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"Mott, Tony"
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1001 video games you must play before you die
Gaming magazine authors from around the globe present a chronological yet qualitative history of the video game, with insight into the development, popularity, and influence of games that can't be missed.
Book
The List: Five most influential video games
With its N64 hardware, Nintendo introduced the analogue joystick to console gaming - a slight touch would result in the company's mascot Mario walking in the appropriate direction, while pushing it to its farthest extent would see the pudgy hero break...
Newspaper Article
A FAMILY AFFAIR
Or, where have I see that game before? traces the roots of console shoot-'em-ups back to the C64 and wonders if things have changed much…
Magazine Article
Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9
Specific modifications to histones are essential epigenetic markers
1
—heritable changes in gene expression that do not affect the DNA sequence. Methylation of lysine 9 in histone H3 is recognized by heterochromatin protein 1 (HP1), which directs the binding of other proteins to control chromatin structure and gene expression
2
,
3
,
4
. Here we show that HP1 uses an induced-fit mechanism for recognition of this modification, as revealed by the structure of its chromodomain bound to a histone H3 peptide dimethylated at N
ζ
of lysine 9. The binding pocket for the
N
-methyl groups is provided by three aromatic side chains, Tyr 21, Trp 42 and Phe 45, which reside in two regions that become ordered on binding of the peptide. The side chain of Lys 9 is almost fully extended and surrounded by residues that are conserved in many other chromodomains. The QTAR peptide sequence preceding Lys 9 makes most of the additional interactions with the chromodomain, with HP1 residues Val 23, Leu 40, Trp 42, Leu 58 and Cys 60 appearing to be a major determinant of specificity by binding the key buried Ala 7. These findings predict which other chromodomains will bind methylated proteins and suggest a motif that they recognize.
Journal Article
Integrating consumer engagement in health and medical research – an Australian framework
Background
Quality practice of consumer engagement is still in its infancy in many sectors of medical research. The South Australian Health and Medical Research Institute (SAHMRI) identified, early in its development, the opportunity to integrate evidence-driven consumer and community engagement into its operations.
Process
SAHMRI partnered with Health Consumers Alliance and consumers in evidence generation. A Partnership Steering Committee of researchers and consumers was formed for the project. An iterative mixed-method qualitative process was used to generate a framework for consumer engagement. This process included a literature review followed by semi-structured interviews with experts in consumer engagement and lead medical researchers, group discussions and a consensus workshop with the Partnership Steering Committee, facilitated by Health Consumer Alliance.
Outcomes
The literature revealed a dearth of evidence about effective consumer engagement methodologies. Four organisational dimensions are reported to contribute to success, namely governance, infrastructure, capacity and advocacy. Key themes identified through the stakeholder interviews included sustained leadership, tangible benefits, engagement strategies should be varied, resourcing, a moral dimension, and challenges. The consensus workshop produced a framework and tangible strategies.
Conclusion
Comprehensive examples of consumer participation in health and medical research are limited. There are few documented studies of what techniques are effective. This evidence-driven framework, developed in collaboration with consumers, is being integrated in a health and medical research institute with diverse programs of research. This framework is offered as a contribution to the evidence base around meaningful consumer engagement and as a template for other research institutions to utilise.
Journal Article
