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"Morrison, Slade"
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Please, Louise
On a gray, rainy day, everything seems particularly frightening and bad to Louise until she enters a library and finds books that help her to know and imagine the beauty and wonder that have been there all along.
Book
Root-zone management of container-grown herbaceous perennials
Media moisture levels, fertilizer concentrations, and nutrient-solution reactions were evaluated for the effect on plant growth and development during the forcing into flower of 15 different container-grown herbaceous perennial species in a greenhouse. There were no treatment effects on floral initiation and development. In general, both shoot fresh weight and plant height increased with increasing water availability, while percent dry weight was affected minimally. Both low and high fertilizer rates generally decreased shoot fresh weight and only the high fertilizer rate decreased the height. An acidic nutrient solution had less effect on lowering medium pH than an basic nutrient solution had on raising medium pH. Both nutrient solutions had minimal effect on plant growth and appearance. Shoot and leaf tissue macronutrient and micronutrient concentrations were determined for 15 container-grown herbaceous perennial species forced into flower in a greenhouse. Averaged over all species, the six NS produced a range of values for each macronutrient that varied by ≤0.5, 1.0, or ≥1.5% for P and Mg2+, N and Ca2+, or K, respectively. In general, N and P showed minimal differences while K concentrations increased with increasing fertilizer rate. The ranges of Fe, Mn, Zn, B, and Cu concentration over all treatments were 33 to 1515, 40 to 483, 21 to 244, 16 to 205, and 1 to 10 μg·g–1, respectively.
Dissertation
The tortoise or the hare
Jamey Tortoise is smarter than anyone else and Jimi Hare is faster, but when a race is announced each consults a reporter about how to get what he really wants when and if he should win in this updated twist on the familiar fable.
Book
Fusobacterium nucleatum infection modulates the transcriptome and epigenome of HCT116 colorectal cancer cells in an oxygen-dependent manner
Fusobacterium nucleatum
, a gram-negative oral bacterium, has been consistently validated as a strong contributor to the progression of several types of cancer, including colorectal (CRC) and pancreatic cancer. While previous in vitro studies have shown that intracellular
F. nucleatum
enhances malignant phenotypes such as cell migration, the dependence of this regulation on features of the tumor microenvironment (TME) such as oxygen levels are wholly uncharacterized. Here we examine the influence of hypoxia in facilitating
F. nucleatum
invasion and its effects on host responses focusing on changes in the global epigenome and transcriptome. Using a multiomic approach, we analyze epigenomic alterations of H3K27ac and global transcriptomic alterations sustained within a hypoxia and normoxia conditioned CRC cell line HCT116 at 24 h following initial infection with
F. nucleatum
. Our findings reveal that intracellular
F. nucleatum
activates signaling pathways and biological processes in host cells similar to those induced upon hypoxia conditioning in the absence of infection. Furthermore, we show that a hypoxic TME favors
F. nucleatum
invasion and persistence and therefore infection under hypoxia may amplify malignant transformation by exacerbating the effects induced by hypoxia alone. These results motivate future studies to investigate host-microbe interactions in tumor tissue relevant conditions that more accurately define parameters for targeted cancer therapies.
Multiomic study reveals that tumor microenvironmental factors such as hypoxia influence intracellular infection of
Fusobacterium nucleatum
in colorectal cancer cells and provides clues to malignant transformation of infected cells.
Journal Article
Preoperative gefitinib versus gefitinib and anastrozole in postmenopausal patients with oestrogen-receptor positive and epidermal-growth-factor-receptor-positive primary breast cancer: a double-blind placebo-controlled phase II randomised trial
Some oestrogen-receptor (ER) positive breast cancers express epidermal growth factor receptor (EGFR), but whether inhibition of EGFR can suppress proliferation of breast cancer cells and ER function is not known.
In a double-blind, placebo-controlled randomised trial of 56 postmenopausal patients with ER-positive and EGFR-positive primary breast cancer, 27 women were randomly assigned to the tyrosine-kinase inhibitor of EGFR gefitinib (250 mg given orally once a day) and the aromatase inhibitor anastrozole (1 mg given orally once a day), and 29 women to gefitinib (250 mg given orally once a day) and placebo of identical appearance to anastrozole given orally once a day, all given for 4–6 weeks before surgery. Primary outcome was inhibition of tumour-cell proliferation, as measured by Ki67 antigen labelling index. Secondary outcomes were reduction in EGFR phosphorylation at Tyr 845, reduction in ER phosphorylation at Ser 118, tumour size, and toxic effects. Analyses were by intention to treat.
Patients assigned gefitinib and anastrozole had a greater reduction from pretreatment values in proliferation-related Ki67 labelling index than did those assigned gefitinib alone (mean % reduction 98·0 [95% CI 96·1–98·9]
vs 92·4 [85·1–96·1]; difference between groups 5·6% [5·1–6·0], p=0·0054). Tumour size was reduced by 30–99% (partial response) in 14 of 28 patients assigned gefitinib and anastrozole and in 12 of 22 assigned gefitinib, as assessed by ultrasonography. Reduction in phosphorylation of ER at Ser 118 was similar for both groups. Treatment was well tolerated and much the same for both groups.
Single-agent gefitinib and gefitinib combined with anastrozole are well-tolerated and effective treatments for reducing the size of breast tumours and levels of ER phosphorylation when given as neoadjuvant therapy.
Journal Article
Developing GM insects for sustainable pest control in agriculture and human health
Doc number: O43
Journal Article
