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Directing attention to racial ignorance as a core dimension of racialized social systems, this article advances a process-focused Theory of Racial Ignorance (TRI), grounded in Critical Race Theory and the philosophical construct white ignorance. TRI embodies five tenets—epistemology of ignorance, ignorance as ends-based technology, corporate white agency, centrality of praxis, and interest convergence. TRI’s tenets explain how racial ignorance reinforces white domination, attending to mechanisms of white knowledge evasion and resistance that facilitate racial reproduction—in everyday life, through institutions, and across societies more broadly. I illustrate TRI’s assets by comparison to an extant theory of racial cognition—color-blind theory (CBT). I argue TRI generates returns by shifting from racial ideology to racial ignorance, and from era-defined structures to ongoing historical processes; and demonstrate TRI’s unique capacity to explain and predict changes in dominant logics, supporting more strategic resistance.

Many analysts argue colorblindness as the reigning ideological buttress of a historically distinct form of structural white supremacy, color-blind racism. In contrast to slavery and legal segregation, color-blind racism is theorized as covert and highly institutionalized. As such, analyses of contemporary racial reproduction often emphasize the structure of colorblindness, particularly the habitual routines and discursive patterns of everyday white actors. Though invaluable, this work may conceal whites’ innovation in reproducing, revising, and at times resisting white supremacy and corresponding logics. As opposed to focusing on the structural elements of colorblindness, I elevate colorblindness as a culturally recursive accomplishment grounded in an epistemology of ignorance—that is a process of knowing designed to produce not knowing surrounding white privilege and structural white supremacy. Qualitatively analyzing 105 family wealth analyses produced by white college undergraduates researching racial inequality and the wealth gap, I identify four epistemic maneuvers by which students creatively repaired a breach in normative colorblindness. Demonstrating innovative means by which ordinary whites bypass and mystify racial learning highlights their vested commitment to maintaining and creatively defending the ideologies that buttress racial domination and white supremacy. As such, this research additionally advises updating strategies for challenging whites’ colorblindness in efforts to advance racial justice.

People often reject creative ideas, even when espousing creativity as a desired goal. To explain this paradox, we propose that people can hold a bias against creativity that is not necessarily overt and that is activated when people experience a motivation to reduce uncertainty. In two experiments, we manipulated uncertainty using different methods, including an uncertaintyreduction prime. The results of both experiments demonstrated the existence of a negative bias against creativity (relative to practicality) when participants experienced uncertainty. Furthermore, this bias against creativity interfered with participants' ability to recognize a creative idea. These results reveal a concealed barrier that creative actors may face as they attempt to gain acceptance for their novel ideas.

A damning investigation of dark money by a senior member of the Senate Judiciary Committee (Kirkus Reviews) with a new preface on recent disclosures about efforts to influence the Court Theres no senator I can think of whos done more sleuthing to figure out the money trail in American politics, particularly as it affects the courts.Jane Mayer, author of the national bestseller Dark Money As the story of Supreme Court malfeasance and ethics violations repeatedly makes front-page news, the paperback version ofThe Schemecomes at a time of crisis for the American judiciary. Following his book Captured on corporate capture of regulatory and government agencies, and his years of experience as a prosecutor, Senator Sheldon Whitehouse, whom Senator Elizabeth Warren calls a a powerful voice in defending our American democracy against the relentless, pervasiveand often hiddenpower of corporate special interests, here turns his attention to the right-wing scheme to capture the United States Supreme Court. Whitehouse chronicles a hidden-money campaign using an armada of front groups, helped by the infamousCitizens UnitedSupreme Court decision, employing the Federalist Society as an appointments turnstile, and with the same small handful of right-wing billionaires and corporations enticing the Senate to break rules, norms, and precedents to confirm wildly inappropriate nominees who would advance their anti-government agenda. Now available in an affordable paperback edition with a new preface addressing the Reverend Schenck disclosures about politicking the justices and Justice Thomass recently disclosed conflicts of interest,The Schemeoffers whatKirkus Reviewscalls a maddening indictment of a corrupt and corrupted judiciary.

Bedside imaging of ventilation and perfusion is a leading application of 2-D medical electrical impedance tomography (EIT), in which dynamic cross-sectional images of the torso are created by numerically solving the inverse problem of computing the conductivity from voltage measurements arising on electrodes due to currents applied on electrodes on the surface. Methods of reconstruction may be direct or iterative. Calderón’s method is a direct reconstruction method based on complex geometrical optics solutions to Laplace’s equation capable of providing real-time reconstructions in a region of interest. In this paper, the importance of accurate modeling of the electrode location on the body is demonstrated on simulated and experimental data, and a method of including a priori spatial information in dynamic human subject data is presented. The results of accurate electrode modeling and a spatial prior are shown to improve detection of inhomogeneities not included in the prior and to improve the resolution of ventilation and perfusion images in a human subject.

Douglas Levine and colleagues identify recurrent inactivating mutations in the SWI/SNF complex member SMARCA4 in 12 of 12 samples of small cell carcinoma of the ovary, hypercalcemic type. These findings open the door for the development of targeted therapies to treat this rare but deadly cancer. Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare, highly aggressive form of ovarian cancer primarily diagnosed in young women. We identified inactivating biallelic SMARCA4 mutations in 100% of the 12 SCCOHT tumors examined. Protein studies confirmed loss of SMARCA4 expression, suggesting a key role for the SWI/SNF chromatin-remodeling complex in SCCOHT.

International human rights law and international humanitarian law (IHL) contain few obligations for rebel groups, yet those groups are nonetheless under pressure to comply with their foundational international norms. This case study of the Kosovo Liberation Army (KLA) analyzes the evolution of its discourse and behavior related to human rights and IHL. It then compares changes in the group’s discourse to evidence of changes in behavior. The study finds that the KLA does significantly change its language, gradually incorporating such language over time, but it also demonstrates that this change is not accompanied by improvements in human rights and IHL adherence in its behavior. The study considers whether greater adoption of these norms is better explained by a constructivist or a rationalist approach and, in particular, looks at the role of legitimacy. In addition, it offers insight into how groups may respond to future pressure to follow these norms.

In this video, we review the steps of uterine transposition, emphasizing robotic trocar placement and docking, how to optimize organ manipulation and tissue handling, and our pearls for successful perioperative management. The patient is a 27-year-old woman with T2 node-positive rectal cancer. Uterine transposition is a new surgical procedure with limited information regarding outcomes. Although evolving over time, we present our preferred patient selection criteria and identify key stakeholders, which include colorectal surgeons, radiation oncologists, fertility specialists, social workers, and radiologists.

Obesity is the foremost risk factor in the development of endometrial cancer (EC). However, the impact of obesity on the response to immune checkpoint inhibitors (ICI) in EC remains poorly understood. This retrospective study investigates the association between body mass index (BMI), body fat distribution, and clinical and molecular characteristics of EC patients treated with ICI. We analyzed progression-free survival (PFS) and overall survival (OS) in EC patients treated with ICI, categorized by BMI, fat mass distribution, and molecular subtypes. Incidence of immune-related adverse events (irAE) after ICI was also assessed based on BMI status. 524 EC patients were included in the study. Overweight and obese patients exhibited a significantly prolonged PFS and OS compared to normal BMI patients after treatment with ICI. Multivariable Cox regression analysis confirmed the independent association of overweight and obesity with improved PFS and OS. Elevated visceral adipose tissue (VAT) was identified as a strong independent predictor for improved PFS to ICI. Associations between obesity and OS/PFS were particularly significant in the copy number-high/TP53abnormal (CN-H/TP53abn) EC molecular subtype. Finally, obese patients demonstrated a higher irAE rate compared to normal BMI individuals. Obesity is associated with improved outcomes to ICI in EC patients and a higher rate of irAEs. This association is more pronounced in the CN-H/TP53abn EC molecular subtype. NIH/NCI Cancer Center Support Grant P30CA008748 (MSK). K08CA266740 and MSK Gerstner Physician Scholars Program (J.C.O). RUCCTS Grant #UL1 TR001866 (N.G-B and C.S.J). Cycle for survival and Breast Cancer Research Foundation grants (B.W).

Viruses are the most common biological entities in the marine environment. There has not been a global survey of these viruses, and consequently, it is not known what types of viruses are in Earth's oceans or how they are distributed. Metagenomic analyses of 184 viral assemblages collected over a decade and representing 68 sites in four major oceanic regions showed that most of the viral sequences were not similar to those in the current databases. There was a distinct \"marine-ness\" quality to the viral assemblages. Global diversity was very high, presumably several hundred thousand of species, and regional richness varied on a North-South latitudinal gradient. The marine regions had different assemblages of viruses. Cyanophages and a newly discovered clade of single-stranded DNA phages dominated the Sargasso Sea sample, whereas prophage-like sequences were most common in the Arctic. However most viral species were found to be widespread. With a majority of shared species between oceanic regions, most of the differences between viral assemblages seemed to be explained by variation in the occurrence of the most common viral species and not by exclusion of different viral genomes. These results support the idea that viruses are widely dispersed and that local environmental conditions enrich for certain viral types through selective pressure.