pathway in which actin dynamically assembles in an Arp2/3- and formin-dependent manner around a subset of cellular mitochondria, promoting localized Drp1-dependent fission and impeding fusion.

Interstitial lung fibrosis can develop as a consequence of occupational or medical exposure, as a result of genetic defects, and after trauma or acute lung injury leading to fibroproliferative acute respiratory distress syndrome, or it can develop in an idiopathic manner. The pathogenesis of each form of lung fibrosis remains poorly understood. They each result in a progressive loss of lung function with increasing dyspnea, and most forms ultimately result in mortality. To better understand the pathogenesis of lung fibrotic disorders, multiple animal models have been developed. This review summarizes the common and emerging models of lung fibrosis to highlight their usefulness in understanding the cell-cell and soluble mediator interactions that drive fibrotic responses. Recent advances have allowed for the development of models to study targeted injuries of Type II alveolar epithelial cells, fibroblastic autonomous effects, and targeted genetic defects. Repetitive dosing in some models has more closely mimicked the pathology of human fibrotic lung disease. We also have a much better understanding of the fact that the aged lung has increased susceptibility to fibrosis. Each of the models reviewed in this report offers a powerful tool for studying some aspect of fibrotic lung disease.

Symmetric cell division requires the even partitioning of genetic information and cytoplasmic contents between daughter cells. Whereas the mechanisms coordinating the segregation of the genome are well known, the processes that ensure organelle segregation between daughter cells remain less well understood 1 . Here we identify multiple actin assemblies with distinct but complementary roles in mitochondrial organization and inheritance in mitosis. First, we find a dense meshwork of subcortical actin cables assembled throughout the mitotic cytoplasm. This network scaffolds the endoplasmic reticulum and organizes three-dimensional mitochondrial positioning to ensure the equal segregation of mitochondrial mass at cytokinesis. Second, we identify a dynamic wave of actin filaments reversibly assembling on the surface of mitochondria during mitosis. Mitochondria sampled by this wave are enveloped within actin clouds that can spontaneously break symmetry to form elongated comet tails. Mitochondrial comet tails promote randomly directed bursts of movement that shuffle mitochondrial position within the mother cell to randomize inheritance of healthy and damaged mitochondria between daughter cells. Thus, parallel mechanisms mediated by the actin cytoskeleton ensure both equal and random inheritance of mitochondria in symmetrically dividing cells. During mitosis, complementary actin-based mechanisms ensure equal and random distributions of mitochondria among daughter cells following symmetrical cell division.

Exciton polaritons are quasiparticles of photons coupled strongly to bound electron-hole pairs, manifesting as an anti-crossing light dispersion near an exciton resonance. Highly anisotropic semiconductors with opposite-signed permittivities along different crystal axes are predicted to host exotic modes inside the anti-crossing called hyperbolic exciton polaritons (HEPs), which confine light subdiffractionally with enhanced density of states. Here, we show observational evidence of steady-state HEPs in the van der Waals magnet chromium sulfide bromide (CrSBr) using a cryogenic near-infrared near-field microscope. At low temperatures, in the magnetically-ordered state, anisotropic exciton resonances sharpen, driving the permittivity negative along one crystal axis and enabling HEP propagation. We characterize HEP momentum and losses in CrSBr, also demonstrating coupling to excitonic sidebands and enhancement by magnetic order: which boosts exciton spectral weight via wavefunction delocalization. Our findings open new pathways to nanoscale manipulation of excitons and light, including routes to magnetic, nonlocal, and quantum polaritonics. Hyperbolic exciton polaritons (HEPs) are anisotropic light-matter excitations with promising applications, but their steady-state observation is challenging. Here, the authors report experimental evidence of HEPs in a van der Waals magnet, CrSBr, via cryogenic infrared near-field microscopy.

Sounding more like a new Republican than a second-term Democrat, Gov. Lawton Chiles renewed calls on Tuesday for smaller government, more jail time for criminals and no new taxes. Chiles bowed to Florida's new political reality in his annual State of the State address - his first since narrowly winning re-election last November and since Republicans took control of the state Senate and came within four seats of seizing the state House. \"Let us make this great challenge one our legacies to Florida - to stop the insanity of rules and regulations and start the rule of common sense,\" Chiles told a joint session of the Legislature as it convened for its 60-day session.