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Effectiveness of corona virus disease-19 (COVID-19) vaccines used in India is unexplored and need to be substantiated. The present case-control study was planned to elicit the effectiveness of COVID-19 vaccines in preventing infection and disease severity in the general population of Bihar, India. This case-control study was conducted among people aged ≥45 years during April to June 2021. The cases were the COVID-19 patients admitted or visited All India Institute of Medical Sciences (AIIMS), Patna, Bihar, India, and were contacted directly. The controls were the individuals tested negative for severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) at the Virology laboratory, AIIMS-Patna and contacted telephonically for collection of relevant information. The vaccine effectiveness (VE) was calculated by using the formula (VE = 1 – odds ratio). The adjusted VE for partial and full vaccination were estimated to be 52.0% (95% confidence interval (CI) 39.0–63.0%) and 83.0% (95% CI 73.0–89.0%) respectively for preventing SARS CoV-2 infection. The sub-group analyses of the cases have shown that the length of hospital stays (LOS) (partially vaccinated: 9 days vs. unvaccinated: 12 days; P = 0.028) and the severity of the disease (fully vaccinated: 30.3% vs. partially vaccinated: 51.3% and unvaccinated: 54.1%; P = 0.035) were significantly low among vaccinated compared to unvaccinated individuals. To conclude, four out of every five fully vaccinated individuals are estimated to be protected from contracting SARS CoV-2 infection. Vaccination lowered LOS and chances of development of severe disease.

Background: Early detection of cervical cancer can significantly reduce the associated morbidities and mortality. However, uptake of screening for cervical cancer in India is not encouraging. Objectives: To assess the awareness about cervical cancer, willingness, and barriers for undergoing screening of cervical cancer among women in urban Pondicherry. Methods: This cross-sectional study was conducted among women of 30-65 years in urban Pondicherry during January - July 2019. A total of 219 women, selected using two-stage random sampling, were interviewed using a pretested semi-structured questionnaire. Multistep multivariable logistic regression was done to identify the independent correlates of willingness to undergo screening for cervical cancers. Results: About one-third women were aware of cervical cancer. Awareness was more among women who were young, had higher education, had family history of cancer, and currently working. Awareness of risk factors, signs and symptoms of cancer cervix was low. Although 60% of the women, who have been aware of cervical cancer, were aware of possibility of early detection, <15% were aware of the various methods. 32% of the women were willing to undergo screening for cervical cancer, and occupation, family history of cancer, and knowledge about risk factors were found to be independent correlates. Fear and \"not having signs and symptoms\" were the major reasons for unwillingness. Conclusion: Level of awareness and willingness for undergoing screening of cervical cancer was low in study area. Targeted interventions for awareness and health system efforts for addressing the reasons behind unwillingness are required.

The World Health Organization (WHO) advocates for voluntary blood donation by healthy donors to ensure the availability of safe blood. India faces a significant gap between blood demand and supply for various acute and chronic conditions. This study assesses blood donation knowledge, attitudes, and practices, as well as the barriers affecting the willingness to donate blood and predictors of good knowledge and favorable attitudes toward blood donation among the rural adult population in Bihar. A community-based cross-sectional study was conducted from January to June 2023 in the Naubatpur block of Patna district, Bihar, involving 500 adults aged 18-59 years via a multistage sampling technique for the enrollment of participants. Data were collected via a pretested semistructured questionnaire. Descriptive and inferential statistics were used, and multivariable logistic regression was used to identify predictors of knowledge and attitude scores. Approximately 67.4% of the respondents were aware of blood donation, while 39.8% were aware of their blood group. Only 10.8% had donated blood, with 58.5% having donated only once. Nearly 29.08% had good knowledge regarding blood donation. Major barriers included no specific reason, perceived pain, and a fear of needles. In our study, nearly two out of three participants were aware of blood donation, but hardly one out of three was aware of their blood group. Only slightly more than one-fourth had good knowledge and a favorable attitude toward blood donation, while only one out of 10 had donated blood in the past. Despite good knowledge about blood donation, actual practices were low among the study population. Educational level significantly influences awareness and attitudes. Health education and periodic awareness programs are essential to dispel myths and promote voluntary blood donation in rural areas.

Background Adolescence is a crucial period for growth and dietary habit formation among females for leading a healthy life in future. Objective To assess the dietary habits and nutritional status using the body mass index (BMI) among adolescent girls from a rural village in Puducherry. Methodology This community-based cross-sectional study was conducted during February 2017 among 252 adolescent girls in rural Puducherry. A semi-structured pre-tested interview schedule was used to obtain information on socio-demographic details and dietary habits from adolescent girls. Height and weight were measured by standard techniques recommended by the World Health Organization (WHO). Nutritional status was assessed according to the WHO BMI for age for 5-19 years. Regular and occasional food consumption were defined as consumption of particular items >3 and <3 times a week, respectively. Results Mean age of the participants was 13.79 + 2.11 years and 91.3% were non-vegetarians. The majority of adolescent girls ate cereals (97.4%) and pulses (54%) regularly. However, regular vegetable (34.5%) and fruit (13.1%) consumption was low. Only about 10% and <2% had regular consumption of milk and iron-rich vegetables and fruits, respectively. Regular consumption of junk food items was found among 5.6%. Prevalence of thinness among adolescent girls was 10.7% (95% CI: 7.3-15) and overweight was 13.5% (95% CI: 9.7-18.1). Conclusion In this adolescent population, though consumption of cereals and pulses were adequate and satisfactory, the consumption of fruits, vegetables and iron/calcium rich foods was inadequate and poor. About one-fourth of adolescent girls had an abnormal nutritional status. Hence, focused nutritional and health-education intervention should be given to encourage the consumption of fruits and vegetables, iron-rich and calcium-rich food items.

This study was conducted to assess the quality of life (QOL) in children between 2 and 18 years of age with primary idiopathic nephrotic syndrome (NS) using Pediatric Quality of Life Inventory (PedsQL™ 4.0 Generic Core Scales). This cross-sectional comparative study was conducted at a tertiary care hospital in South India between December 2014 and February 2015. In this questionnaire-based study, 50 children with primary idiopathic NS and an equal number of age-matched controls with other chronic ailments were recruited. Their clinical and demographic details were recorded, and QOL was assessed using PedsQL™ 4.0 Generic Core Scales. The median (interquartile range) total QOL score in children with NS [65 (59–68.75)] was found to be higher compared to controls [62.19 (58.05–65.78)] (P = 0.012). Children with NS had significantly higher QOL scores in physical (P = 0.004), emotional (0.029), and social functioning (0.010) domains as compared to controls; however, the school performance was not different from controls. The QOL scores did not significantly differ between the various clinical phenotypes of NS. Demographic details such as age, gender, duration of illness, and steroid resistance did not significantly influence the total QOL scores among the nephrotic children. The present study shows that the overall QOL in children with NS was better than in children with other chronic illnesses. Further studies are needed to confirm these findings and explore the underlying cause of poor school performance.

Background Despite the increasing integration of competency-based education in medicine, there remains a significant gap in effectively assessing educational outcomes, underscoring the urgent need for designed assessment blueprints that accurately reflect both curriculum content and competency standards in Community Medicine for undergraduate students. This study, conducted across the All-India Institute of Medical Sciences (AIIMS) network, develops a summative assessment blueprint aimed at standardizing evaluations in medical education across diverse geographic locations in India. Methods Twenty-five experts from 10 All India Institutes of Medical Science were invited via email and contributed for summative assessment for a theory paper. Each week, the study lead team sent an online form containing 25 topics. A total of 269 topics were selected to be included in the blueprint development. An Impact and Frequency score was obtained for each topic, with a score between 1 and 3 for both its “Impact (I)” and “Frequency” (F). Results The overall response rate was 71%. “Principle of epidemiology” (14.7%) had the most weight, followed by “Epidemiology of communicable disease” (13.4%) and “National Health Program” (10%). These three chapters constituted more than one-third of the total weight of the summative assessment (theory). 20 out of 24 (83%) chapters have moderate-to-good interrater reliability. Conclusions The blueprint developed in this study is intended to serve as a guideline for setting question papers and aims to enhance objectivity, uniformity, and validity in assessment construction. While it provides a structured approach within the AIIMS network, its broader applicability may be limited, suggesting that its effectiveness in other educational contexts remains to be validated. Continued research is encouraged to explore its utility across diverse educational settings.

Background Community-based screening is one of the key preventive strategies to tackle the ever-rising burden of non-communicable diseases (NCDs) under the National Programme for Prevention & Control of Cancer, Diabetes, Cardiovascular Diseases and Stroke (NPCDCS). Objective The current study was aimed to build capacity among frontline health workers (FHWs) in screening for cardiovascular diseases (CVDs) under NPCDCS in the selected districts of Bihar state. Methodology This was an implementation study with follow-up components, conducted among 75 FHWs [14 auxiliary nurse midwives (ANMs) and 61 accredited social health activists (ASHAs)] from 15 primary healthcare facilities across four districts of Bihar state from October 2019 to September 2021. The selected FHWs were initially trained on NPCDCS for a day, including pre- and post-training knowledge assessment. Then, supportive supervision (SS) visits using a predesigned questionnaire were done. Results The pre- and post-training mean knowledge scores of the FHWs were 12.9 and 22.1, respectively, with an overall effect size of 2.5. During SS visits, only 20.0% of the visited primary healthcare facilities had all the required logistics to conduct weekly NCD screening clinics for CVDs. Considering different measurements and operative skill proficiencies of FHWs, waist circumference skills (41.7% for ANMs and 50.8% for ASHAs), followed by blood pressure (BP) (41.7%) and random blood sugar (RBS) measurement (25.0%), were found to be the most deficient skills (among ANMs). Moreover, the quality of initial and follow-up home visits was found to be satisfactory for only 54.1% of the ASHAs. The reported barriers of NCD screening were reported to be non-cooperation, unawareness among community dwellers, lack of knowledge and skill of FHWs, logistic constraints and delayed honorarium credit. Conclusion One-day training on NCDs for FHWs was quite effective. However, for translating all the desired skills for CVD screening into action, periodic training needs assessment, and SS of FHWs might be fruitful.

Background: In the behavioural change model for smoking cessation 'willingness to quit' forms the starting point. Identifying these sects of smokers who are willing to quit can lead to important policy development and program implementation in any country. To determine the prevalence and correlates of willingness to quit among smokers in India from Global Adult Tobacco Survey (GATS), 2009-10. Methods: Secondary data analysis of GATS, 2009-10 was done to find the correlates of willingness to quit among smokers. All the socio-demographic variables, smoking related factors like frequency, previous attempt to quit and also effect of anti-tobacco messages delivered to various media were tested for association using multivariate analysis. Prevalence rate ratio with 95% CI was used to report the risk. Results: Of the 9627 current smokers analysed, 50.9% (95% CI: 49.9% to 51.9%) were willing to quit smoking. Among these; 25.1% and 26.0% were willing to quit within the next month and within next 12 months respectively. Multivariate analysis showed that younger age, individuals who have their first smoke after 60 minutes of wakeup, those living in a house with smoking restriction, those who received advice to quit from doctor, those who attempted to quit in the past 12 months, having knowledge about illness caused due to smoking and those who have noticed anti-smoking messages in billboards / hoardings were willing to quit smoking compared to their counterparts. Conclusions: About one in two smokers were willing to quit smoking and, among those who were willing to quit, half of them were willing to do so within the next one year. Targeted interventions can be planned in the sub-groups identified.

Introduction: Knowledge on epidemiology of the disease in the contemporary world will help to develop appropriate strategies to curtail the transmission during an outbreak. This study was carried out during an outbreak of conjunctivitis in selected areas of Puducherry, South India, to assess the attack rate of conjunctivitis, identify factors associated with developing conjunctivitis and calculate household secondary attack rate (HSAR) of conjunctivitis and its correlates. Methodology: During December 2014, a community-based survey was conducted in a selected urban and rural area in Puducherry, South India. Simple random sampling was used to select primary sampling units and systematic sampling to select households. All individuals in the selected households were studied. A questionnaire was used to obtain data on sociodemographic characteristics, conjunctivitis during September-November, 2014, and number of household contacts who developed conjunctivitis within 7 days of index case. The attack rate and HSAR of conjunctivitis was expressed as percentage. Multivariate logistic regression was used to find factors independently associated with developing conjunctivitis and also 100% HSAR. Results: Of 3193 study participants from 772 households, 509 (15.9%, 95% confidence interval 14.7-17.2%) had an attack of conjunctivitis during the reference period. Of the 772 households, 218 (28.2%) had at least one case of conjunctivitis. Of 218 households, 33 (15.1%) households had 100% HSAR. Lower age, not being unemployed, low socioeconomic status, and residing in rural area were independently associated with developing conjunctivitis. Index case being male and living in a household with ≥5 members were independently associated with 100% HSAR. Conclusion: In the outbreak under study, more than one-fourth of households had at least one case of conjunctivitis and about one in every six individuals had an attack of conjunctivitis.