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"Moore, Kathleen M."
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Humpback Whale Populations Share a Core Skin Bacterial Community: Towards a Health Index for Marine Mammals?
Microbes are now well regarded for their important role in mammalian health. The microbiology of skin--a unique interface between the host and environment--is a major research focus in human health and skin disorders, but is less explored in other mammals. Here, we report on a cross-population study of the skin-associated bacterial community of humpback whales (Megaptera novaeangliae), and examine the potential for a core bacterial community and its variability with host (endogenous) or geographic/environmental (exogenous) specific factors. Skin biopsies or freshly sloughed skin from 56 individuals were sampled from populations in the North Atlantic, North Pacific and South Pacific oceans and bacteria were characterized using 454 pyrosequencing of SSU rRNA genes. Phylogenetic and statistical analyses revealed the ubiquity and abundance of bacteria belonging to the Flavobacteria genus Tenacibaculum and the Gammaproteobacteria genus Psychrobacter across the whale populations. Scanning electron microscopy of skin indicated that microbial cells colonize the skin surface. Despite the ubiquity of Tenacibaculum and Psychrobater spp., the relative composition of the skin-bacterial community differed significantly by geographic area as well as metabolic state of the animals (feeding versus starving during migration and breeding), suggesting that both exogenous and endogenous factors may play a role in influencing the skin-bacteria. Further, characteristics of the skin bacterial community from these free-swimming individuals were assembled and compared to two entangled and three dead individuals, revealing a decrease in the central or core bacterial community members (Tenacibaculum and Psychrobater spp.), as well as the emergence of potential pathogens in the latter cases. This is the first discovery of a cross-population, shared skin bacterial community. This research suggests that the skin bacteria may be connected to humpback health and immunity and could possibly serve as a useful index for health and skin disorder monitoring of threatened and endangered marine mammals.
Journal Article
An assessment of temporal, spatial and taxonomic trends in harmful algal toxin exposure in stranded marine mammals from the U.S. New England coast
Despite a long-documented history of severe harmful algal blooms (HABs) in New England coastal waters, corresponding HAB-associated marine mammal mortality events in this region are far less frequent or severe relative to other regions where HABs are common. This long-term survey of the HAB toxins saxitoxin (STX) and domoic acid (DA) demonstrates significant and widespread exposure of these toxins in New England marine mammals, across multiple geographic, temporal and taxonomic groups. Overall, 19% of the 458 animals tested positive for one or more toxins, with 15% and 7% testing positive for STX and DA, respectively. 74% of the 23 different species analyzed demonstrated evidence of toxin exposure. STX was most prevalent in Maine coastal waters, most frequently detected in common dolphins ( Delphinus delphis ), and most often detected during July and October. DA was most prevalent in animals sampled in offshore locations and in bycaught animals, and most frequently detected in mysticetes, with humpback whales ( Megaptera novaeangliae ) testing positive at the highest rates. Feces and urine appeared to be the sample matrices most useful for determining the presence of toxins in an exposed animal, with feces samples having the highest concentrations of STX or DA. No relationship was found between the bloom season of toxin-producing phytoplankton and toxin detection rates, however STX was more likely to be present in July and October. No relationship between marine mammal dietary preference and frequency of toxin detection was observed. These findings are an important part of a framework for assessing future marine mammal morbidity and mortality events, as well as monitoring ecosystem health using marine mammals as sentinel organisms for predicting coastal ocean changes.
Journal Article
Harmful Algal Blooms: Identifying Effective Adaptive Actions Used in Fishery-Dependent Communities in Response to a Protracted Event
The ‘blob’ of anomalously warm surface water that persisted in the North Pacific Ocean from 2013-2016 resulted in a massive harmful algal bloom (HAB) of Pseudo-nitzschia along the entire U.S. West Coast. The bloom produced record-breaking concentrations of domoic acid, a marine neurotoxin, that contaminated seafood and necessitated fisheries harvest closures beginning in May 2015. The subsequent closures were unprecedented in length and geographic extent, generating an economic shock for fishing communities. We sought to identify effective adaptive actions used in fishery-dependent communities in response to this event. Using survey data collected across 16 fishing communities following the 2015 HAB event, we empirically identified factors affecting an individual’s: 1) absolute magnitude of income loss, 2) likelihood of income loss recovery, and 3) severity of emotional stress. Our findings indicate that individuals who suffered greater absolute income losses were exposed to longer fisheries closures, more dependent on shellfish as a source of income, and employed in the fishing industry. Income diversification was an effective strategy for reducing and/or recovering HAB related income losses. Advertising was also found to be an effective income recovery strategy, but for fishers it was associated with increased emotional stress. If increasing the adaptive capacity of fishery-dependent coastal communities to HAB events is a policy goal, then costs to adaptive action such as emotional stress, limited access to alternate fisheries, new fishing gear, a lack of alternate job skills or access to job networks, and a lack of advertising know-how will need to be addressed.
Journal Article
Muslim women in America : the challenge of Islamic identity today
The treatment and role of women is one of the most discussed and controversial aspects of Islam. In this volume, three scholars of Islam survey the situation of women in Islam, focusing on how Muslim views about and experiences of gender are changing in the Western diaspora. It offers an overview of the teachings of the Qur'an and the Prophet Muhammad on gender, analyzes the ways in which the West has historically viewed Muslim women, and examines how the Muslim world has changed in response to Western critiques. The volume then centers on the Muslim experience in America, examining Muslim American analyses of gender, Muslim attempts to form a new “American” Islam, and the legal issues surrounding equal rights for Muslim females. Such specific issues as dress, marriage, child custody, and asylum are addressed. It also looks at the ways in which American Muslim women have tried to create new paradigms of Islamic womanhood and are reinterpreting the traditions apart from the males who control the mosque institutions.
eBook
Circulating Tumor Cell-Free DNA Genes as Prognostic Gene Signature for Platinum Resistant Ovarian Cancer Diagnosis
Clinical management of gynecological cancer begins by optimal debulking with first-line platinum-based chemotherapy. However, in ~80% patients, ovarian cancer will recur and is lethal. Prognostic gene signature panel identifying platinum-resistance enables better patient stratification for precision therapy. Retrospectively collected serum from 11 “poor” (<6 months progression free interval [PFI]) and 22 “favorable” (>24 months PFI) prognosis patients, were evaluated using circulating cell-free DNA (cfDNA). DNA from both groups showed 50 to 10 000 bp fragments. Pairwise analysis of sequenced cfDNA from patients showed that gene dosages were higher for 29 genes and lower for 64 genes in poor than favorable prognosis patients. Gene ontology analysis of higher dose genes predominantly grouped into cytoskeletal proteins, while lower dose genes, as hydrolases and receptors. Higher dosage genes searched for cancer-relatedness in Reactome database indicated 15 genes were referenced with cancer. Among them 3 genes, TGFBR2, ZMIZ2, and NRG2, were interacting with more than 4 cancer-associated genes. Protein expression analysis of tumor samples indicated that TGFBR2 was downregulated and ZMIZ2 was upregulated in poor prognosis patients. Our results indicate that the cfDNA gene dosage combined with protein expression in tumor samples can serve as gene signature panel for prognosis determination amongst ovarian cancer patients.
Journal Article
Shari‘a Consciousness
Shari‘a (commonly translated as Islamic law) is at the epicenter of anti-Muslim discourses in the United States. How do Muslims in the United States understand and experience shari‘a in the context of virulent attacks on it and on Islam and Muslims more generally? This article explores the meanings Californian Muslims give to and the intentions they derive from shari‘a when dominant discourses represent shari‘a as a cause for concern in American life. Drawing from fieldwork and interviews with Muslims across California, as well as scholarship on legal consciousness and lived religion, we document three interrelated stages of shari‘a consciousness: perceiving shari‘a and discriminatory depictions of it; educating oneself about shari‘a’s social and political relevance; and forming an intention for social action. Documenting these interrelated stages and theorizing the relationship between legal consciousness, religion, and inequality, this article reveals how religious identity formation is a significant precursor of legal mobilization and how nonstate normative orders provide interpretive frames for understanding human rights and social justice. Ultimately, legal consciousness may stem from sacred sensibilities and the desire to be a more ethical servant of God and not merely to be a more ethical subject of the state.
Journal Article
Google Haul Out
As the sampling frequency and resolution of Earth observation imagery increase, there are growing opportunities for novel applications in population monitoring. New methods are required to apply established analytical approaches to data collected from new observation platforms (e.g., satellites and unmanned aerial vehicles). Here, we present a method that estimates regional seasonal abundances for an understudied and growing population of gray seals (Halichoerus grypus) in southeastern Massachusetts, using opportunistic observations in Google Earth imagery. Abundance estimates are derived from digital aerial survey counts by adapting established correction-based analyses with telemetry behavioral observation to quantify survey biases. The result is a first regional understanding of gray seal abundance in the northeast US through opportunistic Earth observation imagery and repurposed animal telemetry data. As species observation data from Earth observation imagery become more ubiquitous, such methods provide a robust, adaptable, and cost-effective solution to monitoring animal colonies and understanding species abundances.
Journal Article