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"Moran, Christopher"
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Autonomous multi-robot synthesis and optimization of metal halide perovskite nanocrystals
Metal halide perovskite (MHP) nanocrystals (NCs) offer extraordinary tunability in their optical properties, yet fully exploiting this potential is challenged by a vast and complex synthesis parameter space. Herein, we introduce Rainbow, a multi-robot self-driving laboratory that integrates automated NC synthesis, real-time characterization, and machine learning (ML)-driven decision-making to efficiently navigate MHP NCs’ mixed-variable high-dimensional landscape. Using parallelized, miniaturized batch reactors, robotic sample handling, and continuous spectroscopic feedback, Rainbow autonomously optimizes MHP NC optical performance—including photoluminescence quantum yield and emission linewidth at a targeted emission energy—through closed-loop experimentation. By systematically exploring varying ligand structures and precursor conditions, Rainbow elucidates critical structure–property relationships and identifies scalable Pareto-optimal formulations for targeted spectral outputs. Rainbow provides a versatile blueprint for accelerated, data-driven discovery and retrosynthesis of high-performance metal halide perovskite nanocrystals, facilitating the on-demand realization of next-generation photonic materials and technologies.
The full potential of tunable perovskite nanocrystals is limited by complex synthesis space. Here, authors developed a self-driving lab that autonomously discovers and produces optimal scalable nanocrystals for next-generation photonic technologies.
Journal Article
Long-Term Clinical and Angiographic Outcomes Following Pipeline Embolization Device Treatment of Complex Internal Carotid Artery Aneurysms: Five-Year Results of the Pipeline for Uncoilable or Failed Aneurysms Trial
Abstract
BACKGROUND: Early and mid-term safety and efficacy of aneurysm treatment with the Pipeline Embolization Device (PED) has been well demonstrated in prior studies.
OBJECTIVE: To present 5-yr follow-up for patients treated in the Pipeline for Uncoilable or Failed Aneurysms clinical trial.
METHODS: In our prospective, multicenter trial, 109 complex internal carotid artery (ICA) aneurysms in 107 subjects were treated with the PED. Patients were followed per a standardized protocol at 180 d and 1, 3, and 5 yr. Aneurysm occlusion, in-stent stenosis, modified Rankin Scale scores, and complications were recorded.
RESULTS: The primary endpoint of complete aneurysm occlusion at 180 d (73.6%) was previously reported. Aneurysm occlusion for those patients with angiographic follow-up progressively increased over time to 86.8% (79/91), 93.4% (71/76), and 95.2% (60/63) at 1, 3, and 5 yr, respectively. Six aneurysms (5.7%) were retreated. New serious device-related events at 1, 3, and 5 yr were noted in 1% (1/96), 3.5% (3/85), and 0% (0/81) of subjects. There were 4 (3.7%) reported deaths in our trial. Seventy-eight (96.3%) of 81 patients with 5-yr clinical follow-up had modified Rankin Scale scores ≤2. No delayed neurological deaths or hemorrhagic or ischemic cerebrovascular events were reported beyond 6 mo. No recanalization of a previously occluded aneurysm was observed.
CONCLUSION: Our 5-yr findings demonstrate that PED is a safe and effective treatment for large and giant wide-necked aneurysms of the intracranial ICA, with high rates of complete occlusion and low rates of delayed adverse events.
Journal Article
Trust in nuclear disarmament verification
In the nuclear arena, disarmament verification is often viewed purely in terms of a dispassionate, scientific process. Yet this view is fundamentally flawed since the technical impossibility of 100 per cent verification opens the door to a host of complex issues and questions regarding the process and its outcomes. Central among these is the fact that those involved in any verification inspection process must inevitably conduct their work in a space that falls well short of absolute certainty. The lines between scientific enquiry and human psychology can become blurred and outcomes have the potential to be influenced by perceptions. Drawing on extensive empirical evidence, the authors explore the complex interplay between evidence-based judgements and perceptions of intentions that frames the science of verification. The book provides new insights into the role and influence of human factors in the verification process.
Book
Lessons in planning from mass casualty events in UK
Plan for long term disruption and enduring effects on healthcare staff
Journal Article
Spy chiefs
Throughout history and across cultures, the spy chief has been an essential advisor for heads of state and the leader of the state security apparatus. In democracies, the spy chief has become a public figure, and intelligence activities have been largely brought under the rule of law. In authoritarian regimes, the spy chief was and remains a frightening and opaque figure who designs intrigue abroad and fosters repression at home. This second volume of Spy Chiefs provides a close-up look at intelligence leadership, good and bad. The contributors to the volumes try to answer the following questions: how do intelligence leaders operate in different national, institutional and historical contexts? What role have they played in the conduct of international relations? How much power do they possess? What qualities make an effective intelligence leader? How secretive and accountable to the public have they been? This book goes beyond the commonly studied spy chiefs of the United States and Britain to examine leaders from Renaissance Venice to twentieth century Russia, Germany, India, Egypt, and Lebanon.
Book
Benchmarking performance of annual burn probability modeling against subsequent wildfire activity in California
Wildfire simulation is deployed extensively to support risk management, and in the US has driven billions in federal investment. Foundational to strategic risk analysis is spatial information on the likelihood of burning in a fire year, typically provided by burn probability (BP) models. The recency of BP maps is a key driver of their accuracy, especially in disturbed landscapes that have experienced changes in fire spread potential. Few published examples exist comparing BP values against subsequent fire activity, and none to our knowledge evaluate annually updated BP maps. Here, we present a novel performance evaluation of the operational wildfire simulation system FSim, confronting updated BP maps with subsequent fire activity across the state of California over a 4-year period (2020–2023). Results show strong predictive ability: across 5 equal-area BP classes, 56.7–79.8% of the burned area occurred in the top 20% of mapped area; mean (median) BP values in burned areas were 238.5–348.8% (551.4–880.7%) greater than in unburned areas; differences in empirical cumulative distribution functions of BP for burned/unburned areas were statistically significant; Logarithmic Skill Scores ranged from − 0.072 to 0.389 against two reference models. Findings indicate reliable forecast performance and useful application of up-to-date BP maps, critical to support ongoing wildfire risk mitigation.
Journal Article
Paediatric Crohn’s disease: histologic findings at initial presentation
BackgroundDiagnosing paediatric Crohn’s disease (CD) based on histology can present challenges. We evaluate the histological spectrum of treatment-naïve biopsies from children with CD and assess these findings’ diagnostic and predictive value.MethodsThree cohorts were identified: (1) 137 patients with CD, (2) 116 patients with ulcerative colitis (UC) and (3) 50 patients without inflammatory bowel disease. Biopsies from the gastrointestinal (GI) tract were re-examined for signs of active and chronic inflammation, including lymphocyte-pattern oesophagitis, focal enhancing gastritis and indicators of chronicity. Additionally, granulomas and microgranulomas (defined as clusters of 4–9 epithelioid histiocytes) were evaluated.ResultsLymphocyte-pattern oesophagitis was observed in 15% of patients (n=20). Moderate-to-severe diffuse gastritis was noted in 50.4% of patients (n=68), while focal enhancing gastritis was identified in 11.1% (n=15). In terminal ileal biopsies, 46.1% exhibited activity and 5.3% showed features of chronicity. Active colitis was present in 73% of patients (n=100), with chronic colitis seen in 11.7% (n=16). Granulomas and microgranulomas were observed in 31.4% (43/137) and 48.9% (67/137) of patients, respectively. Notably, 30.7% (42/137) of patients with microgranulomas were without granulomas. Previously undetected microgranulomas were found in 20 of 27 cases. 2.5% of patients with UC and none of the control cohort showed microgranulomas. Lymphocyte-pattern oesophagitis was associated with an increased need for anti-tumor necrosis factor (TNF) therapy (p=0.007).ConclusionsGI microgranulomas, often overlooked, are specific to CD in the proper clinical context. Oesophageal lymphocytosis may predict a need for more aggressive treatment. The study brings to light under-recognised aspects of CD’s histological diagnosis, including the oversight of microgranulomas, the high prevalence of diffuse gastritis and low prevalence of focal enhancing gastritis, the frequent absence of terminal ileitis and the infrequent occurrence of chronic colitis.
Journal Article
Concealing Collusion
The Suez crisis in 1956 has long been recognised as a watershed in British history—precipitating the fall of Anthony Eden’s government, accelerating the end of empire, and underscoring how weak Britain had become on the international stage, especially in relation to the United States, which emerged from the episode as undeniably the senior partner in the ‘Special Relationship’. Less understood is the important role that the crisis played in weakening the foundations of official secrecy in Britain, especially what might be described as the social underpinnings of secrecy. This article explores how sensitive details about Suez eventually came to light in the period 1956 to 1969, despite concerted and sometimes cunning efforts by the Whitehall machine to prevent disclosure. Contrary to conventional wisdom, which suggests that socialist parliamentary firebrands like Michael Foot proved the most difficult to control, it is argued that the greatest challenge to secret-keepers came from senior conservative politicians writing memoirs—chief among them Eden himself—who were headstrong, not easily intimidated, and unafraid to bypass rules and codes of discretion to vindicate their careers. Fascinatingly, memoir writers not only ignored legal mechanisms such as the much-feared Official Secrets Act, but, against the backdrop of profound social and cultural change, they also dismissed attempts by mandarins to exploit gentlemanly bonds and loyalties, which in the past had been an effective method of promoting self-censorship by members of the elite.
Journal Article