Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
6
result(s) for
"Morelli, R. (Ralph)"
Sort by:
Comparison of abdominal MRI with diffusion-weighted imaging to 68Ga-DOTATATE PET/CT in detection of neuroendocrine tumors of the pancreas
Purpose
The aim of the study was to evaluate contrast-enhanced MRI, diffusion-weighted MRI (DW MRI), and
68
Ga-DOTATATE positron emission tomography (PET)/CT in the detection of intermediate to well-differentiated neuroendocrine tumors (NET) of the pancreas.
Methods
Eighteen patients with pathologically proven pancreatic NET who underwent MRI including DW MRI and PET/CT within 6 weeks of each other were included in this retrospective study. Two radiologists evaluated T2-weighted (T2w), T2w + DW MRI, T2w + contrast-enhanced T1-weighted (CE T1w) MR images, and PET/CT for NET detection. The sensitivity and level of diagnostic confidence were compared among modalities using McNemar’s test and a Wilcoxon signed rank test. Apparent diffusion coefficients (ADC) of pancreatic NETs and normal pancreatic tissue were compared with Student’s
t
test.
Results
Of the NETs, 8/23 (34.8 %) and 9/23 (39.1 %) were detected on T2w images by observers 1 and 2, respectively. Detection rates improved significantly by combining T2w images with DW MRI (observer 1: 14/23 = 61 %; observer 2: 15/23 = 65.2 %;
p
< 0.05) or CE T1w images (observer 1: 14/23 = 61 %; observer 2: 15/23 = 65.2 %;
p
< 0.05). Detection rates of pancreatic NET with PET/CT (both observers: 23/23 = 100 %) were statistically significantly higher than with MRI (
p
< 0.05). The mean ADC value of NET (1.02 ± 0.26 × 10
−3
mm
2
/s) was statistically significantly lower than that of normal pancreatic tissue (1.48 ± 0.39 × 10
−3
mm
2
/s).
Conclusion
DW MRI is a valuable adjunct to T2w imaging and comparable to CE T1w imaging in pancreatic NET detection, quantitatively differentiating between NET and normal pancreatic tissue with ADC measurements.
68
Ga-DOTATATE PET/CT is more sensitive than MRI in the detection of pancreatic NET.
Journal Article
Comparison of abdominal MRI with diffusion-weighted imaging to ^sup 68^Ga-DOTATATE PET/CT in detection of neuroendocrine tumors of the pancreas
The aim of the study was to evaluate contrast-enhanced MRI, diffusion-weighted MRI (DW MRI), and ^sup 68^Ga-DOTATATE positron emission tomography (PET)/CT in the detection of intermediate to well-differentiated neuroendocrine tumors (NET) of the pancreas. Eighteen patients with pathologically proven pancreatic NET who underwent MRI including DW MRI and PET/CT within 6 weeks of each other were included in this retrospective study. Two radiologists evaluated T2-weighted (T2w), T2w+DW MRI, T2w+contrast-enhanced T1-weighted (CE T1w) MR images, and PET/CT for NET detection. The sensitivity and level of diagnostic confidence were compared among modalities using McNemar's test and a Wilcoxon signed rank test. Apparent diffusion coefficients (ADC) of pancreatic NETs and normal pancreatic tissue were compared with Student's t test. Of the NETs, 8/23 (34.8 %) and 9/23 (39.1 %) were detected on T2w images by observers 1 and 2, respectively. Detection rates improved significantly by combining T2w images with DW MRI (observer 1: 14/23=61 %; observer 2: 15/23=65.2 %; p<0.05) or CE T1w images (observer 1: 14/23=61 %; observer 2: 15/23=65.2 %; p<0.05). Detection rates of pancreatic NET with PET/CT (both observers: 23/23=100 %) were statistically significantly higher than with MRI (p<0.05). The mean ADC value of NET (1.02±0.26×10^sup -3^mm^sup 2^/s) was statistically significantly lower than that of normal pancreatic tissue (1.48±0.39×10^sup -3^mm^sup 2^/s). DW MRI is a valuable adjunct to T2w imaging and comparable to CE T1w imaging in pancreatic NET detection, quantitatively differentiating between NET and normal pancreatic tissue with ADC measurements. ^sup 68^Ga-DOTATATE PET/CT is more sensitive than MRI in the detection of pancreatic NET.[PUBLICATION ABSTRACT]
Journal Article
Comparison of abdominal MRI with diffusion-weighted imaging to super(68)Ga-DOTATATE PET/CT in detection of neuroendocrine tumors of the pancreas
Purpose: The aim of the study was to evaluate contrast-enhanced MRI, diffusion-weighted MRI (DW MRI), and super(68)Ga-DOTATATE positron emission tomography (PET)/CT in the detection of intermediate to well-differentiated neuroendocrine tumors (NET) of the pancreas. Methods: Eighteen patients with pathologically proven pancreatic NET who underwent MRI including DW MRI and PET/CT within 6 weeks of each other were included in this retrospective study. Two radiologists evaluated T2-weighted (T2w), T2w+DW MRI, T2w+contrast-enhanced T1-weighted (CE T1w) MR images, and PET/CT for NET detection. The sensitivity and level of diagnostic confidence were compared among modalities using McNemar's test and a Wilcoxon signed rank test. Apparent diffusion coefficients (ADC) of pancreatic NETs and normal pancreatic tissue were compared with Student's t test. Results: Of the NETs, 8/23 (34.8 %) and 9/23 (39.1 %) were detected on T2w images by observers 1 and 2, respectively. Detection rates improved significantly by combining T2w images with DW MRI (observer 1: 14/23=61 %; observer 2: 15/23=65.2 %; p<0.05) or CE T1w images (observer 1: 14/23=61 %; observer 2: 15/23=65.2 %; p<0.05). Detection rates of pancreatic NET with PET/CT (both observers: 23/23=100 %) were statistically significantly higher than with MRI (p<0.05). The mean ADC value of NET (1.02 plus or minus 0.2610 super(-3)mm super(2)/s) was statistically significantly lower than that of normal pancreatic tissue (1.48 plus or minus 0.3910 super(-3)mm super(2)/s). Conclusion: DW MRI is a valuable adjunct to T2w imaging and comparable to CE T1w imaging in pancreatic NET detection, quantitatively differentiating between NET and normal pancreatic tissue with ADC measurements. super(68)Ga-DOTATATE PET/CT is more sensitive than MRI in the detection of pancreatic NET.
Journal Article
Re: Collagenase Clostridium Histolyticum for the Treatment of Peyronie’s Disease: A Prospective Italian Multicentric Study
Collagenase clostridium histolyticum (CCH) is the first licensed drug for the treatment of Peyronie’s diease and is indicated in
patients with palpable plaque and a curvature deformity of ≥30°.
Journal Article
The Humanitarian FOSS Project
The Humanitarian Free and Open Source Software (Humanitarian FOSS) Project is primarily an educational project whose goal is to engage more undergraduates in building free and open source software (FOSS) that benefits their community. Over the past four years, increasing numbers of undergraduates and computer science programs have been inspired by the Humanitarian FOSS project to make significant contributions to several active open source software development projects that have benefited organizations such as the Portland, Maine Ronald McDonald House, and the New York City Salvation Army. This article provides examples of several Humanitarian FOSS projects and describes other initiatives aimed at promoting undergraduate education about FOSS and its application within the community.
Journal Article