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Targeted protein degraders crowd into the clinic
At least 15 targeted degraders — from heterobifunctional PROTACs to molecular glues — should be in patients by the end of the year.At least 15 targeted degraders — from heterobifunctional PROTACs to molecular glues — should be in patients by the end of the year.
Journal Article
FDA approves 100th monoclonal antibody product
Thirty-five years on from the FDA’s approval of a first monoclonal antibody, these biologics account for nearly a fifth of the agency’s new drug approvals each year.Thirty-five years on from the FDA’s approval of a first monoclonal antibody, these biologics account for nearly a fifth of the agency’s new drug approvals each year.
Journal Article
2018 FDA drug approvals
The FDA approved a record 59 drugs last year, but the commercial potential of these drugs is lacklustre.The FDA approved a record 59 drugs last year, but the commercial potential of these drugs is lacklustre.
Journal Article
2023 FDA approvals
The FDA approved 55 novel therapeutics in 2023, the second highest count in the past 30 years.The FDA approved 55 novel therapeutics in 2023, the second highest count in the past 30 years.
Journal Article
2020 FDA drug approvals
The FDA approved 53 novel drugs in 2020, the second highest count in over 20 years.The FDA approved 53 novel drugs in 2020, the second highest count in over 20 years.
Journal Article
2021 FDA approvals
The FDA approved 50 novel drugs in 2021, including the first KRAS inhibitor for cancer and the first anti-amyloid antibody for Alzheimer’s disease.The FDA approved 50 novel drugs in 2021, including the first KRAS inhibitor for cancer and the first anti-amyloid antibody for Alzheimer’s disease.
Journal Article
2022 FDA approvals
The FDA approved 37 novel drugs in 2022, the fewest to pass regulatory scrutiny since 2016.The FDA approved 37 novel drugs in 2022, the fewest to pass regulatory scrutiny since 2016.
Journal Article
2019 FDA drug approvals
The FDA approved 48 new drugs last year, keeping up the momentum of recent years.The FDA approved 48 new drugs last year, keeping up the momentum of recent years.
Journal Article
Addressing cancer’s grand challenges
The National Cancer Institute and Cancer Research UK’s US$380 million “Cancer Grand Challenges” programme highlights understudied knowledge gaps that could yet make big differences to patients.The National Cancer Institute and Cancer Research UK’s US$380 million “Cancer Grand Challenges” programme highlights understudied knowledge gaps that could yet make big differences to patients.
Journal Article