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Aims To evaluate the efficacy of methotrexate (MTX) in preventing the recurrence of acute anterior uveitis (AAU). Methods This prospective, open, longitudinal study included patients from June 2002 to March 2005 who had either three or more episodes of AAU in the previous year, or a recurrence of AAU within 3 months before starting the trial. We excluded uveitis of infectious origin, masquerade syndromes, and patients with contraindications to MTX. The response criteria were defined as an absence of symptoms and the presence of a normal ophthalmologic examination. The study outcome compared the number of flare-ups of uveitis over an MTX-treated for 1 year to the number of flare-ups of the same group during the previous year without MTX. Results A total of 571 patients with uveitis were evaluated during the period of the study, and 10 fulfilled the inclusion criteria. One patient refused the treatment, and nine completed the study. The mean number of recurrences in the pre-MTX year was 3.4 (SD: 0.52), which was significantly reduced to 0.89 (SD: 1.17) in the year of treatment ( P =0.011). Conclusion MTX treatment seems to reduce the number of flare-ups in patients with recurrent AAU.

Winners get to take home championship trophies and medals, and last year it was the Green Barons, Miriam College, Xavier Football Club, Roxas Wildcats Football Club, Masbate Football Club, Makati Football Club, De La Salle University, FC Sikat, De La Salle Zobel, Makati FC Elite, and Makati Football School who won in their respective categories. Besides the Football Festival, Coca-Cola is also sponsoring the ongoing Coca-Cola PBA Youngstars, and upcoming Red Cross Million Volunteer Run this November.

The local government of Quezon City also supported GCash to help rev-up disbursements and tax payments, and also boost transparency, when it launched the Scaling Innovations and Mobile Money Project with United States Agency for International Development (USAID) on December last year.

Department of Energy (DOE) Secretary Carlos Jericho Petilla on Tuesday expressed his gratitude to all participants of the Consultative Dialogue on Epira Review held at the SMX Convention Center, Taguig City.

The Company exceeded its 2013 gold and copper production guidance at lower than planned costs on the back of strong fourth quarter production from both our New Zealand and Philippine operations,\" Mick Wilkes, Managing Director and CEO of OGC commented.

First Gen Corporation, the country's leading renewable energy company, has embarked on a 2.5-billion-US dollar investment to provide more than 1000 MW of clean energy to millions of Filipino homes.

[...]you tie that in with the almost completed framework agreement with the Bangsamoro and the MILF (Moro Islamic Liberation Front)... and I want to announce to everybody, we are really at the penultimate steps of all of the negotiations, that will spur quite a lot of development in Mindanao, a lot of economic activity, and of course the anchor point from Luzon for this new nautical highway is also Batangas,\" he said.

President Benigno S. Aquino III on Tuesday expressed his thoughts on the ongoing energy crisis at the sidelines of the groundbreaking ceremony of the 414-megawatt (MW) San Gabriel Power Plant in Sta. [...]yung price increases, I also asked the DOJ (Department of Justice), DOE, and also Department of Finance (DOF) -- the Secretary of Finance is the head of the economic cluster -- we were in a period of state of national calamity -- and DTI (Department of Trade and Industry) is also involved.

Xanthomonas arboricola pv. pruni is the causal agent of the bacterial spot disease of stone fruits, almond and some ornamental Prunus species. In Spain it was first detected in 2002 and since then, several outbreaks have occurred in different regions affecting mainly Japanese plum, peach and almond, both in commercial orchards and nurseries. As the origin of the introduction(s) was unknown, we have assessed the genetic diversity of 239 X. arboricola pv. pruni strains collected from 11 Spanish provinces from 2002 to 2013 and 25 reference strains from international collections. We have developed an optimized multilocus variable number of tandem repeat analysis (MLVA) scheme targeting 18 microsatellites and five minisatellites. A high discriminatory power was achieved since almost 50% of the Spanish strains were distinguishable, confirming the usefulness of this genotyping technique at small spatio-temporal scales. Spanish strains grouped in 18 genetic clusters (conservatively delineated so that each cluster contained haplotype networks linked by up to quadruple-locus variations). Furthermore, pairwise comparisons among populations from different provinces showed a strong genetic differentiation. Our results suggest multiple introductions of this pathogen in Spain and redistribution through contaminated nursery propagative plant material.

Translational cancer research is highly dependent of large series of cases including high quality samples and their associated data. Comprehensive Cancer Centers should be involved in networks to enable large-scale multi-center research projects between the centers [Ringborg, U., de Valeriola, D., van Harten, W., Llombart-Bosch, A., Lombardo, C., Nilsson, K., Philip, T., Pierotti, M.A., Riegman, P., Saghatchian, M., Storme, G., Tursz, T., Verellen, D, 2008. Improvement of European translational cancer research. Collaboration between comprehensive cancer centers. Tumori 94, 143–146.]. Combating cancer knows many frontiers. Research is needed for prevention as well as better care for those who have acquired the disease. This implies that human samples for cancer research need to be sourced from distinct forms of biobanking. An easier access to these samples for the scientific community is considered as the main bottleneck for research for health, and biobanks are the most adequate site to try to resolve this issue [Ozols, R.F., Herbst, R.S., Colson, Y.L., Gralow, J., Bonner, J., Curran Jr., W.J., Eisenberg, B.L., Ganz, P.A., Kramer, B.S., Kris, M.G., Markman, M., Mayer, R.J., Raghavan, D., Reaman, G.H., Sawaya, R., Schilsky, R.L., Schuchter, L.M., Sweetenham, J.W., Vahdat, L.T., Winn, R.J., and the American Society of Clinical Oncology, 2007. Clinical cancer advances 2006: major research advances in cancer treatment, prevention, and screening: a report from the American Society of Clinical Oncology. J. Clin. Oncol. 25, 146–162.]. However, biobanks should not be considered a static activity. On the contrary, biobanking is a young discipline [Morente, M.M., Fernandez, P.L., de Alava, E. Biobanking: old activity or young discipline? Semin. Diagn. Pathol., in press.], which need continuously evolve according to the permanent development of new techniques and new scientific goals. To accomplish current requirements of the scientific community biobanks need to face some essential challenges including an appropriate design, harmonized and more suitable procedures, and sustainability, all of them in the framework of their ethic, legal and social dimensions. This review therefore presents an overview on these issues, based on the works and discussions of the Marble Arch International Working Group on Biobanking for Biomedical Research, integrated by experts in biobanking from five continents.