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"Moore, Tom"
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Undocumented : immigration and the militarization of the United States-Mexico border
\"Moore has photographed the entire length of the U.S. southern border, and traveled extensively throughout Central America and Mexico, as well as to many immigrant communities in the United States ... [This book is a] record on the prevailing U.S. domestic topic of immigration and border security\"--Amazon.com.
Book
Obinutuzumab for the First-Line Treatment of Follicular Lymphoma
Obinutuzumab is an anti-CD20 antibody engineered to elicit killing mechanisms distinct from rituximab. In a trial of chemotherapy plus obinutuzumab or rituximab that used the antibody as maintenance therapy for 2 years, obinutuzumab prolonged progression-free survival.
Journal Article
Bride or burglar
\"A young admirer of Bruce Wayne's, Mattie, wants nothing more than to grow up to be like his millionaire idol. But what would happen if Mattie was forced to relive the worst tragedy of Bruce Wayne's life and his parents were murdered? Batman's hunt for the killer brings him face to face with a strange mirror image of his own painful past. This stunning series continues as Batman and Wonder Woman's storied friendship--one that has stood at the heart of the DC Universe since the beginning--unravels while the universe itself begins to crumble around them.\"-- Provided by publisher.
BOOK
Interleukin-33 is activated by allergen- and necrosis-associated proteolytic activities to regulate its alarmin activity during epithelial damage
Interleukin (IL)-33 is an IL-1 family alarmin released from damaged epithelial and endothelial barriers to elicit immune responses and allergic inflammation via its receptor ST2. Serine proteases released from neutrophils, mast cells and cytotoxic lymphocytes have been proposed to process the N-terminus of IL-33 to enhance its activity. Here we report that processing of full length IL-33 can occur in mice deficient in these immune cell protease activities. We sought alternative mechanisms for the proteolytic activation of IL-33 and discovered that exogenous allergen proteases and endogenous calpains, from damaged airway epithelial cells, can process full length IL-33 and increase its alarmin activity up to ~60-fold. Processed forms of IL-33 of apparent molecular weights ~18, 20, 22 and 23 kDa, were detected in human lungs consistent with some, but not all, proposed processing sites. Furthermore, allergen proteases degraded processed forms of IL-33 after cysteine residue oxidation. We suggest that IL-33 can sense the proteolytic and oxidative microenvironment during tissue injury that facilitate its rapid activation and inactivation to regulate the duration of its alarmin function.
Journal Article
The hottie and the nottie
Nate Cooper has been smitten with Cristabel Abbott since he first laid eyes on her at the impressionable age of six. But before he could try and snuggle up to her at nap time, his family moved away. In the intervening years, no one could measure up to Cristabel. Convinced she is the only girl for him, Nate decides to move back to L.A. and track her down. She's still single and stunning, but for a reason. Cristabel is still best friends with the same ugly little girl Nate remembers from first grade, June Phigg. The two are inseparable. They would even go on double dates together if only June could get a date. And Cristabel refuses to leave June home alone. Determined to spend as much time as possible with Cristabel, Nate sets out to find a boyfriend for June. But even when he pays them, guys flee at the sight of her. And then it hits him: June needs a makeover. But as Nate and June become friends and she emerges from her cocoon, Nate slowly realizes that the girl of his dreams isn't the hottie at all. It's the nottie - who turns out to be something of a hottie herself.
DVD
Haemoadsorption reduces the inflammatory response and improves blood flow during ex vivo renal perfusion in an experimental model
Background
Ex-vivo normothermic perfusion strategies are a promising new instrument in organ transplantation. The perfusion conditions are designed to be protective however the artificial environment can induce a local inflammatory response. The aim of this study was to determine the effect of incorporating a Cytosorb adsorber into an isolated kidney perfusion system.
Methods
Porcine kidneys were subjected to 22 h of cold ischaemia then reperfused for 6 h on an ex vivo reperfusion circuit. Pairs of kidneys were randomised to either control (n = 5) or reperfusion with a Cytosorb adsorber (n = 5) integrated into the circuit. Tissue, blood and urine samples were taken for the measurement of inflammation and renal function.
Results
Baseline levels of cytokines (IL-6, TNFα, IL-8, IL-10, IL-1β, IL-1α) were similar between groups. Levels of IL-6 and IL-8 in the perfusate significantly increased during reperfusion in the control group but not in the Cytosorb group (P = 0.023, 0.049). Levels of the other cytokines were numerically lower in the Cytosorb group; however, this did not reach statistical significance. The mean renal blood flow (RBF) was significantly higher in the Cytosorb group (162 ± 53 vs. 120 ± 35 mL/min/100 g; P = 0.022). Perfusate levels of prostaglandin E2 were significantly lower in the Cytosorb group (642 ± 762 vs. 3258 ± 980 pg/mL; P = 0.0001). Levels of prostacyclin were significantly lower in the Cytosorb group at 1, 3 and 6 h of reperfusion (P = 0.008, 0.003, 0.0002). Levels of thromboxane were also significantly lower in the Cytosorb group throughout reperfusion (P = 0.005). Haemoadsorption had no effect on creatinine clearance (P = 0.109).
Conclusion
Haemoadsorption can reduce the inflammatory response and improve renal blood flow during perfusion. Nonetheless, in this model haemoadsorption had no influence on renal function and this may relate to the broad-spectrum action of the Cytosorb adsorber that also removes potentially important anti-inflammatory mediators.
Journal Article
Thanos. Cosmic powers
\"The ever-scheming Thanos forges unlikely alliances! But what secret mission could lead Rhino, Super-Skrull, Titanium Man and more to join Thanos's new team of would-be Defenders?... The battle begins as the cosmic firmament holds its breath. But in a war between two evils, either outcome may result in death!\"--Back cover.
Book
Restoration as a meaningful aid to ecological recovery of coral reefs
Restoration supports the recovery of ecological attributes such as cover, complexity, and diversity to slow the areal decline of natural ecosystems. Restoration activity is intensifying worldwide to combat persistent stressors that are driving global declines to the extent and resilience of coral reefs. However, restoration is disputed as a meaningful aid to reef ecological recovery, often as an expensive distraction to addressing the root causes of reef loss. We contend this dispute partly stems from inferences drawn from small-scale experimental restoration outcomes amplified by misconceptions around cost-based reasoning. Alongside aggressive emissions reductions, we advocate urgent investment in coral reef ecosystem restoration as part of the management toolbox to combat the destruction of reefs as we know them within decades.
Journal Article
Batman : preludes to the wedding
\"You are cordially invited... Bruce Wayne and Selina Kyle are about to tie the knot, uniting two of Gotham's greatest vigilantes in the wedding of the century. But the city's deadliest villains are determined to crash the party, and only Batman and Catwoman's closest allies stand in their way! Robin vs. Ra's al Ghul: It's grandson versus grandfather as the son of the Bat faces the head of the Demon in a fatal family feud! Nightwing vs. Hush: Batman's original partner turned best man squares off against Bruce Wayne's oldest friend turned bitterest enemy! Batgirl vs. the Riddler: Two of Gotham City's greatest minds clash as the one-time Oracle and the overlord of Zero Year launch a war of wits! Red Hood vs. Anarky: Agents of chaos collide in a battle between the Dark Knight's rogue Robin and the underworld's most unpredictable mastermind! Harley Quinn vs. The Joker: Once upon a time, they too might have said, \"I do.\" Now the Clown Prince of Crime and the Mistress of Mayhem are at each other's throats, with all nine of Catwoman's lives hanging in the balance!\"-- Provided by publisher.
Book
Detecting sedimentation impacts to coral reefs resulting from dredging the Port of Miami, Florida USA
The federal channel at Port of Miami, Florida, USA, was dredged between late 2013 and early 2015 to widen and deepen the channel. Due to the limited spatial extent of impact-assessment monitoring associated with the project, the extent of the dredging impacts on surrounding coral reefs has not been well quantified. Previously published remote sensing analyses, as well as agency and anecdotal reports suggest the most severe and largest area of sedimentation occurred on a coral reef feature referred to as the Inner Reef, particularly in the sector north of the channel. A confounding regional warm-water mass bleaching event followed by a coral disease outbreak during this same time frame made the assessment of dredging-related impacts to coral reefs adjacent to the federal channel difficult but still feasible. The current study sought to better understand the sedimentation impacts that occurred in the coral reef environment surrounding Port of Miami, to distinguish those impacts from other regional events or disturbances, and provide supplemental information on impact assessment that will inform discussions on compensatory mitigation requirements. To this end, in-water field assessments conducted after the completion of dredging and a time series analysis of tagged corals photographed pre-, during, and post-dredging, are used to discern dredging-related sedimentation impacts for the Inner Reef north. Results indicate increased sediment accumulation, severe in certain times and places, and an associated biological response (e.g., higher prevalence of partial mortality of corals) extended up to 700 m from the channel, whereas project-associated monitoring was limited to 50 m from the channel. These results can contribute to more realistic prediction of areas of indirect effect from dredging projects needed to accurately evaluate proposed projects and design appropriate compliance monitoring. Dredging projects near valuable and sensitive habitats subject to local and global stressors require monitoring methods capable of discerning non-dredging related impacts and adaptive management to ensure predicted and unpredicted project-related impacts are quantified. Anticipated increasing frequency and intensity of seasonal warming stress also suggests that manageable- but- unavoidable local stressors such as dredging should be partitioned from such seasonal thermal stress events.
Journal Article