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The dynamics of a nuclear open quantum system could be revealed in the correlations between the breakup fragments of halo nuclei. The breakup mechanism of a proton halo nuclear system is of particular interest as the Coulomb polarization may play an important role, which, however, remains an open question. Here we use a highly efficient silicon detector array and measure the correlations between the breakup fragments of 8 B incident on 120 Sn at near-barrier energies. The energy and angular correlations can be explained by a fully quantum mechanical method based on the state-of-the-art continuum discretized coupled channel calculations. The results indicate that, compared to the neutron halo nucleus 6 He, 8 B presents distinctive reaction dynamics: the dominance of the elastic breakup. This breakup occurs mainly via the short-lived continuum states, almost exhausts the 7 Be yield, indicating the effect of Coulomb polarization on the proton halo state. The correlation information reveals that the prompt breakup mechanism dominates, occurring predominantly on the outgoing trajectory. We also show that, as a large environment, the continuum of 8 B breakup may not significantly influence elastic scattering and complete fusion. Halo-structured nuclei are examples of many-body open quantum system. Here the authors use a complete kinematics measurement and find an elastic breakup of proton halo nucleus 8 B.

. We present an account of the current status of the theoretical treatment of inclusive ( d , p ) reactions in the breakup-fusion formalism, pointing to some applications and making the connection with current experimental capabilities. Three independent implementations of the reaction formalism have been recently developed, making use of different numerical strategies. The codes also originally relied on two different but equivalent representations, namely the prior (Udagawa-Tamura, UT) and the post (Ichimura-Austern-Vincent, IAV) representations. The different implementations have been benchmarked for the first time, and then applied to the Ca isotopic chain. The neutron-Ca propagator is described in the Dispersive Optical Model (DOM) framework, and the interplay between elastic breakup (EB) and non-elastic breakup (NEB) is studied for three Ca isotopes at two different bombarding energies. The accuracy of the description of different reaction observables is assessed by comparing with experimental data of ( d , p ) on 40,48 Ca. We discuss the predictions of the model for the extreme case of an isotope ( 60 Ca) currently unavailable experimentally, though possibly available in future facilities (nominally within production reach at FRIB). We explore the use of ( d , p ) reactions as surrogates for ( n , γ ) processes, by using the formalism to describe the compound nucleus formation in a ( d , p γ ) reaction as a function of excitation energy, spin, and parity. The subsequent decay is then computed within a Hauser-Feshbach formalism. Comparisons between the ( d , p γ ) and ( n , γ ) induced gamma decay spectra are discussed to inform efforts to infer neutron captures from ( d , p γ ) reactions. Finally, we identify areas of opportunity for future developments, and discuss a possible path toward a predictive reaction theory.

Fruits and vegetables are extensively processed and the residues are often discarded. However, due to their rich composition, they could be used to minimize food waste. This study aimed to develop food products based on the solid residue generated from the manufacture of an isotonic beverage. This beverage was produced based on integral exploitation of several fruits and vegetables: orange, passion fruit, watermelon, lettuce, courgette, carrot, spinach, mint, taro, cucumber and rocket. The remaining residue was processed into flour and its functional properties were evaluated. The fruit and vegetable residue (FVR) flour was incorporated with different levels (20 to 35 %) into biscuits and cereal bars. The proximate composition, microbiological stability until 90 days and consumer acceptance were analyzed. The FVR flour presented a higher water holding capacity than oil holding capacity, respectively 7.43 and 1.91 g g −1 of flour, probably associated with its high levels of carbohydrates (53 %) and fibres (21.5 %). Biscuits enriched with 35 % of FVR flour presented significantly higher fibre, ranging from 57 % to 118 % and mineral contents, from 25 % to 37 % than when only 20 % was added. Cereal bars presented about 75 % of fibres and variable mineral contents between 14 % and 37 %. The incorporation of FVR did not change the fat content. The microbiological examinations are within acceptable limits according to international regulation. The incorporation of FVR flour did not impair consumer acceptance, the sensory attributes averaged around 6. The chemical, microbiological and sensorial results of the designed products attested for an alternative towards applying and reducing agro-industrial wastes.

Stroke is a devastating disease with an increasing prevalence. Part of the current development in stroke therapy is focused in the chronic phase, where neurorepair mechanisms such as neurogenesis, are involved. In the adult brain, one of the regions where neurogenesis takes place is the subventricular zone (SVZ) of the lateral ventricles. Given the possibility to develop pharmacological therapies to stimulate this process, we have performed a longitudinal analysis of neurogenesis in a model of cortical ischemia in mice. Our results show an initial decrease of SVZ proliferation at 24 h, followed by a recovery leading to an increase at 14d and a second decrease 28d after stroke. Coinciding with the 24 h proliferation decrease, an increase in the eutopic neuroblast migration towards the olfactory bulb was observed. The analysis of the neuroblast ectopic migration from the SVZ toward the lesion showed an increase in this process from day 14 after the insult. Finally, our data revealed an increased number of new cortical neurons in the peri-infarct cortex 65d after the insult. In summary, we report here critical check-points about post-stroke neurogenesis after cortical infarcts, important for the pharmacological modulation of this process in stroke patients.

A line of research has been developed to describe structure and dynamics of weakly-bound systems with one or more valence particles. To simplify the problem we are assuming particles moving in one dimension and, despite the drastic assumption, the model encompasses many characteristics observed in experiments. Within this model we can describe, for example, one- and two-particle breakup and one- and two-particle transfer processes. We concentrate here in models involving weakly-bound nuclei with just one valence particle. Exact solutions obtained by directly solving the time-dependent Schroedinger equation can be compared with the results obtained with different approximation schemes (coupled-channels formalism, continuum discretization, etc). Our goal is to investigate the limitations of the models based on approximations, and in particular to understand the role of continuum in the reaction mechanism.

Industrial passion fruit juice production generates a large amount of passion fruit waste, which contains about 60% of fibers when dried and could be used as reinforcement of thermoplastic starch. This study aimed to develop an extruded starchy bioplastic reinforced with passion fruit peel (Pfp) (0, 4, 10, 16, and 20%), glycerol (60, 64, 70, 76, and 80 wt%), and starch mix (55% corn and 45% cassava) that were processed at varied screw speeds (66, 80, 100, 120, and 134 rpm). The response surface methodology was applied to analyze the effects of Pfp, glycerol, and screw speed. Mechanical properties, contact angle, and water permeability and solubility were the response variables. Addition of Pfp, up to 4%, improved the bioplastic mechanical properties. High addition of Pfp (16 and 20%) combined with the lowest screw speed (66 rpm) reduced bioplastic water solubility. Water vapor permeability slightly increased with the combination of increasing glycerol content and screw speed. Contact angle was not statically affected by the independent variables. The extrusion showed as an interesting tool that provided greater homogeneity of Pfp incorporated in starch bioplastic, though the mix would benefit from finer Pfp particle size distribution.

At present, the goal of stroke research is the identification of a potential recoverable tissue surrounding the ischemic core, suggested as ischemic penumbra, with the aim of applying a treatment that attenuates the growth of this area. Our purpose was to determine whether a combination of imaging techniques, including 18F-FDG PET and MRI could identify the penumbra area. Longitudinal studies of 18F-FDG PET and MRI were performed in rats 3h, 24h and 48h after the onset of ischemia. A transient and a permanent model of focal cerebral ischemia were performed. Regions of interest were located, covering the ischemic core, the border that progresses to infarction (recruited tissue), and the border that recovers (recoverable tissue) with early reperfusion. Analyses show that permanent ischemia produces severe damage, whereas the transient ischemia model does not produce clear damage in ADC maps at the earliest time studied. The only significant differences between values for recoverable tissue, 18F-FDG (84±2%), ADC (108±5%) and PWI (70±8%), and recruited tissue, 18F-FDG (77±3%), ADC (109±4%) and PWI (77±4%), are shown in 18F-FDG ratios. We also show that recoverable tissue values are different from those in non-infarcted tissue. The combination of 18F-FDG PET, ADC and PWI MRI is useful for identification of ischemic penumbra, with 18F-FDG PET being the most sensitive approach to its study at early times after stroke, when a clear DWI deficit is not observed. ► DWI–PWI-MRI and 18F-FDG PET are available and feasible techniques. ► Ischemic lesion based on DWI, PWI deficits is not always detectable after stroke. ► Metabolic activity measured as 18F-FDG PET allows identifying a salvageable area.

The Transfer to the Continuum method has been applied to describe the 11Li(p, pn) and 14Be(p, pn) reactions in inverse kinematics, using structure overlaps computed within a full three-body model for the projectile. Calculations agree with the available experimental data on the unbound 10Li and 13Be nuclei.

The Continuum-Discretized Coupled-Channels (CDCC) has been successfully employed to describe elastic and breakup of nuclear reactions induced by weakly bound projectiles. In this contribution, we review some other, less widespread applications of the CDCC wavefunction, some of them in combination with other reaction formalisms, which are being currently employed in the analysis of reactions involving three or more fragments in the initial or final state.

The L-arginine:nitric oxide (NO) pathway is believed to exert many of its physiological effects via stimulation of the soluble guanylyl cyclase (SGC); however, the lack of a selective inhibitor of this enzyme has prevented conclusive demonstration of this mechanism of action. We have found that the compound 1H-[1,2,4]oxadiazolo[4,3,-a]quinoxalin-1-one (ODQ) inhibits the elevation of cGMP induced by the NO donor S-nitroso-DL-penicillamine in human platelets and rat vascular smooth muscle (IC50= 10-60 nM and <10 nM, respectively) and that this is accompanied by prevention of the platelet inhibitory and vasodilator actions of NO donors. ODQ also inhibited the antiaggregatory action of NO generated by the platelets but did not affect the action of prostacyclin or that of a cGMP mimetic. In addition, ODQ inhibited the vasodilator actions of endogenously released NO and of NO generated after induction of NO synthase in vascular preparations. It did not, however, affect the increase in vascular smooth muscle cGMP or the dilatation induced by atrial natriuretic factor. ODQ had no effect on NO synthase activity, nor did it react with NO. It did, however, potently (IC50≈ 10 nM) inhibit the activity of the SGC in cytosol obtained from crude extract of rat aortic smooth muscle. Thus ODQ prevents the actions of NO on platelets and vascular smooth muscle through its potent inhibitory effect on the SGC.