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"Morrison, David"
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On the classification of 6D SCFTs and generalized ADE orbifolds
A
bstract
We study (1, 0) and (2, 0) 6D superconformal field theories (SCFTs) that can be constructed in F-theory. Quite surprisingly, all of them involve an orbifold singularity ℂ
2
/Γ with Γ a discrete subgroup of U(2). When Γ is a subgroup of
SU
(2), all discrete subgroups are allowed, and this leads to the familiar ADE classification of (2, 0) SCFTs. For more general U(2) subgroups, the allowed possibilities for Γ are not arbitrary and are given by certain generalizations of the A- and D-series. These theories should be viewed as the minimal 6D SCFTs. We obtain all other SCFTs by bringing in a number of E-string theories and/or decorating curves in the base by non-minimal gauge algebras. In this way we obtain a vast number of new 6D SCFTs, and we conjecture that our construction provides a full list.
Journal Article
6D SCFTs and phases of 5D theories
A
bstract
Starting from 6D superconformal field theories (SCFTs) realized via F-theory, we show how reduction on a circle leads to a uniform perspective on the phase structure of the resulting 5D theories, and their possible conformal fixed points. Using the correspon-dence between F-theory reduced on a circle and M-theory on the corresponding elliptically fibered Calabi-Yau threefold, we show that each 6D SCFT with minimal supersymmetry directly reduces to a collection of between one and four 5D SCFTs. Additionally, we find that in most cases, reduction of the tensor branch of a 6D SCFT yields a 5D generalization of a quiver gauge theory. These two reductions of the theory often correspond to different phases in the 5D theory which are in general connected by a sequence of flop transitions in the extended Kähler cone of the Calabi-Yau threefold. We also elaborate on the structure of the resulting conformal fixed points, and emergent flavor symmetries, as realized by M-theory on a canonical singularity.
Journal Article
Batman by Grant Morrison omnibus
\"One of the greatest storytellers of his generation, Grant Morrison's arrival onto the Dark Knight was one of the most hyped debuts in industry history. This collection includes time-spanning epic graphic novels featuring the cataclysmic events of FINAL CRISIS and the introduction of Batman's son, Damian Wayne! These blockbuster stories featured a deconstruction of super hero comics like never before, with challenging, thought-provoking takes on the modern, four-color icons.\"-- Provided by publisher.
Book
On the frozen F-theory landscape
A
bstract
We study 6d
= (1, 0) supergravity theories arising in the frozen phase of F-theory. For each of the known global models, we construct an F-theory compactification in the unfrozen phase with an identical non-abelian gauge algebra and massless matter content. Two such low energy effective theories are then distinguished through gauge enhancements in moduli space. We study potentially new global models obtained via compact embeddings of a plethora of 6d
= (1, 0) superconformal field theories and little string theories constructed using frozen 7-branes. In some cases, these provably do not exist, and in other cases, we explicitly construct a compact embedding, yielding 6d supergravity theories with new massless spectra. Finally, by using gravitational anomaly cancellation, we conjecture the existence of localized neutral hypermultiplets along frozen 7-brane loci.
Journal Article
F-theory on genus-one fibrations
A
bstract
We argue that M-theory compactified on an arbitrary genus-one fibration, that is, an elliptic fibration which need not have a section, always has an F-theory limit when the area of the genus-one fiber approaches zero. Such genus-one fibrations can be easily constructed as toric hypersurfaces, and various SU(5) × U(1)
n
and
E
6
models are presented as examples. To each genus-one fibration one can associate a
τ
-function on the base as well as an SL(2
,
ℤ
) representation which together define the IIB axio-dilaton and 7-brane content of the theory. The set of genus-one fibrations with the same
τ
-function and SL(2
,
ℤ
) representation, known as the Tate-Shafarevich group, supplies an important degree of freedom in the corresponding F-theory model which has not been studied carefully until now.
Six-dimensional anomaly cancellation as well as Witten’s zero-mode count on wrapped branes both imply corrections to the usual F-theory dictionary for some of these models. In particular, neutral hypermultiplets which are localized at codimension-two fibers can arise. (All previous known examples of localized hypermultiplets were charged under the gauge group of the theory.) Finally, in the absence of a section some novel monodromies of Kodaira fibers are allowed which lead to new breaking patterns of non-Abelian gauge groups.
Journal Article
Systemic Inflammation Predicts All-Cause Mortality: A Glasgow Inflammation Outcome Study
Markers of the systemic inflammatory response, including C-reactive protein and albumin (combined to form the modified Glasgow Prognostic Score), as well as neutrophil, lymphocyte and platelet counts have been shown to be prognostic of survival in patients with cancer. The aim of the present study was to examine the prognostic relationship between these markers of the systemic inflammatory response and all-cause, cancer, cardiovascular and cerebrovascular mortality in a large incidentally sampled cohort.
Patients (n = 160 481) who had an incidental blood sample taken between 2000 and 2008 were studied for the prognostic value of C-reactive protein (>10mg/l, albumin (>35mg/l), neutrophil (>7.5×109/l) lymphocyte and platelet counts. Also, patients (n = 52 091) sampled following the introduction of high sensitivity C-reactive protein (>3mg/l) measurements were studied. A combination of these markers, to make cumulative inflammation-based scores, were investigated.
In all patients (n = 160 481) C-reactive protein (>10mg/l) (HR 2.71, p<0.001), albumin (>35mg/l) (HR 3.68, p<0.001) and neutrophil counts (HR 2.18, p<0.001) were independently predictive of all-cause mortality. These associations were also observed in cancer, cardiovascular and cerebrovascular mortality before and after the introduction of high sensitivity C-reactive protein measurements (>3mg/l) (n = 52 091). A combination of high sensitivity C-reactive protein (>3mg/l), albumin and neutrophil count predicted all-cause (HR 7.37, p<0.001, AUC 0.723), cancer (HR 9.32, p<0.001, AUC 0.731), cardiovascular (HR 4.03, p<0.001, AUC 0.650) and cerebrovascular (HR 3.10, p<0.001, AUC 0.623) mortality.
The results of the present study showed that an inflammation-based prognostic score, combining high sensitivity C-reactive protein, albumin and neutrophil count is prognostic of all-cause mortality.
Journal Article
Vitamin D and COVID-19 susceptibility and severity in the COVID-19 Host Genetics Initiative: A Mendelian randomization study
Increased vitamin D levels, as reflected by 25-hydroxy vitamin D (25OHD) measurements, have been proposed to protect against COVID-19 based on in vitro, observational, and ecological studies. However, vitamin D levels are associated with many confounding variables, and thus associations described to date may not be causal. Vitamin D Mendelian randomization (MR) studies have provided results that are concordant with large-scale vitamin D randomized trials. Here, we used 2-sample MR to assess evidence supporting a causal effect of circulating 25OHD levels on COVID-19 susceptibility and severity.
Genetic variants strongly associated with 25OHD levels in a genome-wide association study (GWAS) of 443,734 participants of European ancestry (including 401,460 from the UK Biobank) were used as instrumental variables. GWASs of COVID-19 susceptibility, hospitalization, and severe disease from the COVID-19 Host Genetics Initiative were used as outcome GWASs. These included up to 14,134 individuals with COVID-19, and up to 1,284,876 without COVID-19, from up to 11 countries. SARS-CoV-2 positivity was determined by laboratory testing or medical chart review. Population controls without COVID-19 were also included in the control groups for all outcomes, including hospitalization and severe disease. Analyses were restricted to individuals of European descent when possible. Using inverse-weighted MR, genetically increased 25OHD levels by 1 standard deviation on the logarithmic scale had no significant association with COVID-19 susceptibility (odds ratio [OR] = 0.95; 95% CI 0.84, 1.08; p = 0.44), hospitalization (OR = 1.09; 95% CI: 0.89, 1.33; p = 0.41), and severe disease (OR = 0.97; 95% CI: 0.77, 1.22; p = 0.77). We used an additional 6 meta-analytic methods, as well as conducting sensitivity analyses after removal of variants at risk of horizontal pleiotropy, and obtained similar results. These results may be limited by weak instrument bias in some analyses. Further, our results do not apply to individuals with vitamin D deficiency.
In this 2-sample MR study, we did not observe evidence to support an association between 25OHD levels and COVID-19 susceptibility, severity, or hospitalization. Hence, vitamin D supplementation as a means of protecting against worsened COVID-19 outcomes is not supported by genetic evidence. Other therapeutic or preventative avenues should be given higher priority for COVID-19 randomized controlled trials.
Journal Article