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"Moore, Stephen"
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Pacific payback : the carrier aviators who avenged Pearl Harbor at the Battle of Midway
Describes the fearless crew of the USS Enterprise whose offensive blow in the Marshall Islands against the Japanese led the turning of the tide during World War II.
Book
VaMiAnalyzer: an open source, Python-based application for analysis of 3D in vitro vasculogenic mimicry assays
Background
Vasculogenic mimicry (VM) is the phenomenon whereby non-vascular tumor cells develop vascular-like structures. VM is linked to more aggressive tumor phenotypes including higher rates of metastasis and invasion and is potentially resistant to anti-angiogenic cancer therapies. VM is investigated in vitro using 3D assays with microscopy images capturing the resulting VM structures, including loops, branch points, and tubes. The standard method to quantify endpoint data is to count various structural features manually, which is time-consuming and open to bias. At present, no software solutions have been developed to specifically address the analysis and quantification of VM structures.
Results
To address this limitation, we developed an open source, Python-based application, VaMiAnalyzer, allowing straightforward quantification of several VM structural features. The application follows a two-step approach that optionally corrects and enhances the raw input images and then analyzes and quantifies the VM features.
Conclusions
VaMiAnalyzer is stand-alone software that allows automated measurement of VM structural features from phase-contrast microscopy images. It produces results that are strongly consistent with manual counts but in a significantly shorter time, allowing quick, non-biased analysis of VM from microscopy images.
Journal Article
Uncommon valor : the recon company that earned five Medals of Honor and included America's most decorated Green Beret
\"Uncommon Valor is about the formation and operation of an advanced Special Forces recon company during the Vietnam War. Code-named the Studies and Observations Group, SOG was the most covert U.S. military unit in its time and contained only volunteers from such elite units as the Army Green Berets, Navy SEALs, and USAF Air Commandos. SOG warriors operated in small teams, going behind enemy lines in Laos and Cambodia and along the Ho Chi Minh Trail, tasked with performing special reconnaissance, sabotaging NVA ammunition, attempting to rescue downed U.S. pilots, and other black ops missions\"-- Provided by publisher.
Book
Multi-step ahead streamflow and uncertainty forecasting using a HyMoLAP rainfall-runoff model-based framework integrated with Bayesian neural networks in the Ouémé river basin, Benin
Multi-step forecasting is crucial for capturing future streamflow variations and managing water resources but remains challenging due to limited accuracy of upstream flow forecasts and meteorological predictions over lead times. While data-driven methods are commonly used, this study extends the Hydrological Model based on the Least Action Principle (HyMoLAP) from daily rainfall-runoff simulation to multi-day-ahead streamflow predictions. Additionally, it integrates Bayesian Long Short-Term Memory (Bayesian LSTM), primarily to enable uncertainty quantification (UQ). Applied to the Bonou and Savè sub-catchments of the Ouémé River Basin, Benin, the HyMoLAP-based framework yields NSE values ranging from 0.997 to 0.921 at Bonou and from 0.970 to 0.799 at Savè, showing slightly higher performance than the LSTM model overall, except at Savè from the 3-day lead time onward where it becomes slightly lower, with a more pronounced difference at the 7-day horizon. Our UQ approach provides reliable prediction intervals, with a coverage probability around 90%, as nearly 90% of the observed data fall within the 90% credible intervals in both sub-catchments.
Journal Article
Development and Characterization of a High Density SNP Genotyping Assay for Cattle
The success of genome-wide association (GWA) studies for the detection of sequence variation affecting complex traits in human has spurred interest in the use of large-scale high-density single nucleotide polymorphism (SNP) genotyping for the identification of quantitative trait loci (QTL) and for marker-assisted selection in model and agricultural species. A cost-effective and efficient approach for the development of a custom genotyping assay interrogating 54,001 SNP loci to support GWA applications in cattle is described. A novel algorithm for achieving a compressed inter-marker interval distribution proved remarkably successful, with median interval of 37 kb and maximum predicted gap of <350 kb. The assay was tested on a panel of 576 animals from 21 cattle breeds and six outgroup species and revealed that from 39,765 to 46,492 SNP are polymorphic within individual breeds (average minor allele frequency (MAF) ranging from 0.24 to 0.27). The assay also identified 79 putative copy number variants in cattle. Utility for GWA was demonstrated by localizing known variation for coat color and the presence/absence of horns to their correct genomic locations. The combination of SNP selection and the novel spacing algorithm allows an efficient approach for the development of high-density genotyping platforms in species having full or even moderate quality draft sequence. Aspects of the approach can be exploited in species which lack an available genome sequence. The BovineSNP50 assay described here is commercially available from Illumina and provides a robust platform for mapping disease genes and QTL in cattle.
Journal Article
Language for specific purposes
\"Language for Specific Purposes provides a concise history of the roots of LSP, and an analysis of the current trends in globalization, technology and applied linguistics that directly affect the learning, teaching and researching of LSP. The book provides insights into language course planning, design and implementation, assessment and evaluation, as well as issues in pedagogy, classroom management and professional development of particular interest to LSP practitioners. Another important focus of the book is research: the nature of research in LSP, typical research methods in the field, and ideas for researchable projects. Numerous case studies and lists of useful resources for further study and research make this book a rich resource, not only for graduate students planning to teach LSP, but also for professionals looking to update or extend their knowledge of the field\"-- Provided by publisher.
Book
The efficacy of selinexor (KPT-330), an XPO1 inhibitor, on non-hematologic cancers: a comprehensive review
Purpose
Selinexor is a novel XPO1 inhibitor which inhibits the export of tumor suppressor proteins and oncoprotein mRNAs, leading to cell-cycle arrest and apoptosis in cancer cells. While selinexor is currently FDA approved to treat multiple myeloma, compelling preclinical and early clinical studies reveal selinexor’s efficacy in treating hematologic and non-hematologic malignancies, including sarcoma, gastric, bladder, prostate, breast, ovarian, skin, lung, and brain cancers. Current reviews of selinexor primarily highlight its use in hematologic malignancies; however, this review seeks to summarize the recent evidence of selinexor treatment in solid tumors.
Methods
Pertinent literature searches in PubMed and the Karyopharm Therapeutics website for selinexor and non-hematologic malignancies preclinical and clinical trials.
Results
This review provides evidence that selinexor is a promising agent used alone or in combination with other anticancer medications in non-hematologic malignancies.
Conclusion
Further clinical investigation of selinexor treatment for solid malignancies is warranted.
Journal Article
Season of the witch
Fourteenth century Crusaders return to a homeland devastated by the Black Plague. A beleaguered church, deeming sorcery the culprit of the plague, commands two knights to transport an accused witch to a remote abbey, where monks will perform a ritual in hopes of ending the pestilence.
DVD
Characterization of the urinary microbiome in healthy dogs
The urinary bladder in healthy dogs has dogmatically been considered free of bacteria. This study used culture independent techniques to characterize the healthy canine urinary microbiota. Urine samples collected by antepubic cystocentesis from dogs without urinary infection were used for DNA extraction. Genital tract and rectal samples were collected simultaneously from the same dogs. The V4 hypervariable region of the 16S rRNA bacterial gene was amplified and compared against Greengenes database for OTU assignment and relative abundance for urine, genital, and rectal samples. After excluding 4 dogs with cultivable bacteria, samples from 10 male (M; 1 intact) and 10 female (F) spayed dogs remained. All samples provided adequate genetic material for analysis. Four taxa (Pseudomonas sp., Acinetobacter sp., Sphingobium sp. and Bradyrhizobiaceae) dominated the urinary microbiota in all dogs of both sexes. These taxa were also detected in the genital swabs of both sexes, while the rectal microbiota differed substantially from the other sample sites. Principal component (PC) analysis of PC1 through PC3 showed overlap of urinary and genital microbiota and a clear separation of rectal swabs from the other sample sites along PC1, which explained 44.94% variation. Surprisingly, the urinary microbiota (mean # OTU 92.6 F, 90.2 M) was significantly richer than the genital (67.8 F, 66.6 M) or rectal microbiota (68.3 F, 71.2 M) (p < 0.0001), with no difference between sexes at any sample site. The canine urinary bladder is not a sterile environment and possesses its own unique and diverse microbiota compared to the rectal and genital microbiota. There was no difference between the sexes at any microbiota sample site (urine, genital, and rectal). The predominant bacterial genus for either sex in the urine and genital tracts was Pseudomonas sp.
Journal Article