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Pluto's twin is out in the cold Four trans-Neptunian objects are currently recognized as dwarf planets: Eris, Haumea, Makemake and Pluto. Of these, the 'demoted' planet Pluto has been studied for many years and has a detected atmosphere. The others are difficult to observe because of their extreme distance from the Sun, but a stellar occultation event on 6 November 2010 provided an opportunity for a closer look at Eris. The data obtained reveal Eris as a 'twin' for Pluto in terms of size, and previous work showed the two to have similar surface compositions. Eris, however, has no detectable atmosphere and its surface is bright, possibly a result of atmospheric collapse in an extremely cold environment. The dwarf planet Eris is a trans-Neptunian object with an orbital eccentricity of 0.44, an inclination of 44 degrees and a surface composition very similar to that of Pluto 1 . It resides at present at 95.7 astronomical units (1  au is the Earth-Sun distance) from Earth, near its aphelion and more than three times farther than Pluto. Owing to this great distance, measuring its size or detecting a putative atmosphere is difficult. Here we report the observation of a multi-chord stellar occultation by Eris on 6 November 2010 ut . The event is consistent with a spherical shape for Eris, with radius 1,163 ± 6 kilometres, density 2.52 ± 0.05 grams per cm 3 and a high visible geometric albedo, . No nitrogen, argon or methane atmospheres are detected with surface pressure larger than ∼1 nanobar, about 10,000 times more tenuous than Pluto's present atmosphere 2 , 3 , 4 , 5 . As Pluto's radius is estimated 3 , 4 , 5 , 6 , 7 , 8 to be between 1,150 and 1,200 kilometres, Eris appears as a Pluto twin, with a bright surface possibly caused by a collapsed atmosphere, owing to its cold environment. We anticipate that this atmosphere may periodically sublimate as Eris approaches its perihelion, at 37.8 astronomical units from the Sun.

Aims. In this work, we present an extended study of the dust environment of a sample of short period comets and their dynamical history. With this aim, we characterized the dust tails when the comets are active, and we made a statistical study to determine their dynamical evolution. The targets selected were 22P/Kopff, 30P/Reinmuth 1, 78P/Gehrels 2, 115P/Maury, 118P/Shoemaker-Levy 4, 123P/West-Hartley, 157P/Tritton, 185/Petriew, and P/2011 W2 (Rinner). Methods. We use two different observational data: a set of images taken at the Observatorio de Sierra Nevada and the Afrho curves provided by the amateur astronomical association Cometas-Obs. To model these observations, we use our Monte Carlo dust tail code. From this analysis, we derive the dust parameters, which best describe the dust environment: dust loss rates, ejection velocities, and size distribution of particles. On the other hand, we use a numerical integrator to study the dynamical history of the comets, which allows us to determine with a 90% of confidence level the time spent by these objects in the region of Jupiter Family Comets. Results. From the Monte Carlo dust tail code, we derived three categories attending to the amount of dust emitted: Weakly active (115P, 157P, and Rinner), moderately active (30P, 123P, and 185P), and highly active (22P, 78P, and 118P). The dynamical studies showed that the comets of this sample are young in the Jupiter Family region, where the youngest ones are 22P (100 yr), 78P (500 yr), and 118P (600 yr). The study points to a certain correlation between comet activity and time spent in the Jupiter Family region, although this trend is not always fulfilled. The largest particle sizes are not tightly constrained, so that the total dust mass derived should be regarded as lower limits.}

Sil (SCL interrupting locus) was cloned from the most common chromosomal rearrangement in T-cell acute lymphoblastic leukemia. It is an immediate early gene whose expression is associated with cell proliferation. Sil protein levels are tightly regulated during the cell cycle, reaching peak levels in mitosis and disappearing on transition to G1. A recent study found Sil to be one of 17 genes whose overexpression in primary adenocarcinomas predicts metastatic spread. We hypothesized that Sil might have a role in carcinogenesis. To address this question, we utilized several approaches. Using a multitumor tissue array, we found that Sil protein expression was increased mostly in lung cancer, but also at lower levels, in a subset of other tumors. Microarray gene expression analysis and immunohistochemistry of lung cancer samples verified these observations. Sil gene expression in lung cancer correlated with the expression of several kinetochore check-point genes and with the histopathologic mitotic index. These observations suggest that overexpression of the Sil gene characterizes tumors with increased mitotic activity.