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This study aims to analyze the effects of exercise on the mass and function of pancreatic beta cells. This type of systematic review research uses searches from journal databases such as Science Direct, Pubmed, and Web of Science. The inclusion criteria for this study are studies that discuss the hormone insulin, pancreatic beta cells, diabetes mellitus, and physical activity published in the last five years (2018-2023). The exclusion criteria for this research are publications published in non-reputable journals or not indexed by Scopus and Web of Science.Article titles, abstracts, and complete texts were vetted, confirmed, and entered into Mendeley software. 10 articles that met the inclusion criteria were selected and analyzed for this systematic review. This systematic review study's findings indicate that enhancing the mass and functionality of pancreatic beta cells led to by physical exercise can increase the sensitivity of the action of the hormone insulin. This has an influence on the maintenance of the pancreas organ, especially beta cells which work to maintain blood glucose balance in the body by secreting the hormone insulin. We recommend that physical exercise be a preventive effort for each individual to maintain the body to care for one of the organs that is very important in blood glucose balance, namely the pancreas by increasing the size and functionality of beta cells in the pancreas. And maintain general body health.

Introduction: Increased levels of TNF-a in the blood after exercise can cause muscle pain. Objective: This study aims to analyze the potential of sea cucumber phytochemical compounds in reducing TNF-a levels after exercise. Methodology: This type of research is experimental research. Subject selection was carried out using the purposive sampling method. Next, the subjects were divided into two groups, namely the treatment group (K1) received sea cucumbers, and the control group (K2) received placebo. Sea cucumber is given in supplementation form at a dose of 500 mg. This study involved 16 healthy guys. The study's participants were between the ages of 20 and 25. Three days were dedicated to data collection, starting with the collection of information on the subjects' characteristics. Subjects were then instructed to warm up. Practice is done afterwards. The exercises carried out include weight training with maximum intensity. 24 hours after exercise, blood was taken for pre-test data to measure TNF-a levels. Then the samples were given placebo intervention and sea cucumber supplements based on their respective groups. 48 hours after exercise, blood was taken for post test data to measure TNF-a levels. Results: The results showed that sea cucumber supplementation after exercise was shown to significantly reduce TNF-α levels in healthy men p<0.05*. Discussion: The anti-inflammatory properties of sea cucumber can have a positive impact in reducing TNF-α levels after exercise. Conclusions: Sea cucumber supplementation at a dose of 500 mg was able to reduce TNF-α levels significantly. We recommend investigating the effect of sea cucumber supplementation on IL-6 levels in the future.

Introduction: Increased levels of TNF-a in the blood after exercise can cause muscle pain. Objective: This study aims to analyze the potential of sea cucumber phytochemical compounds in reducing TNF-a levels after exercise. Methodology: This type of research is experimental research. Subject selection was carried out using the purposive sampling method. Next, the subjects were divided into two groups, namely the treatment group (K1) received sea cucumbers, and the control group (K2) received placebo. Sea cucumber is given in supplementation form at a dose of 500 mg. This study involved 16 healthy guys. The study's participants were between the ages of 20 and 25. Three days were dedicated to data collection, starting with the collection of information on the subjects' characteristics. Subjects were then instructed to warm up. Practice is done afterwards. The exercises carried out include weight training with maximum intensity. 24 hours after exercise, blood was taken for pre-test data to measure TNF-a levels. Then the samples were given placebo intervention and sea cucumber supplements based on their respective groups. 48 hours after exercise, blood was taken for post test data to measure TNF-a levels. Results: The results showed that sea cucumber supplementation after exercise was shown to significantly reduce TNF-α levels in healthy men p<0.05*. Discussion: The anti-inflammatory properties of sea cucumber can have a positive impact in reducing TNF-α levels after exercise. Conclusions: Sea cucumber supplementation at a dose of 500 mg was able to reduce TNF-α levels significantly. We recommend investigating the effect of sea cucumber supplementation on IL-6 levels in the future.

The purpose of this study was to analyze and prove the effect of curcumin on TNF-a levels, and pain intensity after high-intensity physical exercise. This experimental research uses pre and post control group design. Research subjects were selected using random sampling technique. Next, the subjects were divided into 2 groups, K1 given placebo and K2 was given curcumin at a dose of 400 mg. A total of 20 healthy men participated in this study who were selected based on inclusion and exclusion criteria. On the first day, all subjects collected data on the characteristics of the research subjects, then did a warm-up, and then the subjects did physical exercises in the form of squad exercises and leg presses with an intensity of 80-90% of their maximum ability. Exercise is done 4 sets of each form of exercise and rest between sets of about 1 minute. The second day, after 24 hours post-exercise, all subjects measured pain intensity and took pre-test blood samples to measure TNF-a levels, then administer interventions based on each group. Pain intensity was measured using a VAS. On the third day, after 48 hours post-exercise, all subjects measured pain intensity and took post-test blood samples to measure TNF-a levels. The results of this study reported that the group that was given curcumin after high-intensity physical exercise was able to significantly reduce levels of TNF-a, and pain intensity (*p<0.05) compared to the placebo group. Giving a dose of 400 mg of curcumin after high-intensity physical exercise can reduce TNF-a levels and pain intensity after high-intensity physical exercise. Because reduction in pain intensity after high-intensity exercise is necessary to support body function, we recommend the use of curcumin for individuals who actively exercise. For future studies, we suggest testing the effects of curcumin on other inflammatory biomarkers.

This study aims to analyze and highlight the potential of citrus limon in reducing inflammation and oxydatif stress after physical activity/exercise. This study uses a systematic review method by searching various journal databases such as Scopus, Web of Science, Pubmed, and Embase. The inclusion criteria in this study were articles published within the last 5 years and articles discussing Limon, Inflammation, Free Radicals, and physical exercise. Exclusion criteria in this study were articles published in disreputable journals. A total of 1665 articles from Scopus, Web of Science Pubmed and Embase databases were identified. A total of 7 articles that met the inclusion criteria were selected and analyzed for this systematic review. For standard operations, this study follows the Preferred Reporting Items for Systematic review and Meta-Analyses (PRISMA) assessment. The results of this systematic research review report that the flavanoid content found in citrus limon has anti-oxidant properties that can reduce oxidative stress. Furthermore, the anti-inflammatory properties of citrus limon can reduce uncontrolled inflammation due to physical activity and intense exercise. In this case, citrus limon works by inhibiting inflammation through NF-kB signaling and reducing inflammation by suppressing the secretion of pro-inflammatory cytokines such as TNF-a. Reducing inflammation can potentially reduce the intensity of muscle pain. We recommend that citrus limon be used in individuals to reduce oxidative stress and inflammation caused by physical activity and intense exercise.

This study aims to analyze and highlight the potential of citrus limon in reducing inflammation and oxydatif stress after physical activity/exercise. This study uses a systematic review method by searching various journal databases such as Scopus, Web of Science, Pubmed, and Embase. The inclusion criteria in this study were articles published within the last 5 years and articles discussing Limon, Inflammation, Free Radicals, and physical exercise. Exclusion criteria in this study were articles published in disreputable journals. A total of 1665 articles from Scopus, Web of Science Pubmed and Embase databases were identified. A total of 7 articles that met the inclusion criteria were selected and analyzed for this systematic review. For standard operations, this study follows the Preferred Reporting Items for Systematic review and Meta-Analyses (PRISMA) assessment. The results of this systematic research review report that the flavanoid content found in citrus limon has anti-oxidant properties that can reduce oxidative stress. Furthermore, the anti-inflammatory properties of citrus limon can reduce uncontrolled inflammation due to physical activity and intense exercise. In this case, citrus limon works by inhibiting inflammation through NF-kB signaling and reducing inflammation by suppressing the secretion of pro-inflammatory cytokines such as TNF-a. Reducing inflammation can potentially reduce the intensity of muscle pain. We recommend that citrus limon be used in individuals to reduce oxidative stress and inflammation caused by physical activity and intense exercise. Keywords: Citrus Limon; Oxydative Stress; Inflammation; Physical training; Healthy Lifestyle