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2,446 result(s) for "Morgan, George"
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A spreadsheet for calculating normative mole fractions of end-member species for Na-Ca-Li-Fe2+-Mg-Al tourmalines from electron microprobe data
This work presents a spreadsheet that calculates the mole fractions of end-member components for simple Na-Ca-Li-Mg-Fe2+-Al tourmalines from electron microprobe data. The input includes the B2O3 concentration obtained either from direct analysis or by estimation on the basis of stoichiometry. The concentration of Li2O can either be input from other analysis or estimated by the spreadsheet. The spreadsheet does not address the mole fractions of Cr, V, oxidized or deprotonated tourmaline species, nor account for species involving tetrahedral boron or aluminum. Therefore, the spreadsheet is not a comprehensive tool that includes all IMA approved tourmaline species, and so is not intended for naming tourmalines according to IMA convention. The present method includes a useful subset of end-member species that can be described simply from electron microprobe data and so, akin to a normative mineralogical analysis for rock composition, the calculations are intended to provide a normative result that serves as simple basis for comparing tourmalines that is more direct than names derived from the most abundant species present.
Understanding and Evaluating Research in Applied and Clinical Settings
Clinically oriented professionals and students need to understand and evaluate the research and statistics in professional articles, especially given today's emphasis on evidence-based practice. This book demonstrates how the research approach and design help determine the appropriate statistical analysis. Understanding and Evaluating Research in Applied and Clinical Settings features: short, independent, chapters that do not have to be read in order; a guide to understanding why a particular statistic was selected an emphasis on effects sizes including measures of risk potency; numerous cross-disciplinary examples to illustrate the material; and methods to help determine practical and clinical significance and their relation to meta-analysis and evidence-based practice. This book is intended for practitioners and students in psychology, education, counseling, mental and allied health, nursing, and medicine, and as a text for courses on understanding research methods and statistics.
The value-based price of transformative gene therapy for sickle cell disease: a modeling analysis
Sickle cell disease (SCD) is an inherited, progressively debilitating blood disorder. Emerging gene therapies (GTx) may lead to a complete remission, the benefits of such can only be realized if GTx is affordable and accessible in the low-and middle-income countries (LMIC) with the greatest SCD burden. To estimate the health impacts and country-specific value-based prices (VBP) of a future gene therapy for SCD using a cost-utility model framework. We developed a lifetime Markov model to compare the costs and health outcomes of GTx versus standard of care for SCD. We modeled populations in seven LMICs and six high-income countries (HICs) estimating lifetime costs and disability-adjusted life-years (DALYs) in comparison to estimates of a country’s cost-effectiveness threshold. Each country’s unique VBP for GTx was calculated via threshold analysis. Relative to SOC treatment alone, we found that hypothetical GTx reduced the number of people symptomatic with SCD over time leading to fewer DALYs. Across countries, VBPs ranged from $3.6 million (US) to $700 (Uganda). Our results indicate a wide range of GTx prices are required if it is to be made widely available and may inform burden and affordability for ‘target product profiles’ of GTx in SCD.
REVERSED ITEMS IN LIKERT SCALES: FILTERING OUT INVALID RESPONDERS
Likert type scales are commonly used in social sciences. Most of the Likert scales include both positively- and negatively worded items. However, the use of negatively worded (reversed) items is supported by some researchers but not others. This study analyzes the reversed items in educational settings. The school age, self-rating version of the Dimensions of Mastery Questionnaire (DMQ 17) was used. The sample consisted of 7261 Hungarian students, age 10 to 16. An iteration method was developed and used to filter our presumably invalid responders. The analysis is based on the empirical inconsistency between the reversed and the positively worded items. The iteration eliminated step-by-step the possibly invalid questionnaires. The reliabilities of the scales were increased with the iteration process. After eliminating about 20% of the sample, the reliabilities were somewhat higher with all scales having acceptable alphas. If one would like to use this iteration method for eliminating the invalid responders, he or she needs to oversample the accessible population. Based on this results we eliminated the reversed items form the new DMQ persistence and pleasure scales.
بناء الاختبارات والاستبانات للتقيم الوطني للتحصيل التعليمي
يأتي هذا الكتاب ضمن سلسلة من الكتب تعالج قضايا التقييمات الوطنية للتحصيل التعليمي، عن طريق اطلاع القراء على التكنولوجيا المعقدة التي تطورت حول إجراء التقييمات الوطنية والدولية. ويتناول هذا الكتاب (الثاني) بناء الاختبارات والاستبانات للتقييم الوطني للتحصيل التعليمي بناء نوعين من أدوات جمع البيانات : اختبارات تحصيل الطلاب والاستبانات حول الخلفية، ويغطي الجزء الأول وضع إطار للتقييم ومخططـا للاختبار وكتابة فقرات الاختبار والاختبار التجريبي وتخطيط الاختبار النهائي. ويحدد الجزء الثاني المراحل والأنشطة المماثلة في بناء الاستبانات، والتي تستخدم لجمع المعلومات من الطلاب والمعلمين ومديري المدارس، أو أولياء الأمور حول المتغيرات التي قد تساعد في تفسير الاختلافات في أداء الطلاب في اختباء التحصيل. ويصف الجزء الثالث كيفية إعداد دليل لإجراء الاختبار والذي ساعد على ضمان أن جميع الطلاب يجرون الاختبار في ظروف موحدة. وذيل الكتاب بقائمة المراجع التي اعتمد عليها المؤلفان في إعداد الكتاب.
Surgical trends, outcomes and disparities in minimal invasive surgery for patients with endometrial cancer in England: a retrospective cohort study
ObjectiveTo examine surgical outcomes and trends in the implementation of minimally invasive surgery (MIS) use for endometrial cancer (EC).DesignRetrospective cohort study.SettingEnglish National Health Service hospitals 2011–2017/2018.Population35 304 patients having a hysterectomy for EC identified from Hospital Episode Statistics.MethodsUnivariate and multivariate analyses compared MIS to open hysterectomy (OH) by assessing the association between demographic, clinical and hospital characteristics by using logistic regression. A propensity score was created, to control for confounding factors including demographics, clinical and hospital characteristics, from a logistic regression which enabled the inverse probability weighting of treatment to be applied in order to compare outcomes of treatment.Main outcome measuresThe association between route of surgery on perioperative morbidity and mortality.ResultsThe MIS rate rose from 40.3% in 2011 to 68.7% in 2017/2018, however, there was significant geographical variation (p<0.001). The overall 90-day mortality was significantly higher with OH versus MIS (OR 0.34, 95% CI 0.18 to 0.62, p=0.0002). MIS rates were significantly lower in patients from the lowest socioeconomic group (LSEG) compared with patients from the highest group (HSEG) (55.4% vs 59.9%, p<0.01), and in the black population as compared with white and Asian populations (40.4% vs 58.6% and 56.0%, p<0.0001). When patients from LSEG and black patients were treated in hospitals with high MIS rates, the MIS rate increased close to that of the HSEG and white patients (81.0% and 74.1% vs 83.2% and 82.6%).ConclusionsFurther investigation is needed to understand the barriers to MIS and improve access so that as many patients as possible can benefit from the reduced morbidity/mortality associated with MIS.