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In Nishitani’s The Self-Overcoming of Nihilism, Nishitani explores, among other related topics, the history of the problem of Nihilism in the West. Conspicuously absent from Nishitani’s historical analysis is the thought of Friedrich Heinrich Jacobi, who famously raised the charge of Nihilism against Fichte’s philosophy in 1799. As is evident from a variety of Hegel’s texts, Hegel explicitly responds to Jacobi’s charge against Speculative Idealism and designs his philosophy in part as a response to Jacobi’s charge of Nihilism. On the one hand, Nishitani fails to appreciate Hegel’s philosophy as a response to the problem of Nihilism because he has an incomplete possession of the history of the problem. On the other hand, Nishitani’s critique of Hegel begs the question. Nishitani’s dogmatic rejection of Hegel appears to be grounded in his methodological approach to the philosophy of history, which assumes the falsehood of Hegel’s account. Jacobi’s charge against Speculative Idealism consists in the Idealist’s failure to account for the very existence of the world. On his view, philosophy is Nihilism because the world disappears completely from philosophical speculation. Hegel attempts to overcome this charge of Nihilism by re-thinking the structure and content of reason.

Derrida defines différance as the “interruption of Hegelian dialectics.” Although scholars have noted that Derrida pursues his critique of Hegel by means of Hegelian concepts, the way that Derrida employs specific Hegelian concepts in his critique, such as non-positionality, self-reference, and contradiction, has not been sufficiently investigated. In this essay, I reconstruct Derrida’s critique of Hegel with special focus on the Hegelian concepts of non-positionality, self-reference, and contradiction.

In Prajñā and Reason Nishitani presents a powerful vision of philosophy as Absolute knowing. Nishitani’s conclusions are striking: Absolute knowing can only fulill its potential by beginning without any presuppositions and affirming the truth of contradiction. Because Hegel’s philosophy also purports to be a science of Absolute knowing, in Prajñā and Reason Nishitani develops his own account of the Absolute in conversation with Hegel’s philosophy. We reconstruct Nishitani’s reading and various critiques of Hegel, and thereafter evaluate its merits. Our inquiry shows that Hegel too begins without presuppositions and affirms the truth of contradiction. As a result, we argue that Nishitani’s profound reflections on Absolute knowing draw him into close proximity with Hegel’s thinking and call us to re-think the very being of philosophy and philosophical practice today.

Herein I investigate how four dogmas underpinning the traditional concepts of universality, the genus, class, and abstract universal, generate four paradoxes of self-reference. The four dogmas are the following: (1) that contradiction entails the total absence of determinacy, (2) the necessary finitude of the concept, (3) the separation of principles of universality and particularity, and (4) the necessity of appealing to foundations. I show how these dogmas underpin the paradoxes of self-reference and how one cannot make progress on these paradoxes as long as these four dogmas are in place. Corresponding to the abovementioned dogmas are the four paradoxes of self-reference: (1a) the problem of the differentia, (2b) the problem of psychologism, (3c) the problem of participation, and (4d) the problem of ontotheology.

The Problem of Evil: New Philosophical Directions brings together a diversity of philosophical views, methods, and approaches to the much-discussed topic of evil and its bearing on religious belief. Through both general and specific examinations of the problem of evil, this book proposes new directions for philosophical thought.

[...]the author connects the various texts systematically by setting each into dialogue with the others and by comparing and contrasting their various positions on central issues in the discipline. [...]the text illuminates difficult and sometimes quite technical philosophy in digestible and accessible terms and is highly recommended as a supplementary text for a course or seminar in philosophy of language.

Metastatic DNA mismatch repair-deficient (dMMR)/microsatellite instability-high (MSI-H) colorectal cancer has a poor prognosis after treatment with conventional chemotherapy and exhibits high levels of tumour neoantigens, tumour-infiltrating lymphocytes, and checkpoint regulators. All of these features are associated with the response to PD-1 blockade in other tumour types. Therefore, we aimed to study nivolumab, a PD-1 immune checkpoint inhibitor, in patients with dMMR/MSI-H metastatic colorectal cancer. In this ongoing, multicentre, open-label, phase 2 trial, we enrolled adults (aged ≥18 years) with histologically confirmed recurrent or metastatic colorectal cancer locally assessed as dMMR/MSI-H from 31 sites (academic centres and hospitals) in eight countries (Australia, Belgium, Canada, France, Ireland, Italy, Spain, and the USA). Eligible patients had progressed on or after, or been intolerant of, at least one previous line of treatment, including a fluoropyrimidine and oxaliplatin or irinotecan. Patients were given 3 mg/kg nivolumab every 2 weeks until disease progression, death, unacceptable toxic effects, or withdrawal from study. The primary endpoint was investigator-assessed objective response as per Response Evaluation Criteria in Solid Tumors (version 1.1). All patients who received at least one dose of study drug were included in all analyses. This trial is registered with ClinicalTrials.gov, number NCT02060188. Of the 74 patients who were enrolled between March 12, 2014, and March 16, 2016, 40 (54%) had received three or more previous treatments. At a median follow-up of 12·0 months (IQR 8·6–18·0), 23 (31·1%, 95% CI 20·8–42·9) of 74 patients achieved an investigator-assessed objective response and 51 (69%, 57–79) patients had disease control for 12 weeks or longer. Median duration of response was not yet reached; all responders were alive, and eight had responses lasting 12 months or longer (Kaplan-Meier 12-month estimate 86%, 95% CI 62–95). The most common grade 3 or 4 drug-related adverse events were increased concentrations of lipase (six [8%]) and amylase (two [3%]). 23 (31%) patients died during the study; none of these deaths were deemed to be treatment related by the investigator. Nivolumab provided durable responses and disease control in pre-treated patients with dMMR/MSI-H metastatic colorectal cancer, and could be a new treatment option for these patients. Bristol-Myers Squibb.

A bstract We consider the possibility that small black holes can act as nucleation seeds for the decay of a metastable vacuum, focussing particularly on the Higgs potential. Using a thin-wall bubble approximation for the nucleation process, which is possible when generic quantum gravity corrections are added to the Higgs potential, we show that primordial black holes can stimulate vacuum decay. We demonstrate that for suitable parameter ranges, the vacuum decay process dominates over the Hawking evaporation process. Finally, we comment on the application of these results to vacuum decay seeded by black holes produced in particle collisions.