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"Murphy, Matt"
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Batman : white knight
\"The impossible has happened: the Joker has become ... sane. Now calling himself Gotham's newest protector, the Joker now spearheads a task force to take down the dangerous masked vigilante known as Batman. Visionary creator Sean Murphy (Punk Rock Jesus, American Vampire) unveils his radical take on the greatest rivalry in comics in Batman: White Knight! After years of epic battles, the Dark Knight finally finds a way to cure the twisted mind of his archenemy. The Clown Prince of Crime has now changed his ways, fighting for good in Gotham City, and it may just cause Batman to go over the edge of his own sanity. Writer/artist Sean Murphy takes the helm of this Batman/Joker story like no one else could, delivering an alternative examination of the relationship between the greatest rivals in the DC Universe, exploring the darkest corners of justice and madness.\"-- Provided by publisher.
Book
An update on the distribution, bionomics, and insecticide susceptibility of Anopheles stephensi in Ethiopia, 2018–2020
Background
Anopheles stephensi
, an invasive malaria vector, was first detected in Africa nearly 10 years ago. After the initial finding in Djibouti, it has subsequently been found in Ethiopia, Sudan and Somalia. To better inform policies and vector control decisions, it is important to understand the distribution, bionomics, insecticide susceptibility, and transmission potential of
An. stephensi
. These aspects were studied as part of routine entomological monitoring in Ethiopia between 2018 and 2020.
Methods
Adult mosquitoes were collected using human landing collections, pyrethrum spray catches, CDC light traps, animal-baited tent traps, resting boxes, and manual aspiration from animal shelters. Larvae were collected using hand-held dippers. The source of blood in blood-fed mosquitoes and the presence of sporozoites was assessed through enzyme-linked immunosorbent assays (ELISA). Insecticide susceptibility was assessed for pyrethroids, organophosphates and carbamates.
Results
Adult
An. stephensi
were collected with aspiration, black resting boxes, and animal-baited traps collecting the highest numbers of mosquitoes. Although sampling efforts were geographically widespread,
An. stephensi
larvae were collected in urban and rural sites in eastern Ethiopia, but
An. stephensi
larvae were not found in western Ethiopian sites. Blood-meal analysis revealed a high proportion of blood meals that were taken from goats, and only a small proportion from humans.
Plasmodium vivax
was detected in wild-collected
An. stephensi
. High levels of insecticide resistance were detected to pyrethroids, carbamates and organophosphates. Pre-exposure to piperonyl butoxide increased susceptibility to pyrethroids. Larvae were found to be susceptible to temephos.
Conclusions
Understanding the bionomics, insecticide susceptibility and distribution of
An. stephensi
will improve the quality of a national response in Ethiopia and provide additional information on populations of this invasive species in Africa. Further work is needed to understand the role that
An. stephensi
will have in
Plasmodium
transmission and malaria case incidence. While additional data are being collected, national programmes can use the available data to formulate and operationalize national strategies against the threat of
An. stephensi
.
Journal Article
Batman : curse of the White Knight
\"Ancient curses are awoken and timeless secrets are revealed in this explosive sequel to the critically acclaimed blockbuster Batman: White Knight from writer/artist Sean Murphy! The Joker recruits Azrael to help him expose a shocking secret about the Wayne family's legacy--and run Gotham City into the ground! As Batman rushes to protect the city and his loved ones from danger, the mystery of his ancestry unravels and Batman begins to question everything he thought he knew about himself and his place in Gotham. With Gotham City's identity and institutions hanging in the balance, Barbara Gordon decides to take matters into her own hands -- but will her rogue actions play right into The Joker's plans? After tragedy strikes, Renee Montoya steps into the fray to lead the GTO and restore order to the chaos that is quickly consuming Gotham City.\"-- Provided by publisher
Book
Investigation of Plasmodium falciparum pfhrp2 and pfhrp3 gene deletions and performance of a rapid diagnostic test for identifying asymptomatic malaria infection in northern Ethiopia, 2015
Background
Rapid diagnostic tests (RDTs) are widely used for malaria diagnosis of both symptomatic and asymptomatic infections. Although RDTs are a reliable and practical diagnostic tool, the sensitivity of histidine-rich protein 2 (HRP2)-based RDTs can be reduced if
pfhrp2
or
pfhrp3
(
pfhrp2/3
) gene deletions exist in the
Plasmodium falciparum
parasite population. This study evaluated dried blood spot (DBS) samples collected from a national household survey to investigate the presence of
pfhrp2/3
deletions and the performance of the RDT used in the cross-sectional survey in a low transmission setting.
Methods
The 2015 Ethiopia Malaria Indicator Survey tested household members by RDT and collected DBS samples. DBS (n = 2648) from three regions in northern Ethiopia were tested by multiplex bead-based antigen detection assay after completion of the survey. The multiplex assay detected pan-
Plasmodium
lactate dehydrogenase (LDH), pAldolase, and HRP2 antigens in samples. Samples suspected for
pfhrp2/3
gene deletions (pLDH and/or pAldolase positive but low or absent HRP2) were further investigated by molecular assays for gene deletions. Antigen results were also compared to each individual’s RDT results. Dose–response logistic regression models were fit to estimate RDT level of detection (LOD) antigen concentrations at which 50, 75, 90, and 95% of the RDTs returned a positive result during this survey.
Results
Out of 2,648 samples assayed, 29 were positive for pLDH or pAldolase antigens but low or absent for HRP2 signal, and 15 of these samples (51.7%) were successfully genotyped for
pfhrp2/3
. Of these 15
P. falciparum
infections, eight showed single deletions in
pfhrp3,
one showed a single
pfhrp2
deletion, and six were
pfhrp2/3
double-deletions. Six
pfhrp2
deletions were observed in Tigray and one in Amhara. Twenty-five were positive for HRP2 by the survey RDT while the more sensitive bead assay detected 30 HRP2-positive samples. A lower concentration of HRP2 antigen generated a positive test result by RDT compared to pLDH (95% LOD: 16.9 ng/mL vs. 319.2 ng/mL, respectively).
Conclusions
There is evidence of dual
pfhrp2/3
gene deletions in the Tigray and Amhara regions of Ethiopia in 2015. As the prevalence of malaria was very low (< 2%), it is difficult to make strong conclusions on RDT performance, but these results challenge the utility of biomarkers in household surveys in very low transmission settings.
Journal Article
Weight of Evidence
In 1794 and 1799 Superintendent of Convicts Nicholas Devine was granted 210 acres on the edge of the current CBD of Sydney. After the demise of Governor Bligh (to whom he was closely allied) Devine reluctantly retired to his estate where, as an old man living alone, he was constantly beaten and robbed.
eBook
Negotiating Meaning Systems in Multi-stakeholder Partnerships Addressing Grand Challenges: Homelessness in Western Canada
While multi-stakeholder partnerships are emerging as an increasingly popular approach to address grand challenges, they are not well studied or understood. Such partnerships are rife with difficulties arising from the fact that actors in the partnership have different understandings of the grand challenge based on meaning systems which have distinct and often opposing assumptions, values, and practices. Each partnership actor brings with them their individual values as well as the values and work practices of their home organization’s culture, alongside the wider meaning systems present within the sectoral spaces in which each organization is situated—public, private, or nonprofit. Yet, there is little understanding of how actors in multi-stakeholder partnerships negotiate multi-level meaning systems to reach partnership goals. In this 16-month ethnographic study, we take up a negotiated culture perspective to holistically examine the negotiation of multi-level meaning related to a focal grand challenge in a multi-stakeholder partnership established to end homelessness in Western Canada. Based on our findings, we contribute a process model to explain the ongoing negotiation of multi-level meanings in multi-stakeholder partnerships working to address grand challenges.
Journal Article
Drinkable in situ-forming tough hydrogels for gastrointestinal therapeutics
Pills are a cornerstone of medicine but can be challenging to swallow. While liquid formulations are easier to ingest, they lack the capacity to localize therapeutics with excipients nor act as controlled release devices. Here we describe drug formulations based on liquid in situ-forming tough (LIFT) hydrogels that bridge the advantages of solid and liquid dosage forms. LIFT hydrogels form directly in the stomach through sequential ingestion of a crosslinker solution of calcium and dithiol crosslinkers, followed by a drug-containing polymer solution of alginate and four-arm poly(ethylene glycol)-maleimide. We show that LIFT hydrogels robustly form in the stomachs of live rats and pigs, and are mechanically tough, biocompatible and safely cleared after 24 h. LIFT hydrogels deliver a total drug dose comparable to unencapsulated drug in a controlled manner, and protect encapsulated therapeutic enzymes and bacteria from gastric acid-mediated deactivation. Overall, LIFT hydrogels may expand access to advanced therapeutics for patients with difficulty swallowing.
Sequential drinks of crosslinker and polymer solutions form a tough hydrogel in the stomach, enabling delivery of drugs and biologics in this harsh chemical environment.
Journal Article
