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The present study was simultaneously conducted in two distantly located areas to assess the impacts of COVID-19 on farming processes, instantaneous financial impacts and mitigation strategies adopted by the farmers in the small scale freshwater carp farming and coastal brackish water shrimp farming sectors in India. Primary data were collected through interview of the farmers with the help of pre-tested structured interview schedules. Though the initial impact in both the sectors were substantial, freshwater carp farmers mitigated the crises comparatively well because of wider option in alternative livelihood, low cost locally available inputs, mobilization of local market, direct door to door vending of live fish and mobilization of women work force from the family in the farming sector. Untapped resource in the form of women's' participation in the freshwater farming practices was noteworthy during the pandemic period which increased polynomially ( y   =  –1.0714 x 2  + 7.5286 x − 2.2; R 2  = 0.9648). As the shrimp farming sector was dependent upon external markets and burdened with high cost inputs primarily supplied by the input dealers on credit basis, the sector has to bear the burden most. Garret's Rank analysis revealed that integration with other production sectors ranked first as mitigation perception to the freshwater carp farmers, whereas, to the coastal shrimp farmers, the highest rank was with the perception that everything will be normalized within 2–3 months naturally. Garret's Rank analysis also revealed that in both the sectors, the farmers most important need was credit from the Govt. source in mitigating COVID-19 like crisis in future.

Multidrug-resistant bacterial pathogen has emerged as a significant global health challenge, underscoring the urgent need to identify and develop alternative therapeutic agents including plant natural products. In this study, the extract from plant extract was analyzed for antibacterial properties against and component composition. The plant extract was obtained from leaves of and its antibacterial activity against was determined in Kirby-Bauer disc diffusion assay. In this assay, the activity of the extract was tested at two different concentrations of 50 and 100 μg/mL. The minimum inhibitory concentration (MIC) of the extract against was used with its MIC values against Vero cells to determine the selectivity index. GC-MS determined the phytochemical composition of the plant extract. The property of different extract components to bind the target receptor Penicillin Binding Protein 2a (7KIS) was assessed studies including docking and molecular dynamics (MD) analyses. In these analyses, the stability and interaction dynamics of the Penicillin Binding Protein 2a (7KIS) protein complexed with selected extract components. The plant extracts had antibacterial activity against , with inhibition zones measuring 13 mm and 19 mm for 50 and 100 μg/mL concentrations, respectively. The MIC of the plant extract was determined to be 20 μg/mL, while its selectivity index was 4.54, indicating its antibiotic potential. One extract component, 2, 4-di-tert-butylphenol compound holds a binding affinity of -6.2 kcal/mol in molecular docking studies. MD simulations revealed stable binding interactions between the 7KIS protein and the tested ligands, characterized by reduced atomic fluctuations and energetically favorable binding profiles. This study showed that extract has a robust antibacterial potential against . Furthermore, GC-MS profiling molecular docking, and dynamic simulation data showed that such antibacterial potential might be attributed to its one component, 2, 4-di-tert-butylphenol. Further, and studies are needed to show the applicability of bioactive compounds from in combating resistant bacterial pathogens.

Disordered superconductors offer new impedance regimes for quantum circuits, enable a pathway to protected qubits, and can improve superconducting detectors due to their high kinetic inductance and sheet resistance. The performance of these devices can be limited, however, by quasiparticles—the fundamental excitations of a superconductor. While experiments have shown that disorder affects the relaxation of quasiparticles drastically, the microscopic mechanisms are still not understood. We address this issue by measuring quasiparticle relaxation in a disordered β -Ta film, which we pattern as the inductor of a microwave resonator. We observe that quasiparticle recombination is governed by the phonon scattering time, which is faster than conventional recombination in ordered superconductors. We interpret the results as recombination of localized quasiparticles, induced by disorder, which first delocalize via phonon absorption. We analyze quasiparticle relaxation measurements on superconductors with different degrees of disorder and conclude that this phenomenon is inherent to disordered superconductors. The authors study a disordered β -Ta film, finding that quasiparticle recombination is governed by the phonon scattering time, which is faster than conventional recombination in ordered superconductors. The authors interpret the results in terms of quasiparticle localization, which helps to understand the quasiparticle relaxation in disordered superconducting circuits.

Integrated superconducting spectrometer (ISS) technology will enable ultra-wideband, integral-field spectroscopy for (sub)millimeter-wave astronomy, in particular, for uncovering the dust-obscured cosmic star formation and galaxy evolution over cosmic time. Here, we present the development of DESHIMA 2.0, an ISS for ultra-wideband spectroscopy toward high-redshift galaxies. DESHIMA 2.0 is designed to observe the 220–440 GHz band in a single shot, corresponding to a redshift range of z  = 3.3–7.6 for the ionized carbon emission ([C II] 158  μ m). The first-light experiment of DESHIMA 1.0, using the 332–377 GHz band, has shown an excellent agreement among the on-sky measurements, the laboratory measurements, and the design. As a successor to DESHIMA 1.0, we plan the commissioning and the scientific observation campaign of DESHIMA 2.0 on the ASTE 10-m telescope in 2023. Ongoing upgrades for the full octave-bandwidth system include the wideband 347-channel chip design and the wideband quasi-optical system. For efficient measurements, we also develop the observation strategy using the mechanical fast sky-position chopper and the sky-noise removal technique based on a novel data-scientific approach. In the paper, we show the recent status of the upgrades and the plans for the scientific observation campaign.

We are developing an ultra-wideband spectroscopic instrument, DESHIMA (DEep Spectroscopic HIgh-redshift MApper), based on the technologies of an on-chip filter bank and microwave kinetic inductance detector (MKID) to investigate dusty starburst galaxies in the distant universe at millimeter and submillimeter wavelengths. An on-site experiment of DESHIMA was performed using the ASTE 10-m telescope. We established a responsivity model that converts frequency responses of the MKIDs to line-of-sight brightness temperature. We estimated two parameters of the responsivity model using a set of skydip data taken under various precipitable water vapor (PWV 0.4–3.0 mm) conditions for each MKID. The line-of-sight brightness temperature of sky is estimated using an atmospheric transmission model and the PWVs. As a result, we obtain an average temperature calibration uncertainty of 1 σ = 4 %, which is smaller than other photometric biases. In addition, the average forward efficiency of 0.88 in our responsivity model is consistent with the value expected from the geometrical support structure of the telescope. We also estimate line-of-sight PWVs of each skydip observation using the frequency response of MKIDs and confirm the consistency with PWVs reported by the Atacama Large Millimeter/submillimeter Array.

Introduction: Pain is an unavoidable squeal of orthodontic treatment and it is known to decrease patient compliance and eventually affects treatment results. Numerous methods are available in literature to manage orthodontic pain after activation but they have their own limitations. This has led to exploring further options for management of pain. Aim: The aim of this study was to evaluate the effectiveness of low-level laser therapy (LLLT) in alleviating orthodontic pain after activation. Materials and Methods: 20 subjects were randomly divided into an experimental and a control group. Each participant was given a retraction force of 200gm/cm2/side. Subjects in the experimental group were exposed to low-level laser light at 980nm and those in the control group were exposed to red LED light as placebo. The pain perceived after 0 hour, 1 hour, 3 hours, 48 hours, and 1 week of activation was recorded by patient using Visual Analog Scale. Statistical analysis was done using Mann-Whitney test. Results: Results of the study showed that pain experienced by the subjects after orthodontic activation was higher in experimental group at T0 than in placebo group. At T1, T2, T4, and T5, the pain experienced by the subjects was less in the experimental group compared to the placebo group. Pain experienced by the subjects in the experimental group at T3 was significantly less as compared to those in the placebo group. Conclusion: A single dose of LLLT at 980nm, 2.5 W/cm2, and 600 J is effective in relieving orthodontic pain after activation.

Purpose The purpose of this study is to understand experimentally the mixing characteristics of a two-stream exhaust system with a supersonic Mach 1.5 primary jet that exits the rectangular C-D nozzle surrounded by a sonic secondary jet from a convergent rectangular nozzle by varying the aspect ratio (AR = 2 and 3) similar to those that can be available for future high-speed commercial aircraft. Design/methodology/approach This paper focuses on the experimental results of effects of AR at various expansion levels of jets issued/delivered from a central rectangular convergent-divergent nozzle of AR 2 and 3 surrounded by a coflow from a convergent rectangular sonic nozzle. The lip thickness of the primary nozzle is 2.2 mm. various nozzle pressure ratios (NPRs) ranging from 2, 3, 3.69 and 4 were chosen for pressure measurements. Findings For all the NPRs, AR 3 had a shorter core than AR 2. Also, AR 3 was found to decay faster in the transition and fully developed zones. The lateral plots show that the AR has an influence on the jet spread. Originality/value The structure of waves existing in the potential core of the rectangular coflow jet along with the major and minor axis planes was visualized by the shadowgraph technique.

Ultra-wideband, three-dimensional (3D) imaging spectrometry in the millimeter–submillimeter (mm–submm) band is an essential tool for uncovering the dust-enshrouded portion of the cosmic history of star formation and galaxy evolution1–3. However, it is challenging to scale up conventional coherent heterodyne receivers4 or free-space diffraction techniques5 to sufficient bandwidths (≥1 octave) and numbers of spatial pixels2,3 (>102). Here, we present the design and astronomical spectra of an intrinsically scalable, integrated superconducting spectrometer6, which covers 332–377 GHz with a spectral resolution of F/ΔF ~ 380. It combines the multiplexing advantage of microwave kinetic inductance detectors (MKIDs)7 with planar superconducting filters for dispersing the signal in a single, small superconducting integrated circuit. We demonstrate the two key applications for an instrument of this type: as an efficient redshift machine and as a fast multi-line spectral mapper of extended areas. The line detection sensitivity is in excellent agreement with the instrument design and laboratory performance, reaching the atmospheric foreground photon noise limit on-sky. The design can be scaled to bandwidths in excess of an octave, spectral resolution up to a few thousand and frequencies up to ~1.1 THz. The miniature chip footprint of a few cm2 allows for compact multi-pixel spectral imagers, which would enable spectroscopic direct imaging and large-volume spectroscopic surveys that are several orders of magnitude faster than what is currently possible1–3.By using a superconducting integrated circuit to filter incoming millimetre, submillimetre and far-infrared light from distant galaxies, a prototype spectrometer holds promise for wideband spectrometers that are small, sensitive and scalable to wideband spectroscopic imagers.

Dystrophin of the dystrophin-glycoprotein complex connects the actin cytoskeleton to basement membranes and loss of dystrophin results in Duchenne muscular dystrophy. We have previously shown injury-induced neointima formation of the carotid artery in mice with the mdx mutation (causing dystrophin deficiency) to be increased. To investigate the role of dystrophin in intimal recruitment of smooth muscle cells (SMCs) that maintains plaque stability in atherosclerosis we applied a shear stress-modifying cast around the carotid artery of apolipoprotein E (ApoE)-null mice with and without the mdx mutation. The cast induces formation of atherosclerotic plaques of inflammatory and SMC-rich/fibrous phenotypes in regions of low and oscillatory shear stress, respectively. Unexpectedly, presence of the mdx mutation markedly reduced the development of the inflammatory low shear stress plaques. Further characterization of the low shear stress plaques in ApoE-null mdx mice demonstrated reduced infiltration of CD3 + T cells, less laminin and a higher SMC content. ApoE-null mdx mice were also found to have a reduced fraction of CD3 + T cells in the spleen and lower levels of cytokines and monocytes in the circulation. The present study is the first to demonstrate a role for dystrophin in atherosclerosis and unexpectedly shows that this primarily involves immune cells.

Background: Smooth muscle cells are important for atherosclerotic plaque stability. Their proper ability to communicate with the extracellular matrix is crucial for maintaining the correct tissue integrity. In this study, we have investigated the role of β-sarcoglycan within the matrix-binding dystrophin-glycoprotein complex in the development of atherosclerosis. Results: Atherosclerotic plaque development was significantly reduced in ApoE-deficient mice lacking β-sarcoglycan, and their plaques contained an increase in differentiated smooth muscle cells. ApoE-deficient mice lacking β-sarcoglycan showed a reduction in ovarian adipose tissue and adipocyte size, while the total weight of the animals was not significantly different. Western blot analysis of adipose tissues showed a decreased activation of protein kinase B, while that of AMP-activated kinase was increased in mice lacking β-sarcoglycan. Analysis of plasma in β-sarcoglycan-deficient mice revealed reduced levels of leptin, adiponectin, insulin, cholesterol, and triglycerides but increased levels of IL-6, IL-17, and TNF-α. Conclusions: Our results indicate that the dystrophin-glycoprotein complex and β-sarcoglycan can affect the atherosclerotic process. Furthermore, the results show the effects of β-sarcoglycan deficiency on adipose tissue and lipid metabolism, which may also have contributed to the atherosclerotic plaque reduction.