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"Morgan, L"
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The Cambridge introduction to Emmanuel Levinas
\"This book provides a clear and helpful overview of the philosophical core of the thought of Emmanuel Levinas, one of the most significant and interesting philosophers of the late twentieth century\"-- Provided by publisher.
Book
Exploring the Use of Artificial Intelligence for Qualitative Data Analysis: The Case of ChatGPT
The potential use of artificial intelligence programs such as a ChatGPT to analyze qualitative data raises any number of questions, most notably whether it is possible to produce similar results without the demanding process of manual coding. In addition, there are questions about both the simplicity of using ChatGPT for qualitative data analysis and the potential time savings that it might provide This article addresses these questions by using ChatGPT to reinvestigate two qualitative datasets that were previously analyzed by more traditional methods. In particular, it examines the extent to which the responses from ChatGPT can recreate the themes that were originally chosen to summarize the two previous analyses. The results show that ChatGPT performed reasonably well, but in both cases it was less successful at locating subtle, interpretive themes, and more successful at reproducing concrete, descriptive themes. In doing so, the program was quite easy to use and required very little effort in comparison to approaches that rely on manual coding. It is important to recognize, however, that both coding and approaches based on artificial intelligence are simply tools that must be applied within a larger analytic process. Overall, this exploration suggests that artificial intelligence may well have the power to disrupt the coding of data segments as a dominant paradigm for qualitative data analysis.
Journal Article
New frontiers in translational control of the cancer genome
Key Points
Oncogenic signalling rewires the translational machinery to support the expression of specific functional classes of pro-tumorigenic genes.
An expanding list of structural and sequence-specific
cis
-regulatory elements control expression of the oncogenic translation programme.
Specific
trans
-acting factors, such as RNA-binding proteins, interact with
cis
-regulatory elements to dictate mRNA translation in cancer cells.
Tumour cells alter tRNA expression and modification patterns to match the codon-usage bias of mRNA networks that support the transformed phenotype.
Translational control is crucial for the adaptive response to tumour-associated stress and represents a new therapeutic target for selectively killing cancer cells.
Recent technological advances in profiling genome-wide translation, RNA–protein interactions, RNA structure, RNA modifications and tRNA expression are driving a new understanding of the molecular mechanisms underlying translational control in cancer.
This Review summarizes our current understanding of the molecular mechanisms that regulate translation in cancer cells. The authors highlight the technological advances that have fuelled progress in this field and discuss how cancer cells tailor translation to adapt to oncogenic stress.
The past several years have seen dramatic leaps in our understanding of how gene expression is rewired at the translation level during tumorigenesis to support the transformed phenotype. This work has been driven by an explosion in technological advances and is revealing previously unimagined regulatory mechanisms that dictate functional expression of the cancer genome. In this Review we discuss emerging trends and exciting new discoveries that reveal how this translational circuitry contributes to specific aspects of tumorigenesis and cancer cell function, with a particular focus on recent insights into the role of translational control in the adaptive response to oncogenic stress conditions.
Journal Article
Counterfactuals and causal inference : methods and principles for social research
\"In this second edition of Counterfactuals and Causal Inference, completely revised and expanded, the essential features of the counterfactual approach to observational data analysis are presented with examples from the social, demographic, and health sciences. Alternative estimation techniques are first introduced using both the potential outcome model and causal graphs; after which, conditioning techniques, such as matching and regression, are presented from a potential outcomes perspective. For research scenarios in which important determinants of causal exposure are unobserved, alternative techniques, such as instrumental variable estimators, longitudinal methods, and estimation via causal mechanisms, are then presented. The importance of causal effect heterogeneity is stressed throughout the book, and the need for deep causal explanation via mechanisms is discussed\"-- Provided by publisher.
Book
Autocrine STAT3 activation in HPV positive cervical cancer through a virus-driven Rac1—NFκB—IL-6 signalling axis
Persistent human papillomavirus (HPV) infection is the leading cause of cervical cancer. Although the fundamental link between HPV infection and oncogenesis is established, the specific mechanisms of virus-mediated transformation are not fully understood. We previously demonstrated that the HPV encoded E6 protein increases the activity of the proto-oncogenic transcription factor STAT3 in primary human keratinocytes; however, the molecular basis for STAT3 activation in cervical cancer remains unclear. Here, we show that STAT3 phosphorylation in HPV positive cervical cancer cells is mediated primarily via autocrine activation by the pro-inflammatory cytokine Interleukin 6 (IL-6). Antibody-mediated blockade of IL-6 signalling in HPV positive cells inhibits STAT3 phosphorylation, whereas both recombinant IL-6 and conditioned media from HPV positive cells leads to increased STAT3 phosphorylation within HPV negative cervical cancer cells. Interestingly, we demonstrate that activation of the transcription factor NFκB, involving the small GTPase Rac1, is required for IL-6 production and subsequent STAT3 activation. Our data provides new insights into the molecular re-wiring of cancer cells by HPV E6. We reveal that activation of an IL-6 signalling axis drives the autocrine and paracrine phosphorylation of STAT3 within HPV positive cervical cancers cells and that activation of this pathway is essential for cervical cancer cell proliferation and survival. Greater understanding of this pathway provides a potential opportunity for the use of existing clinically approved drugs for the treatment of HPV-mediated cervical cancer.
Journal Article
Careers in psychology : opportunities in a changing world
\"Connecting career aspirations with the post-college world is crucial for students today. Learners must keep sight of future career opportunities while exploring a broad expanse of degrees paths and career options. Careers in Psychology, Fifth Edition helps students navigate and plan for their futures by offering exposure to the rich careers in each subfield of psychology and prompting students to consider the what, why and how of each option. In doing so, the text supports students as they determine whether a major and career in psychology is for them. Offering salary and career information, advice on getting a job after graduation, and information on applying to graduate school in psychology Tara L. Kuther and Robert D. Morgan support students in making an educated decision about their futures and career options\"-- Provided by publisher.
Book
Addressing disparities in the global epidemiology of stroke
Stroke is the second leading cause of death and the third leading cause of disability worldwide. Though the burden of stroke worldwide seems to have declined in the past three decades, much of this effect reflects decreases in high-income countries (HICs). By contrast, the burden of stroke has grown rapidly in low-income and middle-income countries (LMICs), where epidemiological, socioeconomic and demographic shifts have increased the incidence of stroke and other non-communicable diseases. Furthermore, even in HICs, disparities in stroke epidemiology exist along racial, ethnic, socioeconomic and geographical lines. In this Review, we highlight the under-acknowledged disparities in the burden of stroke. We emphasize the shifting global landscape of stroke risk factors, critical gaps in stroke service delivery, and the need for a more granular analysis of the burden of stroke within and between LMICs and HICs to guide context-appropriate capacity-building. Finally, we review strategies for addressing key inequalities in stroke epidemiology, including improvements in epidemiological surveillance and context-specific research efforts in under-resourced regions, development of the global workforce of stroke care providers, expansion of access to preventive and treatment services through mobile and telehealth platforms, and scaling up of evidence-based strategies and policies that target local, national, regional and global stroke disparities.Though the burden of stroke has declined, it has grown rapidly in low-income and middle-income countries, and disparities still exist within high-income countries. In this Review, the authors highlight under-acknowledged disparities in the burden of stroke and review strategies for addressing key inequalities.
Journal Article
Genome-editing Technologies for Gene and Cell Therapy
Gene therapy has historically been defined as the addition of new genes to human cells. However, the recent advent of genome-editing technologies has enabled a new paradigm in which the sequence of the human genome can be precisely manipulated to achieve a therapeutic effect. This includes the correction of mutations that cause disease, the addition of therapeutic genes to specific sites in the genome, and the removal of deleterious genes or genome sequences. This review presents the mechanisms of different genome-editing strategies and describes each of the common nuclease-based platforms, including zinc finger nucleases, transcription activator-like effector nucleases (TALENs), meganucleases, and the CRISPR/Cas9 system. We then summarize the progress made in applying genome editing to various areas of gene and cell therapy, including antiviral strategies, immunotherapies, and the treatment of monogenic hereditary disorders. The current challenges and future prospects for genome editing as a transformative technology for gene and cell therapy are also discussed.
Journal Article