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The main objective of this report is to help policymakers in the Caribbean design an agenda of policy actions to accelerate trade integration and growth, and to reduce poverty. Each part of the report focuses on a key question and provides an in-depth analysis of the issues raised, laying the foundations for policy recommendations described in the last chapter of the report. Part I asks whether the Caribbean's economic and trade system are sound enough to sustain the new era of its global trade relations. Part II addresses the opportunities and challenges that the new trade environment offers to the Caribbean. Part III assesses the impact of the recently-negotiated Economic Partnership Agreement on growth and poverty reduction using two types of macroeconomic models. The report concludes with policy priorities for accelerating Caribbean integration into the world economy and for reaping the benefits of global competition.--Publisher's description.

This final report updates preliminary data on Zika virus infection among pregnant women in Rio de Janeiro. ZIKV infection during pregnancy was associated with fetal death, fetal growth restriction, and central nervous system abnormalities. We have been conducting active surveillance for dengue infection in the general population of Rio de Janeiro since 2007. In 2012, we established a prospective cohort for dengue surveillance in mother–infant pairs within the Manguinhos Rio de Janeiro area. In 2015, we noted an increase in cases of a denguelike illness that was characterized by a descending rash, generally without fever; this increase coincided with a surge in the number of cases of illness characterized by a pruriginous rash in northeastern Brazil. 1 In early 2015, most cases were originally reported to surveillance systems as dengue; however, Zika virus (ZIKV) was . . .

Existing computational methods for drug repositioning either rely only on the gene expression response of cell lines after treatment, or on drug-to-disease relationships, merging several information levels. However, the noisy nature of the gene expression and the scarcity of genomic data for many diseases are important limitations to such approaches. Here we focused on a drug-centered approach by predicting the therapeutic class of FDA-approved compounds, not considering data concerning the diseases. We propose a novel computational approach to predict drug repositioning based on state-of-the-art machine-learning algorithms. We have integrated multiple layers of information: i) on the distances of the drugs based on how similar are their chemical structures, ii) on how close are their targets within the protein-protein interaction network, and iii) on how correlated are the gene expression patterns after treatment. Our classifier reaches high accuracy levels (78%), allowing us to re-interpret the top misclassifications as re-classifications, after rigorous statistical evaluation. Efficient drug repurposing has the potential to significantly impact the whole field of drug development. The results presented here can significantly accelerate the translation into the clinics of known compounds for novel therapeutic uses.

Future fault-tolerant quantum computers will require storing and processing quantum data in logical qubits. Here we realize a suite of logical operations on a distance-2 surface code qubit built from seven physical qubits and stabilized using repeated error-detection cycles. Logical operations include initialization into arbitrary states, measurement in the cardinal bases of the Bloch sphere and a universal set of single-qubit gates. For each type of operation, we observe higher performance for fault-tolerant variants over non-fault-tolerant variants, and quantify the difference. In particular, we demonstrate process tomography of logical gates, using the notion of a logical Pauli transfer matrix. This integration of high-fidelity logical operations with a scalable scheme for repeated stabilization is a milestone on the road to quantum error correction with higher-distance superconducting surface codes. Large-scale quantum computers will manipulate quantum information encoded in error-corrected logical qubits. A complete set of operations has now been realized on a logical qubit with error detection.

Comparative genomic analyses of primates offer considerable potential to define and understand the processes that mold, shape, and transform the human genome. However, primate taxonomy is both complex and controversial, with marginal unifying consensus of the evolutionary hierarchy of extant primate species. Here we provide new genomic sequence (~8 Mb) from 186 primates representing 61 (~90%) of the described genera, and we include outgroup species from Dermoptera, Scandentia, and Lagomorpha. The resultant phylogeny is exceptionally robust and illuminates events in primate evolution from ancient to recent, clarifying numerous taxonomic controversies and providing new data on human evolution. Ongoing speciation, reticulate evolution, ancient relic lineages, unequal rates of evolution, and disparate distributions of insertions/deletions among the reconstructed primate lineages are uncovered. Our resolution of the primate phylogeny provides an essential evolutionary framework with far-reaching applications including: human selection and adaptation, global emergence of zoonotic diseases, mammalian comparative genomics, primate taxonomy, and conservation of endangered species.

Earth’s mantle is shown to display heterogeneous sulphur isotope ratios, with a depleted end-member that is not chondritic as has been thought; the mantle’s inferred composition can be accounted for by fractionation during core–mantle differentiation. Fractionated sulphur in the mantle The differentiation of early Earth's subsurface material into core and mantle layers should be reflected in the residual mantle composition, as most of the iron-loving elements, presumably including sulphur, would have been scavenged by the liquid core. However, previous analyses of Earth's mantle have identified stable sulphur isotope ratios resembling those seen in chondritic meteorites, perhaps the result of a 'late veneer' meteoritic origin for mantle material. But here Jabrane Labidi et al . provide evidence that the mantle displays heterogeneous sulphur isotope ratios directly correlated to strontium and neodymium isotope ratios. The authors conclude that these results can be reconciled by fractionation during core-mantle differentiation. Core–mantle differentiation is the largest event experienced by a growing planet during its early history. Terrestrial core segregation imprinted the residual mantle composition by scavenging siderophile (iron-loving) elements such as tungsten, cobalt and sulphur. Cosmochemical constraints suggest that about 97% of Earth’s sulphur should at present reside in the core 1 , which implies that the residual silicate mantle should exhibit fractionated 34 S/ 32 S ratios according to the relevant metal–silicate partition coefficients 2 , together with fractionated siderophile element abundances. However, Earth’s mantle has long been thought to be both homogeneous and chondritic for 34 S/ 32 S, similar to Canyon Diablo troilite 3 , 4 , 5 , 6 , as it is for most siderophile elements. This belief was consistent with a mantle sulphur budget dominated by late-accreted chondritic components. Here we show that the mantle, as sampled by mid-ocean ridge basalts from the south Atlantic ridge, displays heterogeneous 34 S/ 32 S ratios, directly correlated to the strontium and neodymium isotope ratios 87 Sr/ 86 Sr and 143 Nd/ 144 Nd. These isotope trends are compatible with binary mixing between a low- 34 S/ 32 S ambient mantle and a high- 34 S/ 32 S recycled component that we infer to be subducted sediments. The depleted end-member is characterized by a significantly negative δ 34 S of −1.28 ± 0.33‰ that cannot reach a chondritic value even when surface sulphur (from continents, altered oceanic crust, sediments and oceans) is added. Such a non-chondritic 34 S/ 32 S ratio for the silicate Earth could be accounted for by a core–mantle differentiation record in which the core has a 34 S/ 32 S ratio slightly higher than that of chondrites (δ 34 S = +0.07‰). Despite evidence for late-veneer addition of siderophile elements (and therefore sulphur) after core formation, our results imply that the mantle sulphur budget retains fingerprints of core–mantle differentiation.

Exposure to Zika virus in utero has been associated with neurodevelopmental abnormalities. In this letter, the results of long-term follow-up of Brazilian children exposed to ZIKV in utero are reported.

Friction stir welding (FSW) is a solid-state joining technique, which has been developed remarkably during the last decade. Due to its benefits over conventional welding techniques, along with growing industrial demands for lightweight design structures, FSW found its way into becoming one of the fascinating engineering subjects of today. FSW process is based on the generation of heat due to friction and material deformation under an axial force. Originally, this method was developed for welding metallic materials which were difficult to weld with conventional techniques. However, due to the significant increase in polymeric materials consumption in the industry, the possibility for implementing this technique in polymer welding received a considerable share of interest. Nevertheless, polymeric materials behave differently from metallic ones and, currently, there is still a limited number of research works in the literature concerning this specific topic. This article reviews previous studies, which were focused on welding polymers using the FSW technique. Development of FSW tools, welds strength and the most effective welding parameters for different polymeric materials are now analysed. New materials, configurations and test specifications are currently under research, including the possibility for dissimilar materials joining, taking FSW into a new phase in industrial applications.

With the increase in the world population, the overexploitation of the planet’s natural resources is becoming a worldwide concern. Changes in the way humankind thinks about production and consumption must be undertaken to protect our planet and our way of living. For this change to occur, sustainable development together with a circular economic approach and responsible consumption are key points. Agriculture activities are responsible for more than 10% of the greenhouse gas emissions; moreover, by 2050, it is expected that food production will increase by 60%. The valorization of food waste is therefore of high importance to decrease the environmental footprint of agricultural activities. Fruits and vegetables are wildly consumed worldwide, and grapes are one of the main producers of greenhouse gases. Grape biomass is rich in bioactive compounds that can be used for the food, pharmaceutical and cosmetic industries, and their extraction from this food residue has been the target of several studies. Among the extraction techniques used for the recovery of bioactive compounds from food waste, subcritical water extraction (SWE) has been the least explored. SWE has several advantages over other extraction techniques such as microwave and ultrasound extraction, allowing high yields with the use of only water as the solvent. Therefore, it can be considered a green extraction method following two of the principles of green chemistry: the use of less hazardous synthesis (principle number 3) and the use of safer solvents and auxiliaries (principle number 5). In addition, two of the green extraction principles for natural products are also followed: the use of alternative solvents or water (principle number 2) and the use of a reduced, robust, controlled and safe unit operation (principle number 5). This review is an overview of the extraction process using the SWE of grape biomass in a perspective of the circular economy through valorization of the bioactive compounds extracted. Future perspectives applied to the SWE are also discussed, as well as its ability to be a green extraction technique.

Introduction Mitral valve (MV) prolapse (MVP) is a primary valvular abnormality. We hypothesized that additionally there are concomitant abnormalities of the left ventricle (LV) and MV apparatus in this entity even in the absence of significant mitral regurgitation (MR). Objective To characterize MV and LV anatomic and functional features in MVP with preserved LV ejection fraction, with and without significant MR, using cardiovascular magnetic resonance (CMR). Methods Consecutive MVP patients (n = 80, mean 52 years, 37% males) with preserved LV ejection fraction, and 44 controls (46 years, 52% males) by CMR were included, as well as 13 additional patients with “borderline” MVP. From cine images we quantified LV volumes, MV and LV anatomic measurements (including angle between diastolic and systolic annular planes, annular displacement, and basal inferolateral hypertrophy) and, using feature tracking, longitudinal and circumferential peak systolic strains. Results Significant MR was found in 46 (56%) MVP patients. Compared with controls, MVP patients had LV enlargement, basal inferolateral hypertrophy, higher posterior annular excursion, and reduced shortening of the papillary muscles. LV basal strains were significantly increased, particularly in several basal segments. These differences remained significant in patients without significant MR, and many persisted in “borderline” MVP. Conclusions In patients with MVP and preserved LV ejection fraction there is LV dilatation, basal inferolateral hypertrophy, exaggerated posterior annular displacement and increased basal deformation, even in the absence of significant MR or overt MVP. These findings suggest that MVP is a disease not only of the MV but also of the adjacent myocardium.