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\"The Useless Mouths\" and Other Literary Writings brings to English-language readers literary writings--several previously unknown--by Simone de Beauvoir. Culled from sources including various American university collections, the works span decades of Beauvoir's career. Ranging from dramatic works and literary theory to radio broadcasts, they collectively reveal fresh insights into Beauvoir's writing process, personal life, and the honing of her philosophy. The volume begins with a new translation of the 1945 play The Useless Mouths, written in Paris during the Nazi occupation. Other pieces were discovered after Beauvoir's death in 1986, such as the 1965 short novel \"Misunderstanding in Moscow,\" involving an elderly French couple who confront their fears of aging. Two additional previously unknown texts include the fragmentary \"Notes for a Novel,\" which contains the seed of what she later would call \"the problem of the Other,\" and a lecture on postwar French theater titled Existentialist Theater. The collection notably includes the eagerly awaited translation of Beauvoir's contribution to a 1965 debate among Jean-Paul Sartre and other French writers and intellectuals, \"What Can Literature Do?\" Prefaces to well-known works such as Bluebeard and Other Fairy Tales, La Bâtarde, and James Joyce in Paris: His Final Years are also available in English for the first time, alongside essays and other short articles. A landmark contribution to Beauvoir studies and French literary studies, the volume includes informative and engaging introductory essays by prominent and rising scholars. Contributors are Meryl Altman, Elizabeth Fallaize, Alison S. Fell, Sarah Gendron, Dennis A. Gilbert, Laura Hengehold, Eleanore Holveck, Terry Keefe, J. Debbie Mann, Frederick M. Morrison, Catherine Naji, Justine Sarrot, Liz Stanley, Ursula Tidd, and Veronique Zaytzeff

•We studied EEG brain states in disorders of consciousness and healthy controls using two independent datasets of resting-state and task-based data.•Brain states are remarkably similar after injury compared to those of healthy controls.•Brain state dynamics are more unstable in higher frequencies in DoC.•Anticorrelation between active states is lower in DoC patients in higher frequencies.•Using combined learning classification, we show that brain state dynamics could serve as biomarkers to assess consciousness levels in DoC. This multi-centric study aimed to explore differences in brain activity patterns in patients with disorders of consciousness (DoC), including unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS). Using high-density electroencephalographic (EEG) recordings from 368 DoC patients, 39 who emerged from MCS (eMCS), and 73 healthy controls, we examined instantaneous functional connectivity-based meta-states acting as attractors in a dynamical system, extracted by means of community detection algorithms and recurrence analysis. We analyzed data from two patient cohorts and included resting-state and auditory processing tasks in four frequency bands (delta, theta, alpha, beta) and from three perspectives, namely: (i) discrete activation of dominant states, (ii) a dynamical system composed of attractor states and (iii) the correlation and anticorrelation patterns of the active states. Findings revealed that while the overall structure of brain connectivity remained stable after injury, patients with DoC and those who emerged showed notable differences in the speed and consistency of how their brain states activated. Specifically, in higher frequencies, UWS patients exhibited faster, and less stable dynamics, shorter dwell times and decreased meta-state anticorrelation compared to those in MCS and eMCS. Moreover, a four-way combined learning classification analysis showed that the measures were able to distinguish the UWS and MCS subgroups. These brain state dynamics could serve as valuable markers for assessing states of consciousness. Our results highlight the potential of using high-temporal resolution dynamic brain activity patterns to improve the understanding of altered consciousness and their application to clinical settings.

OBJECTIVE: Many of the metabolic benefits of Roux-en-Y gastric bypass (RYGB) occur before weight loss. In this study we investigated the influence of caloric restriction on the improvements in the metabolic responses that occur within the 1st week after RYGB. RESEARCH METHODS AND DESIGN: A mixed meal was administered to nine subjects before and after RYGB (average 4 ± 0.5 days) and to nine matched, obese subjects before and after 4 days of the post-RYGB diet. RESULTS: Weight loss in both groups was minimal; the RYGB subjects lost 1.4 ± 5.3 kg (P = 0.46) vs. 2.2 ± 1.0 kg (P = 0.004) in the calorically restricted group. Insulin resistance (homeostasis model assessment of insulin resistance) improved with both RYGB (5.0 ± 3.1 to 3.3 ± 2.1; P = 0.03) and caloric restriction (4.8 ± 4.1 to 3.6 ± 4.1; P = 0.004). The insulin response to a mixed meal was blunted in both the RYGB and caloric restriction groups (113 ± 67 to 65 ± 33 and 85 ± 59 to 65 ± 56 nmol · l⁻¹ · min⁻¹, respectively; P < 0.05) without a change in the glucose response. Glucagon-like peptide 1 levels increased (9.2 ± 8.6 to 12.2 ± 5.5 pg · l⁻¹ · min⁻¹; P = 0.04) and peaked higher (45.2 ± 37.3 to 84.8 ± 33.0 pg/ml; P = 0.01) in response to a mixed meal after RYGB, but incretin responses were not altered after caloric restriction. CONCLUSIONS: These data suggest that an improvement in insulin resistance in the 1st week after RYGB is primarily due to caloric restriction, and the enhanced incretin response after RYGB does not improve postprandial glucose homeostasis during this time.

Public health endorsements during the present COVID-19 pandemic has led the governments of largely affected countries to imply policies that restrict social mobility to slow COVID-19 spread. The study aimed to explore the effects of COVID-19 home quarantine on lifestyle and health behavior of Saudi residents. An online survey in Saudi Arabia was launched from May 11 to June 6, 2020. The survey was designed by multidisciplinary scientists and academics uploaded and shared through the Google platform in Arabic and English languages. Questions presented related to responses “before” and “during” COVID-19 home quarantine. A total of 1965 respondents participated and were included in the analysis [921 (47.0%) males and 1044 (53.0%) females]. Non-Saudis were more likely to increase their physical activity during quarantine [odds ratio (95% confidence interval 1.41 (1.11–1.79); p  < 0.005]. Prevalence of participants walking daily for more than 4 times per week significantly decreased during pandemic (before vs during, 30.5% vs 29.1%) which was in parallel to the significant increase in the prevalence of participants who did not perform daily walking during the quarantine (21% vs 22.9%; p  < 0.001). The prevalence of participants who often consume snacks between meals increased during quarantine (27.4% vs 29.4%, p  < 0.001), while the prevalence of participants who never consumed fresh fruits and vegetables significantly increased during home quarantine (2.4% vs 3.7%; p  = 0.019). The lockdown imposed in Saudi Arabia modestly but significantly impacted physical activity and dietary behaviors of several citizens and residents in an unhealthy way. Interventions to alleviate these acute adverse lifestyle behaviors during pandemic should be formulated.

Social media networking is a prominent topic in real life, particularly at the current moment. The impact of comments has been investigated in several studies. Twitter, Facebook, and Instagram are just a few of the social media networks that are used to broadcast different news worldwide. In this paper, a comprehensive AI-based study is presented to automatically detect the Arabic text misogyny and sarcasm in binary and multiclass scenarios. The key of the proposed AI approach is to distinguish various topics of misogyny and sarcasm from Arabic tweets in social media networks. A comprehensive study is achieved for detecting both misogyny and sarcasm via adopting seven state-of-the-art NLP classifiers: ARABERT, PAC, LRC, RFC, LSVC, DTC, and KNNC. To fine tune, validate, and evaluate all of these techniques, two Arabic tweets datasets (i.e., misogyny and Abu Farah datasets) are used. For the experimental study, two scenarios are proposed for each case study (misogyny or sarcasm): binary and multiclass problems. For misogyny detection, the best accuracy is achieved using the AraBERT classifier with 91.0% for binary classification scenario and 89.0% for the multiclass scenario. For sarcasm detection, the best accuracy is achieved using the AraBERT as well with 88% for binary classification scenario and 77.0% for the multiclass scenario. The proposed method appears to be effective in detecting misogyny and sarcasm in social media platforms with suggesting AraBERT as a superior state-of-the-art deep learning classifier.

The gut-to-brain axis exhibits significant control over motivated behavior. However, mechanisms supporting this communication are poorly understood. We reveal that a gut-based bariatric surgery chronically elevates systemic bile acids and attenuates cocaine-induced elevations in accumbal dopamine. Notably, this surgery reduces reward-related behavior and psychomotor sensitization to cocaine. Utilizing a knockout mouse model, we have determined that a main mediator of these post-operative effects is the Takeda G protein-coupled bile acid receptor (TGR5). Viral restoration of TGR5 in the nucleus accumbens of TGR5 knockout animals is sufficient to restore cocaine reward, centrally localizing this TGR5-mediated modulation. These findings define TGR5 and bile acid signaling as pharmacological targets for the treatment of cocaine abuse and reveal a novel mechanism of gut-to-brain communication.

The use of redox-active organic molecules for aqueous electrochemical carbon dioxide capture is limited by their tendency to undergo reversible oxidation by oxygen. Here we show that a naphthoquinone derivative, when reduced in the presence of tetraalkylammonium countercations, displays enhanced stability toward oxygen while maintaining carbon dioxide binding ability. By combining structural modification with control of non-covalent interactions, we mitigate a previously observed trade-off between carbon dioxide capture performance and resistance to aerobic oxidation. In situ spectrophotometry and comparative voltammetry indicate that ion pairing stabilizes the reduced quinone both by shifting its redox potential and by promoting carbon dioxide adduct formation. Among the cations tested, tetraethylammonium provides the most favorable balance, supporting efficient capture and release cycle with 87 % Coulombic efficiency and an energy cost of 157 kilojoules per mole of carbon dioxide from a gas mixture containing carbon dioxide, oxygen, and nitrogen. These findings illustrate how molecular design combined with electrolyte engineering can improve the durability of aqueous quinone-based electrochemical carbon capture systems and may inform the development of more robust and energy-efficient approaches for sustainable carbon management. Quinone-based electrochemical systems can capture carbon dioxide but are limited by oxygen reactivity. Here, authors present a naphthoquinone and electrolyte design that improves oxygen tolerance while maintaining efficient carbon dioxide capture and concentration in aqueous flow cells.

Although epidemiological evidence suggests a human genetic basis of pulmonary tuberculosis (PTB) susceptibility, the identification of specific genes and alleles influencing PTB risk has proven to be difficult. Previous genome-wide association (GWA) studies have identified only three novel loci with modest effect sizes in sub-Saharan African and Russian populations. We performed a GWA study of 550,352 autosomal SNPs in a family-based discovery Moroccan sample (on the full population and on the subset with PTB diagnosis at <25 years), which identified 143 SNPs with p  < 1 × 10 −4 . The replication study in an independent case/control sample identified four SNPs displaying a p  < 0.01 implicating the same risk allele. In the combined sample including 556 PTB subjects and 650 controls these four SNPs showed suggestive association (2 × 10 −6  <  p  < 4  × 10 −5 ): rs358793 and rs17590261 were intergenic, while rs6786408 and rs916943 were located in introns of FOXP1 and AGMO , respectively. Both genes are involved in the function of macrophages, which are the site of latency and reactivation of Mycobacterium tuberculosis. The most significant finding ( p  = 2 × 10 −6 ) was obtained for the AGMO SNP in an early (<25 years) age-at-onset subset, confirming the importance of considering age-at-onset to decipher the genetic basis of PTB. Although only suggestive, these findings highlight several avenues for future research in the human genetics of PTB.